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Agnieszka Wierzbowska
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Journal Articles

2025 Update on MRD in Acute Myeloid Leukemia: A Consensus Document from the ELN-DAVID MRD Working Party

Open Access
Jacqueline Cloos, Peter J.M. Valk, Christian Thiede, Konstanze Döhner, Gail J Roboz, Brent L. Wood, Roland B. Walter, Sa A Wang, Agnieszka Wierzbowska, Andrew H Wei, David Wu, Francois Vergez, Adriano Venditti, Bert A. van der Reijden, Arjan A van de Loosdrecht, Ing Soo Tiong, Felicitas R Thol, Marion Subklewe, Christophe Roumier, Tom Reuvekamp, Farhad Ravandi, Claude Preudhomme, Adriana Plesa, Jad Othman, Gert J. Ossenkoppele, Yishai Ofran, Aguirre Mimoun, Luca Maurillo, Agata Majchrzak, David C. de Leeuw, Wolfgang Kern, Dennis Dong Hwan Dong Hwan Kim, Maura Rosane Valério Ikoma-Colturato, Lukas H. Haaksma, Monica L Guzman, Michaela Feuring, Barbara Depreter, Anna Czyz, Veit L. Bücklein, Constance Baer, Costa Bachas, Sylvie D Freeman, Francesco Buccisano, Christopher S Hourigan, Richard James Dillon, Michael Heuser
Journal: Blood
Blood blood.2025031480.
https://doi.org/10.1182/blood.2025031480
Published: 2025
Includes: Supplemental data
Journal Articles

A compelling case for central pathology review of multiparameter flow cytometry measurable residual disease results in Acute Myeloid Leukemia (AML) clinical trials: Data from the PALG-AML1/2016 multicenter randomized study

Free
Agnieszka Wierzbowska, Anna Czyz, Agnieszka Pluta, Marta Libura, Magdalena Czemerska, Zuzanna Nowicka, Agata Majchrzak, Michał Soin, Anna Kopinska, Krzysztof Wozniczka, Martyna Wlodarczyk, Joanna Dziaczkowska, Krystyna Jagoda, Grzegorz Helbig, Karol Wojcik, Małgorzata Razny, Marta Sobas, Donata Szymczak, Tomasz Wrobel, Andrzej Szczepaniak, Jolanta Parulska, Lidia Gil, Magdalena Dutka, Krzysztof Lewandowski, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elżbieta Patkowska, Jolanta Wozniak, Ewa Lech-Marańda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Sebastian Giebel, Jerzy Holowiecki, Krzysztof Gawronski, Grzegorz Charlinski, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin Kaner, Michal Bar-Natan, Jonathan Canaani, Ellen Ritchie, Monica Guzman, Sylvie Freeman, Gail Roboz
Journal: Blood
Blood (2025) 146 (Supplement 1): 1737.
https://doi.org/10.1182/blood-2025-1737
Published: 2025
Journal Articles

Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)

Free
Marc Raaijmakers, Hartmut Döhner, Dimitri Breems, John Byrd, Konstanze Döhner, Jordi Esteve, Bjørn Gjertsen, Patrycja Gradowska, Gerwin A. Huls, Ain Kaare, Heeje Kim, Hitoshi Kiyoi, Mika Kontro, Janusz Krawczyk, Vladimir Lazarevic, Andrea Lenartova, Alice Mims, Jeannine Refos, Christoph Röllig, Anika Schrade, Karolina Sikorska, Alexandre Theocharides, Peter Valk, Adriano Venditti, Jianxiang Wang, Andrew Wei, Agnieszka Wierzbowska, Andrius Zucenka, Lucille Ferrante, Christina Drenberg Guttke, Angélique Langlois, Christina Loefgren, Kathryn Packman, Prathap Nagaraja Shastri, Natasha Schuier, Meena Thayu, Danielle Trancucci, Bob Lowenberg, Lars Bullinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 1654.
https://doi.org/10.1182/blood-2025-1654
Published: 2025
Journal Articles

