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Journal Articles

Progressive chromatin rewiring by ETO2::GLIS2 revealed in a human iPSC model of pediatric leukemia initiation

Fabien Boudia, Marie Baille, Loelia Babin, Zakia Aid, Elie Robert, Julie Riviere, Klaudia Galant, Verónica Alonso-Pérez, Laura Anselmi, Brahim Arkoun, Nassera Abermil, Christophe Marzac, Salvatore Nicola Bertuccio, Alexia Regnault de Premesnil, Cecile K. Lopez, Alexandre Eeckhoutte, Audrey Naimo, Betty Leite, Cyril Catelain, Christophe Metereau, Patrick Gonin, Nathalie Gaspar, Juerg Schwaller, Olivier A Bernard, Hana Raslova, Murielle Gaudry, Antonin Marchais, Hélène Lapillonne, Arnaud Petit, Francoise Pflumio, Marie-Laure Arcangeli, Erika Brunet, Thomas Mercher
Journal: Blood
Blood blood.2024024505.
https://doi.org/10.1182/blood.2024024505
Published: 2024
Includes: Supplemental data
Journal Articles

Sinusoidal Obstruction Syndrome in Children with CD22+ B-Cell Precursors Acute Lymphoblastic Leukemia (BCP-ALL) Treated with Inotuzumab Ozogamicin in Trial ITCC-059: Risk Factors and Outcomes

Erica Brivio, Edoardo Pennesi, Yilin Jang, Anneke Ammerlaan, Susana Rives, Inge M. van der Sluis, Caroline Lindemans, Bella Bielorai, Cristina Díaz De Heredia, Andrej Lissat, Claudia Rossig, Arnaud Petit, Fanny Rialland Battisti, Carmelo Rizzari, Anna B Nilsson, Benedicte Bruno, Alba Rubio-san-Simón, Lucie Sramkova, Gernot Engstler, Uta Dirksen, Benoit Brethon, Barbara De Moerloose, Marlène Pasquet, Peter McCarthy, Karsten Nysom, Carine Halfon-Domenech, Nicoletta Bertorello, Jochen Büchner, Franco Locatelli, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (Supplement 1): 310.
https://doi.org/10.1182/blood-2024-193946
Published: 2024
Journal Articles

Favourable Outcomes in Newly Diagnosed Paediatric AML with Gemtuzumab Ozogamicin and Risk-Stratified Therapy: Results from the International Phase III Myechild 01 Trial

Brenda Gibson, Andre Baruchel, Andrew Moore, Shanna Maycock, Owen Smith, Geoff Shenton, Jean-Pierre Bourquin, Yves Bertrand, Nicholas Heaney, Anna Lawson, Persis Jal Amrolia, Gerard Michel, Jean-Hugues Dalle, Marc Ansari, Hélène Lapillonne, Richard Dillon, Jelena Jovanovic, Siobhan Cross, Paul Virgo, Lucy Wheeler, Christophe Roumier, Nicolas Duployez, Christine Harrison, Claire Schwab, Wendy Cuccuini, Marina Lafage-Pochitaloff, Claude Preudhomme, Paresh Vyas, Pierre Hirsch, Gareth Veal, David Gillis, Pam Kearns, Guy Leverger, Phil Ancliff, Aimee Jackson, Arnaud Petit
Journal: Blood
Blood (2024) 144 (Supplement 1): 968.
https://doi.org/10.1182/blood-2024-198419
Published: 2024
Journal Articles

How to Administer Pegaspargase during Induction Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents? Results of the Caall-F01, a Multicentre Randomized Clinical Trial from the French Pediatric Cancer Society (SFCE)

Marion Strullu, Arnaud Petit, Carine Halfon-Domenech, Anne-France Ray-Lunven, Paul Saultier, Wadih Abou Chahla, Stéphane Ducassou, Marlène Pasquet, Caroline Thomas, Cécile Pochon, Virginie Gandemer, Catherine Paillard, Alexandre Theron, Claire Pluchart, Pascale Schneider, Damien Bodet, Isabelle Pellier, Pierre Simon Rohrlich, Anne-France Jourdain, Pauline Simon, Frederic Millot, Liana Carausu, Corinne Armari Alla, Camille Leglise, Justyna Kanold, Claire Desplantes, Sandrine Thouvenin, Christophe Piguet, Nicolas Boissel, Wendy Cuccuini, Vahid Asnafi, Aurélie Caye-Eude, Hélène Cavé, Guy Leverger, Jean-François Benoist, Yves Bertrand, Sylvie Chevret, André Baruchel
Journal: Blood
Blood (2024) 144 (Supplement 1): 2814.
https://doi.org/10.1182/blood-2024-205327
Published: 2024
Journal Articles

