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Journal Articles

Pharmacological Modulation of CD21 Antigen Density Enhances Chimeric Antigen Receptor (CAR-T) Cell Function

Nicola C Maciocia, Amy Burley, Malika Hoekx, Thaneswari Karpanasamy, Lydia Lee, David O'Connor, Marc R. Mansour, Asim Khwaja, Paul M Maciocia, Martin Pule
Journal: Blood
Blood (2022) 140 (Supplement 1): 4529–4530.
https://doi.org/10.1182/blood-2022-158973
Published: 2022
Journal Articles

Olutasidenib (FT-2102) Induces Durable Complete Remissions in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia. Results from a Planned Interim Analysis of a Phase 2 Pivotal Clinical Trial

Jorge E. Cortes, Pierre Fenaux, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David C Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Pierre Peterlin, Olga Polyanskaya, Jennifer Sweeney, Julie Brevard, Emma Barrett, Stephane De Botton
Journal: Blood
Blood (2022) 140 (Supplement 1): 6193–6196.
https://doi.org/10.1182/blood-2022-167330
Published: 2022
Journal Articles

Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL)

Nicola C Maciocia, Amy Burley, Francesco Nannini, Patrycja Wawrzyniecka, Margarida Neves, Thaneswari Karpanasamy, Mathieu Ferrari, Teresa Marafioti, Shimobi Onuoha, Asim Khwaja, Paul M Maciocia, Martin Pule
Journal: Blood
Blood (2021) 138 (Supplement 1): 902.
https://doi.org/10.1182/blood-2021-145725
Published: 2021
Journal Articles

Venetoclax with Azacitidine or Low Dose Cytarabine As an Alternative to Intensive Chemotherapy in Fit Adults during the COVID19 Pandemic: Real World Data from the UK National Health Service

Jad Othman, Mariam Amer, Ruebina Amofa, Laura Anderson, Michael J Austin, Alex Bashford, Edward Belsham, Jesca Boot, Victoria Louise Campbell, Thomas Coats, Angela Collins, Charles Crawley, Francesca Crolla, Joe W Cross, Chris Dalley, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliott, Sofia Galli, Paolo Gallipoli, Katherine Hodgson, Manish Jain, Pallavi Kalkur, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, Eleana Loizou, Justin Loke, Deepak Mannari, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Vidhya Murthy, Odong Ochaya, Shahzad Orthi, Renuka Palanicawandar, Srinivas Pillai, Dominika Radzova, Adam Rye, Jamie Saunders, Matthew Smith, David Taussig, Tom Taylor, Richard Whitmill, Rui Zhao, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 2321.
https://doi.org/10.1182/blood-2021-149685
Published: 2021
Journal Articles

Molecular Characteristics of Response to Olutasidenib (FT-2102) in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia

Stephane De Botton, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Jordi Esteve, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Olivier Legrand, Pierre Peterlin, Montserrat Arnan Sangerman, William G. Blum, Daniela Cilloni, Devendra Hiwase, Joseph G. Jurcic, Jürgen Krauter, Xavier Thomas, Justin Watts, Jay Yang, Zihao Xin, Alex Sedkov, Sylvie Guichard, Jennifer Sweeney, Christophe Marzac, Jorge E. Cortes, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 2351.
https://doi.org/10.1182/blood-2021-144912
Published: 2021
Journal Articles

Co-Operation of MCL-1 and BCL-X L Anti-Apoptotic Proteins in Stromal Protection of MM Cells from Carfilzomib Mediated Cytotoxicity

Daria Galas-Filipowicz, Selina J Chavda, Jianan Gong, David C.S. Huang, Asim Khwaja, Kwee Yong
Journal: Blood
Blood (2021) 138 (Supplement 1): 2677.
https://doi.org/10.1182/blood-2021-149160
Published: 2021
Journal Articles

Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health Service

Jad Othman, Usman Afzal, Ruebina Amofa, Michael J Austin, Alex Bashford, Edward Belsham, Jennifer Byrne, Thomas Coats, Raymond Dang, Mike Dennis, Saniya Dhawan, Johnathon Elliot, Sebastian Francis, Paolo Gallipoli, Katherine Hodgson, Charlotte Kallmeyer, Manish Jain, Vana Katsomitrou, Anjum Khan, Asim Khwaja, Seye Kolade, Pramila Krishnamurthy, Annie Latif, John Laurie, Michael Lim, (Justin) Ching Ting Loke, Cara Manson, Scott R. Marshall, Behnaz Mobashwera, Sreetharan Munisamy, Duncan Murray, Vidhya Murthy, Renuka Palanicawandar, Jamie Saunders, Matthew Smith, Katherine Smith, Alex Sternberg, David Taussig, Tom Taylor, Sylvie D Freeman, Charles Craddock, Richard Dillon
Journal: Blood
Blood (2021) 138 (Supplement 1): 1254.
https://doi.org/10.1182/blood-2021-150169
Published: 2021
Journal Articles

Autophagy Blockade Disrupts Myeloma Cell Recovery from Proteasome Inhibition and Enhances Apoptosis

Selina J Chavda, Daria Galas-Filipowicz, Evelyn Fitzsimons, Anna Mikolajczak, Sharon Tooze, Holger W Auner, Katja Simon, Asim Khwaja, Kwee Yong
Journal: Blood
Blood (2021) 138 (Supplement 1): 1567.
https://doi.org/10.1182/blood-2021-146400
Published: 2021
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

A Phase I Study Evaluating the Safety and Persistence of Allorestricted WT1-TCR Gene Modified Autologous T Cells in Patients with High-Risk Myeloid Malignancies Unsuitable for Allogeneic Stem Cell Transplantation

Emma C Morris, Rita Tendeiro-Rego, Rachel Richardson, MSc, Thomas A Fox, BSc, MSc, MRCP, Francesca Sillito, BSc, MRCP, FRCPath, Angelika Holler, Sharyn Thomas, Shao-An Xue, Irma Alicia Martínez-Dávila, Emma Nicholson, Mandana Ahmadi, Judith King, Panagiotis Kottaridis, Ronjon Chakraverty, BMBS, PhD, Kirsty Thomson, Stephen Robinson, MBBS, PhD BSc, Andres E. Virchis, FRCP, FRCPath, Asim Khwaja, Michelle Quaye, Hong Zhan, Waseem Qasim, MBBS, PhD, Nourredine Himoudi, Jacqueline Barry, Natalie Mount, PhD, Terri Gaskell, Michaela Sharpe, Shannon M Inman, Kurt C. Gunter, MD, Hans Stauss
Journal: Blood
Blood (2019) 134 (Supplement_1): 1367.
https://doi.org/10.1182/blood-2019-128044
Published: 2019
Journal Articles

Utility of FDG-PET/CT in Lymphoblastic Lymphoma

Thomas A Fox, BSc, MSc, MRCP, Ben Carpenter, PhD, Asim Khwaja, Richard Halsey, MRCP, Victoria Grandage, Marc R. Mansour, MD PhD FRCPath, Adele K. Fielding, MBBS,PhDFRCP,FRCPath, Rachael E Hough, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2890.
https://doi.org/10.1182/blood-2019-127379
Published: 2019
Journal Articles

Pre-Transplant NPM1 Mutant Transcript Level Is Highly Predictive of Outcome after Allograft and Thresholds Are Dependent on FLT3 ITD Status

Richard Dillon, MA, PhD MRCP, FRCPath, Robert K. Hills, MA, DPhil, MSc, Sylvie D Freeman, MBChB, DPhil, Nicola Potter, PhD, Adam Ivey, BSc, MSc, PhD, Jelena Jovanovic, PhD, Anju Kanda, MSc, Manohursingh Runglall, MSc, Nicola Foot, MSc, Laura Upton, Asim Khwaja, MD PhD, Jamie Cavenagh, MD PhD, Ruth Spearing, MD, Alan K. Burnett, MD, Nigel H. Russell, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2739.
https://doi.org/10.1182/blood-2018-99-113662
Published: 2018
Journal Articles

The Incidence of Invasive Fungal Infections in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukaemia/Lymphoma Treated with the UKALL2011 Protocol: a Multicentre Retrospective Study

Maeve A O'Reilly, MB, Dinisha Govender, Ajay Vora, MD, Sujith Samarasinghe, Asim Khwaja, Victoria Grandage, Anupama Rao, Phil Ancliff, Danny Cheng, Ben Carpenter, Stephen Daw, David O'Connor, Rachael Hough, MD BMBS, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 102.
https://doi.org/10.1182/blood.V130.Suppl_1.102.102
Published: 2017
Journal Articles

