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Journal Articles

Mechanisms and Therapeutic Strategies to Reverse TET2 Mutant Clonal Hematopoiesis and the Risk of MDS, AML, and Atherosclerotic Cardiovascular Disease

Nicole Prutsch, Amélie Vromman, Brittaney Leeper, Mengyu Chen, Shuning He, Siyang Ren, Christopher J. Walker, Mark W. Zimmerman, Mariana Janini Gomes, Eduardo J. Folco, Philipp J. Rauch, Prafulla C. Gokhale, Brian J. Abraham, Donna S. Neuberg, Benjamin L. Ebert, Peter Libby, A. Thomas Look

Blood (2023) 142 (Supplement 1): 937.

https://doi.org/10.1182/blood-2023-181149

Published: 2023

Journal Articles

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Joana R Costa, David O'Connor, Nurkaiyisah Anuar, Sunniyat Rahman, Nivedita Singh, Zhaodong China, Tanya Rapoz-D'Silva, Yang Li, Kent Fung, Sara Hyseni, Stephen Henderson, George Morrow, Yanping Guo, Javier Herrero, Richard Jenner, Dennis Keppei, A. Thomas Look, Marc R. Mansour

Blood (2022) 140 (Supplement 1): 3046–3047.

https://doi.org/10.1182/blood-2022-166396

Published: 2022

Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD

Blood (2019) 134 (Supplement_1): 406.

https://doi.org/10.1182/blood-2019-123573

Published: 2019

Journal Articles

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Andrew E. Place, MD PhD, Traci M. Blonquist, MS, Elliot Stieglitz, MD, Todd M Cooper, DO, Lia Gore, MD, Richard Aplenc, MD PhD, Mignon L. Loh, MD, Melinda Pauly, MD, Rachel E. Rau, MD, Michael J. Burke, MD, Julia Etchin, PhD, A. Thomas Look, MD, Maria Luisa Sulis, MD, Lewis B. Silverman, MD

Blood (2018) 132 (Supplement 1): 1405.

https://doi.org/10.1182/blood-2018-99-116689

Published: 2018

Journal Articles

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Blood (2017) 129 (24): 3221–3226.

https://doi.org/10.1182/blood-2016-09-742148

Published: 2017

Includes: Supplemental data

Journal Articles

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Koshi Akahane, MD PhD, Zhaodong Li, PhD, Julia Etchin, PhD, Alla Berezovskaya, Evisa Gjini, PhD, Craig E Masse, PhD, Wenyan Miao, PhD, Jennifer Rocnik, PhD, Rosana Kapeller, MD PhD, Jeremy R Greenwood, PhD, Hong Tiv, Takaomi Sanda, MD PhD, David M Weinstock, MD, A. Thomas Look, MD

Blood (2016) 128 (22): 1596.

https://doi.org/10.1182/blood.V128.22.1596.1596

Published: 2016

Journal Articles

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Sunniyat Rahman, PhD DIC, MBiochem, Michael Magnussen, MSc, BSc, Theresa E. León, PhD MSc, BSc, Nadine Farah, FRCPath, MBBChir, MA, MRCP, Brian J. Abraham, PhD BSc, Zhaodong Li, PhD, Krisztina Z. Alapi, PhD MSc, BSc, Rachel J. Mitchell, MSc, Bsc, Tom Naughton, MSc, BSc, Adele K. Fielding, MB BS, PhD FRCP, FRCPath, Arnold Pizzey, Sophia Bustraan, BSc, Christopher Allen, BSc, Rosemary E. Gale, PhD BSc, David C. Linch, MD MRCP, MB BCh, BA, Richard A. Young, PhD BS, A. Thomas Look, MD, Marc R Mansour, MBChB, MRCP, PhD FRCPath

Blood (2016) 128 (22): 733.

https://doi.org/10.1182/blood.V128.22.733.733

Published: 2016

Journal Articles

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Julia Etchin, PhD, Alla Berezovskaya, Amy Saur Conway, Weihsu Claire Chen, PhD, Erkan Baloglu, PhD, Yosef Landesman, PhD, William Senapedis, PhD, Joel Ellis, PhD, Dilara McCauley, PhD, Richard M. Stone, MD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Michael Kauffman, Sharon Shacham, Jean C.Y. Wang, MDPhD, A. Thomas Look, MD

Blood (2015) 126 (23): 326.

https://doi.org/10.1182/blood.V126.23.326.326

Published: 2015

Journal Articles

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Adam Deveau, BSc, MSc, Alexander Michael Forrester, BSc, PhD, Andrew J Coombs, BScH, Gretchen S Wagner, BScH, Clemens Grabher, PhD, Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, Matthew Mingay, BSc, Martin Hirst, PhD, A. Thomas Look, MD, Jason N. Berman, MD

Blood (2014) 124 (21): 436.

https://doi.org/10.1182/blood.V124.21.436.436

Published: 2014

Journal Articles

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD PhD, Marc R Mansour, MDPhD, Alla Berezovskaya, B.S., Richard M. Stone, MD, Ilene Galinsky, RNP, Daniel J. DeAngelo, MDPhD, Dilara McCauley, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Jean C.Y. Wang, MDPhD, Andrew L Kung, MD PhD, A. Thomas Look, MD

