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Robert K. Hills
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Journal Articles

A Randomised Comparison of CPX-351 Versus Standard Daunorubicin and Cytarabine Plus Fractionated Gemtuzumab Ozogamicin in Older Adults with AML without Adverse Risk Cytogenetics: Results of the NCRI AML18 Trial

Steven Knapper, Laura W Dillon, Malavika Babu, Abin Thomas, Ian Thomas, Christopher S. Hourigan, Georgia Andrew, Richard Dillon, Amanda Gilkes, Nuria M Almuina, Sophie King, Thomas Coats, Nicholas McCarthy, Jennifer Byrne, Simone Green, Ulrik Malthe Overgaard, Leanne Berkahn, Louisa Stone, Rasha W Al-Ali, Reem Bahr, Rob Sellar, Mike Dennis, Priyanka Mehta, Robert K Hills, Sylvie D Freeman, Nigel H. Russell
Journal: Blood
Blood (2024) 144 (Supplement 1): 59.
https://doi.org/10.1182/blood-2024-200027
Published: 2024
Journal Articles

Fractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial

CME Clinical Trials & Observations
Sylvie D. Freeman, Abin Thomas, Ian Thomas, Robert K. Hills, Paresh Vyas, Amanda Gilkes, Marlen Metzner, Niels Asger Jakobsen, Alison Kennedy, Rachel Moore, Nuria Marquez Almuina, Sarah Burns, Sophie King, Georgia Andrew, Kathleen M. E. Gallagher, Rob S. Sellar, Paul Cahalin, Duruta Weber, Mike Dennis, Priyanka Mehta, Steven Knapper, Nigel H. Russell
Journal: Blood
Blood (2023) 142 (20): 1697–1707.
https://doi.org/10.1182/blood.2023020630
Published: 2023
Includes: Supplemental data
Journal Articles

Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

Friederike Christen, Kaja Hoyer, Kenichi Yoshida, Hsin-An Hou, Nils Waldhueter, Michael Heuser, Robert K. Hills, Willy Chan, Raphael Hablesreiter, Olga Blau, Yotaro Ochi, Piroska Klement, Wen-Chien Chou, Igor-Wolfgang Blau, Jih-Luh Tang, Tomasz Zemojtel, Yuichi Shiraishi, Yusuke Shiozawa, Felicitas Thol, Arnold Ganser, Bob Löwenberg, David C. Linch, Lars Bullinger, Peter J. M. Valk, Hwei-Fang Tien, Rosemary E. Gale, Seishi Ogawa, Frederik Damm
Journal: Blood
Blood (2019) 133 (10): 1140–1151.
https://doi.org/10.1182/blood-2018-05-852822
Published: 2019
Includes: Supplemental data
Journal Articles

The Achievement of Complete Remission Is Associated with Improved Quality of Life in Non-Intensively Treated Patients with Acute Myeloid Leukemia: Results of the UK NCRI LI-1 Tria

Robert K. Hills, MA,DPhil,MSc, Ian Thomas, Alan K. Burnett, MD, Claire Jane Hemmaway, MD, Helen Dignum, Nigel H. Russell, Michael Dennis, MDMRCP,FRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 372.
https://doi.org/10.1182/blood-2018-99-116173
Published: 2018
Journal Articles

Therapy-Related Myeloid Neoplasms with Balanced Chromosome Rearrangements Frequently Arise from Pre-Existing Clonal Haematopoiesis

Richard Dillon, MA, PhD MRCP, FRCPath, Jelena Jovanovic, PhD, Nicola Potter, PhD, Nicola Foot, MSc, Matthew J Ahearne, MD MBBS, Sandrine Jayne, PhD, Michael Dennis, MD MRCP, FRCPath, Ann E. Hunter, MBBS, FRCP, FRCPath, Martin J.S. Dyer, Paresh Vyas, Lynn Quek, FRCPath, DPhil, MBBS, Nigel H. Russell, Robert K. Hills, MA, DPhil, MSc, Ellen Solomon, PhD, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2570.
https://doi.org/10.1182/blood-2018-99-114233
Published: 2018
Journal Articles

Comparison of Cure Rates between Gemtuzumab Ozogamicin Plus Standard of Care Chemotherapy Vs Standard of Care Alone in Patients with Newly Diagnosed Acute Myeloid Leukemia

Bogdan Muresan, MSc, Carla M. Mamolo, PhD, Joseph C Cappelleri, PhD MPH, MS, Ruth Mokgokong, Athina Palaka, Robert K. Hills, MA, DPhil, MSc, Nicholas Latimer, PhD, Bart Heeg, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2712.
https://doi.org/10.1182/blood-2018-99-110800
Published: 2018
Journal Articles

Outcomes of Relapsed/Refractory Patients with IDH1/2 Mutated AML Treated with Non-Targeted Therapy: Results from the NCRI AML Trials

