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Journal Articles

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Blood (2024) 144 (Supplement 1): 822.

https://doi.org/10.1182/blood-2024-208902

Published: 2024

Journal Articles

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Alastair L Smith, Nicholas Denny, Catherine M Chahrour, Natalina Elliott, Thomas Jackson, Joe Harman, Huimin Geng, Irene Roberts, Nicholas Crump, James Oliver Davies, Anindita Roy, Thomas A Milne

Blood (2024) 144 (Supplement 1): 201.

https://doi.org/10.1182/blood-2024-208035

Published: 2024

Journal Articles

Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan

Tomoya Isobe, Mariana Quiroga Londoño, Nicole Mende, Emily Stephenson, Deena Iskander, Simone Webb, Issac Goh, Vijay Shanmugiah, Rebecca Hannah, Anindita Roy, Irene Roberts, Elisa Laurenti, Muzlifah Haniffa, Nicola K. Wilson, Berthold Gottgens

Blood (2024) 144 (Supplement 1): 2659.

https://doi.org/10.1182/blood-2024-204131

Published: 2024

Journal Articles

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Rebecca E Ling, Thomas Jackson, Natalina Elliott, Joe W Cross, Lucy Hamer, Arundhati S Wuppalapati, Alastair L Smith, Catherine M Chahrour, Okan Sevim, Deena Iskander, Guanlin Wang, Sorcha I O'Byrne, Siobhan Rice, Joe R Harman, Bethan Psaila, Rhys G Morgan, Irene Roberts, Thomas A Milne, Anindita Roy

Blood (2024) 144 (Supplement 1): 199.

https://doi.org/10.1182/blood-2024-198819

Published: 2024

Journal Articles

Introduction to a review series on globin disorders

Thomas D. Coates, Irene Roberts

Blood (2024) 144 (8): 797–798.

https://doi.org/10.1182/blood.2024025678

Published: 2024

Journal Articles

Optimal, Off-the-Shelf, CAR-iNKT Cell Platform-Based Immunotherapy for Multiple Myeloma

Kanagaraju Ponnusamy, Lyra Randzavola, Hongwei Ren, Klesti Karaxhuku, Bryan Lye, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Ilia Leontari, Farah Sabrin, Mehmood Zaidi, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris

Blood (2023) 142 (Supplement 1): 3459.

https://doi.org/10.1182/blood-2023-189905

Published: 2023

Journal Articles

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

David Cruz Hernandez, Nicolas Papadopoulos, Elise Sepulchre, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Leila Varghese, Gabriel Levy, Irene Roberts, Stefan N Constantinescu, Paresh Vyas

Blood (2023) 142 (Supplement 1): 404.

https://doi.org/10.1182/blood-2023-174449

Published: 2023

Journal Articles

Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia

Hongwei Ren, Natalina Elliott, Bryan Lye, Joe Cross, Lucy Field, Kanagaraju Ponnusamy, Irene Roberts, Christina Halsey, Thomas Arthur Milne, Anindita Roy, Anastasios Karadimitris

Blood (2023) 142 (Supplement 1): 766.

https://doi.org/10.1182/blood-2023-186442

Published: 2023

Journal Articles

Development of Novel Invariant TCR-Anchored Bispecific Engagers to Enhance Anti-Cancer Activity of iNKT Cells

Klesti Karaxhuku, Kanagaraju Ponnusamy, Hongwei Ren, Bryan Lye, Ilia Leontari, Mehmood Zaidi, Farah Sabrin, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris

Blood (2023) 142 (Supplement 1): 4828.

https://doi.org/10.1182/blood-2023-190598

Published: 2023

Journal Articles

Introduction to a review series on pediatric hematology

Thomas L. Ortel, Irene Roberts

Blood (2022) 140 (6): 523.

https://doi.org/10.1182/blood.2022017225

Published: 2022

Journal Articles

CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Blood (2022) 140 (1): 38–44.

https://doi.org/10.1182/blood.2021014840

Published: 2022

Includes: Supplemental data

Journal Articles

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome

Blood (2021) 138 (Supplement 1): 214.

https://doi.org/10.1182/blood-2021-151454

Published: 2021

Journal Articles

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Peng Hua, Joanna Hester, George Adigbli, Rong Li, Bethan Psaila, Anindita Roy, Carole J. R. Bataille, Graham M. Wynne, Thomas Jackson, Thomas A. Milne, Angela J. Russell, James Davies, Irene Roberts, Fadi Issa, Suzanne M. Watt

