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Denise Bonney
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Journal Articles

Bridging Pediatric B-Cell Acute Lymphoblastic Leukemia (ALL) Patients to CAR-T Cell Therapy: A National Perspective

Gustavo De Oliveira Canedo, Macarena Oporto Espuelas, Saskia Burridge, Priti Mehta, Orpheas Iosifidis, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna Jalowiec, Maeve O'Reilly, Claire Roddie, Katherine Clesham, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Juliana Silva, Sujith Samarasinghe, Ajay Vora, David Marks, Persis Jal Amrolia, Rachael Hough, Sara Ghorashian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4206.
https://doi.org/10.1182/blood-2024-200239
Published: 2024
Journal Articles

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL

Clinical Trials & Observations Brief Report
Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Aleks Guvenel, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-Yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Rebecca Thomas, Christopher Connor, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Allan Hackshaw, Evangelia Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Denise Bonney, Robert Wynn, Martin Pule, Rachael Hough, Persis J. Amrolia
Journal: Blood
Blood (2024) 143 (2): 118–123.
https://doi.org/10.1182/blood.2023020621
Published: 2024
Includes: Supplemental data
Journal Articles

Risk Factors for CD19-Targeting CAR T Manufacturing Failure and Patient Outcomes: A Report from the UK National CAR T Panel

Vaishali Dulobdas, Amy A Kirkwood, Fabio Serpenti, Brijesh Gautama, Aikaterini Panapoulou, Sumantha Gabriel, Ram Malladi, Jessica Pealing, Denise Bonney, Emma Nicholson, Caroline Besley, Sara Ghorashian, Elizabeth Davies, Jackie Chappell, Anne Black, Tobias Menne, Maeve O'Reilly, Robin Sanderson, Sridhar Chaganti
Journal: Blood
Blood (2023) 142 (Supplement 1): 495.
https://doi.org/10.1182/blood-2023-178834
Published: 2023
Journal Articles

Reduced Intensity Reinduction Followed By Blinatumomab Achieves Excellent MRD Clearance with Reduced Toxicity and Facilitates Timely Transplant in Children and Young People with Relapsed B-Precursor Acute Lymphoblastic Leukemia

Angus Hodder, Avijeet K Mishra, Katherine Clesham, Susan Baird, Kaljit Bhuller, Ismail Bisho, Denise Bonney, Anna Castleton, Michelle Cummins, Emmy Dickens, Lindsay George, Sara Ghorashian, Brenda Gibson, Chris Hasley, Nicholas Heaney, Rachael E Hough, Danielle Ingham, Galina Jigoulina, Katherine Lindsay, Donna Lancaster, Majid Madni, Andrea Malone, Bethany Mitchell, Anthony V. Moorman, John Moppett, Vanessa McLelland, Jayashree Motwani, Emma Nicholson, Caroline Osborne, Katharine Patrick, Lamia Samrin, Sanjay Tewari, Indu Rakesh Thakur, Sujith Samarasinghe, Ajay Vora, David O'Connor
Journal: Blood
Blood (2022) 140 (Supplement 1): 3268–3270.
https://doi.org/10.1182/blood-2022-162565
Published: 2022
Journal Articles

Blinatumomab As Toxicity Sparing First Line Treatment of Children and Young Persons with B-Precursor Acute Lymphoblastic Leukaemia (B-ALL)

Angus Hodder, Avijeet K Mishra, Susan Baird, Ismail Bisho, Denise Bonney, Katherine Clesham, Michelle Cummins, Emmy Dickens, Brenda Gibson, Lindsay George, Danielle Ingham, Galina Jigoulina, Donna Lancaster, Katherine Lindsay, Majid Madni, Andrea Malone, Bethany Mitchell, John Moppett, Jayashree Motwani, Anthony V. Moorman, Katharine Patrick, Lamia Samrin, Sanjay Tewari, Indu Rakesh Thakur, David O'Connor, Ajay Vora, Sujith Samarasinghe
Journal: Blood
Blood (2022) 140 (Supplement 1): 8987–8988.
https://doi.org/10.1182/blood-2022-162475
Published: 2022
Journal Articles

Systematic Intention to Treat Analysis of Real-World Outcomes in Children and Young Adults Receiving Tisagenlecleucel: From Elegibility through Treatment Failure