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients

Clinical Trials & Observations
Mathieu Simonin, Loïc Vasseur, Etienne Lengliné, Ludovic Lhermitte, Aurélie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie-Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stéphane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Arnaud Petit, Philippe Rousselot, Jérôme Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (15): 1570–1580.
https://doi.org/10.1182/blood.2023023754
Published: 2024
Includes: Supplemental data
Journal Articles

Genomic imbalance analysis provides new insight into prognostic factors in adult and pediatric T-ALL

Estelle Balducci, Mathieu Simonin, Nicolas Duployez, Thomas Steimlé, Marie-Emilie Dourthe, Patrick Villarese, Stéphane Ducassou, Isabelle Arnoux, Jean-Michel Cayuela, Marie Balsat, Lucien Courtois, Guillaume Andrieu, Aurore Touzart, Françoise Huguet, Arnaud Petit, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Claude Preudhomme, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2024) 144 (9): 988–1000.
https://doi.org/10.1182/blood.2023022154
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes for Children with High Risk Acute Myeloid Leukemia on the Myechild 01 International Phase III Clinical Trial

Andrew Moore, Shanna Maycock, Guy Leverger, Owen Smith, Andre Baruchel, Yves Bertrand, Phil Ancliff, Nicholas Heaney, Geoff Shenton, Arnaud Petit, Jean-Pierre Bourquin, Aimee Jackson, Anna Lawson, Persis Amrolia, Gerard Michel, Jean-Hugues Dalle, Marc Ansari, Hélène Lapillonne, Richard Dillon, Jelena Jovanovic, Christophe Roumier, Nicolas Duployez, Christine Harrison, Claire Schwab, Wendy Cuccuini, Marina Lafage-Pochitaloff, Paresh Vyas, Pierre Hirsch, Gareth Veal, Pam Kearns, Brenda Gibson
Journal: Blood
Blood (2023) 142 (Supplement 1): 730.
https://doi.org/10.1182/blood-2023-181593
Published: 2023
Journal Articles

NGS-Based Stratification Refines the Risk Stratification in T-ALL and Identifies a Very High-Risk Subgroup of Patients

Mathieu Simonin, Loïc Vasseur, Etienne Lengline, Ludovic Lhermitte, Aurelie Cabannes-Hamy, Marie Balsat, Aline Schmidt, Marie Emilie Dourthe, Aurore Touzart, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Françoise Huguet, Stephane Ducassou, Véronique Lhéritier, Yves Chalandon, Norbert Ifrah, Herve Dombret, Elizabeth A. Macintyre, Arnaud Petit, Philippe Rousselot, Jerome Lambert, André Baruchel, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 844.
https://doi.org/10.1182/blood-2023-179298
Published: 2023
Journal Articles

Chromothripsis and Genomic Complexity As Pejorative Prognostic Markers in Pediatric and Adult T-ALL

Estelle Balducci, Mathieu Simonin, Nicolas Duployez, Thomas Steimlé, Marie-Emilie Dourthe, Patrick Villarese, Stéphane Ducassou, Isabelle Arnoux, Jean-Michel Cayuela, Marie Balsat, Lucien Courtois, Guillaume P Andrieu, Aurore Touzart, Françoise Huguet, Arnaud Petit, Norbert Ifrah, Hervé Dombret, André Baruchel, Claude Preudhomme, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2980.
https://doi.org/10.1182/blood-2023-185831
Published: 2023
Journal Articles

Efficacy and Tolerance of the BNT162b2 Vaccine in Children with Acute Leukemia and Their Siblings: Results of the Phase I-II Pacific Trial

Fanny Alby Laurent, Amani Ouedrani, Pierre Jatteau, Marion Strullu, Claire Montlahuc, Chaima Mrad, Audrey Guilmatre, Maxime Ferreboeuf, Anne-France Ray-Lunven, Florentia Kaguelidou, Lucienne Chatenoud, Laurence Morand-Joubert, Sylvie Chevret, Arnaud Petit
Journal: Blood
Blood (2023) 142 (Supplement 1): 4246.
https://doi.org/10.1182/blood-2023-181899
Published: 2023
Journal Articles