Blood (2020) 136 (21): 2410–2415.

https://doi.org/10.1182/blood.2020005357

Published: 2020

Includes: Supplemental data

Journal Articles

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-141535

Published: 2020

Journal Articles

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome

David Cruz Hernandez, Marlen Metzner, Anne Pieta de Groot, Batchimeg Usukhbayar, Natalina Elliott, Irene Roberts, Paresh Vyas

Blood (2020) 136 (12): 1460–1465.

https://doi.org/10.1182/blood.2020005610

Published: 2020

Includes: Supplemental data

Journal Articles

Single-cell analysis of bone marrow–derived CD34 + cells from children with sickle cell disease and thalassemia

Peng Hua, Noemi Roy, Josu de la Fuente, Guanlin Wang, Supat Thongjuea, Kevin Clark, Anindita Roy, Bethan Psaila, Neil Ashley, Yvonne Harrington, Claus Nerlov, Suzanne M. Watt, Irene Roberts, James O. J. Davies

Blood (2019) 134 (23): 2111–2115.

https://doi.org/10.1182/blood.2019002301

Published: 2019

Includes: Supplemental data

Journal Articles

Distinct Chromatin Accessibility Changes, Aberrant Transcription Factor Networks Combined with Novel Oncogenic Enhancers Characterise Myeloma-Initiating Genetic Events

Nikolaos Trasanidis, Jaime Alvarez-Benayas, Alexia Katsarou, Aristeidis Chaidos, Philippa C May, Kanagaraju Ponnusamy, Xiaolin Xiao, Marco Bua, MD, Maria Atta, MD, Irene Roberts, Holger W Auner, MD PhD, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S Caputo, Ian Sudbery, Anastasios Karadimitris

Blood (2019) 134 (Supplement_1): 1769.

https://doi.org/10.1182/blood-2019-124761

Published: 2019

Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris

Blood (2019) 134 (Supplement_1): 2521.

https://doi.org/10.1182/blood-2019-125768

Published: 2019

Journal Articles

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Sorcha Isabella O'Byrne, BSc, Natalina Elliott, PhD, Gemma Buck, BSc, Siobhan Rice, David O'Connor, Jana Oswald, Hannah Fuchs, Ella-Mae Labbett, Nicholas James Fordham, MBBS, BSc, Anindita Roy, MD PhD, Irene Roberts

Blood (2019) 134 (Supplement_1): 1206.

https://doi.org/10.1182/blood-2019-130180

Published: 2019

Journal Articles

Oncogenic MAF in Co-Operation with IRF4 Confers Extensive Chromatin Re-Arrangement in Plasma Cells and Generates 'Neo-Enhancers' That Regulate Genes Critical for Myeloma Biology

Alexia Katsarou, Nikolaos Trasanidis, Jaime Alvarez-Benayas, Foteini Papaleonidopoulou, Keren Keren, Ioannis V. Kostopoulos, Kanagaraju Ponnusamy, Xiaolin Xiao, Niklas Feldhahn, Irene Roberts, Evdoxia Hatjiharissi, Maria Papaioannou, Ian Sudbery, Aristeidis Chaidos, Valentina S Caputo, Anastasios Karadimitris

Blood (2019) 134 (Supplement_1): 3783.

https://doi.org/10.1182/blood-2019-122371

Published: 2019

NARROW

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Introduction to a review series on globin disorders

Optimal, Off-the-Shelf, CAR-iNKT Cell Platform-Based Immunotherapy for Multiple Myeloma

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia

Development of Novel Invariant TCR-Anchored Bispecific Engagers to Enhance Anti-Cancer Activity of iNKT Cells

Introduction to a review series on pediatric hematology

CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome

Single-cell analysis of bone marrow–derived CD34 + cells from children with sickle cell disease and thalassemia

Distinct Chromatin Accessibility Changes, Aberrant Transcription Factor Networks Combined with Novel Oncogenic Enhancers Characterise Myeloma-Initiating Genetic Events

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Oncogenic MAF in Co-Operation with IRF4 Confers Extensive Chromatin Re-Arrangement in Plasma Cells and Generates 'Neo-Enhancers' That Regulate Genes Critical for Myeloma Biology

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American Society of Hematology

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ASH Publications

American Society of Hematology

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