Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

2.

Kunz

JB

,

Rausch

T

,

Bandapalli

OR

, et al.

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

.

Haematologica

.

2015

;

100

(

11

):

1442

-

1450

.

3.

Tzoneva

G

,

Perez-Garcia

A

,

Carpenter

Z

, et al.

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

.

Nat Med

.

2013

;

19

(

3

):

368

-

371

.

4.

Szczepanski

T

,

van der Velden

VHJ

,

Waanders

E

, et al.

Late recurrence of childhood T-cell acute lymphoblastic leukemia frequently represents a second leukemia rather than a relapse: first evidence for genetic predisposition

.

J Clin Oncol

.

2011

;

29

(

12

):

1643

-

1649

.

5.

Furness

CL

,

Mansur

MB

,

Weston

VJ

, et al.

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia

.

Leukemia

.

2018

;

32

(

9

):

1984

-

1993

.

6.

Mansour

MR

,

Duke

V

,

Foroni

L

, et al.

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

.

Clin Cancer Res

.

2007

;

13

(

23

):

6964

-

6969

.

7.

Albertí-Servera

L

,

Demeyer

S

,

Govaerts

I

, et al.

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia

.

Blood

.

2021

;

137

(

6

):

801

-

811

.

8.

Wright

G

,

Watt

E

,

Inglott

S

,

Brooks

T

,

Bartram

J

,

Adams

SP

.

Clinical benefit of a high-throughput sequencing approach for minimal residual disease in acute lymphoblastic leukemia

.

Pediatr Blood Cancer

.

2019

;

66

(

8

):

e27787

.

9.

Richter-Pechańska

P

,

Kunz

JB

,

Rausch

T

, et al.

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution

.

Leukemia

.

2022

;

36

(

7

):

1759

-

1768

.

10.

Yang

F

,

Brady

SW

,

Tang

C

, et al.

Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse

.

Nat Cancer

.

2021

;

2

(

8

):

819

-

834

.

11.

Liu

Y

,

Easton

J

,

Shao

Y

, et al.

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

.

Nat Genet

.

2017

;

49

(

8

):

1211

-

1218

.

12.

O’Connor

D

,

Demeulemeester

J

,

Conde

L

, et al.

The clinicogenomic landscape of induction failure in childhood and young adult T-cell acute lymphoblastic leukemia

.

J Clin Oncol

.

2023

;

41

(

19

):

3545

-

3556

.

13.

Mansour

MR

,

Abraham

BJ

,

Anders

L

, et al.

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

.

Science

.

2014

;

346

(

6215

):

1373

-

1377

.

14.

Liu

Y

,

Li

C

,

Shen

S

, et al.

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

.

Nat Genet

.

2020

;

52

(

8

):

811

-

818

.

15.

Smith

C

,

Goyal

A

,

Weichenhan

D

, et al.

TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3′ neo-enhancer

.

Haematologica

.

2023

;

108

(

5

):

1259

-

1271

.

16.

Rahman

S

,

Magnussen

M

,

León

TE

, et al.

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia

.

Blood

.

2017

;

129

(

24

):

3221

-

3226

.

17.

Abraham

BJ

,

Hnisz

D

,

Weintraub

AS

, et al.

Small genomic insertions form enhancers that misregulate oncogenes

.

Nat Commun

.

2017

;

8

:

14385

.

18.

Ford

AM

,

Fasching

K

,

Panzer-Grümayer

ER

,

Koenig

M

,

Haas

OA

,

Greaves

MF

.

Origins of “late” relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes

.

Blood

.

2001

;

98

(

3

):

558

-

564

.

19.

van Delft

FW

,

Horsley

S

,

Colman

S

, et al.

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

.

Blood

.

2011

;

117

(

23

):

6247

-

6254

.

20.

Tzoneva

G

,

Dieck

CL

,

Oshima

K

, et al.

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

.

Nature

.

2018

;

553

(

7689

):

511

-

514

.

21.

Williams

N

,

Lee

J

,

Mitchell

E

, et al.

Life histories of myeloproliferative neoplasms inferred from phylogenies

.

Nature

.

2022

;

602

(

7895

):

162

-

168

.

22.

Gallon

R

,

Phelps

R

,

Betts

L

, et al.

Detection of constitutional mismatch repair deficiency in children and adolescents with acute lymphoblastic leukemia

.

Leuk Lymphoma

.

2023

;

64

(

1

):

217

-

220

.

23.

Larson

RC

,

Lavenir

I

,

Larson

TA

, et al.

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice

.

EMBO J

.

1996

;

15

(

5

):

1021

-

1027

.