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Journal Articles

Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL)

Nicola C Maciocia, Amy Burley, Francesco Nannini, Patrycja Wawrzyniecka, Margarida Neves, Thaneswari Karpanasamy, Mathieu Ferrari, Teresa Marafioti, Shimobi Onuoha, Asim Khwaja, Paul M Maciocia, Martin Pule
Journal: Blood
Blood (2021) 138 (Supplement 1): 902.
https://doi.org/10.1182/blood-2021-145725
Published: 2021
Journal Articles

A High Sensitivity aCD22 CAR Combined with aCD19 CAR to Generate Dual Targeting CAR T Cells for the Treatment of r/r B-ALL

Evangelia K Kokalaki, Biao Ma, Mathieu Ferrari, Thomas Grothier, Warren Hazelton, Somayya Manzoor, Eren Costu, Saket Srivastava, Ram Jha, Rosalind Gealy, Lukas Stanczuk, Mathew Robson, Julia Taylor, Mohamed El-Kholy, Vania Baldan, Matteo Righi, James Sillibourne, Shimobi Onuoha, Sara Ghorashian, Shaun P Cordoba, Persis J Amrolia, Martin Pule
Journal: Blood
Blood (2021) 138 (Supplement 1): 1710.
https://doi.org/10.1182/blood-2021-152655
Published: 2021
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Generation of a Highly Sensitive CD22 CAR

Evangelia K Kokalaki, Biao Ma, PhD, Thomas Grothier, MSc, Warren Hazelton, MSc, Eren Costu, BSc, Somayya Manzoor, MSc, Ram Jha, MSc, Simon Thomas, PhD, Shimobi Onuoha, PhD, Shaun P Cordoba, PhD, Martin Pule, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5747.
https://doi.org/10.1182/blood-2019-128002
Published: 2019
Journal Articles

Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy Targeting CD19 and CD22, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael E Hough, MD, Ajay Vora, Denise Bonney, Paul Veys, MD PhD, Robert Chiesa, Kanchan Rao, Liz Clark, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, MD, Vijay G R Peddareddigari
Journal: Blood
Blood (2019) 134 (Supplement_1): 2620.
https://doi.org/10.1182/blood-2019-123424
Published: 2019
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018
Journal Articles

Structure Guided Engineering of Highly Specific Chimeric Antigen Receptors for the Treatment of T Cell Lymphomas

Shimobi Onuoha, PhD, Mathieu Ferrari, Anna Bulek, Reyisa Bughda, Somayya Manzoor, Saket Srivastava, Biao Ma, Rajesh Karattil, Alex Kinna, PhD, Patrycja Wawrzyniecka, Simon Thomas, PhD, Shaun P Cordoba, PhD, Paul Maciocia, BSc, MBChB, MRCP, Martin Pule, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1661.
https://doi.org/10.1182/blood-2018-99-119564
Published: 2018
Journal Articles

Analysis of T-Cell Receptor Beta-Constant Region Expression for Rapid Assessment of T-Cell Clonality

Paul Maciocia, BSc, MBChB, MRCP, Margarida Neves, MSc, Shimobi Onuoha, PhD, Patrycja Wawrzyniecka, Giuseppe Gritti, Manuela Tosi, Alessia Moioli, Martin Pule, MD, Teresa Marafioti, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2867.
https://doi.org/10.1182/blood-2018-99-112569
Published: 2018
Journal Articles

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma

Lydia Lee, Benjamin Draper, Neil Chaplin, Brian Philip, Melody Chin, Daria Galas-Filipowicz, Shimobi Onuoha, Simon Thomas, Vania Baldan, Reyisa Bughda, Paul Maciocia, Eva Kokalaki, Margarida P. Neves, Dominic Patel, Manuel Rodriguez-Justo, James Francis, Kwee Yong, Martin Pule
Journal: Blood
Blood (2018) 131 (7): 746–758.
https://doi.org/10.1182/blood-2017-05-781351
Published: 2018
Includes: Supplemental data
Journal Articles

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

Vania Baldan, PhD, Priyanka Ghongane, MSc, Evangelia Kokalaki, PhD, Wen Chean Lim, PhD, Shimobi Onuoha, PhD, Shaun Paul Cordoba, PhD, Simon Thomas, PhD, Martin Pule, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3190.
https://doi.org/10.1182/blood.V130.Suppl_1.3190.3190
Published: 2017
Journal Articles

Construction and Pre-Clinical Evaluation of a New Anti-CD19 Chimeric Antigen Receptor

Anne Marijn Kramer, MD, Sara Ghorashian, MD PhD FRCPath, Gordon Weng-Kit Cheung, MSc, Winston Vetharoy, BVSc, Dale Moulding, PhD, Leila Mekkaoui, MSc, Shimobi Onuoha, PhD, Persis J Amrolia, Professor, Martin A Pule, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1627.
https://doi.org/10.1182/blood.V128.22.1627.1627
Published: 2016
Journal Articles

Targeting T-Cell Receptor β-Constant Domain for Immunotherapy of T-Cell Malignancies

Paul Michael Maciocia, BSc,MBBS,MRCP, Patrycja Wawrzyniecka, MSc, Brian Philip, PhD, Ida Ricciardelli, PhD, Ayse U. Akarca, BSc, Shimobi Onuoha, PhD, David Cole, PhD, Andrew Sewell, PhD, Karl S Peggs, MD, David C. Linch, MD MRCP, MB BCh, BA, Teresa Marafioti, MD, Martin A Pule, MD PhD
Journal: Blood
Blood (2016) 128 (22): 811.
https://doi.org/10.1182/blood.V128.22.811.811
Published: 2016