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Lennart Lenk
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Journal Articles

Results in Pediatric T-ALL Patients Treated in Trial AIEOP-BFM ALL 2009: Exploring Prognostic Factors in the Context of Modern Risk Adapted Therapy

Gunnar Cario, Maria Grazia Valsecchi, Valentino Conter, Giacomo Gotti, Anja Möricke, Martin Stanulla, Michaela Vossen-Gajcy, Lennart Lenk, Jan Stary, Michael Dworzak, Andishe Attarbaschi, Draga Barbaric, Franco Locatelli, Nicole Bodmer, Sarah Elitzur, Daniela Silvestri, Luciano Dalla-Pozza, Andreas E. Kulozik, Shai Izraeli, Carmelo Rizzari, Barbara Buldini, Jean-Pierre Bourquin, Francesca Graziano, Martin Zimmermann, Martin Schrappe, Andrea Biondi
Journal: Blood
Blood (2024) 144 (Supplement 1): 730.
https://doi.org/10.1182/blood-2024-201936
Published: 2024
Journal Articles

Drug Sensitivity and Treatment Response Are Modulated By the Cell of Origin, the Underlying Gene Fusion, and Patient Age in KMT2A -Rearranged BCP-ALL

Alina M. Hartmann, Lorenz Bastian, Malwine J Barz, Eric Amelunxen, Johannes Haas, Lennart Lenk, Michaela Kotrova, Thomas Beder, Fabio D. Steffen, Kerstin K. Rauwolf, Nadine Wolgast, Patrick Ehm, Sonja Bendig, Julia Alten, Mayukh Mondal, Aeint-Steffen Ströh, Thomas Burmeister, Nicola Goekbuget, Beat Bornhauser, Jean-Pierre Bourquin, Monika Brüggemann, Martin Schrappe, Gunnar Cario, Claudia D Baldus
Journal: Blood
Blood (2024) 144 (Supplement 1): 318.
https://doi.org/10.1182/blood-2024-199017
Published: 2024
Journal Articles

CD127-Directed Immunotherapy with Lusvertikimab Outperforms Imatinib in Preclinical ABL-Class-Fusion-Positive BCP-ALL

Anna Dietterle, Julia Heymann, Anna Laqua, Claas Reimer, Denny Takudzwa Mahachi, Carina Lynn Gehlert, Dorothee Winterberg, Maja Kowol, Alexander Arthur Wurm, Philipp Fanter, Denis Pinkle, Dennis Das Gupta, Christian Vokuhl, Jan Philipp Schmid, Matthias Peipp, Martin Schrappe, Irène Baccelli, Nicolas Poirier, Monika Brüggemann, Gunnar Cario, Denis Martin Schewe, Lennart Lenk
Journal: Blood
Blood (2024) 144 (Supplement 1): 636.
https://doi.org/10.1182/blood-2024-205421
Published: 2024
Journal Articles

IDH2 Mutations from Clonal Hematopoiesis and Acquired IKZF1 Deletions Define a Novel B-ALL Subtype after Lenalidomide Therapy for Multiple Myeloma

Johanna Maria Horns, Thomas Beder, Malwine J Barz, Aeint-Steffen Ströh, Axel Künstner, Sonja Bendig, Guranda Chitadze, Cecilia Bozzetti, Nikos Darzentas, Katharina Iben, Michaela Kotrova, Martin Neumann, Wiebke Weßels, Hauke Busch, Lennart Lenk, Judith S. Hecker, Stefan Knop, Boris Böll, Johannes Duell, Walter Fiedler, Christoph Faul, Christoph Röllig, Bernd Spriewald, Björn Steffen, Maher Hanoun, Nicola Goekbuget, Claudia D Baldus, Lorenz Bastian, Monika Brüggemann
Journal: Blood
Blood (2024) 144 (Supplement 1): 631.
https://doi.org/10.1182/blood-2024-199601
Published: 2024
Journal Articles

Preclinical Development of a Novel Humanized and Fc-Engineered Antibody-Drug Conjugate for the Therapy of T-Cell Acute Lymphoblastic Leukemia

Steffen Krohn, Carina Lynn Gehlert, Dorothee Winterberg, Alexander Jochimsen, Ammelie Svea Boje, Natalie Baum, Claudia D Baldus, Monika Brüggemann, Gunnar Cario, Martin Schrappe, Lennart Lenk, Martin Gramatzki, Katja Klausz, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2024) 144 (Supplement 1): 4173.
https://doi.org/10.1182/blood-2024-207737
Published: 2024
Journal Articles