Venetoclax in combination with hypomethylating agents in adult patients with newly diagnosed AML with CBFB::MYH11 or RUNX1::RUNX1T1 fusions: Real-world outcomes based on international registry data

Free
Leo Ruhnke, Christoph Röllig, Lydia Kretschmer, Jan Moritz Middeke, Sylvia Herold, David Poitz, Pau Montesinos, Maria Del Carmen Martinez Chamorro, Josefina Serrano, Joaquín Sánchez-García, Lara María Gómez García, Francisco-Javier Peñalver, Guillermo Quintero, Virginia Abello, Pierre Yves Dumas, Sarah Bertoli, Christian Recher, Arnaud Pigneux, Jenny O'Nions, Hannah Al-Yousuf, Jad Othman, Richard Dillon, Jiri Mayer, Stephane De Botton, Raphael Itzykson, Herve Dombret, Magdalena Czemerska, Agnieszka Wierzbowska, Anne Weigert, Madlen Jentzsch, Uwe Platzbecker, Karsten Spiekermann, Tim Sauer, Carsten Müller-Tidow, Hubert Serve, Claudia Baldus, Martin Bornhäuser, Klaus Metzeler
Journal: Blood
Blood (2025) 146 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2025-5230
Published: 2025
Journal Articles

Prospective assessment of measurable residual disease kinetics in intensively treated patients with Acute Myeloid Leukemia (AML) - results of the PALG-AML1/2016 study

Free
Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Libura, Magdalena Czemerska, Zuzanna Nowicka, Agata Majchrzak, Michał Soin, Anna Kopinska, Krzysztof Wozniczka, Martyna Wlodarczyk, Grzegorz Helbig, Karol Wojcik, Małgorzata Razny, Marta Sobas, Donata Szymczak, Tomasz Wrobel, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elzbieta Patkowska, Ewa Lech-Marańda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Sebastian Giebel, Jerzy Holowiecki, Krzysztof Gawronski, Grzegorz Charlinski, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin Kaner, Michal Bar-Natan, Ellen Ritchie, Jonathan Canaani, Monica Guzman, Sylvie Freeman, Gail Roboz
Journal: Blood
Blood (2025) 146 (Supplement 1): 344.
https://doi.org/10.1182/blood-2025-344
Published: 2025
Journal Articles

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations

Free
Hartmut Döhner, Courtney D. DiNardo, Frederick R. Appelbaum, Charles Craddock, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Lucy A. Godley, Robert P. Hasserjian, Richard A. Larson, Ross L. Levine, Yasushi Miyazaki, Dietger Niederwieser, Gert Ossenkoppele, Christoph Röllig, Jorge Sierra, Eytan M. Stein, Martin S. Tallman, Hwei-Fang Tien, Jianxiang Wang, Agnieszka Wierzbowska, Andrew H. Wei, Bob Löwenberg
Journal: Blood
Blood (2024) 144 (21): 2169–2173.
https://doi.org/10.1182/blood.2024025409
Published: 2024
Journal Articles

Standard Non-Intensive Chemotherapy Vs Venetoclax-Azacytidine (Ven-AZA) for Unfit AML Patients with Therapy-Related Acute Myeloid Leukaemia (t-AML) - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Free
Lukasz Bolkun, Judyta Strzala, Magdalena Czemerska, Bozena Katarzyna Budziszewska, Aleksandra Golos, Anna Holownia, Wanda Knopinska-Posluszny, Ewa Lech Marańda, Jaroslaw Piszcz, Janusz Halka, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 6056.
https://doi.org/10.1182/blood-2024-207883
Published: 2024
Journal Articles

The Experience of Commercially Available CPX-351 Use As First-Line Treatment for Patients with Acute Myeloid Leukemia - a Report of Polish Adult Leukemia Group (PALG)

