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Rachael Hough
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Journal Articles

Bridging Pediatric B-Cell Acute Lymphoblastic Leukemia (ALL) Patients to CAR-T Cell Therapy: A National Perspective

Gustavo De Oliveira Canedo, Macarena Oporto Espuelas, Saskia Burridge, Priti Mehta, Orpheas Iosifidis, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna Jalowiec, Maeve O'Reilly, Claire Roddie, Katherine Clesham, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Juliana Silva, Sujith Samarasinghe, Ajay Vora, David Marks, Persis Jal Amrolia, Rachael Hough, Sara Ghorashian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4206.
https://doi.org/10.1182/blood-2024-200239
Published: 2024
Journal Articles

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL

Clinical Trials & Observations Brief Report
Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Aleks Guvenel, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-Yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Rebecca Thomas, Christopher Connor, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Allan Hackshaw, Evangelia Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Denise Bonney, Robert Wynn, Martin Pule, Rachael Hough, Persis J. Amrolia
Journal: Blood
Blood (2024) 143 (2): 118–123.
https://doi.org/10.1182/blood.2023020621
Published: 2024
Includes: Supplemental data
Journal Articles

Title: Risk Factors and Natural History of Vincristine Induced Neuropathy on UKALL 2011: A Randomised Controlled Trial of the Effect of Omitting Vincristine Pulses

Lucy Alderson, Lucy Waller, Mario Cortina Borja, Amy A Kirkwood, Vickaynne Carruthers, David Jamieson, Pam Kearns, Amrana Qureshi, Susan Baird, Jayashree Motwani, Rachael Hough, John Moppett, Ajay Vora, Gareth Veal, Sujith Samarasinghe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2831.
https://doi.org/10.1182/blood-2023-181721
Published: 2023
Journal Articles

Allogeneic stem cell transplantation compared to conservative management in adults with inborn errors of immunity

Clinical Trials & Observations
Morgane Cheminant, Thomas A. Fox, Mickael Alligon, Olivier Bouaziz, Bénédicte Neven, Despina Moshous, Stéphane Blanche, Aurélien Guffroy, Claire Fieschi, Marion Malphettes, Nicolas Schleinitz, Antoinette Perlat, Jean-François Viallard, Nathalie Dhedin, Françoise Sarrot-Reynauld, Isabelle Durieu, Sébastien Humbert, Fanny Fouyssac, Vincent Barlogis, Benjamin Carpenter, Rachael Hough, Arian Laurence, Ambroise Marçais, Ronjon Chakraverty, Olivier Hermine, Alain Fischer, Siobhan O. Burns, Nizar Mahlaoui, Emma C. Morris, Felipe Suarez
Journal: Blood
Blood (2023) 141 (1): 60–71.
https://doi.org/10.1182/blood.2022015482
Published: 2023
Includes: Supplemental data
Journal Articles

CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL): A Large Real-World Series from Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Eolia Brissot, Christophe Peczynski, Myriam Labopin, Federico Lussana, Rachael Hough, Jurgen Kuball, Wolf Roesler, Sabine Furst, Pere Barba, Michael Daskalakis, Tayfun Gungor, Marc Bierings, Caroline Besley, Ioanna Sakellari, Dimitrios Karakasis, Mi Kwon, Nathalie Fegueux, Annalisa Ruggeri, Christian Chabannon, Sebastian Giebel, Zinaida Peric, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 10389–10390.
https://doi.org/10.1182/blood-2022-158880
Published: 2022
Journal Articles

High Dose Methotrexate Does Not Reduce the Risk of CNS Relapse in Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoblastic Lymphoma. Results of the Randomised Phase III Study UKALL 2011

Amy A. Kirkwood, Nicholas Goulden, John Moppett, Sujith Samarasinghe, Jon Mee, Rachael Hough, Pamela R. Kearns, Sarah Lawson, Clare J. Rowntree, Ajay Vora
Journal: Blood
Blood (2022) 140 (Supplement 1): 516–518.
https://doi.org/10.1182/blood-2022-160129
Published: 2022
Journal Articles

SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome

Claire Schwab, Kathryn Roberts, Judith M. Boer, Gudrun Göhring, Doris Steinemann, Ajay Vora, Christine Macartney, Rachael Hough, Zoe Thorn, Richard Dillon, Gabriele Escherich, Giovanni Cazzaniga, Brigitte Schlegelberger, Mignon Loh, Monique L. den Boer, Anthony V. Moorman, Christine J. Harrison
Journal: Blood
Blood (2021) 137 (13): 1835–1838.
https://doi.org/10.1182/blood.2020008536
Published: 2021
Includes: Supplemental data
Journal Articles

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Amir Enshaei, David O’Connor, Jack Bartram, Jeremy Hancock, Christine J. Harrison, Rachael Hough, Sujith Samarasinghe, Monique L. den Boer, Judith M. Boer, Hester A. de Groot-Kruseman, Hanne V. Marquart, Ulrika Noren-Nystrom, Kjeld Schmiegelow, Claire Schwab, Martin A. Horstmann, Gabriele Escherich, Mats Heyman, Rob Pieters, Ajay Vora, John Moppett, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (17): 1438–1446.
https://doi.org/10.1182/blood.2019003191
Published: 2020
Includes: Supplemental data
Journal Articles

Clonal Dynamics of Early Responder and Long-Term Surviving CAR-T Cells in Humans

Christine Rivat, Natalia Izotova, Rachel Richardson, MSc, Danilo Pellin, Rachael Hough, Robert Wynn, MD, Kim Champion, Andre Lopes, Sara Ghorashian, FRCPath, PhD, Martin Pule, Adrian J. Thrasher, MBBS, PhD FMedSci, Luca Biasco, PhD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 52.
https://doi.org/10.1182/blood-2019-125916
Published: 2019
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018
Journal Articles

Preliminary Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia and Down Syndrome (DS-ALL) on UKALL 2011. Reduction in Treatment-Related Mortality with De-Escalated Therapy

Sara Ghorashian, FRCPath, PhD, Sujith Samarasinghe, Amy A Kirkwood, MSc, Rachael Hough, MD BMBS, FRCP, FRCPath, Clare Rowntree, MD, Sarah Lawson, MD, Nicholas John Goulden, MD PhD MRCPath, Emma Pond, PhD, Pamela R. Kearns, PhDFRCPC, Anthony V. Moorman, PhD, John Moppett, Ajay Vora, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 656.
https://doi.org/10.1182/blood-2018-99-118426
Published: 2018
Journal Articles

Acute Neurotoxicity during ALL Therapy Is Associated with Treatment Intensity, Age and Female Sex - an Analysis of SAE Reports from the UKALL 2003 Trial

Qurat-ul-Ain Wahid, Lina Hamadeh, Sheena McGowan, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Anthony V. Moorman, PhD, Christina Halsey, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1379.
https://doi.org/10.1182/blood-2018-99-113267
Published: 2018
Journal Articles

Predictors of Response in Patients Receiving CD34-Selected Stem Cell Infusions without Conditioning to Correct Graft Failure Following Allogeneic Stem Cell Transplantation

Maria del Mar Cuadrado, MBBS, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Stuart Ings, Michael J. Watts, PhD, Richard Szydlo, PhD, Chloe Anthias, MD, J. Alejandro Madrigal, MDPhDDSc,FRCP,FRCPath, Panagiotis Kottaridis, FRCPath,PhDMSc, Ben Carpenter, PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Karl Peggs, MBBChir, Kirsty Thomson, PhD, Emma Morris, FRCPath, MA, MBBChir, PhD MRCP, Ronjon Chakraverty, BMBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 204.
https://doi.org/10.1182/blood-2018-99-115054
Published: 2018
Journal Articles

Cord Blood Transplantation in Adolescents and Young Adults with Acute Leukemia: On Behalf of Eurocord, Ctiwp and PDWP of EBMT