Diagnosing and Staging Central Nervous System Involvement in Pediatric ALL: A Global Survey on Its Heterogeneity

Laura Almási, Cornelia Eckert, Maria Thastrup, Vera Münch, Dániel Maszárovics, Bernadett Hon-Balla, Lennart Lenk, Gábor Barna, Wenyu Yang, Mignon L. Loh, Hyoung Jin Kang, Sophia Polychronopoulou, Arja Harila, Marko Kavcic, Kjeld Schmiegelow, Lüder Hinrich Meyer, Christina Halsey, Daniel J Erdelyi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2805.
https://doi.org/10.1182/blood-2024-201255
Published: 2024
Journal Articles

The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis

Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Anna Dietterle, Dorothee Winterberg, Caroline Mary, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Stéphanie Neyton, Mylène Déramé, Sabrina Pengam, Fotini Vogiatzi, Beat Bornhauser, Jean-Pierre Bourquin, Simon Raffel, Vladyslava Dovhan, Thomas Schüler, Gabriele Escherich, Monique L. den Boer, Judith M. Boer, Wiebke Wessels, Matthias Peipp, Julia Alten, Željko Antić, Anke K. Bergmann, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis M. Schewe
Journal: Blood
Blood (2024) 143 (26): 2735–2748.
https://doi.org/10.1182/blood.2023021088
Published: 2024
Includes: Supplemental data
Journal Articles

A Novel Fc-Optimized Antibody Drug Conjugate Targeting CD7 As a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia

Carina Lynn Gehlert, Denis Martin Schewe, Katja Klausz, Steffen Krohn, Dorothee Winterberg, Fotini Vogiatzi, Ammelie Svea Boje, Anja Lux, Falk Nimmerjahn, Regina Scherließ, Andreas Humpe, Martin Schrappe, Gunnar Cario, Thomas Valerius, Lars Fransecky, Monika Brüggemann, Claudia D Baldus, Martin Gramatzki, Lennart Lenk, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2023) 142 (Supplement 1): 4190.
https://doi.org/10.1182/blood-2023-185875
Published: 2023
Journal Articles

CNS Invasion of TCF3::PBX1 + Leukemia Cells Requires Upregulation of AP-1 Signaling As Revealed By Brain Organoid Model

Philip Gebing, Stefanos Loizou, Sebastian Hänsch, Julian Schliehe-Diecks, Lea Spory, Pawel Stachura, Aleksandra Pandyra, Martin Schrappe, Gunnar Cario, Ameera Alsadeq, Denis Martin Schewe, Arndt Borkhardt, Lennart Lenk, Ute Fischer, Sanil Bhatia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1407.
https://doi.org/10.1182/blood-2023-178613
Published: 2023
Journal Articles

The IL7R-Antagonist OSE-127 Blocks Acute Lymphoblastic Leukemia Development Via a Dual Mode of Action

Lennart Lenk, Irène Baccelli, Dorothee Winterberg, Anna Dietterle, Frédérique Corallo, Julien Taurelle, Emma Narbeburu, Anna Laqua, Beat Bornhauser, Jean-Pierre Bourquin, Fotini Vogiatzi, Martin Schrappe, Gunnar Cario, Monika Brüggemann, Nicolas Poirier, Denis Martin Schewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 1045–1047.
https://doi.org/10.1182/blood-2022-162261
Published: 2022
Journal Articles

Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Kristina Müller, Fotini Vogiatzi, Dorothee Winterberg, Thies Rösner, Lennart Lenk, Lorenz Bastian, Carina L. Gehlert, Marie-Pauline Autenrieb, Monika Brüggemann, Gunnar Cario, Martin Schrappe, Andreas E. Kulozik, Cornelia Eckert, Anke K. Bergmann, Beat Bornhauser, Jean-Pierre Bourquin, Thomas Valerius, Matthias Peipp, Christian Kellner, Denis M. Schewe
Journal: Blood
Blood (2022) 140 (1): 45–57.
https://doi.org/10.1182/blood.2021014485
Published: 2022
Includes: Supplemental data
Journal Articles

IL7R Targeting Using OSE-127 Shows Robust Anti-Leukemic Activity in B-Cell Precursor Acute Lymphoblastic Leukemia Xenografts

Lennart Lenk, Irène Baccelli, Dorothee Winterberg, Frédérique Corallo, Fotini Vogiatzi, Lea Spory, Martin Schrappe, Gunnar Cario, Anna Laqua, Monika Brüggemann, Nicolas Poirier, Denis Martin Schewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2021-150323
Published: 2021
Journal Articles

