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Journal Articles

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A- rearranged acute myeloid leukemia

Sun Loo, Nicola Potter, Adam Ivey, Jenny O’Nions, Roderick Moon, Jelena Jovanovic, Chun Y. Fong, Natasha S. Anstee, Ing Soo Tiong, Jad Othman, Chong Chyn Chua, Hanna Renshaw, Robert Baker, Shaun Fleming, Nigel H. Russell, David Ritchie, Ashish Bajel, Hsin-An Hou, Richard Dillon, Andrew H. Wei
Journal: Blood
Blood (2024) 144 (24): 2554–2557.
https://doi.org/10.1182/blood.2024026605
Published: 2024
Includes: Supplemental data
Journal Articles

Favourable Outcomes in Newly Diagnosed Paediatric AML with Gemtuzumab Ozogamicin and Risk-Stratified Therapy: Results from the International Phase III Myechild 01 Trial

Brenda Gibson, Andre Baruchel, Andrew Moore, Shanna Maycock, Owen Smith, Geoff Shenton, Jean-Pierre Bourquin, Yves Bertrand, Nicholas Heaney, Anna Lawson, Persis Jal Amrolia, Gerard Michel, Jean-Hugues Dalle, Marc Ansari, Hélène Lapillonne, Richard Dillon, Jelena Jovanovic, Siobhan Cross, Paul Virgo, Lucy Wheeler, Christophe Roumier, Nicolas Duployez, Christine Harrison, Claire Schwab, Wendy Cuccuini, Marina Lafage-Pochitaloff, Claude Preudhomme, Paresh Vyas, Pierre Hirsch, Gareth Veal, David Gillis, Pam Kearns, Guy Leverger, Phil Ancliff, Aimee Jackson, Arnaud Petit
Journal: Blood
Blood (2024) 144 (Supplement 1): 968.
https://doi.org/10.1182/blood-2024-198419
Published: 2024
Journal Articles

Impact of Cytogenetics, Induction Chemotherapy and MRD on Outcomes of Intensively Treated AML with KMT2A Rearrangements - Experience from UK NCRI AML17 and AML19

Jad Othman, Nicola Potter, Sylvie D Freeman, Nicholas McCarthy, Jelena Jovanovic, Manohursingh Runglall, Joanna Canham, Ian Thomas, Sean Johnson, Jamie Cavenagh, Panagiotis Kottaridis, David Taussig, Claire Arnold, Claire Hemmaway, Dominic J. Culligan, Ulrik Malthe Overgaard, Alan K. Burnett, Mike Dennis, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 845.
https://doi.org/10.1182/blood-2024-201097
Published: 2024
Journal Articles

Bleximenib Dose Optimization and Determination of RP2D from a Phase 1 Study in Relapsed/Refractory Acute Leukemia Patients with KMT2A and NPM1 Alterations

Emma Searle, Christian Recher, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Pierola, Juan M. Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Hagop M. Kantarjian, Min Chul Kwon, Anita J Kumar, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Olga Salamero, Madhu Sanga, Prathap Nagaraja Shastri, Richard M. Stone, Peter Tan, Trevor Tucker, Paresh Vyas, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 212.
https://doi.org/10.1182/blood-2024-207106
Published: 2024
Journal Articles

Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1 -Mutated AML - the SAL/AMLCG Vincent Trial

Lydia Kretschmer, Leo Ruhnke, Christoph Schliemann, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Christoph Schmid, Maher Hanoun, Tim Sauer, Klaus H Metzeler, Kerstin Schäfer-Eckart, Mathias Hänel, Martina Crysandt, Paul Jäger, Stefan W. Krause, Christine Dierks, Stefan Klein, Nadia Maguire, Lukas Peter Frenzel, Veit L. Buecklein, Frank Fiebig, Anna Harig, Christian Thiede, Moritz Middeke, Richard Dillon, Claudia D Baldus, Hubert Serve, Uwe Platzbecker, Karsten Spiekermann, Wolfgang Hiddemann, Martin Bornhäuser, Richard F. Schlenk, Carsten Müller-Tidow, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.1.
https://doi.org/10.1182/blood-2024-198164
Published: 2024
Journal Articles