Free
Agnieszka Pluta, Olga Racinska, Magdalena Dutka, Karolina Beldzinska-Gondek, Jan Maciej Zaucha, Natalia Bujko-Wasiak, Katarzyna Brzezniakiewicz-Janus, Andrzej Szczepaniak, Zuzanna Rzetelska, Lidia Gil, Ryszard Swoboda, Sebastian Giebel, Marta Sobas, Krzysztof Madry, Michal Górka, Grzegorz Basak, Anna Labedz, Malgorzata Razny, Agnieszka Kopacz, Kamila Kruczkowska-Tarantowicz, Piotr Rzepecki, Magdalena Czemerska, Piotr Strzalka, Kinga Krawiec, Jerzy Holowiecki, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 4268.
https://doi.org/10.1182/blood-2024-203488
Published: 2024
Journal Articles

A Polish Adult Leukemia Group (PALG) Prospective International Randomized Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) in Acute Myeloid Leukemia (AML) Patients ≤ 60 Years Old (PALG-AML1/2016) - Topline Results

Free
Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Libura, Sebastian Giebel, Michał Soin, Damian Mikulski, Kacper Kościelny, Wojciech Fendler, Magdalena Czemerska, Agata Majchrzak, Anna Kopinska, Krzysztof Woźniczka, Martyna Włodarczyk, Karol Wójcik, Grzegorz Helbig, Małgorzata Raźny, Marta Sobas, Tomasz Wróbel, Donata Szymczak, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elzbieta Patkowska, Marzena Wątek, Jolanta Wozniak, Ewa Lech-Maranda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Grzegorz Charlinski, Jerzy Holowiecki, Andi Rustani, Ameenah Sukkur, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin D. Kaner, Michal Bar-Natan, Jonathan Canaani, Ellen K. Ritchie, Monica L Guzman, Sylvie D Freeman, Gail J. Roboz
Journal: Blood
Blood (2024) 144 (Supplement 1): 970.
https://doi.org/10.1182/blood-2024-202365
Published: 2024
Journal Articles

The Premature Reduction of Venetoclax in an Initial Cycle of Ven-AZA Regimen for Unfit AML Patients Leads to Shortened Overall Survival - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Free
Lukasz Bolkun, Bozena Katarzyna Budziszewska, Bartosz Michal Pula, Joanna Drozd-Sokolowska, Krzysztof Mądry, Paweł Główka, Marta Sobas, Kinga Krawiec, Piotr Strzalka, Sylwia Kościołek-Zgódka, Jaroslaw Piszcz, Janusz Halka, Edyta Cichocka, Kamila Kruczkowska-Tarantowicz, Judyta Strzala, Agnieszka Mosler, Ewa Lech Marańda, Aleksandra Butrym, Sebastian Giebel, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2024-208144
Published: 2024
Journal Articles

A Phase 1 Dose-Escalation Study of the Cladribine Added to CPX-351 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML) - the Polish Adult Leukemia Group AML-1/2018 Study

Free
Agnieszka Wierzbowska, Agnieszka Pluta, Piotr Stelmach, Kamil Brzozowski, Magdalena Czemerska, Marta Sobas, Justyna Rybka, Tomasz Wróbel, Ewa Zarzycka, Witold Prejzner, Jan M. Zaucha, Andrzej Szczepaniak, Lidia Gil, Sebastian Giebel
Journal: Blood
Blood (2023) 142 (Supplement 1): 5914.
https://doi.org/10.1182/blood-2023-181633
Published: 2023
Journal Articles

Proteomic Landscape of Circulating Exosomes during Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients

Free
Damian Mikulski, Izabela Dróżdż, Mateusz Nowicki, Małgorzata Misiewicz, Grzegorz Mirocha, Ewelina Perdas, Agnieszka Wierzbowska, Wojciech Fendler
Journal: Blood
Blood (2023) 142 (Supplement 1): 6614.
https://doi.org/10.1182/blood-2023-190171
Published: 2023
Journal Articles

