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Journal Articles

CPX-351 versus daunorubicin, cytarabine plus gemtuzumab ozogamicin in older adults with non-adverse risk AML: NCRI AML18

Open Access
Clinical Trials & Observations
Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S Hourigan, Georgia M Andrew, Richard James Dillon, Amanda Frances Gilkes, Nuria Marquez-Almuina, Sophie King, Nicholas McCarthy, Reem Bahr, Rasha W Al-Ali, Louisa Stone, Tom Coats, Jennifer L Byrne, Simone Green, Ulrik Malthe Overgaard, Rob S. Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood blood.2025031006.
https://doi.org/10.1182/blood.2025031006
Published: 2025
Includes: Supplemental data
Journal Articles

A multicenter, randomized, open-label study of dexamethasone versus romiplostim plus dexamethasone as first line treatment in patients with newly diagnosed immune thrombocytopenia: Interim results of rodex study

Free
Maria Eva Mingot, Monica Carpenedo, Mariana Canaro Hinryk, Roberto Trelles, Laura Entrena Ureña, Jose Ramon Gonzalez Porras, Maria Cristina Pascual Izquierdo, Maria Carmen Gomez del Castillo, Pedro Rosique Cortina, Cristina Santoro, Valerio De Stefano, Andrea Artoni, Nicola Vianelli, James Clark, Juana Clavel, Blanca Sánchez González, Michael Desborough, Catherine Bagot, David Valcarcel, María Teresa Álvarez Román, Maria Luisa Lozano Almela, Gillian Lowe, Clara Rosso Fernandez, Silvia Jimenez Jorge, Maria Angeles Lobo Acosta, Ian Thomas, Joanna Smith, Charlotte Bradbury
Journal: Blood
Blood (2025) 146 (Supplement 1): 733.
https://doi.org/10.1182/blood-2025-733
Published: 2025
Journal Articles

Outcomes of mecom rearranged AML undergoing intensive chemotherapy in the NCRI AML17 and AML19 trials.

Free
Mike Dennis, Jad Othman, Joanna Canham, Ian Thomas, Sean Johnson, Nick Telford, Beth Harrison, Jeyaprakash Ramachandran, James Cavenagh, Claire Arnold, Claus Marcher, Richard Kelly, Mhairi Copland, Alan Burnett, Richard Dillon, Nigel Russell
Journal: Blood
Blood (2025) 146 (Supplement 1): 3435.
https://doi.org/10.1182/blood-2025-3435
Published: 2025
Journal Articles

Randomized comparison of ponatinib versus imatinib in combination with chemotherapy in patients 55 years of age and older with newly diagnosed ph+ ALL: Molecular response and initial outcome analysis of the EWALL PH03 Study

Free
Oliver Ottmann, Tongtong Shi, Kimmo Porkka, Anna Lübking, Emmanuelle Clappier, Yosr Hicheri, Thibaut Leguay, Emilie Lemasle, Sarah Burns, Charlotte Letterme, Catharine Porter, Mia Sydenham, Ian Thomas, Jean-Michel Cayuela, Philippe Rousselot
Journal: Blood
Blood (2025) 146 (Supplement 1): 440.
https://doi.org/10.1182/blood-2025-440
Published: 2025
Journal Articles

Detection of KMT2A fusion transcripts after induction chemotherapy is strongly predictive of outcome in KMT2A rearranged AML: Results of an international collaborative study

Free
Jad Othman, Hsin-An Hou, Nicola Potter, Hannah Al-Yousuf, Pablo Prieto-Martinez, John Chadwick, Marzia Rahman, Sun Loo, Wen-Chien Chou, Yu-Sung Chang, Ing Tiong, Rea Grace Maamari, Hans Ommen, Robert Baker, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Raminta Batiuskaite, Tautvile Smalinskaite, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Gilkes, Alan Burnett, Andrius Zucenka, Pramila Krishnamurthy, Andrew Wei, Mike Dennis, Jenny O'Nions, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 346.
https://doi.org/10.1182/blood-2025-346
Published: 2025
Journal Articles

FLT3-ITD NGS-MRD refines risk stratification in NPM1 and FLT3 co-mutated AML beyond NPM1 PCR-MRD: Analysis of the UK NCRI AML17 and AML19 trials

Free
Aditya Tedjaseputra, Nicola Potter, Jelena Jovanovic, Adam Ivey, Manohursingh Runglall, William Villiers, Phoebe Aucken, Michael Lim, Thadsha Arumugam, Olivia Grimwade, Amanda Gilkes, Joanna Canham, Sean Johnson, Ian Thomas, Hans Ommen, Ulrik Overgaard, Ruth Spearing, Mike Dennis, Jenny O'Nions, Andrew King, Paul Cahalin, Priyanka Mehta, David Taussig, Ellen Solomon, Alan Burnett, Sylvie Freeman, Steve Knapper, Andrew Wei, Jad Othman, Nigel Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (Supplement 1): 345.
https://doi.org/10.1182/blood-2025-345
Published: 2025
Journal Articles

Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials

Free
Jesse Tettero, Sträng Eric, Sylvie Freeman, Richard Dillon, Jacqueline Cloos, Peter Valk, Konstanze Döhner, Michael Heuser, Christoph Röllig, Christian Thiede, Axel Benner, Luciana Carota, Daniele Dall'Olio, Ana Garcia, Alberto Hernandez Sanchez, Sean Johnson, Soren Lehmann, Javier Martinez Elicegui, Rabea Mecklenbrauck, Klaus Metzeler, Marta Sobas, Ian Thomas, Amin Turki, Laura Tur Gimenez, Brain Huntley, Nigel Russell, Jurjen Versluis, Hartmut Döhner, Jesus Maria Hernandez Rivas, Lars Bullinger, Gert J. Ossenkoppele
Journal: Blood
Blood (2025) 146 (Supplement 1): 343.
https://doi.org/10.1182/blood-2025-343
Published: 2025
Journal Articles

Diagnostic evaluation methods and prognostic impact of FLT3-ITD microclones in Acute Myeloid Leukemia (AML): A retrospective multicenter study on behalf of the EHA AML-specialized working group (SWG)

Free
Carmelo Gurnari, Tiziana Ottone, Alfonso Piciocchi, Daniela Späth, Annika Meid, Giovanni Marsili, Emiliano Fabiani, Francesca Romano, Maria Rosaria Pascale, Patrizia Chiusolo, Mauro Di Ianni, Marta Sobas, Lorenzo Brunetti, Guadalupe Oñate, Joana Brioso Infante, Jacopo Nanni, Calogero Vetro, Matilde Boada, Anna Candoni, Jorge Sierra, Nicola Potter, Amanda Gilkes, Sean Johnson, Ian Thomas, Brain Huntley, Nigel Russell, Richard Dillon, Hartmut Döhner, Konstanze Döhner, Maria Teresa Voso
Journal: Blood
Blood (2025) 146 (Supplement 1): 217.
https://doi.org/10.1182/blood-2025-217
Published: 2025
Journal Articles

Induction chemotherapy and molecular MRD influence outcomes in KMT2A -rearranged AML

Available to Purchase
Clinical Trials & Observations
Jad Othman, Nicola Potter, Sylvie D. Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Amanda Gilkes, Jamie Cavenagh, Panagiotis Kottaridis, David Taussig, Claire Arnold, Claire Hemmaway, Dominic Culligan, Ulrik Malthe Overgaard, Mike Dennis, Alan K. Burnett, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2025) 146 (15): 1862–1867.
https://doi.org/10.1182/blood.2025029556
Published: 2025
Includes: Supplemental data
Journal Articles

Acute promyelocytic leukemia: long-term outcomes from the HARMONY project

Available to Purchase
Clinical Trials & Observations
Maria Teresa Voso, Luca Guarnera, Söhren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Torsten Haferlach, Marco Vignetti, Edoardo La Sala, Alfonso Piciocchi, Paola Fazi, Angela Villaverde Ramiro, Laura Tur Giménez, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas
Journal: Blood
Blood (2025) 145 (2): 234–243.
https://doi.org/10.1182/blood.2024026186
Published: 2025
Includes: Supplemental data
Journal Articles

Genetic Diversity Drives Differing Morphological and Clinical Presentation and Survival in Myelodysplastic-Type CMML with a Low Absolute Monocyte Count

Free
Curtis A Lachowiez, Georgios Asimomitis, Elsa Bernard, Yanis Tazi, Maria Creignou, Ulrich Germing, Norbert Gattermann, Amanda Gilkes, Ian Thomas, Lars Bullinger, Konstanze Döhner, Luca Malcovati, Nigel H. Russell, Mario Cazzola, Hartmut Döhner, Brian J P Huntly, Robert P Hasserjian, Eva Hellstrom Lindberg, Sanam Loghavi, Elli Papaemmanuil
Journal: Blood
Blood (2024) 144 (Supplement 1): 1830.
https://doi.org/10.1182/blood-2024-209450
Published: 2024
Journal Articles

Impact of Cytogenetics, Induction Chemotherapy and MRD on Outcomes of Intensively Treated AML with KMT2A Rearrangements - Experience from UK NCRI AML17 and AML19

Free
Jad Othman, Nicola Potter, Sylvie D Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Jamie Cavenagh, Panagiotis Kottaridis, David Taussig, Claire Arnold, Claire Hemmaway, Dominic J. Culligan, Ulrik Malthe Overgaard, Alan K. Burnett, Mike Dennis, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 845.
https://doi.org/10.1182/blood-2024-201097
Published: 2024
Journal Articles

The Prognostic Impact of Myelodysplasia-Related Gene Mutations in Acute Myeloid Leukemia with FLT3 -ITD Mutations