A Randomised Comparison of CPX-351 Versus Standard Daunorubicin and Cytarabine Plus Fractionated Gemtuzumab Ozogamicin in Older Adults with AML without Adverse Risk Cytogenetics: Results of the NCRI AML18 Trial

Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S. Hourigan, Georgia Andrew, Richard Dillon, Amanda Gilkes, Nuria M Almuina, Sophie King, Thomas Coats, Nicholas McCarthy, Jennifer Byrne, Simone Green, Ulrik Malthe Overgaard, Leanne Berkahn, Louisa Stone, Rasha W Al-Ali, Reem Bahr, Rob Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 59.
https://doi.org/10.1182/blood-2024-200027
Published: 2024
Journal Articles

The LMO2-LDB1-TAL1 Complex Regulates Transcription Networks in AML Relapse

Nicholas Dunham, Zhenjia Wang, Yaseswini Neelamraju, Yan Guo, Joyce Hardwick, Bernhard Maier, Cem Meydan, Jorge A Gandara, Tak Lee, Subhash Prajapati, Franck Rapaport, Caroline Sheridan, Paul Zumbo, Michael W. Becker, Lars Bullinger, Martin P Carroll, Richard J D'Andrea, Richard Dillon, Ross L Levine, Christopher Mason, Ari M Melnick, Donna S. Neuberg, Stefan Bekiranov, Chongzhi Zang, Utpal P. Dave, Francine E. Garrett-Bakelman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2711.
https://doi.org/10.1182/blood-2024-200289
Published: 2024
Journal Articles

Optimising Therapy in FLT3 -Mutated Acute Myeloid Leukaemia

Joanna Canham, Angela Casbard, Sylvie D Freeman, Nicola Potter, Abin Thomas, Amanda Gilkes, Sean Johnson, Lucy Marsh, Jane Leahy, Hayley Timmins, Richard Dillon, Steve Knapper
Journal: Blood
Blood (2024) 144 (Supplement 1): 4191.1.
https://doi.org/10.1182/blood-2024-204975
Published: 2024
Journal Articles

Clinical networking results in continuous improvement of the outcome of patients with acute promyelocytic leukemia

Clinical Trials & Observations
Luísa Corrêa de Araújo Koury, Haesook T. Kim, Maria Soledad Undurraga, Juan Ramon Navarro-Cabrera, Victor Salinas, Pablo Muxi, Raul A. M. Melo, Ana Beatriz Glória, Katia Pagnano, Elenaide C. Nunes, Rosane I. Bittencourt, Ninoska Rojas, Shirley Quintana, Ana Ayala-Lugo, Ana Carolina Oliver, Lorena Figueiredo-Pontes, Fabiola Traina, Frederico Moreira, Evandro M. Fagundes, Bruno K. L. Duarte, Analí Pamela Mora-Alferez, Percy Ortiz, Jose Untama, Martin Tallman, Raul Ribeiro, Arnold Ganser, Richard Dillon, Peter J. M. Valk, Miguel Sanz, Bob Löwenberg, Nancy Berliner, Eduardo M. Rego
Journal: Blood
Blood (2024) 144 (12): 1257–1270.
https://doi.org/10.1182/blood.2024023890
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular, clinical, and therapeutic determinants of outcome in NPM1 -mutated AML

Clinical Trials & Observations
Jad Othman, Nicola Potter, Adam Ivey, Yanis Tazi, Elli Papaemmanuil, Jelena Jovanovic, Sylvie D. Freeman, Amanda Gilkes, Rosemary Gale, Tanya Rapoz-D’Silva, Manohursingh Runglall, Michelle Kleeman, Pawan Dhami, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Brian Huntly, Nigel H. Russell, Richard Dillon
Journal: Blood
Blood (2024) 144 (7): 714–728.
https://doi.org/10.1182/blood.2024024310
Published: 2024
Includes: Supplemental data
Journal Articles

Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission

Clinical Trials & Observations Brief Report
Jad Othman, Nicola Potter, Adam Ivey, Jelena Jovanovic, Manohursingh Runglall, Sylvie D. Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panagiotis Kottaridis, Claire Arnold, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Alan Burnett, Charlotte Wilhelm-Benartzi, Richard Dillon, Nigel H. Russell
Journal: Blood
Blood (2024) 143 (19): 1931–1936.
https://doi.org/10.1182/blood.2023023096
Published: 2024
Includes: Supplemental data
Journal Articles

Molecular MRD is strongly prognostic in patients with NPM1 -mutated AML receiving venetoclax-based nonintensive therapy

Clinical Trials & Observations Brief Report
Jad Othman, Ing S. Tiong, Jenny O'Nions, Mike Dennis, Katya Mokretar, Adam Ivey, Michael Austin, Anne-Louise Latif, Mariam Amer, Wei Yee Chan, Charles Crawley, Francesca Crolla, Joe Cross, Ray Dang, Johnathon Elliot, Chun Y. Fong, Sofia Galli, Paolo Gallipoli, Francesca Hogan, Pallavi Kalkur, Anjum Khan, Pramila Krishnamurthy, John Laurie, Sun Loo, Scott Marshall, Priyanka Mehta, Vidhya Murthy, Sateesh Nagumantry, Srinivas Pillai, Nicola Potter, Rob Sellar, Tom Taylor, Rui Zhao, Nigel H. Russell, Andrew H. Wei, Richard Dillon
Journal: Blood
Blood (2024) 143 (4): 336–341.
https://doi.org/10.1182/blood.2023021579
Published: 2024
Includes: Supplemental data
Journal Articles

Long-Term Outcome of 1296 Patients with Newly Diagnosed with APL: A Harmony Alliance Study

Luca Guarnera, Soren Lehmann, Konstanze Döhner, Hartmut Döhner, Uwe Platzbecker, Nigel H. Russell, Richard Dillon, Ian Thomas, Gert Ossenkoppele, Marco Vignetti, Edoardo la Sala, Alfonso Piciocchi, Angela Villaverde Ramiro, Laura Tur, Carmelo Gurnari, Lars Bullinger, Jesús María Hernández-Rivas, Maria Teresa Voso
Journal: Blood
Blood (2023) 142 (Supplement 1): 727.
https://doi.org/10.1182/blood-2023-185121
Published: 2023
Journal Articles

A First-in-Human Phase 1 Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Adult Patients with Relapsed/Refractory Acute Leukemia Harboring KMT2A or NPM1 Alterations

Elias Jabbour, Emma Searle, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Piérola, Juan Manuel Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Sylvain Garciaz, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Min Chul Kwon, Jonathan Miller, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Christian Recher, Olga Salamero, Madhu Sanga, Richard M Stone, Peter Tan, Jan Willem Thuring, Trevor Tucker, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 57.
https://doi.org/10.1182/blood-2023-172422
Published: 2023
Journal Articles

Pre-Transplant Measurable Residual Disease (MRD) Detection of KMT2A- rearranged Acute Myeloid Leukemia Is Strongly Associated with Inferior Post-Transplant Outcome

Sun Loo, Nicola Potter, Adam Ivey, Jenny O'Nions, Roderick Moon, Chun Yew Fong, Natasha Anstee, Ing Soo Tiong, Chong Chyn Chua, Jad Othman, Hannah Renshaw, Robert Baker, Nigel H. Russell, Ashish Bajel, Hsin-An Hou, Richard Dillon, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (Supplement 1): 1577.
https://doi.org/10.1182/blood-2023-185541
Published: 2023
Journal Articles

The Benefit of Allogeneic Transplant in 1 st Complete Remission in NPM1 Mutated AML with or without FLT3 ITD Is Restricted to Those Testing MRD Positive after Induction - an Analysis of the UK NCRI AML17 and AML19 Studies