Evaluation of Neddylation and Apoptosis-Related Gene Expression in Patients with Acute Myeloid Leukemia

Free
Kinga Krawiec, Piotr Strzalka, Dariusz Jarych, Aneta Wiśnik, Michał Soin, Magdalena Góralska, Damian Mikulski, Magdalena Czemerska, Izabela Zawlik, Agnieszka Wierzbowska, Agnieszka Pluta
Journal: Blood
Blood (2023) 142 (Supplement 1): 5990.
https://doi.org/10.1182/blood-2023-181739
Published: 2023
Journal Articles

The Signaling Pathways Enriched in High-Risk AML Patients Revealed By the Integrative miRNA-mRNA Analysis - Pilot Study

Free
Magdalena Czemerska, Damian Mikulski, Aneta Wisnik, Dariusz Jarych, Izabela Zawlik, Piotr Strzalka, Kinga Krawiec, Wojciech Fendler, Agnieszka Pluta, Agnieszka Wierzbowska
Journal: Blood
Blood (2023) 142 (Supplement 1): 6029.
https://doi.org/10.1182/blood-2023-174968
Published: 2023
Journal Articles

Assessment of SIRT1-SIRT7 and TP53 Genes Expression in Patients with Acute Myeloid Leukemia

Free
Piotr Strzalka, Kinga Krawiec, Dariusz Jarych, Aneta Wiśnik, Michał Soin, Magdalena Góralska, Damian Mikulski, Magdalena Czemerska, Izabela Zawlik, Agnieszka Pluta, Agnieszka Wierzbowska
Journal: Blood
Blood (2023) 142 (Supplement 1): 6048.
https://doi.org/10.1182/blood-2023-187756
Published: 2023
Journal Articles

Stratification Using ECOG, ADL and HCT-CI Scales, but Not CGA Enables Identifying Elderly AML Patients Fit for Intensive Chemotherapy - a Multicenter Study from Polish Adult Leukemia Group

Free
Bozena Katarzyna Budziszewska, Michał Łomiak, Joanna Barankiewicz, Elzbieta Patkowska, Grzegorz Helbig, Lukasz Bolkun, Anna Irga-Staniukiewicz, Anna Kiżewska, Agnieszka Piekarska, Anna Koclęga, Agnieszka Pluta, Marta Kuydowicz, Sylwia Kościółek- Zgódka, Edyta Cichocka, Agata Malenda, Karol Wójcik, Tomasz Gromek, Piotr Małecki, Sebastian Grosicki, Agnieszka Wierzbowska, Ewa Lech-Maranda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4218.
https://doi.org/10.1182/blood-2023-189713
Published: 2023
Journal Articles

Prognostic Impact of Persistent Measurable Residual Disease in Patients with Acute Myeloid Leukemia FLT3+ Treated with Intensive Chemotherapy Plus Midostaurin - a Retrospective Study of the Polish Adult Leukemia Group (PALG)

Free
Elzbieta Patkowska, Alicja Sadowska-Klasa, Jan Zaucha, Andrzej Szczepaniak, Lidia Gil, Lukasz Bolkun, Michal Gorka, Marta Antonina Libura, Renata Guzicka-Kazimierczak, Marta Anna Sobas, Anna Koclega, Jolanta Wozniak, Krzysztof Lewandowski, Iwona Solarska, Magdalena Wojtas, Aleksandra Leszczynska, Zuzanna Kandula, Edyta Subocz, Edyta Cichocka, Katarzyna Krawczyk, Dorota Hawrylecka, Agnieszka Pluta, Agnieszka Wierzbowska, Sebastian Giebel, Ewa Lech-Marańda
Journal: Blood
Blood (2022) 140 (Supplement 1): 11836–11837.
https://doi.org/10.1182/blood-2022-170126
Published: 2022
Journal Articles

