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Journal Articles

TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation

Marlies P. Rossmann, Song Yang, Brian J. Abraham, Ying Wang, Richard A. Young, Siegfried Hekimi, Leonard I. Zon

Blood (2023) 142 (Supplement 1): 8.

https://doi.org/10.1182/blood-2023-184853

Published: 2023

Journal Articles

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

Blood (2023) 141 (23): 2841–2852.

https://doi.org/10.1182/blood.2022018885

Published: 2023

Includes: Supplemental data

Journal Articles

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

Blood (2023) 141 (4): 391–405.

https://doi.org/10.1182/blood.2022016892

Published: 2023

Includes: Supplemental data

Journal Articles

CDK7 Inhibition Targets Proliferative and Metabolic Oncogenic Vulnerabilities in Multiple Myeloma

Yao Yao, Jessica Fong Ng, Woojun D Park, Mehmet K. Samur, Eugenio Morelli, Nicholas P Kwiatkowski, Jessica Encinas Mayoral, Zuzana Chyra, Yan Xu, Behnam Nabet, Marta Chesi, Nathaniel Gray, Richard A. Young, Kenneth C. Anderson, Charles Y Lin, Nikhil C Munshi, Mariateresa Fulciniti

Blood (2022) 140 (Supplement 1): 9955–9956.

https://doi.org/10.1182/blood-2022-163811

Published: 2022

Journal Articles

Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma

Blood (2022) 140 (Supplement 1): 1551–1552.

https://doi.org/10.1182/blood-2022-167604

Published: 2022

Journal Articles

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

Blood (2021) 138 (Supplement 1): 894.

https://doi.org/10.1182/blood-2021-151705

Published: 2021

Journal Articles

Aberrant CDK7 Activity Drives the Cell Cycle and Transcriptional Dysregulation to Support Multiple Myeloma Growth: An Attractive Molecular Vulnerability

Yao Yao, Woojun D Park, Eugenio Morelli, Mehmet K. Samur, Nicholas P Kwiatkowski, Ryosuke Shirasaki, Yan Xu, Chandraditya Chakraborty, Behnam Nabet, Marta Chesi, Nathaniel Gray, Richard A. Young, Kenneth C. Anderson, Constantine S. Mitsiades, Lin Charles, Nikhil C. Munshi, Mariateresa Fulciniti

Blood (2021) 138 (Supplement 1): 2687.

https://doi.org/10.1182/blood-2021-153469

Published: 2021

Journal Articles

Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition

Yao Yao, Woojun D Park, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Nicholas P Kwiatkowski, PhD, Yan Xu, MD, Chandraditya Chakraborty, PhD, Behnam Nabet, PhD, Marta Chesi, PhD, Herve Avet-Loiseau, Nathaniel Gray, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Nikhil C. Munshi, MD, Mariateresa Fulciniti, PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-142592

Published: 2020

Journal Articles

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Blood (2020) 136 (Supplement 1): 20–21.

https://doi.org/10.1182/blood-2020-142514

Published: 2020

Journal Articles

Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis

Marlies P. Rossmann, MD PhD, Karen Hoi, Victoria Chan, Julie R. Perlin, PhD, Elliott J. Hagedorn, PhD, Brian J. Abraham, PhD, Song Yang, PhD, Lucas B. Sullivan, PhD, Curtis R. Warren, PhD, Sejal Vyas, PhD, Eugenia Custo-Creig, Bilguujin Dorjsuren, Chad Cowan, PhD, Marcia C. Haigis, PhD, Richard A. Young, PhD, Leonard I Zon, MD

Blood (2019) 134 (Supplement_1): 152.

https://doi.org/10.1182/blood-2019-126833

Published: 2019

Journal Articles

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 940.

https://doi.org/10.1182/blood-2018-99-117480

Published: 2018

Journal Articles

Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma

Chandraditya Chakraborty, PhD, Mehmet Kemal Samur, PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 3156.

https://doi.org/10.1182/blood-2018-99-112583

Published: 2018

Journal Articles

Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits

Blood (2018) 132 (Supplement 1): 1277.

