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Journal Articles

The UK Impact Transplant Trials Network: An Effective National Strategy to Accelerate the Delivery of Randomized Trials in Stem Cell Transplantation

Charles Craddock, David Marks, Victoria Potter, Wendy A Ingram, Rebecca Collings, Eleni Tholouli, Rachel Protheroe, Hugh Allen, Alex Ross, Dawn Farrar, Shamyla Siddique, Rebecca Bishop, Ronjon Chakraverty
Journal: Blood
Blood (2023) 142 (Supplement 1): 5097.
https://doi.org/10.1182/blood-2023-188490
Published: 2023
Journal Articles

Validation of the Transplant Conditioning Intensity (TCI) Score for Allogeneic Hematopoietic Cell Transplantation

Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl, Arnold Ganser, Matthias Stelljes, Charles Craddock, Eva Maria Wagner, Jurjen Versluis, Thomas Schroeder, Igor Wolfgang Blau, Gerald Wulf, Peter Dreger, Gitte Olesen, Henrik Sengeloev, Nicolaus Kröger, Victoria Potter, Edouard Forcade, Jakob Passweg, Régis Peffault de Latour, Johan Maertens, Keith Wilson, Jean-Henri Bourhis, Bipin Savani, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 2389–2391.
https://doi.org/10.1182/blood-2022-157890
Published: 2022
Journal Articles

Artificial Intelligence Methods to Estimate Overall Mortality and Non-Relapse Mortality Following Allogeneic Hematopoietic Cell Transplantation in the Modern Era: An EBMT Transplant Complications Working Party Study

Blanca Rius Sansalvador, Alberto Mussetti, Victor Moreno, Christophe Peczynski, Emmanuelle Polge, Nicolaus Kröger, Didier Blaise, Régis Peffault de Latour, Alexander D. Kulagin, Ashrafsadat Mousavi, Matthias Stelljes, Rose-Marie Hamladji, Martin Bornhäuser, Urpu Salmenniemi, Henrik Sengeloev, Edouard Forcade, Uwe Platzbecker, Péter Reményi, Emanuele Angelucci, Patrice Chevallier, Ibrahim Yakoub-Agha, Charles Craddock, Fabio Ciceri, Thomas Schroeder, Mahmoud Aljurf, Ivan Moiseev, Olaf Penack, Helene Schoemans, Mohamad Mohty, Bertram Glass, Anna Sureda, Grzegorz W Basak, Zinaida Peric
Journal: Blood
Blood (2022) 140 (Supplement 1): 7734–7737.
https://doi.org/10.1182/blood-2022-168601
Published: 2022
Journal Articles

Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Jesus Duque Afonso, Jürgen Finke, Maud Ngoya, Jacques-Emmanuel Galimard, Charles Craddock, Kavita Raj, Adrian Bloor, Emma Nicholson, Matthias Eder, Kim H. Orchard, Thomas Valerius, John A. Snowden, Eleni Tholouli, Charles Crawley, Matthew P. Collin, Keith Wilson, Alain Gadisseur, Rachel Elizabeth Protheroe, Eva Maria Wagner, Bipin Savani, Alexandros Spyridonidis, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 2110–2112.
https://doi.org/10.1182/blood-2022-162277
Published: 2022
Journal Articles

Siremadlin Monotherapy and in Combination with Donor Lymphocyte Infusion for Patients with Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation Who Are in Complete Remission but at High Risk for Relapse

Robert Zeiser, Christoph Schmid, Gheath Alatrash, Ron Ram, Yuan Wu, Hans-Jochen Jochen Weber, Stephanie Grzesiak, Lamis K. Eldjerou, Charles Craddock
Journal: Blood
Blood (2022) 140 (Supplement 1): 8944–8945.
https://doi.org/10.1182/blood-2022-167011
Published: 2022
Journal Articles

Venetoclax-Based Non-Intensive Combinations Successfully Salvage Molecular Relapse of Acute Myeloid Leukemia and Are an Important Bridge to Cellular Therapy in Relapsed/Refractory Disease - Real-World Data from a UK-Wide Programme

