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Journal Articles

Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

David O’Connor, Jose Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R. Costa, Jack Bartram, Stuart Adams, Gary Wright, Hillary Elrick, Kerry Wall, Sara Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, Isidro Cortes-Ciriano, Anthony V. Moorman, Marc R. Mansour
Journal: Blood
Blood (2024) 143 (10): 933–937.
https://doi.org/10.1182/blood.2023021906
Published: 2024
Includes: Supplemental data
Journal Articles

Routine Whole Genome Sequencing Offers a More Comprehensive Assessment of IG/TCR Gene Rearrangements for MRD Targets in Acute Lymphoblastic Leukemia - Data from the First 62 Cases from the NHS England Genomic Medicine Service

Stuart Adams, Jeremy Hancock, Joe Kaplinsky, Alona Sosinsky, Gary Wright, Soragia Athina Gkazi, Susanne Kricke, Rebecca Thomas, Natalie Kent, Angus Hodder, Jack Bartram
Journal: Blood
Blood (2023) 142 (Supplement 1): 4351.
https://doi.org/10.1182/blood-2023-187667
Published: 2023
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pablo Menendez, Thomas A. Milne, Irene Roberts, Anindita Roy
Journal: Blood
Blood (2019) 134 (13): 1059–1071.
https://doi.org/10.1182/blood.2019001289
Published: 2019
Includes: Supplemental data
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product in a First-in-Human Trial (PALL) in Pediatric Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Waseem Qasim, MD PhD, Oana Ciocarlie, Stuart Adams, PhD, Sarah Inglott, Claire Murphy, Christine Rivat, Gary Wright, Giovanna Lucchini, MD, Juliana Silva, MD, Kanchan Rao, Amina Zinaï, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Jeanne Pauly, PharmD, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Robert Chiesa, Sujith Samarasinghe, Havinder Hara, Alayna Boyle, Jan Chu, Danielle Pinner, Persis J Amrolia, Ajay Vora, MD, Anupama Rao, Philip Ancliffe, MD, Paul Veys, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1271.
https://doi.org/10.1182/blood.V130.Suppl_1.1271.1271
Published: 2017
Journal Articles

A Novel Second Generation CD19 CAR for Therapy of High Risk/Relapsed Paediatric CD19 + Acute Lymphoblastic Leukaemia and Other Haematological Malignancies: Preliminary Results from the Carpall Study

Sara Ghorashian, MD PhD FRCPath, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Catherine Irving, BSc, Lucas Chan, PhD, Fernanda Castro, PhD, Bilyana Popova, Kim Champion, PhD, Gary Wright, Hong Zhan, PhD, Waseem Qasim, MBBS PhD, Robert Wynn, Rachael Hough, MD BMBS, FRCP, FRCPath, Farzin Farzaneh, Martin A Pule, MD PhD, Persis J Amrolia, Professor
Journal: Blood
Blood (2016) 128 (22): 4026.
https://doi.org/10.1182/blood.V128.22.4026.4026
Published: 2016
Journal Articles

Immunoglobulin/T-Cell Receptor (Ig/TCR) Allele Usage in Normal and on Treatment Bone Marrow Samples in Childhood Acute Lymphoblastic Leukaemia - Implications for NGS Based MRD Analysis

John Moppett, MD PhD, Stephanie Wakeman, BSc, Marc Duez, Jack Bartram, MD, Gary Wright, Mike Hubank, PhD, Helen Williamson, Paul Archer, Jerry Hancock, PhD
Journal: Blood
Blood (2016) 128 (22): 4073.
https://doi.org/10.1182/blood.V128.22.4073.4073
Published: 2016
Journal Articles

Artificial DNA Templates for the Correction of PCR Bias in Next Generation Sequencing Based MRD Analysis for Childhood Acute Lymphoblastic Leukaemia: The Influence of Secondary DNA Structure

John Moppett, MD PhD, Jerry Hancock, PhD, Marc Duez, Jack Bartram, MD, Gary Wright, Mike Hubank, PhD, Paul Archer, Helen Williamson, Stephanie Wakeman, BSc
Journal: Blood
Blood (2016) 128 (22): 4078.
https://doi.org/10.1182/blood.V128.22.4078.4078
Published: 2016
Journal Articles

Vaccination - a Novel Strategy to Improve the Persistence of CD19CAR Transduced T-Cells in Relapsed Paediatric ALL: Preliminary Results from the CD19TPALL Study

Martin Pule, Sara Ghorashian, MD PhD FRCPath, Laura Clifton-Hadley, PhDBSc, Paul Smith, Soraya Saiagh, Paul Veys, FRCP,FRCPath, Nicholas Goulden, MD PhD, Gary Wright, Ettore Biagi, MD PhD, Bianca Altvater, PhD, Brigitte Dreno, MD, Kim Champion, PhD, Michelle Cummins, MD, Rachael Hough, MDBMBS,FRCP,FRCPath, Martin G. Sauer, MD, Claudia Rossig, MD, Persis Amrolia
Journal: Blood
Blood (2014) 124 (21): 383.
https://doi.org/10.1182/blood.V124.21.383.383
Published: 2014