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Pramila Krishnamurthy
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Journal Articles

Clonal Haematopoiesis with TP53 Mutations Exhibits Abnormal Erythropoiesis and Erythroid Metabolic Stress

Xuesen Zheng, Prodromos Chatzikyriakou, Louis-Francois Handfield, Maroof Hasan, Diego A. Pereira-Martins, Sarah J Mackie, Maria del Pilar Casares Alaez, Isabel Weinhäuser, Nogayhan Seymen, Kai Yi Mok, Viktorija Uksaite, Marta Rzepkowska, Laarni Bogaanay, Matthew Sadler, Jovan Mircetic, Martin Bornhäuser, James Carmichael, Daniel Bromage, Pramila Krishnamurthy, Rajasekhar N.V.S. Suragani, Ghulam Mufti, Giorgio Napolitani, Anita K. Gandhi, Lynn Quek
Journal: Blood
Blood (2024) 144 (Supplement 1): 944.
https://doi.org/10.1182/blood-2024-200108
Published: 2024
Journal Articles

Role of Cidofovir in the Treatment of BK Virus Haemorrhagic Cystitis in Patients Undergoing T- Cell Deplete Stem Cell Transplant and Cellular Therapies

Shreyas Hanmantgad, Samitha Fernando, Mark Zuckerman, Pamella Paul, Yahya Almohmeed, Mili Shah, Pramila Krishnamurthy, Daniele Avenoso, Antonio Pagliuca, Austin G. Kulasekararaj, Victoria Potter, Varun Mehra
Journal: Blood
Blood (2024) 144 (Supplement 1): 7293.
https://doi.org/10.1182/blood-2024-208440
Published: 2024
Journal Articles

Prospective Cohort Study of Non-COVID Infection in Patients with AML/MDS Undergoing Treatment: Implications for Practice

Justin CT Loke, Charlotte Gaskell, Emily Yafai, Sonia Fox, Catherine Thomas, Louise Hopkins, Rebecca Boucher, Rebecca Collings, Steve Knapper, Anjum Khan, Jane Nunnick, Katie Randall, Jenny O'Nions, Tom Rider, Arpad Toth, Mary Frances McMullin, Sally Moore, Victoria Drew, Farooq Ahmad Wandroo, Pratap Neelakantan, Pramila Krishnamurthy, Charles Craddock, Sylvia Rofael, Vinit Upsani, David M Lowe, Simon J Stanworth
Journal: Blood
Blood (2024) 144 (Supplement 1): 120.
https://doi.org/10.1182/blood-2024-200732
Published: 2024
Journal Articles

A Dedicated System Accounting for Specific Germline/Somatic Genomic Constellations Is Essential to Predict Outcomes in DDX41 -Mutant Myeloid Neoplasia

Carmelo Gurnari, Hideki Makishima, Arda Durmaz, Enrico Attardi, Ryunosuke Saiki, Alex Bataller, Guilherme Mendes Sapinho, Lukasz P. Gondek, Yasuhito Nannya, Steve Best, Pramila Krishnamurthy, Kar Lok Kong, Yoshiko Atsuta, Senji Kasahara, Kazuma Ohyashiki, Yasushi Miyazaki, Nobuhiro Kanemura, Nobuhiro Hiramoto, Hussein Awada, Valeria Visconte, Courtney D. DiNardo, Maria Teresa Voso, Amy E. DeZern, Guillermo Garcia-Manero, Austin G. Kulasekararaj, Jaroslaw Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1332.
https://doi.org/10.1182/blood-2024-194024
Published: 2024
Journal Articles

Real-World Treatment Patterns and Outcomes with Oral Azacitidine Maintenance Therapy in Patients with Acute Myeloid Leukemia

Pramila Krishnamurthy, Katherine Houghton, Nicola Lorenz, Paula Williams, Lisa Currie, Carlos E. Vigil, Nomthandazo Ziba, Fareedat Bello, Jan Sieluk, Maria Strocchia, Yeran Li, Silke Kapp-Schwoerer
Journal: Blood
Blood (2024) 144 (Supplement 1): 2425.
https://doi.org/10.1182/blood-2024-198362
Published: 2024
Journal Articles

Molecular MRD is strongly prognostic in patients with NPM1 -mutated AML receiving venetoclax-based nonintensive therapy

Clinical Trials & Observations Brief Report
Jad Othman, Ing S. Tiong, Jenny O'Nions, Mike Dennis, Katya Mokretar, Adam Ivey, Michael Austin, Anne-Louise Latif, Mariam Amer, Wei Yee Chan, Charles Crawley, Francesca Crolla, Joe Cross, Ray Dang, Johnathon Elliot, Chun Y. Fong, Sofia Galli, Paolo Gallipoli, Francesca Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Sun Loo, Scott Marshall, Priyanka Mehta, Vidhya Murthy, Sateesh Nagumantry, Srinivas Pillai, Nicola Potter, Rob Sellar, Tom Taylor, Rui Zhao, Nigel H. Russell, Andrew H. Wei, Richard Dillon
Journal: Blood
Blood (2024) 143 (4): 336–341.
https://doi.org/10.1182/blood.2023021579
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of Somatic Second Hit and Comutations in Myeloid Neoplasms with Germline DDX41 Mutations