Henry Wood, Christianne Bourlon, Austin Kulasekararaj, Albert Borg, Jiri Pavlu, Patrick Elder, David C Taussig, Scott Veitch, Steven Knapper, Jad Othman, Richard Dillon, James Aries, Emily Mitchell, Faisal Basheer, Steven Leak, Vidhya Murthy, Joe W Cross, Priyanka Mehta, Manish Jain, Anjum Khan, Ho Lam, Sarah Leong, Jenny O'Nions, Charles Craddock, Victoria Potter, Mhairi Copland, Pramila Krishnamurthy
Journal: Blood
Blood (2022) 140 (Supplement 1): 9016–9018.
https://doi.org/10.1182/blood-2022-167097
Published: 2022
Journal Articles

Improved Post-Transplant Outcomes in Recent Years for AML Patients with Intermediate Karyotype, FLT3 -ITD and Wild Type NPM1 : A Report from the EBMT Acute Leukemia Working Party

Ali Bazarbachi, Myriam Labopin, Tobias Gedde-Dahl, Péter Reményi, Edouard Forcade, Nicolaus Kröger, Gerard Socie, Charles Craddock, Jean-Henri Bourhis, Jurjen Versluis, Ibrahim Yakoub-Agha, Urpu Salmenniemi, Jean Elcheikh, Gesine Bug, Jordi Esteve, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 4897–4898.
https://doi.org/10.1182/blood-2022-165069
Published: 2022
Journal Articles

High Molecular Response Rate and Overall Survival with FLT3 Inhibitors As MRD-Guided Salvage Treatment for Molecular Failure in AML

Jad Othman, Nicola Potter, Katya Mokretar, David Taussig, Anjum Khan, Pramila Krishnamurthy, Anne-Louise Latif, Paul Cahalin, James Aries, Mariam Amer, Edward Belsham, Eibhlin Conneally, Charles Craddock, Dominic Culligan, Mike Dennis, Caroline Duncan, Caroline Furness, Paraskevi Gkreka, Katherine Hodgson, Wendy Ingram, Andrew King, Panagiotis Kottaridis, Mary Frances McMullin, Unmesh Mohite, Loretta Ngu, Katharine Patrick, Tom Rider, Wing Roberts, Marianne Tang Severinsen, Neill Storrar, Tom Taylor, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 2002–2004.
https://doi.org/10.1182/blood-2022-159503
Published: 2022
Journal Articles

Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

Hartmut Döhner, Andrew H. Wei, Frederick R. Appelbaum, Charles Craddock, Courtney D. DiNardo, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Bob Löwenberg
Journal: Blood
Blood (2022) 140 (12): 1345–1377.
https://doi.org/10.1182/blood.2022016867
Published: 2022
Journal Articles

Siremadlin (HDM201) Is Well Tolerated and Demonstrates Clinical Activity in Patients with Acute Myeloid Leukemia Who Have Relapsed after Allogeneic Stem Cell Transplantation: A Subset Analysis of Safety and Preliminary Efficacy

Eytan M. Stein, Jörg Chromik, Cecilia Carpio, Rogier Mous, Jean-Jacques Kiladjian, Gheath Alatrash, Antonio Curti, Charles Craddock, Christoph Schmid, Robert Zeiser, Lamis K. Eldjerou, Hans-Jochen Jochen Weber, Claire Fabre, Jeffrey Scott, Daniel J. DeAngelo
Journal: Blood
Blood (2021) 138 (Supplement 1): 3417.
https://doi.org/10.1182/blood-2021-149751
Published: 2021
Journal Articles

Venetoclax with Azacitidine or Low Dose Cytarabine As an Alternative to Intensive Chemotherapy in Fit Adults during the COVID19 Pandemic: Real World Data from the UK National Health Service