Prognostic value and oncogenic landscape of TP53 alterations in adult and pediatric T-ALL

Clinical Trials & Observations
Mathieu Simonin, Guillaume P. Andrieu, Rudy Birsen, Marie Balsat, Guillaume Hypolite, Lucien Courtois, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Françoise Huguet, Yves Chalandon, Yannick Le Bris, Elizabeth Macintyre, Virginie Gandemer, Arnaud Petit, Philippe Rousselot, André Baruchel, Didier Bouscary, Olivier Hermine, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2023) 141 (11): 1353–1358.
https://doi.org/10.1182/blood.2022017755
Published: 2023
Includes: Supplemental data
Journal Articles

Inotuzumab Ozogamicin (InO) Combined with UKALL-R3 Modified Chemotherapy in Pediatric Patients with B-Cell Precursor CD22+ Acute Lymphoblastic Leukemia (BCP-ALL) - Results from the ITCC-059 Phase 1B Trial

Edoardo Pennesi, Erica Brivio, Anneke C.J. Ammerlaan, Yilin Jiang, Vincent H.J. van der Velden, Berna Beverloo, Barbara Sleight, Susana Rives, Cristina Díaz de Heredia Rubio, Francisco J. Bautista Sirvent, Alba Rubio-San-Simón, Fanny Rialland, Carmelo Rizzari, Bella Bielorai, Arnaud Petit, Bénédicte Bruno, Ingrid Øra, Anna Nilsson, Gernot Engstler, Claudia Rossig, Benoit Brethon, Franco Locatelli, Christian M. Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8976–8978.
https://doi.org/10.1182/blood-2022-163056
Published: 2022
Journal Articles

ALL-REZ BFM 2002 Is Associated with Improved Outcome as Compared to ALL-R3 Strategy in Children with Standard Risk Isolated CNS Relapse of Acute Lymphoblastic Leukemia, while Maintaining Comparable Efficacy in Patients with Bone Marrow Relapse. Results of the Multi-National, Multi-Center Trial IntReALL SR 2010

Arend von Stackelberg, Jean-Pierre Bourquin, Martin Zimmermann, Tamas Revesz, Andishe Attarbaschi, Alina Ferster, Lucie Sramkova, Thomas Leth Frandsen, Päivi Maria Lähteenmäki, Ronit Elhasid, Hidemi Toyoda, Peter M. Hoogerbrugge, Inga M. Johannsdottir, Ximo Duarte, Denise Bonney, Vaskar Saha, Ingo G. Steffen, Andrej Lissat, Christiane Chen-Santel, Cornelia Eckert, Andre Baruchel, Arnaud Petit, Hélène Cavé, Carmelo Rizzari, Giovanni Cazzaniga, Luciana Vinti, Pierre Rohrlich, Franco Locatelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 3247–3249.
https://doi.org/10.1182/blood-2022-166234
Published: 2022
Journal Articles

Population Pharmacokinetics of Inotuzumab Ozogamicin (InO) As Single Agent in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia - Results from the ITCC-059 Phase IA and Phase II Trial

Edoardo Pennesi, Erica Brivio, Kathleen B. Pelletier, Ying Chen, Alwin D.R. Huitema, Yilin Jiang, Anneke C.J. Ammerlaan, Barbara Sleight, Franco Locatelli, Inge M. Van Der Sluis, Claudia Rossig, Christiane Chen-Santel, Bella Bielorai, Arnaud Petit, Jan Stary, Lucie Sramkova, Cristina Díaz de Heredia Rubio, Susana Rives, Aengus O'Marcaigh, Carmelo Rizzari, Gernot Engstler, Karsten Nysom, Alba Rubio-San-Simón, Francisco J. Bautista Sirvent, Bénédicte Bruno, Yives Bertrand, Benoit Brethon, Fanny Rialland, Genevieve Plat, Uta Dirksen, May Garrett, Christian M. Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8845–8847.
https://doi.org/10.1182/blood-2022-165954
Published: 2022
Journal Articles

Superior Overall Survival with Blinatumomab Versus Chemotherapy As Pre-Transplant Consolidation Treatment in Children with High-Risk First-Relapse B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL): Longer Follow-up (FU) of a Phase 3 Randomized Controlled Trial (RCT)