Robert K. Hills, MA,DPhil,MSc, Rosemary Gale, PhD, David C. Linch, Brian J.P Huntly, Elli Papaemmanuil, PhD, Paresh Vyas, Alan K. Burnett, MD, Nigel H. Russell
Journal: Blood
Blood (2018) 132 (Supplement 1): 664.
https://doi.org/10.1182/blood-2018-99-116482
Published: 2018
Journal Articles

Pre-Transplant NPM1 Mutant Transcript Level Is Highly Predictive of Outcome after Allograft and Thresholds Are Dependent on FLT3 ITD Status

Richard Dillon, MA, PhD MRCP, FRCPath, Robert K. Hills, MA, DPhil, MSc, Sylvie D Freeman, MBChB, DPhil, Nicola Potter, PhD, Adam Ivey, BSc, MSc, PhD, Jelena Jovanovic, PhD, Anju Kanda, MSc, Manohursingh Runglall, MSc, Nicola Foot, MSc, Laura Upton, Asim Khwaja, MD PhD, Jamie Cavenagh, MD PhD, Ruth Spearing, MD, Alan K. Burnett, MD, Nigel H. Russell, David Grimwade, PhD MRCP, MRCPath
Journal: Blood
Blood (2018) 132 (Supplement 1): 2739.
https://doi.org/10.1182/blood-2018-99-113662
Published: 2018
Journal Articles

Outcomes in Relapsed/Refractory Patients with FLT3-ITD Mutated AML Are Poor When Treated with Non-Targeted Therapy with a Potential Role for Stem Cell Transplantation: Results from the NCRI AML Trials

Robert K. Hills, MA,DPhil,MSc, Alan K. Burnett, MD, Rosemary Gale, PhD, David C. Linch, Amanda Gilkes, Nigel H. Russell
Journal: Blood
Blood (2018) 132 (Supplement 1): 1392.
https://doi.org/10.1182/blood-2018-99-116542
Published: 2018
Journal Articles

Telomere Length Predicts for Outcome to FCR Chemoimmunotherapy in CLL

Kevin Norris, PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Andy Rawstron, BSc, PhD, Robert K. Hills, MA, DPhil, MSc, Duncan M Baird, PhD, Chris Pepper, BSc, PhD, Christopher Fegan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1854.
https://doi.org/10.1182/blood-2018-99-114448
Published: 2018
Journal Articles

Results of a Phase 2 Trial of the Monocyte-Targeted Histone Deacetylase Inhibitor Tefinostat (CHR-2845) in Chronic Myelomonocytic Leukemia (CMML) — the UK Monocle Study

Steven Knapper, DM, Michael Dennis, MD, MRCP, FRCPath, Mark W Drummond, PhDMD, Robert K. Hills, MA, DPhil, MSc, Richard James Dillon, MA, PhD MRCP, FRCPath, Christopher Pocock, MD PhD, Dominic J. Culligan, Paresh Vyas, Daniel Wiseman, MB, ChB, Joanna Zabkiewicz, PhD, Marie Hodges, PhD MSc, Catherine Cargo, MB, FRCPath, Jan Taylor, PhD MSc, BSc, Laura Upton, Melissa Wright, David Bowen, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1818.
https://doi.org/10.1182/blood-2018-99-110356
Published: 2018
Journal Articles

Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

Clinical Trials & Observations
Gerrit J. Schuurhuis, Michael Heuser, Sylvie Freeman, Marie-Christine Béné, Francesco Buccisano, Jacqueline Cloos, David Grimwade, Torsten Haferlach, Robert K. Hills, Christopher S. Hourigan, Jeffrey L. Jorgensen, Wolfgang Kern, Francis Lacombe, Luca Maurillo, Claude Preudhomme, Bert A. van der Reijden, Christian Thiede, Adriano Venditti, Paresh Vyas, Brent L. Wood, Roland B. Walter, Konstanze Döhner, Gail J. Roboz, Gert J. Ossenkoppele
Journal: Blood
Blood (2018) 131 (12): 1275–1291.
https://doi.org/10.1182/blood-2017-09-801498
Published: 2018
Includes: Supplemental data
Journal Articles

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice

Edwige Voisset, Eva Moravcsik, Eva W. Stratford, Amie Jaye, Christopher J. Palgrave, Robert K. Hills, Paolo Salomoni, Scott C. Kogan, Ellen Solomon, David Grimwade
Journal: Blood
Blood (2018) 131 (6): 636–648.
https://doi.org/10.1182/blood-2017-07-794784
Published: 2018
Includes: Supplemental data
Journal Articles

No evidence that CD33 splicing SNP impacts the response to GO in younger adults with AML treated on UK MRC/NCRI trials

Clinical Trials & Observations
Rosemary E. Gale, Teodora Popa, Melissa Wright, Naeem Khan, Sylvie D. Freeman, Alan K. Burnett, Nigel H. Russell, Robert K. Hills, David C. Linch
Journal: Blood
Blood (2018) 131 (4): 468–471.
https://doi.org/10.1182/blood-2017-08-802157
Published: 2018
Includes: Supplemental data
Journal Articles

HMGA2 Gene Expression Profile Improves Risk Stratification in Acute Myeloid Leukemia