Jad Othman, Mariam Amer, Ruebina Amofa, Laura Anderson, Michael J Austin, Alex Bashford, Edward Belsham, Jesca Boot, Victoria Louise Campbell, Thomas Coats, Angela Collins, Charles Crawley, Francesca Crolla, Joe W Cross, Chris Dalley, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliott, Sofia Galli, Paolo Gallipoli, Katherine Hodgson, Manish Jain, Pallavi Kalkur, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, Eleana Loizou, Justin Loke, Deepak Mannari, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Vidhya Murthy, Odong Ochaya, Shahzad Orthi, Renuka Palanicawandar, Srinivas Pillai, Dominika Radzova, Adam Rye, Jamie Saunders, Matthew Smith, David Taussig, Tom Taylor, Richard Whitmill, Rui Zhao, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 2321.
https://doi.org/10.1182/blood-2021-149685
Published: 2021
Journal Articles

Low Incidence of COVID-19 Infection in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity/Venetoclax Based Treatment: Initial Results of the PACE Prospective Clinical Study from the UK Trials Acceleration Program

(Justin) Ching Ting Loke, Charlotte Gaskell, Sonia Fox, Rachel Fletcher, Catherine Thomas, Louise Hopkins, Anita Kumari, Rebecca H. Boucher, Jane Nunnick, Steve Knapper, Arpad Toth, Jennifer Byrne, Jenny O'Nions, Anjum Khan, Rui Zhao, Arvind Pillai, Eleni Tholouli, Moez Dungarwalla, Katie Randall, Richard Dillon, Duncan Murray, Dominic Culligan, Mary Frances McMullin, Yuen Ling Tracey Chan, Victoria Drew, Vidhya Murthy, Pramila Krishnamurthy, Pratap Neelakantan, Tom Rider, Farooq A Wandroo, Mark Rafferty, Ya-Wen Huang, Sally Moore, Priyanka Mehta, David G Partridge, Charles Craddock, David Lowe, Simon J. Stanworth
Journal: Blood
Blood (2021) 138 (Supplement 1): 1942.
https://doi.org/10.1182/blood-2021-146061
Published: 2021
Journal Articles

Post-Transplant MRD Status and T Cell Chimerism Predict Outcomes in Patients Allografted for AML/MDS-a Prospective Analysis from the UK NCRI Figaro Trial

(Justin) Ching Ting Loke, Nicholas McCarthy, Aimee E Jackson, Shamyla Siddique, Andrea Hodgkinson, John Mason, Charles Crawley, Maria H Gilleece, Andy Peniket, Rachel Elizabeth Protheroe, Rahuman Salim, Eleni Tholouli, Keith Wilson, Georgia M. Andrew, Richard Dillon, Naeem Khan, Victoria Potter, Pramila Krishnamurthy, Charles Craddock, Sylvie D Freeman
Journal: Blood
Blood (2021) 138 (Supplement 1): 415.
https://doi.org/10.1182/blood-2021-149269
Published: 2021
Journal Articles

Ponatinib in Combination with FLAG-IDA Chemotherapy for Blast-Phase Chronic Myeloid Leukemia: Final Results of the Seamless Phase I/II Dose-Finding UK Trials Acceleration Programme (TAP) Matchpoint Trial

Mhairi Copland, Daniel Slade, Graham McIlroy, Gillian Horne, Jennifer Byrne, Kate Rothwell, Kristian Brock, Hugues De Lavallade, Charles Craddock, Richard Clark, Matthew Smith, Rachel Fletcher, Rebecca Bishop, Dragana Milojkovic, Christina Yap
Journal: Blood
Blood (2021) 138 (Supplement 1): 312.
https://doi.org/10.1182/blood-2021-147972
Published: 2021
Journal Articles

Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health Service

Jad Othman, Usman Afzal, Ruebina Amofa, Michael J Austin, Alex Bashford, Edward Belsham, Jennifer Byrne, Thomas Coats, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliot, Sebastian Francis, Paolo Gallipoli, Katherine Hodgson, Charlotte Kallmeyer, Manish Jain, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Seye Kolade, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, (Justin) Ching Ting Loke, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Sreetharan Munisamy, Duncan Murray, Vidhya Murthy, Renuka Palanicawandar, Jamie Saunders, Matthew Smith, Katherine Smith, Alex Sternberg, David Taussig, Tom Taylor, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 1254.
https://doi.org/10.1182/blood-2021-150169
Published: 2021
Journal Articles