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Ahmad Mayar, Christian Vokuhl, Julia Richter, Michela Carlet, Irmela Jeremias, Thomas Valerius, Martin Schrappe, Gunnar Cario, Hassan Jumaa, Elias Hobeika, Monika Brüggemann, Ameera Alsadeq, Denis Martin Schewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 2388.
https://doi.org/10.1182/blood-2021-148429
Published: 2021
Journal Articles

Co-Targeting of CD38 and CD47 in T Cell Acute Lymphoblastic Leukemia

Fotini Vogiatzi, PhD, Kristina Müller, Dorothee Winterberg, Thies Rösner, PhD, Lennart Lenk, PhD, Gunnar Cario, MD PhD, Martin Schrappe, MDPhD, Andreas E. Kulozik, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Thomas Valerius, MD, Matthias Peipp, PhD, Christian Kellner, PhD, Denis Martin Schewe, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-140270
Published: 2020
Journal Articles

Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia

Fotini Vogiatzi, Dorothee Winterberg, Lennart Lenk, Swantje Buchmann, Gunnar Cario, Martin Schrappe, Matthias Peipp, Paulina Richter-Pechanska, Andreas E. Kulozik, Jana Lentes, Anke K. Bergmann, Thomas Valerius, Fabian-Simon Frielitz, Christian Kellner, Denis M. Schewe
Journal: Blood
Blood (2019) 134 (8): 713–716.
https://doi.org/10.1182/blood.2019000904
Published: 2019
Includes: Supplemental data
Journal Articles

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, PhD MSc, Fotini Vogiatzi, PhD, Michela Carlet, PhD, Christian Vokuhl, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Irmela Jeremias, MD PhD, Stephan Fuhrmann, MD, Elias Hobeika, PhD, Hassan Jumaa, Prof. Dr., Ameera Alsadeq, PhD, Denis Martin Schewe, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 386.
https://doi.org/10.1182/blood-2018-99-114595
Published: 2018
Journal Articles

Venetoclax Enhances the Efficacy of Therapeutic Antibodies in B-Cell Malignancies

Fotini Vogiatzi, PhD, Julia Heymann, Thies Rösner, PhD, Lennart Lenk, PhD MSc, Gunnar Cario, MD, Martin Schrappe, MD PhD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Simon Bomken, MD, Thomas Valerius, MD, Matthias Peipp, PhD, Christian Kellner, PhD, Denis Martin Schewe, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4177.
https://doi.org/10.1182/blood-2018-99-114677
Published: 2018
Journal Articles

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

Ameera Alsadeq, Lennart Lenk, Anila Vadakumchery, Antony Cousins, Christian Vokuhl, Ahmad Khadour, Fotini Vogiatzi, Felix Seyfried, Lueder-Hinrich Meyer, Gunnar Cario, Elias Hobeika, Klaus-Michael Debatin, Christina Halsey, Martin Schrappe, Denis M. Schewe, Hassan Jumaa
Journal: Blood
Blood (2018) 132 (15): 1614–1617.
https://doi.org/10.1182/blood-2018-04-844209
Published: 2018
Includes: Supplemental data
Journal Articles

Targeting of the Interleukin-7 Receptor Alpha-Chain (IL-7Rα) Blocks B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Development and Reduces Leukemic Infiltration to the Central Nervous System (CNS)

Ameera Alsadeq, PhD, Anila George Vadakumchery, Ali Almasri, Hend Abdelrasoul, Markus Werner, PhD, Lennart Lenk, Felix Seyfried, Klaus-Michael Debatin, MD, Lueder-Hinrich Myer, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Denis Martin Schewe, MD, Hassan Jumaa, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 479.
https://doi.org/10.1182/blood.V130.Suppl_1.479.479
Published: 2017
Journal Articles

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL -rearranged acute lymphoblastic leukemia xenografts

Denis M. Schewe, Ameera Alsadeq, Cornelia Sattler, Lennart Lenk, Fotini Vogiatzi, Gunnar Cario, Simon Vieth, Thomas Valerius, Sophia Rosskopf, Fabian Meyersieck, Julia Alten, Martin Schrappe, Martin Gramatzki, Matthias Peipp, Christian Kellner
Journal: Blood
Blood (2017) 130 (13): 1543–1552.
https://doi.org/10.1182/blood-2017-01-764316
Published: 2017
Includes: Supplemental data