Macarena Oporto Espuelas, Saskia Burridge, Denise Bonney, Kelly Watts, Claire Roddie, Maeve A O'Reilly, Geoff Shenton, John A Snowden, Caroline Furness, Katarzyna Aleksandra Aleksandra Jalowiec, Lorna Neill, Katherine Clesham, Emma Nicholson, Anna Castleton, Amit Patel, Caroline Besley, Robert F Wynn, Ajay Vora, David I. Marks, Lindsay George, Ben Uttenthal, Sridhar Chaganti, Michelle Cummins, Persis J Amrolia, Rachael E Hough, Sara Ghorashian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2408–2410.
https://doi.org/10.1182/blood-2022-162863
Published: 2022
Journal Articles

ALL-REZ BFM 2002 Is Associated with Improved Outcome as Compared to ALL-R3 Strategy in Children with Standard Risk Isolated CNS Relapse of Acute Lymphoblastic Leukemia, while Maintaining Comparable Efficacy in Patients with Bone Marrow Relapse. Results of the Multi-National, Multi-Center Trial IntReALL SR 2010

Arend von Stackelberg, Jean-Pierre Bourquin, Martin Zimmermann, Tamas Revesz, Andishe Attarbaschi, Alina Ferster, Lucie Sramkova, Thomas Leth Frandsen, Päivi Maria Lähteenmäki, Ronit Elhasid, Hidemi Toyoda, Peter M. Hoogerbrugge, Inga M. Johannsdottir, Ximo Duarte, Denise Bonney, Vaskar Saha, Ingo G. Steffen, Andrej Lissat, Christiane Chen-Santel, Cornelia Eckert, Andre Baruchel, Arnaud Petit, Hélène Cavé, Carmelo Rizzari, Giovanni Cazzaniga, Luciana Vinti, Pierre Rohrlich, Franco Locatelli
Journal: Blood
Blood (2022) 140 (Supplement 1): 3247–3249.
https://doi.org/10.1182/blood-2022-166234
Published: 2022
Journal Articles

Donor-Derived, I n Vivo T-Cell Expansion Using Granulocyte Transfusions after Cord Blood Transplant Induces Remission in Children with Relapsed, Refractory Acute Myeloid Leukemia and Is Associated with a Cytokine Release Syndrome

Roisin Borrill, Helen Campbell, Denise Bonney, Ramya Nataraj, Madeleine Powys, Omima Abdalla Mustafa, Laura Kusyk, Tracy Hussell, Suzy Morton, Simon Stanworth, Kay Poulton, Joanne Konkel, Robert Wynn
Journal: Blood
Blood (2022) 140 (Supplement 1): 10368–10370.
https://doi.org/10.1182/blood-2022-163189
Published: 2022
Journal Articles

Dual Antigen Targeting with Co-Transduced CD19/22 CAR T Cells May Prevent Antigen-Negative Relapse after CAR T Cell Therapy for Relapsed/Refractory ALL

Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Evangelia K Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Katherine Clesham, Denise Bonney, Robert F Wynn, Martin Pule, Rachael E Hough, Persis J Amrolia
Journal: Blood
Blood (2022) 140 (Supplement 1): 10352–10354.
https://doi.org/10.1182/blood-2022-164879
Published: 2022
Journal Articles

Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia Administered Inotuzumab Pre CAR-T Therapy

Khushnuma Mullanfiroze, Giorgio Ottaviano, Avijeet K Mishra, Maria Gabelli, Arina Lazareva, Saskia Burridge, Susan Farish, Jan Chu, Kirsty Sharplin, David I. Marks, Maeve A O'Reilly, Emma Nicholson, Kelly Watts, Denise Bonney, Danny Cheng, Jack Bartram, Sujith Samarasinghe, Vesna Pavasovic, Anupama Rao, Philip Ancliffe, Ajay Vora, Giovanna Lucchini, Robert Chiesa, Paul Veys, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 1743.
https://doi.org/10.1182/blood-2021-148820
Published: 2021
Journal Articles

ALL Maintenance Treatment for Early Loss of B-Cell Aplasia after Tisagenlecleucel Therapy

Maria Gabelli, Macarena Oporto Espuelas, Denise Bonney, Saskia Burridge, Susan Farish, Khushnuma Mullanfiroze, Arina Lazareva, Sujith Samarasinghe, Philip Ancliffe, Ajay Vora, Jack Bartram, Emma Hedges, Kirsty Ware, Lindsey Young, Chiara Cugno, Lenka Chenchara, Juliana Silva, Oana Mirci-Danicar, Lynne Riley, Vesna Pavasovic, Anupama Rao, Paul Veys, Giovanna Lucchini, Robert Chiesa, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2021-152344
Published: 2021
Journal Articles