Jad Othman, Nicola Potter, Adam Ivey, Jelena Jovanovic, Sylvie D Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panos Kottaridis, Claire Arnold, Ulrik Malthe Overgaard, Mike Dennis, Charlotte Wilhelm-Benartzi, Richard Dillon, Nigel Russell
Journal: Blood
Blood (2023) 142 (Supplement 1): 425.
https://doi.org/10.1182/blood-2023-179033
Published: 2023
Journal Articles

A Pro-Inflammatory Gene Signature Characterizes a Better Risk Aged AML Patient Group in ECOG-ACRIN Cancer Research Group's Clinical Trial E3999

Yaseswini Neelamraju, Franck Rapaport, Jorge A Gandara, Nicholas Dunham, Hao Fan, Tak Lee, Subhash Prajapati, Caroline Sheridan, Ling Wang, Larry D. Cripe, Richard Dillon, Maria Kleppe, Ross L Levine, Christopher Mason, Ari M Melnick, Elisabeth Paietta, Gail J. Roboz, Zhuoxin Sun, Martin S. Tallman, Yanming Zhang, Stefan Bekiranov, Francine E. Garrett-Bakelman
Journal: Blood
Blood (2023) 142 (Supplement 1): 4326.
https://doi.org/10.1182/blood-2023-179569
Published: 2023
Journal Articles

Loss of CCAAT‐Enhancer Binding Protein Delta Promotes Acute Myeloid Leukemia Cell Proliferation and Survival By Upregulating Cyclin D1 Expression

Subhash Prajapati, Cem Meydan, Richard Dillon, Nicholas Dunham, Hao Fan, Jorge A Gandara, Tak Lee, Yaseswini Neelamraju, Caroline Sheridan, Zhenjia Wang, Paul Zumbo, Michael W. Becker, Lars Bullinger, Martin Carroll, Richard J D'Andrea, Ross L Levine, Christopher Mason, Ari M Melnick, Chongzhi Zang, Stefan Bekiranov, Francine E. Garrett-Bakelman
Journal: Blood
Blood (2023) 142 (Supplement 1): 1380.
https://doi.org/10.1182/blood-2023-181946
Published: 2023
Journal Articles

Feasibility and Relevance of Incorporating Genetic Testing By Next-Generation Sequencing for Acute Myeloid Leukemia Patients Treated in Low- and Middle-Income Countries

Fabiola Traina, Lorena Lobo Figueiredo-Pontes, Maria Isabel Ayrosa, Katia B Pagnano, Ana Beatriz F Gloria, Elvira Deolinda Rodrigues Pereira Velloso, Elenaide C. Nunes, Marcia Higashi, Bruno Kosa Lino Duarte, Evandro M Fagundes, Wellington F Silva, Brunno Gilberto Santos Macedo, Rita de Cássia Cavaglieri Medeiros, Ana Sílvia Gouvêa Lima Yamada, Patricia C Ruy, Melissa Rijken, Bob Lowenberg, Torsten Haferlach, Arnold Ganser, Richard Dillon, Nancy Berliner, Peter J. M. Valk, Eduardo Magalhães Rego
Journal: Blood
Blood (2023) 142 (Supplement 1): 2929.
https://doi.org/10.1182/blood-2023-189806
Published: 2023
Journal Articles

Interaction between Presenting Features, Co-Occurring Mutations, MRD and Induction Treatment Influences Outcome in Adults with NPM1 Mutated AML - an Analysis of 1357 Patients in the UK NCRI AML17 and AML19 Studies

Jad Othman, Nicola Potter, Adam Ivey, Yanis Tazi, Elli Papaemmanuil, Jelena Jovanovic, Sylvie D Freeman, Amanda Gilkes, Ian Thomas, Sean Johnson, Joanna Canham, Jamie Cavenagh, Panos Kottaridis, Claire Arnold, Ulrik Malthe Overgaard, Mike Dennis, Charlotte Wilhelm-Benartzi, Brian Huntly, Alan K. Burnett, Richard Dillon, Nigel Russell
Journal: Blood
Blood (2023) 142 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2023-179036
Published: 2023