Clinical Outcomes of Phase I/II Clinical Trials for Patients with Relapsed/Refractory Haematological Malignancies: Experience of an Early Phase Clinical Trials Unit

Chin-Hin Ng, MD MRCP, FRCPATH, Dima El-Sharkawi, MD, Elspeth M Payne, MDPhD, Kwee L Yong, Kirit M Ardeshna, MD FRCP, FRCPATH, Asim Khwaja, FRCPath, Rakesh Popat
Journal: Blood
Blood (2016) 128 (22): 3613.
https://doi.org/10.1182/blood.V128.22.3613.3613
Published: 2016
Journal Articles

A Comparison of Single Dose Gemtuzumab Ozogamicin 3mg/m 2 and 6mg/m 2 Combined with Induction Chemotherapy in Younger Patients with AML: Data from the UK NCRI AML17 Trial

Alan K Burnett, MD, Nigel Russell, Robert K. Hills, MA MSc DPhil, Jamie Cavenagh, Jonathan Kell, MD MB, Gail Jones, Asim Khwaja, FRCPath, Mary Frances McMullin, MDFRCPath,FRCP, Mike Dennis, Donald Milligan, MD, Richard E Clark, MBBS MD
Journal: Blood
Blood (2014) 124 (21): 2308.
https://doi.org/10.1182/blood.V124.21.2308.2308
Published: 2014
Journal Articles

Synergistic Induction of Cell Death By Combined Inhibition of PIM and AKT Kinases in Cytogenetically Defined Standard and High-Risk Multiple Myeloma

Koremu Meja, Dean Smith, MBBS, Laura Percy, Dennis Huszar, PhD, Barry R Davies, Kwee L Yong, MBChB, PhD, Asim Khwaja
Journal: Blood
Blood (2014) 124 (21): 4723.
https://doi.org/10.1182/blood.V124.21.4723.4723
Published: 2014
Journal Articles

Impact of FLT3 ITD mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia

Brief Report
David C. Linch, Robert K. Hills, Alan K. Burnett, Asim Khwaja, Rosemary E. Gale
Journal: Blood
Blood (2014) 124 (2): 273–276.
https://doi.org/10.1182/blood-2014-02-554667
Published: 2014
Includes: Supplemental data
Journal Articles

AC220 (Quizartinib) Can Be Safely Combined With Conventional Chemotherapy In Older Patients With Newly Diagnosed Acute Myeloid Leukaemia: Experience From The AML18 Pilot Trial

Alan K. Burnett, MD, David Bowen, MD, PhD, Nigel Russell, MD, Steven Knapper, MD, Donald Milligan, MD, FRCP, FRCPath, Ann E. Hunter, MBBS, FRCP, FRCPath, Asim Khwaja, FRCPath, Richard E. Clark, MBBS, MD, FRCP, FRCPath, Dominic Culligan, Helen Clark, Robert K. Hills, MA, MSc, DPhil
Journal: Blood
Blood (2013) 122 (21): 622.
https://doi.org/10.1182/blood.V122.21.622.622
Published: 2013
Journal Articles

PI3K/mTOR Inhibition Upregulates NOTCH-MYC Signalling Leading to an Impaired Cytotoxic Response

Clare Shepherd, PhD, Lalita Banerjee, FRCPath, Ching Wai Cheung, FRCPath, Marc R Mansour, MRCP, Sarah Jenkinson, MSc, Rosemary E Gale, PhD, Asim Khwaja, FRCPath
Journal: Blood
Blood (2012) 120 (21): 1358.
https://doi.org/10.1182/blood.V120.21.1358.1358
Published: 2012
Journal Articles

PI-103, a Novel Dual Inhibitor of PI3-Kinase and mTOR, Enhances the Activity of Imatinib Mesylate in BCR-ABL-Positive Acute Leukaemia Cells

Zacharoula Nikolakopoulou, MSc, Asim Khwaja, MD
Journal: Blood
Blood (2008) 112 (11): 4232.
https://doi.org/10.1182/blood.V112.11.4232.4232
Published: 2008