A Comparison of Outcomes in Patients with Secondary Acute Promyelocytic Leukemia (APL) and De Novo APL - a Case-Match Retrospective Analysis of Polish Adult Leukemia Group (PALG)

Free
Agnieszka Pluta, Marta Anna Sobas, Damian Mikulski, Kinga Krawiec, Magdalena Czemerska, Bozena Katarzyna Budziszewska, Tomasz Wróbel, Marzena Watek, Ewa Lech-Marańda, Tomasz Gromek, Dorota Hawrylecka, Marek Hus, Ewa Zarzycka, Jan Zaucha, Anna Armatys, Grzegorz Helbig, Jolanta Oleksiuk, Jaroslaw Piszcz, Andrzej Szczepaniak, Lidia Gil, Rafal Becht, Wojciech Fendler, Sebastian Giebel, Agnieszka Wierzbowska
Journal: Blood
Blood (2022) 140 (Supplement 1): 3206–3207.
https://doi.org/10.1182/blood-2022-166227
Published: 2022
Journal Articles

A Polish Acute Leukemia Group Prospective Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) and Two Standard Salvage Regimens (FLAG-IDA vs CLAG-M) in Acute Myeloid Leukemia (AML) Patients ≤ 60 Years Old (PALG-AML1/2016)

Free
Agnieszka Wierzbowska, Anna Czyz, Agnieszka Pluta, Marta Antonina Libura, Sebastian Giebel, Piotr Stelmach, Magdalena Czemerska, Kinga Krawiec, Anna Kopinska, Krzysztof Wozniczka, Grzegorz Helbig, Janusz Halka, Marta Anna Sobas, Tomasz Wróbel, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Elzbieta Patkowska, Marzena Watek, Ewa Lech-Marańda, Agnieszka Kopacz, Katarzyna Dulik, Jerzy Holowiecki, Agata Obara, Edyta Cichocka, Krzysztof Gawronski, Monika Mordak-Domagala, Ameenah Sukkur, Andi Rustani, Pinkal Desai, Michael Samuel, Nuria Mencia Trinchant, Sangmin Lee, Justin D. Kaner, Ellen Ritchie, Monica L. Guzman, Gail J. Roboz
Journal: Blood
Blood (2022) 140 (Supplement 1): 9013–9015.
https://doi.org/10.1182/blood-2022-166184
Published: 2022
Journal Articles

Pre-Transplant Multiparameter Flow Cytometric Measurable Residual Disease in Acute Myeloid Leukemia As an Independent Prognostic Factor for Survival after Myeloablative Allogeneic Hematopoietic Cell Transplantation

Free
Anna Czyz, Malgorzata Maria Sobczyk Kruszelnicka, Tomasz Czerw, Sebastian Giebel, Magdalena Dutka, Agnieszka Piekarska, Maria Bieniaszewska, Jan Zaucha, Maciej Majcherek, Marta Anna Sobas, Tomasz Wróbel, Barbara Nasilowska-Adamska, Halaburda Kazimierz, Andrzej Szczepaniak, Lidia Gil, Anna Kopinska, Grzegorz Helbig, Sylwia Bartyzel-Palinska, Patrycja Mensah-Glanowska, Agnieszka Tomaszewska, Agnieszka Pluta, Elzbieta Patkowska, Jolanta Wozniak, Agnieszka Balana, Donata Szymczak, Jolanta Parulska, Ameenah Sukkur, Andi Rustani, Nuria Mencia Trinchant, Pinkal Desai, Michael Samuel, Justin D. Kaner, Ellen Ritchie, Monica L. Guzman, Gail J. Roboz, Agnieszka Wierzbowska
Journal: Blood
Blood (2022) 140 (Supplement 1): 7747–7749.
https://doi.org/10.1182/blood-2022-167407
Published: 2022