Guilherme Mendes Sapinho, Pramila Krishnamurthy, Guy Hannah, Shreyans Gandhi, Victoria Potter, Mili Shah, Nicholas Lea, Clair Engelbrecht, Heidre Bezuidenhout, Katie Snape, Steve Best, Austin Kulasekararaj
Journal: Blood
Blood (2023) 142 (Supplement 1): 6446.
https://doi.org/10.1182/blood-2023-189451
Published: 2023
Journal Articles

Real-World Mobilization, Harvest, and Transplant Outcomes in Newly Diagnosed Multiple Myeloma Patients Receiving D-VTd: A UK Centre Experience

Christianne Bourlon, Katharine Elizabeth Bailey, Reuben Benjamin, Kirsty Cuthill, Arief Gunawan, Majid Kazmi, Pramila Krishnamurthy, Victoria Potter, Robin Sanderson, Michelle Kenyon, Mili Shah, Matthew Streetly, Fabio Serpenti, Stella J. Bowcock, Lalita Banerjee, John Robert Jones, Sabia Rashid, Ana Isabel Duran Maestre, Satyajit Sahu, Sudarshan Gurung, Lianwea Chia, Haili Cui, Alison Pratt, Maheen Ahsan, Stella Bouziana
Journal: Blood
Blood (2023) 142 (Supplement 1): 4971.
https://doi.org/10.1182/blood-2023-177624
Published: 2023
Journal Articles

Outcome Prediction in DDX41 -Mutant Myelodysplastic Syndromes Is Not Possible with General Disease Schemes and Requires a Dedicated Risk Scoring System

Carmelo Gurnari, Hideki Makishima, Arda Durmaz, Ryunosuke Saiki, Guilherme Mendes Sapinho, Alex Bataller, Lukasz P. Gondek, Yasuhito Nannya, Steve Best, Pramila Krishnamurthy, Hussein Awada, Enrico Attardi, Valeria Visconte, Maria Teresa Voso, Amy E. DeZern, Guillermo Garcia-Manero, Austin Kulasekararaj, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 316.
https://doi.org/10.1182/blood-2023-178116
Published: 2023
Journal Articles

Double, double, TP53, and trouble in myelofibrosis

Pramila Krishnamurthy
Journal: Blood
Blood (2023) 141 (23): 2793–2795.
https://doi.org/10.1182/blood.2023020421
Published: 2023
Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2023) 141 (5): 534–549.
https://doi.org/10.1182/blood.2022018221
Published: 2023
Includes: Supplemental data
Journal Articles

Molecular MRD Assessment Is Strongly Prognostic in Patients with NPM1 Mutated AML Receiving Venetoclax Based Non-Intensive Therapy

Jad Othman, Ing S Tiong, Katya Mokretar, Adam Ivey, Michael James Austin, Anne-Louise Latif, Charles Crawley, Mariam Amer, Francesca Crolla, Joe W Cross, Raymond Dang, Chun Yew Fong, Sofia Galli, Paolo Gallipoli, Francesca L Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Scott R. Marshall, Vidhya Murthy, Sateesh K. Nagumantry, Srinivas Pillai, Nicola Potter, Tom Taylor, Rui Zhao, Andrew H Wei, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 2033–2035.
https://doi.org/10.1182/blood-2022-159467
Published: 2022
Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 208–210.
https://doi.org/10.1182/blood-2022-158851
Published: 2022
Journal Articles

Venetoclax-Based Non-Intensive Combinations Successfully Salvage Molecular Relapse of Acute Myeloid Leukemia and Are an Important Bridge to Cellular Therapy in Relapsed/Refractory Disease - Real-World Data from a UK-Wide Programme

Henry Wood, Christianne Bourlon, Austin Kulasekararaj, Albert Borg, Jiri Pavlu, Patrick Elder, David C Taussig, Scott Veitch, Steven Knapper, Jad Othman, Richard Dillon, James Aries, Emily Mitchell, Faisal Basheer, Steven Leak, Vidhya Murthy, Joe W Cross, Priyanka Mehta, Manish Jain, Anjum Khan, Ho Lam, Sarah Leong, Jenny O'Nions, Charles Craddock, Victoria Potter, Mhairi Copland, Pramila Krishnamurthy
Journal: Blood
Blood (2022) 140 (Supplement 1): 9016–9018.
https://doi.org/10.1182/blood-2022-167097
Published: 2022
Journal Articles