Blood (2014) 124 (21): 995.

https://doi.org/10.1182/blood.V124.21.995.995

Published: 2014

Journal Articles

Notch signaling: switching an oncogene to a tumor suppressor

Camille Lobry, Philmo Oh, Marc R. Mansour, A. Thomas Look, Iannis Aifantis

Blood (2014) 123 (16): 2451–2459.

https://doi.org/10.1182/blood-2013-08-355818

Published: 2014

Journal Articles

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Justine E. Roderick, Jessica Tesell, Leonard D. Shultz, Michael A. Brehm, Dale L. Greiner, Marian H. Harris, Lewis B. Silverman, Stephen E. Sallan, Alejandro Gutierrez, A. Thomas Look, Jun Qi, James E. Bradner, Michelle A. Kelliher

Blood (2014) 123 (7): 1040–1050.

https://doi.org/10.1182/blood-2013-08-522698

Published: 2014

Includes: Supplemental data

Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD

Blood (2013) 122 (21): 3932.

https://doi.org/10.1182/blood.V122.21.3932.3932

Published: 2013

Journal Articles

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

Koshi Akahane, Takaomi Sanda, PhD, Marc R. Mansour, MD PhD FRCPath, Julia Etchin, PhD, Ng Cherry, David M. Weinstock, MD, Anthony Letai, MD, PhD, Daniel J. DeAngelo, MD, Ph.D, A. Thomas Look, MD

Blood (2013) 122 (21): 2528.

https://doi.org/10.1182/blood.V122.21.2528.2528

Published: 2013

Journal Articles

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

Nicole M Anderson, PhD, Hongling Peng, MD, Daniel Helman, BS, Itrat Harrold, PhD, Takaomi Sanda, PhD, Trevor Grant, MS, Nicholas Nagykery, BS, Yasmina Samaha, Meng Le, PhD, Adam Amsterdam, PhD, Donna Neuberg, ScD, Marc R. Mansour, MD PhD FRCPath, Travis Denton, PhD, John Kanki, PhD, Anurag Singh, PhD, A. Thomas Look, MD, Hui Feng, PhD

Blood (2013) 122 (21): 1273.

https://doi.org/10.1182/blood.V122.21.1273.1273

Published: 2013

Journal Articles

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

Blood (2012) 120 (21): 3558.

https://doi.org/10.1182/blood.V120.21.3558.3558

Published: 2012

Journal Articles

The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia

Marc R Mansour, MD FRCPath, Takaomi Sanda, MD, PhD, Lee N Lawton, PhD, Xiaoyu Li, MD, PhD, Taras Kreslavsky, PhD, Carl Novina, MD PhD, Harald von Boehmer, MD PhD, Richard Young, PhD, A. Thomas Look, M.D.

Blood (2012) 120 (21): 1296.

https://doi.org/10.1182/blood.V120.21.1296.1296

Published: 2012

Journal Articles

Epigenetic Therapy Inhibits NUP98-HOXA9 -Mediated Myeloid Disease – Decitabine and Valproic Acid Work Synergistically to Rescue Normal Hematopoiesis in Transgenic Zebrafish.

Adam Deveau, BSc(Hons), A. Michael Forrester, PhD, Clemens Grabher, Andrew J Coombs, BSc(Hon), Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, A. Thomas Look, M.D., Jason N Berman, MD

Blood (2012) 120 (21): 2391.

https://doi.org/10.1182/blood.V120.21.2391.2391

Published: 2012

Journal Articles

L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner

Nirmalee Abayasekara, MS, Anupama Narla, Slater Hurst, BS, Hong Sun, MD, Maria Virgilio, Elspeth Payne, Benjamin L. Ebert, MD, PhD, A. Thomas Look, M.D., Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2012) 120 (21): 1257.

https://doi.org/10.1182/blood.V120.21.1257.1257

Published: 2012

Journal Articles

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

Shuyun Rao, Sang-Yun Lee, Alejandro Gutierrez, Jacqueline Perrigoue, Roshan J. Thapa, Zhigang Tu, John R. Jeffers, Michele Rhodes, Stephen Anderson, Tamas Oravecz, Stephen P. Hunger, Roman A. Timakhov, Rugang Zhang, Siddharth Balachandran, Gerard P. Zambetti, Joseph R. Testa, A. Thomas Look, David L. Wiest

Blood (2012) 120 (18): 3764–3773.

https://doi.org/10.1182/blood-2012-03-415349

Published: 2012

Includes: Supplemental data

NARROW

Mechanisms and Therapeutic Strategies to Reverse TET2 Mutant Clonal Hematopoiesis and the Risk of MDS, AML, and Atherosclerotic Cardiovascular Disease

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Notch signaling: switching an oncogene to a tumor suppressor

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia

Epigenetic Therapy Inhibits NUP98-HOXA9 -Mediated Myeloid Disease – Decitabine and Valproic Acid Work Synergistically to Rescue Normal Hematopoiesis in Transgenic Zebrafish.

L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

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American Society of Hematology

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American Society of Hematology

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