https://doi.org/10.1182/blood-2018-99-118637

Published: 2018

Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 1313.

https://doi.org/10.1182/blood-2018-99-119941

Published: 2018

Journal Articles

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Christopher J. Ott, PhD, Matthew Lawlor, Charles Epstein, Brian J Abraham, PhD, Charles Y Lin, PhD, Linying Zhang, Rao Prabhala, PhD, Nina Farrell, Kenneth Wes, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Giovanni Parmigiani, Richard A. Young, PhD, Kenneth C Anderson, MD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 328.

https://doi.org/10.1182/blood.V130.Suppl_1.328.328

Published: 2017

Journal Articles

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Mehmet Kemal Samur, PhD, Raphael Szalat, MD, Christopher J. Ott, PhD, Charles Epstein, Richard A. Young, PhD, James Bradner, MD, Kenneth C Anderson, MD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 64.

https://doi.org/10.1182/blood.V130.Suppl_1.64.64

Published: 2017

Journal Articles

Distinct Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variations of Red Blood Cell Traits

Avik Choudhuri, PhD, Eirini Trompouki, PhD, Brian J Abraham, PhD, William Mallard, Min-Lee Yang, PhD, Alireza Ghamari, PhD, Kanen Hoi, Barbara Hummel, Sonja Boatman, Victoria Chan, Teresa V. Bowman, PhD, Song Yang, Yi Zhou, Sinichiro Takahashi, MD PhD, Alan B. Cantor, MD, PhD, Santhi Ganesh, MD, John Rinn, PhD, Richard A. Young, PhD, Leonard I. Zon, MD

Blood (2017) 130 (Supplement 1): 773.

https://doi.org/10.1182/blood.V130.Suppl_1.773.773

Published: 2017

Journal Articles

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Blood (2017) 129 (24): 3221–3226.

https://doi.org/10.1182/blood-2016-09-742148

Published: 2017

Includes: Supplemental data

Journal Articles

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Sunniyat Rahman, PhD DIC, MBiochem, Michael Magnussen, MSc, BSc, Theresa E. León, PhD MSc, BSc, Nadine Farah, FRCPath, MBBChir, MA, MRCP, Brian J. Abraham, PhD BSc, Zhaodong Li, PhD, Krisztina Z. Alapi, PhD MSc, BSc, Rachel J. Mitchell, MSc, Bsc, Tom Naughton, MSc, BSc, Adele K. Fielding, MB BS, PhD FRCP, FRCPath, Arnold Pizzey, Sophia Bustraan, BSc, Christopher Allen, BSc, Rosemary E. Gale, PhD BSc, David C. Linch, MD MRCP, MB BCh, BA, Richard A. Young, PhD BS, A. Thomas Look, MD, Marc R Mansour, MBChB, MRCP, PhD FRCPath

Blood (2016) 128 (22): 733.

https://doi.org/10.1182/blood.V128.22.733.733

Published: 2016

Journal Articles

Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma

Bjoern Chapuy, MD, PhD, McKeown Michael, Charles Y. Lin, PhD, Stefano Monti, PhD, Margaretha GM Roemer, Jun Qi, Peter B. Rahl, PhD, Heather Sun, Kelly T. Yeda, Andrew L. Kung, MD, PhD, Scott J. Rodig, MD, PhD, Richard A. Young, PhD, Margaret A. Shipp, MD, James E. Bradner, MD

Blood (2013) 122 (21): 3021.

https://doi.org/10.1182/blood.V122.21.3021.3021

Published: 2013

NARROW

TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma

A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth

CDK7 Inhibition Targets Proliferative and Metabolic Oncogenic Vulnerabilities in Multiple Myeloma

Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma

Identifying Long Noncoding RNA Dependencies Using CRISPR Interference (CRISPRi)-Based Platform in Multiple Myeloma

Aberrant CDK7 Activity Drives the Cell Cycle and Transcriptional Dysregulation to Support Multiple Myeloma Growth: An Attractive Molecular Vulnerability

Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma

Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Distinct Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variations of Red Blood Cell Traits

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma

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American Society of Hematology

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American Society of Hematology

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