High Molecular Response Rate and Overall Survival with FLT3 Inhibitors As MRD-Guided Salvage Treatment for Molecular Failure in AML

Jad Othman, Nicola Potter, Katya Mokretar, David Taussig, Anjum Khan, Pramila Krishnamurthy, Anne-Louise Latif, Paul Cahalin, James Aries, Mariam Amer, Edward Belsham, Eibhlin Conneally, Charles Craddock, Dominic Culligan, Mike Dennis, Caroline Duncan, Caroline Furness, Paraskevi Gkreka, Katherine Hodgson, Wendy Ingram, Andrew King, Panagiotis Kottaridis, Mary Frances McMullin, Unmesh Mohite, Loretta Ngu, Katharine Patrick, Tom Rider, Wing Roberts, Marianne Tang Severinsen, Neill Storrar, Tom Taylor, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 2002–2004.
https://doi.org/10.1182/blood-2022-159503
Published: 2022
Journal Articles

Post-Transplant MRD Status and T Cell Chimerism Predict Outcomes in Patients Allografted for AML/MDS-a Prospective Analysis from the UK NCRI Figaro Trial

(Justin) Ching Ting Loke, Nicholas McCarthy, Aimee E Jackson, Shamyla Siddique, Andrea Hodgkinson, John Mason, Charles Crawley, Maria H Gilleece, Andy Peniket, Rachel Elizabeth Protheroe, Rahuman Salim, Eleni Tholouli, Keith Wilson, Georgia M. Andrew, Richard Dillon, Naeem Khan, Victoria Potter, Pramila Krishnamurthy, Charles Craddock, Sylvie D Freeman
Journal: Blood
Blood (2021) 138 (Supplement 1): 415.
https://doi.org/10.1182/blood-2021-149269
Published: 2021
Journal Articles

Venetoclax with Azacitidine or Low Dose Cytarabine As an Alternative to Intensive Chemotherapy in Fit Adults during the COVID19 Pandemic: Real World Data from the UK National Health Service

Jad Othman, Mariam Amer, Ruebina Amofa, Laura Anderson, Michael J Austin, Alex Bashford, Edward Belsham, Jesca Boot, Victoria Louise Campbell, Thomas Coats, Angela Collins, Charles Crawley, Francesca Crolla, Joe W Cross, Chris Dalley, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliott, Sofia Galli, Paolo Gallipoli, Katherine Hodgson, Manish Jain, Pallavi Kalkur, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, Eleana Loizou, Justin Loke, Deepak Mannari, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Vidhya Murthy, Odong Ochaya, Shahzad Orthi, Renuka Palanicawandar, Srinivas Pillai, Dominika Radzova, Adam Rye, Jamie Saunders, Matthew Smith, David Taussig, Tom Taylor, Richard Whitmill, Rui Zhao, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 2321.
https://doi.org/10.1182/blood-2021-149685
Published: 2021
Journal Articles

Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health Service

Jad Othman, Usman Afzal, Ruebina Amofa, Michael J Austin, Alex Bashford, Edward Belsham, Jennifer Byrne, Thomas Coats, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliot, Sebastian Francis, Paolo Gallipoli, Katherine Hodgson, Charlotte Kallmeyer, Manish Jain, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Seye Kolade, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, (Justin) Ching Ting Loke, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Sreetharan Munisamy, Duncan Murray, Vidhya Murthy, Renuka Palanicawandar, Jamie Saunders, Matthew Smith, Katherine Smith, Alex Sternberg, David Taussig, Tom Taylor, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 1254.
https://doi.org/10.1182/blood-2021-150169
Published: 2021
Journal Articles

Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration Program

(Justin) Ching Ting Loke, Charlotte Gaskell, Sonia Fox, Rachel Fletcher, Catherine Thomas, Louise Hopkins, Anita Kumari, Rebecca H. Boucher, Jane Nunnick, Steve Knapper, Arpad Toth, Jennifer Byrne, Jenny O'Nions, Anjum Khan, Rui Zhao, Arvind Pillai, Eleni Tholouli, Moez Dungarwalla, Katie Randall, Richard Dillon, Duncan Murray, Dominic Culligan, Mary Frances McMullin, Yuen Ling Tracey Chan, Victoria Drew, Vidhya Murthy, Pramila Krishnamurthy, Pratap Neelakantan, Tom Rider, Farooq A Wandroo, Mark Rafferty, Ya-Wen Huang, Sally Moore, Priyanka Mehta, David G Partridge, Charles Craddock, David Lowe, Simon J. Stanworth
Journal: Blood
Blood (2021) 138 (Supplement 1): 1942.
https://doi.org/10.1182/blood-2021-146061
Published: 2021
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data