Free
Rabea Mecklenbrauck, Angela Villaverde Ramiro, Eric Sträng, Razif Gabdoulline, Javier Martínez Elicegui, Marta Sobas, Lisa Pleyer, Maria Teresa Voso, Axel Benner, Alberto Hernández Sánchez, Jesse M. Tettero, Laura Tur, Klaus H Metzeler, Guadalupe Onate, Soren Lehmann, Brian J P Huntly, Ian Thomas, Felicitas R Thol, Florian Heidel, Peter J. M. Valk, Konstanze Döhner, Torsten Haferlach, Ken I Mills, Hartmut Döhner, Gastone Castellani, Gert Ossenkoppele, Jesus Maria Hernandez Rivas, Lars Bullinger, Michael Heuser
Journal: Blood
Blood (2024) 144 (Supplement 1): 844.
https://doi.org/10.1182/blood-2024-202362
Published: 2024
Journal Articles

A Randomized Comparison of CPX-351 and FLAG-Ida in Patients with High-Risk Acute Myeloid Leukemia (AML)/Myelodysplastic Syndrome (MDS) and MDS-Related Gene Mutations: A Subgroup Analysis of the UK NCRI AML19 Trial

Free
Priyanka Mehta, Roderick Murphy, Saemi Park, Nalina Dronamraju, Tony Wagner, Yana Lutska, Stefan Faderl, Ian Thomas, Joanna Canham, Alex Legg
Journal: Blood
Blood (2024) 144 (Supplement 1): 55.
https://doi.org/10.1182/blood-2024-207094
Published: 2024
Journal Articles

Gemtuzumab Based Induction Chemotherapy Combined with Midostaurin for FLT3 Mutated Patients. Results from the Patient- Reported Outcome Measures from the NCRI AML19V2 ‘Midotarg Pilot‘

Free
Joanna Canham, Ian Thomas, Nigel H. Russell, Jane Leahy, Abin Thomas, Steve Knapper, Lucy Marsh, Huda Mohamed, Sean Johnson
Journal: Blood
Blood (2024) 144 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2024-205133
Published: 2024
Journal Articles

A Randomised Comparison of CPX-351 Versus Standard Daunorubicin and Cytarabine Plus Fractionated Gemtuzumab Ozogamicin in Older Adults with AML without Adverse Risk Cytogenetics: Results of the NCRI AML18 Trial

Free
Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S. Hourigan, Georgia Andrew, Richard Dillon, Amanda Gilkes, Nuria M Almuina, Sophie King, Thomas Coats, Nicholas McCarthy, Jennifer Byrne, Simone Green, Ulrik Malthe Overgaard, Leanne Berkahn, Louisa Stone, Rasha W Al-Ali, Reem Bahr, Rob Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 59.
https://doi.org/10.1182/blood-2024-200027
Published: 2024
Journal Articles

Profiling Baseline Health-Related Quality of Life of Patients with Newly Diagnosed Myeloid Malignancies: A Pooled Analysis of 3349 Patients with AML, APL and MDS from the International Proactive Project

Free
Fabio Efficace, Adriano Venditti, Thomas Baldi, Joanna Canham, Giovanni Martinelli, Alfonso Piciocchi, Mike Dennis, Steve Knapper, Nigel H. Russell, Sean Johnson, Maria Teresa Voso, Marco Vignetti, Ian Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 407.
https://doi.org/10.1182/blood-2024-204588
Published: 2024
Journal Articles

Patient-Reported Outcomes in Older Acute Myeloid Leukemia Patients Fit for Intensive Treatment, Who Received Intensified Treatment (DA +/- cladribine) Following No Evidence of Response to Course 1: Results from the NCRI AML18 Trial

Free
Ian Thomas, Joanna Canham, Sean Johnson, Nuria Marquez, Sophie King, Jane Leahy, Mike Dennis, Nigel H. Russell, Abin Thomas, Steven Knapper
Journal: Blood
Blood (2024) 144 (Supplement 1): 3805.
https://doi.org/10.1182/blood-2024-198870
Published: 2024
Journal Articles

Molecular, clinical, and therapeutic determinants of outcome in NPM1 -mutated AML

Free
Clinical Trials & Observations
Jad Othman, Nicola Potter, Adam Ivey, Yanis Tazi, Elli Papaemmanuil, Jelena Jovanovic, Sylvie D. Freeman, Amanda Gilkes, Rosemary Gale, Tanya Rapoz-D’Silva, Manohursingh Runglall, Michelle Kleeman, Pawan Dhami, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Brian Huntly, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2024) 144 (7): 714–728.
https://doi.org/10.1182/blood.2024024310
Published: 2024
Includes: Supplemental data
Journal Articles

Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission

Free
Clinical Trials & Observations Brief Report
Jad Othman, Nicola Potter, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Sylvie D. Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 143 (19): 1931–1936.
https://doi.org/10.1182/blood.2023023096
Published: 2024
Includes: Supplemental data