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Christina Halsey
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Journal Articles

Cerebrospinal Fluid Flow Cytometry Improves Patient Stratification in Central Nervous System Acute Lymphoblastic Leukaemia but Requires Careful Standardization: Results from the ALLTogether1 CSF-FLOW Sub-Study

Ilaria Di Fazio, Lena Behrmann, Valerie de Haas, Victoria Dimitrova, Joaquin Duarte, Gabriele Escherich, Arja Harila, Mats Heyman, Mattias Hofmans, Magnus Hultdin, Inga Johannsdottir, Andrea Malone, Hanne Vibeke Marquart, Reda Matuzeviciene, Veerle Mondelaers, John Moppett, Liv T. N. Osnes, Samuli Rounioja, Kjeld Schmiegelow, Mervi Taskinen, Goda Vaitkeviciene, Inge M. van der Sluis, Lucy Wheeler, Christina Halsey
Journal: Blood
Blood (2024) 144 (Supplement 1): 2831.
https://doi.org/10.1182/blood-2024-203138
Published: 2024
Journal Articles

The Impact of Lineage on CNS Infiltration Dynamics in Infant Leukaemia

Alasdair Duguid, Camille Malouf, Christina Halsey, Katrin Ottersbach
Journal: Blood
Blood (2024) 144 (Supplement 1): 200.
https://doi.org/10.1182/blood-2024-200258
Published: 2024
Journal Articles

Diagnosing and Staging Central Nervous System Involvement in Pediatric ALL: A Global Survey on Its Heterogeneity

Laura Almási, Cornelia Eckert, Maria Thastrup, Vera Münch, Dániel Maszárovics, Bernadett Hon-Balla, Lennart Lenk, Gábor Barna, Wenyu Yang, Mignon L. Loh, Hyoung Jin Kang, Sophia Polychronopoulou, Arja Harila, Marko Kavcic, Kjeld Schmiegelow, Lüder Hinrich Meyer, Christina Halsey, Daniel J Erdelyi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2805.
https://doi.org/10.1182/blood-2024-201255
Published: 2024
Journal Articles

Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia

Hongwei Ren, Natalina Elliott, Bryan Lye, Joe Cross, Lucy Field, Kanagaraju Ponnusamy, Irene Roberts, Christina Halsey, Thomas Arthur Milne, Anindita Roy, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 766.
https://doi.org/10.1182/blood-2023-186442
Published: 2023
Journal Articles

Leukaemia and the CNS Niche: Insights on Bidirectional Communication from a Model of Infant Leukaemia

Alasdair Duguid, Camille Malouf, Vasiliki Symeonidou, Christina Halsey, Katrin Ottersbach
Journal: Blood
Blood (2022) 140 (Supplement 1): 3038–3039.
https://doi.org/10.1182/blood-2022-160176
Published: 2022
Journal Articles

miR-130b and miR-128a are essential lineage-specific codrivers of t(4;11) MLL-AF4 acute leukemia

Camille Malouf, Eric T. B. Antunes, Michael O’Dwyer, Hélène Jakobczyk, Franziska Sahm, Sophie-Luise Landua, Richard A. Anderson, Abdenour Soufi, Christina Halsey, Katrin Ottersbach
Journal: Blood
Blood (2021) 138 (21): 2066–2092.
https://doi.org/10.1182/blood.2020006610
Published: 2021
Includes: Supplemental data
Journal Articles

The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13

Costanza Zanetti, Rahul Kumar, Joscha Ender, Parimala S. Godavarthy, Mark Hartmann, Joschka Hey, Kersten Breuer, Eva S. Weissenberger, Valentina R. Minciacchi, Christina Karantanou, Zhaohui Gu, Kathryn G. Roberts, Markus Metzler, Wendy Stock, Charles G. Mullighan, Clara D. Bloomfield, Natalie Filmann, Katrin Bankov, Sylvia Hartmann, Robert P. Hasserjian, Antony F. Cousins, Christina Halsey, Christoph Plass, Daniel B. Lipka, Daniela S. Krause
Journal: Blood
Blood (2021) 138 (19): 1870–1884.
https://doi.org/10.1182/blood.2021011557
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

A “Goldilocks” approach to CNS leukemia is needed

Christina Halsey, Gabriele Escherich
Journal: Blood
Blood (2021) 138 (4): 288–289.
https://doi.org/10.1182/blood.2021011461
Published: 2021
Journal Articles

Stearoyl-CoA Desaturase (SCD) Enhances Central Nervous System Leukemia

Angela Maria Savino, PhD, Orianne Olivares, PhD, Shani Barel, Lev Yakimov, Ifat Geron, Hila Fishman, Inbal Mor, Ifat Abramovich, Sara Isabel Fernandes, Eyal Gottlieb, Christina Halsey, MD PhD, Shai Izraeli, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 389.
https://doi.org/10.1182/blood-2018-99-114749
Published: 2018
Journal Articles

Acute Neurotoxicity during ALL Therapy Is Associated with Treatment Intensity, Age and Female Sex - an Analysis of SAE Reports from the UKALL 2003 Trial