Intention to Treat Analysis of Real-World Outcomes Following Tisgenlecleucel Therapy for Pediatric and Young Adult ALL through a National Access Programme

Sara Ghorashian, FRCPath, PhD, Caroline Furness, Michelle Cummins, John A Snowden, BSc (Hons), MBChB, MD FRCP, FRCPath, Maeve A O'Reilly, MBBCHBAO, Claire Roddie, PhD MD, Lorna Neill, Emma Nicholson, Caroline Besley, MBBChir, MRCPath, MRCP, Sridhar Chaganti, MDPhDMRCP,FRCPath, John Gillson, MD, Antonio Pagliuca, MBBS, MA, FRCP, FRCPath, Anna Castleton, FRCPath, Amit Patel, MBBS,PhDFRCPath,MRCP, Peter Clark, MA MDFRCP, Robert Fernley, Robert Wynn, MD, Ajay Vora, MD, David I. Marks, MB, MS, FRACP, PhD FRCPath, Geoff Shenton, Persis J Amrolia, FRCP, FRCPath, PhD, Denise Bonney, Rachael E Hough, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-138438
Published: 2020
Journal Articles

Blinatumomab for infant acute lymphoblastic leukemia

Clinical Trials & Observations
Katherine Clesham, Vasudha Rao, Jack Bartram, Philip Ancliff, Sara Ghorashian, David O’Connor, Vesna Pavasovic, Anupama Rao, Sujith Samarasinghe, Michelle Cummins, Andrea Malone, Katharine Patrick, Denise Bonney, Beki James, Brenda Gibson, Ajay Vora
Journal: Blood
Blood (2020) 135 (17): 1501–1504.
https://doi.org/10.1182/blood.2019004008
Published: 2020
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy Targeting CD19 and CD22, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael E Hough, MD, Ajay Vora, Denise Bonney, Paul Veys, MD PhD, Robert Chiesa, Kanchan Rao, Liz Clark, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, MD, Vijay G R Peddareddigari
Journal: Blood
Blood (2019) 134 (Supplement_1): 2620.
https://doi.org/10.1182/blood-2019-123424
Published: 2019
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018
Journal Articles

Immune Mediated Cytopenia's Following Cord Blood Transplantation for Hurler's Syndrome: A Failure of Pre-Transplant Immune Suppression

David Deambrosis, MBBS, FRACP, Ryan Hum, Prashant Hiwarkar, Kay Poulton, Denise Bonney, Helen Jane Campbell, FRCP, MD FRCPath, Robert Wynn, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2018-99-112995
Published: 2018
Journal Articles

The Changing Patterns of Graft Failure in MPS1H, Hurler Syndrome: A Review of 30-Years Experience

Su Han Lum, Weston P Miller, Simon Jones, Jean Mercer, Troy Lund, Denise Bonney, Paul J Orchard, Robert Wynn
Journal: Blood
Blood (2016) 128 (22): 4700.
https://doi.org/10.1182/blood.V128.22.4700.4700
Published: 2016
Journal Articles

Impact of immune modulation with in vivo T-cell depletion and myleoablative total body irradiation conditioning on outcomes after unrelated donor transplantation for childhood acute lymphoblastic leukemia

Clinical Trials & Observations
Paul Veys, Robert F. Wynn, Kwang Woo Ahn, Sujith Samarasinghe, Wensheng He, Denise Bonney, John Craddock, Jacqueline Cornish, Stella M. Davies, Christopher C. Dvorak, Reggie E. Duerst, Thomas G. Gross, Neena Kapoor, Carrie Kitko, Robert A. Krance, Wing Leung, Victor A. Lewis, Colin Steward, John E. Wagner, Paul A. Carpenter, Mary Eapen
Journal: Blood
Blood (2012) 119 (25): 6155–6161.
https://doi.org/10.1182/blood-2012-01-405795
Published: 2012
Journal Articles

Correction of Immune and Enzyme Deficiency by Bone Marrow Transplant in PNP Deficient SCID

Vikramajit Singh, MRCP, Robert Wynn, MD, Denise Bonney, PhD, Stephen Hughes, MD, Kay Poulton, PhD, Helena Lee, PhD
Journal: Blood
Blood (2011) 118 (21): 4556.
https://doi.org/10.1182/blood.V118.21.4556.4556
Published: 2011