Franco Locatelli, Gerhard Zugmaier, Carmelo Rizzari, Joan D Morris, Bernd Gruhn, Thomas Klingebiel, Rosanna Parasole, Christin Linderkamp, Christian Flotho, Arnaud Petit, Concetta Micalizzi, Yi Zeng, Deepali Dilip Pilankar, William N Kormany, Cornelia Eckert, Anja Moericke, Mary Sartor, Ondrej Hrusak, Christina Peters, Vaskar Saha, Luciana Vinti, Arend von Stackelberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 1231.
https://doi.org/10.1182/blood-2021-145476
Published: 2021
Journal Articles

A Phase I/II Study of Bosutinib in Pediatric Patients with Resistant/Intolerant or Newly Diagnosed Philadelphia Chromosome-Positive Chronic Myeloid Leukemia, Study ITCC (Innovative Therapies for Children with Cancer European Consortium) 054 and COG (Children's Oncology Group Consortium) AAML1921: Results from the Phase I Trial in Resistant/Intolerant Patients

Edoardo Pennesi, Erica Brivio, Marieke E. Willemse, Alwin D. R. Huitema, Saurabh Chandra, Ashwini Vijayakumar, Vincent H.J. Van Der Velden, H. Berna Beverloo, Chandra Durairaj, Andrea Viqueira, Antonella Ingrosso, Franco Locatelli, Jayashree Motwani, Jean-Pierre Bourquin, Francisco J. Bautista Sirvent, Carmelo Rizzari, Arnaud Petit, Donna Lancaster, Markus Metzler, Yves Bertrand, Laura Murillo-Sanjuán, Andrew J. Bukowkinski, Julie Krystal, Inge M. Van Der Sluis, Michael E. Roth, Harm Van Tinteren, Nobuko Hijiya, Christian M. Zwaan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2558.
https://doi.org/10.1182/blood-2021-145709
Published: 2021
Journal Articles

Multiparametric Flow Cytometry Evaluation of CD200L/CD200R- LSC/NK Synapse Including Leukemia Stem Cell (LSC) Fraction As a Potential Therapeutic Target and Marker of NK Cell Exhaustion in Pediatric AML-Conect-AML French Collaborative Network

Adriana Plesa, Octavia Cadassou, Joris Gutrin, Marine Villard, Christophe Roumier, Meyling Cheok, Florent Dumezy, Claude Preudhomme, Hélène Lapillonne, Arnaud Petit, Guy Leverger, Carine Halfon-Domenech, Cecile Renard, Yves Bertrand, Charles Dumontet, Sebastien Viel, Veronique Maguer-Satta, Thierry Walzer
Journal: Blood
Blood (2021) 138 (Supplement 1): 2375.
https://doi.org/10.1182/blood-2021-154181
Published: 2021
Journal Articles

IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL

Clinical Trials & Observations
Mathieu Simonin, Ludovic Lhermitte, Marie-Emilie Dourthe, Etienne Lengliné, Carlos Graux, Nathalie Grardel, Jean-Michel Cayuela, Isabelle Arnoux, Virginie Gandemer, Norbert Ifrah, Hervé Dombret, André Baruchel, Elizabeth Macintyre, Arnaud Petit, Nicolas Boissel, Vahid Asnafi
Journal: Blood
Blood (2021) 137 (12): 1690–1694.
https://doi.org/10.1182/blood.2020007959
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase II Study of Single-Agent Inotuzumab Ozogamicin in Pediatric CD22-Positive Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of the ITCC-059 Study

Erica Brivio, MD, Franco Locatelli, MD, Adriana Thano, Arnaud Petit, MD PhD, Britta Julia Vormoor, MD, Susana Rives, Bella Bielorai, MD, Claudia Rossig, Carmelo Rizzari, Vincent H.J. Van Der Velden, PhD, Anneke C.J. Ammerlaan, Monique L. Den Boer, PhD, Barbara Sleight, MD, Gernot Engstler, Jan Stary, MD PhD, Francisco José Bautista Sirvent, MD PhD, Christiane Chen-Santel, Bénédicte Bruno, MD, Yves Bertrand, MD, Fanny Rialland, MD, Geneviève Plat, Dirk Reinhardt, MD, Luciana Vinti, MD, Arend von Stackelberg, MD, Christian Michel Zwaan
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-134774
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020