Qurat-ul-Ain Wahid, Lina Hamadeh, Sheena McGowan, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Anthony V. Moorman, PhD, Christina Halsey, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1379.
https://doi.org/10.1182/blood-2018-99-113267
Published: 2018
Journal Articles

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa
Journal: Blood
Blood (2018) 132 (15): 1614–1617.
https://doi.org/10.1182/blood-2018-04-844209
Published: 2018
Includes: Supplemental data
Journal Articles

Functional SCD1 Is Critical for Acute Lymphoblastic Leukaemia Maintenance in the Central Nervous System

Orianne Olivares, Antony Cousins, Elke Markert, Sergey Tumanov, Gillian Mackay, Jurre Kamphorst, Karen Keeshan, Pawel Herzyk, Eyal Gottlieb, Christina Halsey
Journal: Blood
Blood (2017) 130 (Supplement 1): 2608.
https://doi.org/10.1182/blood.V130.Suppl_1.2608.2608
Published: 2017
Journal Articles

Upregulated Cholesterol Biosynthesis Is a Biomarker for Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukaemia

Antony Cousins, Elke Markert, Matilda Degn, PhD, Orianne Olivares, Yasar Mehmood Yousafzai, MBBS,PhD, Saeeda Bhatti, PhD, Pawel Herzyk, Alison M. Michie, PhD BSc, Kjeld Schmiegelow, MD DMSc, Eyal Gottlieb, PhD, Christina Halsey
Journal: Blood
Blood (2017) 130 (Supplement 1): 3992.
https://doi.org/10.1182/blood.V130.Suppl_1.3992.3992
Published: 2017
Journal Articles

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Mark T. S. Williams, Yasar M. Yousafzai, Alex Elder, Klaus Rehe, Simon Bomken, Liron Frishman-Levy, Sigal Tavor, Paul Sinclair, Katie Dormon, Dino Masic, Tracey Perry, Victoria J. Weston, Pamela Kearns, Helen Blair, Lisa J. Russell, Olaf Heidenreich, Julie A. E. Irving, Shai Izraeli, Josef Vormoor, Gerard J. Graham, Christina Halsey
Journal: Blood
Blood (2016) 127 (16): 1998–2006.
https://doi.org/10.1182/blood-2015-08-665034
Published: 2016
Includes: Supplemental data
Journal Articles

Carma1 Is Important for T-ALL CNS Infiltration and Survival in an Animal Model of T-ALL

Sreenivasa Rao Oruganti, MSc, PhD, Christina Halsey, MDPhD, Savannah Krebsbach, Francois Asperti-Boursin, PhD, Sumit Patel, Ksenia Matlawska-Wasowska, PhD, Stuart S. Winter, MD, Judy Cannon, PhD
Journal: Blood
Blood (2014) 124 (21): 934.
https://doi.org/10.1182/blood.V124.21.934.934
Published: 2014
Journal Articles

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert
Journal: Blood
Blood (2014) 124 (23): 3420–3430.
https://doi.org/10.1182/blood-2014-04-531871
Published: 2014
Includes: Supplemental data
Journal Articles

Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia

Mark T. S. Williams, Yasar Yousafzai, Charlotte Cox, Allison Blair, Ruaidhrí Carmody, Shuji Sai, Karen E. Chapman, Rachel McAndrew, Angela Thomas, Alison Spence, Brenda Gibson, Gerard J. Graham, Christina Halsey
Journal: Blood
Blood (2014) 123 (20): 3116–3127.
https://doi.org/10.1182/blood-2013-05-499970
Published: 2014
Includes: Supplemental data
Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Yasar M Yousafzai, MBBS, Mark TS Williams, PhD, Klaus Rehe, MD, Michelle Le Brocq, PhD, Simon Bomken, MBBS, PhD, Paul B Sinclair, PhD, Katie Dormon, MSc, Dino Masic, MRes, Leanne Archer, B.Sc, Jennifer Watt, BSc, Tracey A Perry, BSc, Victoria J Weston, PhD, Pamela R Kearns, MBChB, PhD, FRCPCH, Helen Blair, PhD, Russel Lisa, PhD, Olaf Heidenreich, PhD, Julie Irving, PhD, Josef Vormoor, MD, Brenda Gibson, MD, Gerard J Graham, PhD, Christina Halsey, PhD, FRCPath
Journal: Blood
Blood (2013) 122 (21): 3866.
https://doi.org/10.1182/blood.V122.21.3866.3866
Published: 2013
Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD
Journal: Blood
Blood (2013) 122 (21): 823.
https://doi.org/10.1182/blood.V122.21.823.823
Published: 2013
Journal Articles

Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1,

Christina Halsey, MD, PhD, Mark TS Williams, PhD, Yasar Yousafzai, MD, Klaus Rehe, MD, Olaf Heidenreich, PhD, Josef Vormoor, MD, Brenda Gibson, Gerard Graham, PhD
Journal: Blood
Blood (2011) 118 (21): 3449.
https://doi.org/10.1182/blood.V118.21.3449.3449
Published: 2011