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Javier Herrero
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Journal Articles

Tumour-Intrinsic Features Shape T-Cell Differentiation through Myeloma Disease Evolution

Kane A Foster, Elise Rees, Louise Ainley, Eileen M Boyle, Lydia Sarah Hui Lee, Gwennan Ward, Daria Galas-Filipowicz, Anna Mikolajczak, Emma J Lyon, Dylan Jankovic, Jasmine Rahman, Mahima Turakhia, Imran Uddin, Gordon Beattie, Yvette Hoade, Catherine Zhu, James L Reading, Ieuan Walker, Michael A. Chapman, Karthik Ramasamy, Javier Herrero, Benny Chain, Sergio A Quezada, Kwee Yong
Journal: Blood
Blood (2024) 144 (Supplement 1): 669.
https://doi.org/10.1182/blood-2024-203306
Published: 2024
Journal Articles

Statin Therapy Is Associated with Reduced Clonal Expansion in TET2 Mutated Clonal Haematopoiesis of Indeterminate Potential

Ellen Nuttall Musson, Yvette Hoade, Phoebe Dace, Helen Brown, Madison Hill, Alexandra Lubin, Katie-Jo Miller, Catherine Zhu, Javier Herrero, Andrew Steptoe, Spiros Denaxas, Elspeth Payne
Journal: Blood
Blood (2024) 144 (Supplement 1): 1283.
https://doi.org/10.1182/blood-2024-203136
Published: 2024
Journal Articles

Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

David O’Connor, Jose Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R. Costa, Jack Bartram, Stuart Adams, Gary Wright, Hillary Elrick, Kerry Wall, Sara Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, Isidro Cortes-Ciriano, Anthony V. Moorman, Marc R. Mansour
Journal: Blood
Blood (2024) 143 (10): 933–937.
https://doi.org/10.1182/blood.2023021906
Published: 2024
Includes: Supplemental data
Journal Articles

High Neoantigen Load Confers a Major Benefit from Autologous Stem Cell Transplantation Compared to Consolidation in Newly Diagnosed Multiple Myeloma

Ieuan Walker, Venetia D'Arcy, Kane Foster, Garima Khandelwal, Georgina S.F. Anderson, William Wilson, Evie Fitzsimons, Daria Galas-Filipowicz, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Sumaiya Kamora, James D. Cavenagh, Elizabeth Phillips, Laura Clifton-Hadley, Charlotte Tyson, Fuad Fananapazir, Krupali Parikh, Roger Owen, Javier Herrero, Kwee Yong, Michael A. Chapman
Journal: Blood
Blood (2023) 142 (Supplement 1): 3306.
https://doi.org/10.1182/blood-2023-186318
Published: 2023
Journal Articles

Developing a Flow Cytometric Signature of Carfilzomib Responsiveness in Myeloma

Ieuan Walker, Venetia D'arcy, Antonio Rodriguez Romera, Georgina Anderson, Anna Aubareda, James Roy, Garima Khandelwal, William Wilson, Evelyn Fitzsimons, Daria Galas-Filipowicz, Kane Foster, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M. de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Elizabeth H. Phillips, Laura Clifton-Hadley, Roger G Owen, Javier Herrero, Kwee Yong, Michael A Chapman
Journal: Blood
Blood (2022) 140 (Supplement 1): 10106–10107.
https://doi.org/10.1182/blood-2022-169882
Published: 2022
Journal Articles

The Clinico-Genomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

David O'Connor, Jonas Demeulemeester, Lucia Conde, Amy A. Kirkwood, Kent Fung, Foteini Papaleonidopoulou, Gianna Bloye, Nadine Farah, Sunniyat Rahman, Jeremy Hancock, Caroline Bateman, Sarah Inglott, Jon Mee, Javier Herrero, Peter Van Loo, Anthony V. Moorman, Ajay Vora, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1720–1721.
https://doi.org/10.1182/blood-2022-165308
Published: 2022
Journal Articles

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Joana R Costa, David O'Connor, Nurkaiyisah Anuar, Sunniyat Rahman, Nivedita Singh, Zhaodong China, Tanya Rapoz-D'Silva, Yang Li, Kent Fung, Sara Hyseni, Stephen Henderson, George Morrow, Yanping Guo, Javier Herrero, Richard Jenner, Dennis Keppei, A. Thomas Look, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 3046–3047.
https://doi.org/10.1182/blood-2022-166396
Published: 2022
Journal Articles

RNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature

Michael A. Chapman, Jonathan Sive, John Ambrose, Claire Roddie, Nicholas Counsell, Anna Lach, Mahnaz Abbasian, Rakesh Popat, Jamie D. Cavenagh, Heather Oakervee, Matthew J. Streetly, Stephen Schey, Mickey Koh, Fenella Willis, Andres E. Virchis, Josephine Crowe, Michael F. Quinn, Gordon Cook, Charles R. Crawley, Guy Pratt, Mark Cook, Nivette Braganza, Toyin Adedayo, Paul Smith, Laura Clifton-Hadley, Roger G. Owen, Pieter Sonneveld, Jonathan J. Keats, Javier Herrero, Kwee Yong
Journal: Blood
Blood (2018) 132 (20): 2154–2165.
https://doi.org/10.1182/blood-2018-05-849893
Published: 2018
Includes: Supplemental data
Journal Articles

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction As a Developmental Susceptibility to ETV6-RUNX1

Simon E Richardson, MA, MD PhD MRCP, FRPATH, Charlotta Boiers, MDPhD, Alya Zriwil, PhD, Emma Laycock, Virginia A Turati, DPhil, John Brown, PhD, Jason Wray, PhD, Chela James, PhD, Dapeng Wang, PhD, Javier Herrero, PhD, Ewa Sitnicka, PhD, Stefan Karlsson, MD, Andrew J.H. Smith, PhD, Sten Eirik Jacobsen, MDPhD, Tariq Enver, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1218.
https://doi.org/10.1182/blood.V130.Suppl_1.1218.1218
Published: 2017
Journal Articles

A Seven Gene Signature to Distinguish Bortezomib- and Lenalidomide-Responsive Myeloma: Rnaseq from the Padimac Study

Michael Chapman, PhD MRCP, FRCPath, Jonathan Sive, John Ambrose, Claire Roddie, PhD MD, Nicholas Counsell, Paul Smith, Nivette Braganza, Toyin Adedayo, Rakesh Popat, MD PhD, James D Cavenagh, Matthew J. Streetly, BMBS, PhD MRCP, FRCPath, Roger G. Owen, MD, Stephen Schey, MBBS, Mickey Koh, MD PhD, Josephine Crowe, Michael F. Quinn, FRCPath, MB, MD MRCP, Shirley D'Sa, MD FRCP, FRCPath, Andres E. Virchis, FRCP, FRCPath, Gordon Cook, PhD, Charles R Crawley, Guy Pratt, MD FRCP, FRCPath, Mark Cook, MBChB,PhD, Laura Clifton-Hadley, PhDBSc, Javier Herrero, PhD, Kwee Yong, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 267.
https://doi.org/10.1182/blood.V130.Suppl_1.267.267
Published: 2017
Journal Articles

Synthetic Lethal Screening Identifies CHK1 Inhibition As an Exploitable Vulnerability in EZH2 Deficient T-ALL

Theresa E. Leon, PhD MSc, BSc, Tanya Rapoz-D'Silva, BSc, MSc, Sunniyat Rahman, MBiochem, DIC, PhD, Michael Magnussen, BSc, MSc, Nadine Farah, MBBChir, MA, MRCP, FRCPath, Jose A. Guerra-Assunção, BSc, PhD, Rajeev Gupta, MB.ChB, PhD FRCP, FRCPath, Elisabeth P. Nacheva, MD PhD, Javier Herrero, PhD, David C. Linch, FRCP, Marc R. Mansour, MD PhD FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 1325.
https://doi.org/10.1182/blood.V130.Suppl_1.1325.1325
Published: 2017
Journal Articles

Single-Cell Analysis of Clonal Dynamics in Childhood ALL Reveals a Key Role for Transcriptional Intratumor Heterogeneity in Driving Resistance to Chemotherapy

Virginia A Turati, PhD, José Afonso Guerra-Assunção, PhD, John C Ambrose, PhD, John Brown, PhD, Mike Hubank, PhD, Alex Hobbs, PhD, Mark Lynch, PhD, Bernadett Gaal, PhD, Sarah Inglott, Lucia Conde, PhD, Simon Richardson, MD PhD, Javier Herrero, PhD, Sten Eirik Jacobsen, MD PhD, Tariq Enver, PhD
Journal: Blood
Blood (2016) 128 (22): 606.
https://doi.org/10.1182/blood.V128.22.606.606
Published: 2016