COVID-19 Infection of HSCT Recipients Is Associated with High Mortality but No Detectable Cytokine Storm at Presentation

Giovanna Lucchini, Elena Cozma, Aimee Jackson, Kimberly Gilmour, Rachel Elizabeth Protheroe, Eleni Tholouli, Robert F Wynn, Keith Wilson, Karl S Peggs, Victoria Potter, Anne Parker, Charles Craddock, Shankara Paneesha, Emma Nicholson, David I. Marks, Oana Mirci-Danicar, Christopher Parrish, Alexander M Martin, Graham McIlroy, Rebecca Bishop, Rebecca Collings, Ellie Williams, Persis J Amrolia
Journal: Blood
Blood (2021) 138 (Supplement 1): 1788.
https://doi.org/10.1182/blood-2021-146515
Published: 2021
Journal Articles

Transplant Outcomes in Patients with Ph+ Chronic Myeloid Leukemia: Haploidentical Donors Compared to Matched Sibling Donors and Matched/Mismatched Unrelated Donors: A Retrospective Analysis from the EBMT Chronic Malignancies Working Party (EBMT-CMWP)

Francesco Onida, Ge Junran, Linda Koster, Rose-Marie Hamladji, Jennifer Byrne, Victoria Potter, Mahmoud Aljurf, Marie Robin, Kazimierz Halaburda, Jakob R. Passweg, Urpu Salmenniemi, Henrik Sengeloev, Jane F Apperley, Andrew Clark, Péter Reményi, Elena V. Morozova, Charles Craddock, Stig Lenhoff, Arnold Ganser, Ka Lung Wu, Antonio Perez Martinez, Patrick John Hayden, Luuk Gras, Sr., Yves Chalandon, Ibrahim Yakoub-Agha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3959.
https://doi.org/10.1182/blood-2021-146366
Published: 2021
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

The Sequential Flamsa-Bu Conditioning Regimen Does Not Improve Outcome in Patients Allografted for High Risk Acute Myeloid and Myelodysplasia Irrespective of Pre-Transplant MRD Status: Results of the UK NCRI Figaro Trial

Charles Craddock, FRCP, FRCPath, Aimee E Jackson, MSc, Ram K Malladi, FRCPath, Maria H Gilleece, MD FRCPath, MB, BSc, FRCP, Andy Peniket, MD, Rahuman Salim, MRCP, FRCPath, Eleni Tholouli, MD PhD, Victoria Potter, MD PhD, Charles R Crawley, Rachel Elizabeth Protheroe, FRCPath,PhDMBBS,FRCP, Anne Parker, MD FRCP, BSc, FRCPath, Keith Wilson, FRCPath, MRCP, MBBS, Jiri Pavlu, MDMRCP,FRCPath, Sandeep Nagra, MBChB, Shamyla Siddique, BSc.(Hons.), MPhil, Andrea Hodgkinson, BSc(Hons),PhD, John Mason, Keith Wheatley, DPhil, Nigel H. Russell, MD, Sylvie D. Freeman, MBChB, DPhil
Journal: Blood
Blood (2019) 134 (Supplement_1): 2031.
https://doi.org/10.1182/blood-2019-125646
Published: 2019
Journal Articles

Low Numbers of CD27 - IgD - 'Double Negative' Senescent B-Cells Early after Reduced Intensity T Cell Depleted Haematopoietic Stem Cell Transplantation Are Predictive of Subsequent Chronic GvHD

Francesca Kinsella, PhD MRCP, FRCPath, Harriet Protheroe, MBChB BSc, Hayden Pearce, BSc. (Hons.), PhD, Charlotte F Inman, BVSc, PhD, Suzy A Eldershaw, BSc. (Hons.), PhD, Joanne Croudace, PhD, Ben E Abbotts, BSc. (Hons.), MSc., Jianmin Zuo, PhD, Ram K Malladi, FRCPath, Charles Craddock, FRCP, FRCPath, Paul Moss, MBBS, PhD FRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 4529.
https://doi.org/10.1182/blood-2019-131130
Published: 2019