Miriam Marquis, PhD, Cyrielle Beaubois, Vincent-Philippe Lavallee, MD, Michal Abrahamowicz, PhD, Coraline Danieli, PhD, Sébastien Lemieux, PhD, Imran Ahmad, MD, Andrew Wei, MBBS, FRACP, FRCPA, PhD, Stephen B Ting, MD PhD, Shaun Fleming, MBBS(Hons) FRACP FRCPA, Anthony P Schwarer, MD MBBS (Hons), FRACP, FRCPA, William Grey, PhD, David Grimwade, MD PhD, Robert K. Hills, DPhil, Paresh Vyas, MD PhD, Nigel H. Russell, MD, Guy Sauvageau, MD, PhD, Josee Hebert, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1402.
https://doi.org/10.1182/blood.V130.Suppl_1.1402.1402
Published: 2017
Journal Articles

A Knowledge-Based Approach for Clinical Annotation of Oncogenic Variants to Support Patient-Tailored Diagnosis in Myeloid Disease

Elsa Bernard, PhD, Kenichi Yoshida, MD PhD, Gunes Gundem, PhD, Jacob Grinfeld, MBChB, BSc, MRCP, FRCPath, Jyoti Nangalia, MBBChir, MA, MRCP, FRCPath, PhD, Daniel Leongamornlert, PhD, Noushin Farnoud, PhD, Juan Medina, Matahi Moarii, PhD, Charlie Massie, PhD, Yasunobu Nagata, MD PhD, Yusuke Okuno, MD PhD, Torsten Haferlach, MD, Seishi Ogawa, MD PhD, Amanda Gilkes, Oliver G. Ottmann, MD, Robert K. Hills, DPhil, Nigel H. Russell, Brian J.P Huntly, Anthony R Green, PhD FRCP, FRCPath, FMedSci, Alan K. Burnett, MD, Peter Campbell, PhD, Elli Papaemmanuil, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1414.
https://doi.org/10.1182/blood.V130.Suppl_1.1414.1414
Published: 2017
Journal Articles

Characteristics and Outcome of Patients with Acute Myeloid Leukemia and t(6;9)(p22;q34)

Sabine Kayser, MD, Robert K. Hills, DPhil, Marlise R. Luskin, MD, Andrew M. Brunner, MD, Carole Shaw, Joerg Westermann, MD, Kamal Menghrajani, MD, Maria R. Baer, MD, Michelle A. Elliott, MD, Alexander E. Perl, MD, Christine Terré, PharmD, PhD, Zdenek Racil, MD, Jiri Mayer, Prof, MD SCs, Pavel Zak, MD, Tomas Szotkowski, MD, David Grimwade, Karin Mayer, MD, Roland B. Walter, MD PhD, Alwin Krämer, MD, Alan K. Burnett, MD, Anthony D. Ho, Richard M. Stone, MD, Martin S. Tallman, MD, Elihu H. Estey, MD, Carsten Müller-Tidow, Nigel H. Russell, Richard F. Schlenk, MD, Mark J. Levis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3906.
https://doi.org/10.1182/blood.V130.Suppl_1.3906.3906
Published: 2017
Journal Articles

An Evaluation of 17 Years of Low Dose Cytarabine As Therapy for AML Patients Not Fit for Intensive Treatment, Including Patients with Adverse Cytogenetics, Shows Improving Survival, Potential Underutilisation and Highlights the Need for New Therapy

Michael Dennis, MDMRCP,FRCPath, Robert K. Hills, DPhil, Nigel H. Russell, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Ian Thomas, Mary Frances Frances McMullin, MB,Bch BAO, MD FRCPath, Sahra Ali, Alan K. Burnett, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3874.
https://doi.org/10.1182/blood.V130.Suppl_1.3874.3874
Published: 2017
Journal Articles

Flow Cytometric Minimal Residual Disease As Risk Stratification Tool in Younger Adults with NPM1 Wild Type Standard Risk Acute Myeloid Leukemia

Sylvie D Freeman, MBChB, DPhil, Robert K. Hills, DPhil, Paul Virgo, Naeem Khan, PhD, Stephen Couzens, Richard James Dillon, MA, PhD MRCP, FRCPath, Laura Upton, Lars Kjeldsen, MD, Ian Thomas, David Grimwade, Alan K. Burnett, MD, Nigel H. Russell
Journal: Blood
Blood (2017) 130 (Supplement 1): 468.
https://doi.org/10.1182/blood.V130.Suppl_1.468.468
Published: 2017
Journal Articles

A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML

Clinical Trials & Observations
Steven Knapper, Nigel Russell, Amanda Gilkes, Robert K. Hills, Rosemary E. Gale, James D. Cavenagh, Gail Jones, Lars Kjeldsen, Michael R. Grunwald, Ian Thomas, Heiko Konig, Mark J. Levis, Alan K. Burnett
Journal: Blood
Blood (2017) 129 (9): 1143–1154.
https://doi.org/10.1182/blood-2016-07-730648
Published: 2017
Includes: Supplemental data