Hiromi Hayashi, MD, Fernanda Volt, MSc, Jaime Sanz, Eefke J. Petersen, MD PhD, Nicolas Boissel, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Noel Milpied, MD, Emanuele Angelucci, MD, Ibrahim Yakoub-Agha, MD PhD, Mauricette Michallet, MD PhD, Gerard Michel, MD, Mahmoud Aljurf, MD, Chantal Kenzey, Vanderson Rocha, MD PhD, Jean-Hugues Dalle, MD PhD, Peter Bader, MD PhD, Eliane Gluckman, MD, Annalisa Ruggeri, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3369.
https://doi.org/10.1182/blood-2018-99-110067
Published: 2018
Journal Articles

Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency

Clinical Trials & Observations
Thomas A. Fox, Ronjon Chakraverty, Siobhan Burns, Benjamin Carpenter, Kirsty Thomson, David Lowe, Adele Fielding, Karl Peggs, Panagiotis Kottaridis, Benjamin Uttenthal, Venetia Bigley, Matthew Buckland, Victoria Grandage, Shari Denovan, Sarah Grace, Julia Dahlstrom, Sarita Workman, Andrew Symes, Stephen Mackinnon, Rachael Hough, Emma Morris
Journal: Blood
Blood (2018) 131 (8): 917–931.
https://doi.org/10.1182/blood-2017-09-807487
Published: 2018
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

The Incidence of Invasive Fungal Infections in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukaemia/Lymphoma Treated with the UKALL2011 Protocol: a Multicentre Retrospective Study

Maeve A O'Reilly, MB, Dinisha Govender, Ajay Vora, MD, Sujith Samarasinghe, Asim Khwaja, Victoria Grandage, Anupama Rao, Phil Ancliff, Danny Cheng, Ben Carpenter, Stephen Daw, David O'Connor, Rachael Hough, MD BMBS, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 102.
https://doi.org/10.1182/blood.V130.Suppl_1.102.102
Published: 2017
Journal Articles

UKALL 2011: Randomised Trial Investigating a Short Induction Dexamethasone Schedule for Children and Young Adults with Acute Lymphoblastic Leukaemia

Nicholas John Goulden, MD PhD MRCPath, Amy A Kirkwood, John Moppett, MD, Sujith Samarasinghe, Sarah Lawson, MD, Clare Rowntree, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Rajbir Athwal, Pamela R. Kearns, PhDFRCPC, Ajay Vora, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 141.
https://doi.org/10.1182/blood.V130.Suppl_1.141.141
Published: 2017
Journal Articles

Dexamethasone Pharmacokinetics Following Standard and Short Dosing Schedules in Patients on the UKALL2011 Trial

Rosanna Jackson, BSc, MSc, Philip Berry, BSc, Julie Errington, MSc, John Moppett, MD, Sujith Samarasinghe, Rachael Hough, MD BMBS, FRCP, FRCPath, Clare Rowntree, MD, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, MD, Pamela R. Kearns, PhDFRCPC, Julie Irving, PhD, Gareth J Veal, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 101.
https://doi.org/10.1182/blood.V130.Suppl_1.101.101
Published: 2017
Journal Articles

A Novel Second Generation CD19 CAR for Therapy of High Risk/Relapsed Paediatric CD19 + Acute Lymphoblastic Leukaemia and Other Haematological Malignancies: Preliminary Results from the Carpall Study

Sara Ghorashian, MD PhD FRCPath, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Catherine Irving, BSc, Lucas Chan, PhD, Fernanda Castro, PhD, Bilyana Popova, Kim Champion, PhD, Gary Wright, Hong Zhan, PhD, Waseem Qasim, MBBS PhD, Robert Wynn, Rachael Hough, MD BMBS, FRCP, FRCPath, Farzin Farzaneh, Martin A Pule, MD PhD, Persis J Amrolia, Professor
Journal: Blood
Blood (2016) 128 (22): 4026.
https://doi.org/10.1182/blood.V128.22.4026.4026
Published: 2016