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Christian Kellner
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Journal Articles

CD47 Upregulation Inhibits Phagocytic Clearance of Alloreactive Donor T Cells after Allo-HCT

Haroon Shaikh, Cindy Flamann, Carina Matos, Hla Ali, Michael AG Kern, Marina Kreutz, Maike Buettner-Herold, Christopher Lischer, Simon Voelkl, Christian Kellner, Katrin Bitterer, Domenica Saul, Ernst Holler, Alma Zernecke, Dimitrios Mougiakakos, Andreas Beilhack, Heiko Bruns
Journal: Blood
Blood (2024) 144 (Supplement 1): 2023.
https://doi.org/10.1182/blood-2024-205870
Published: 2024
Journal Articles

Preclinical Development of a Novel Humanized and Fc-Engineered Antibody-Drug Conjugate for the Therapy of T-Cell Acute Lymphoblastic Leukemia

Steffen Krohn, Carina Lynn Gehlert, Dorothee Winterberg, Alexander Jochimsen, Ammelie Svea Boje, Natalie Baum, Claudia D Baldus, Monika Brüggemann, Gunnar Cario, Martin Schrappe, Lennart Lenk, Martin Gramatzki, Katja Klausz, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2024) 144 (Supplement 1): 4173.
https://doi.org/10.1182/blood-2024-207737
Published: 2024
Journal Articles

A Novel Platform Technology for the Development of NK Cell-Based Cellular Immunotherapies

Ammelie Svea Boje, Anna Langner, Carina Lynn Gehlert, Carmen Reitinger, Falk Nimmerjahn, Eva Maria Murga Penas, Sonja Bendig, Guranda Chitadze, Monika Brüggemann, Katharina Diemer, Alexander Jochimsen, Dorothee Winterberg, Natalie Baum, Steffen Krohn, Thomas Valerius, Friedrich Stölzel, Martin Gramatzki, Katja Klausz, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2024) 144 (Supplement 1): 914.
https://doi.org/10.1182/blood-2024-210243
Published: 2024
Journal Articles

Lysosomal Membrane Permeabilization Sensitizes Ctss-Hyperactive Tumors to BCL2-Targeting Therapies

Johannes Adrian Hildebrand, Sarah Haebe, Verena Passerini, Michael Heide, William Keay, Louisa Adolph, Lukas Ulrich, Natyra Tahiri, Raphael Koch, Jessica Duffy, Haley Martin, Liam Hackett, Jeremy Zhang, Christina Ludwig, Stefanie Wilhelm, Björn Häupl, Carmen Doebele, Michael von Bergwelt-Baildon, Axel Lechner, Tobias Herold, Christian Kellner, Martina Rudelius, Thomas Oellerich, Marc Schmidt-Supprian, Abner Louissaint, Matthew S Davids, Oliver Weigert
Journal: Blood
Blood (2023) 142 (Supplement 1): 4358.
https://doi.org/10.1182/blood-2023-174384
Published: 2023
Journal Articles

A Novel Fc-Optimized Antibody Drug Conjugate Targeting CD7 As a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia

Carina Lynn Gehlert, Denis Martin Schewe, Katja Klausz, Steffen Krohn, Dorothee Winterberg, Fotini Vogiatzi, Ammelie Svea Boje, Anja Lux, Falk Nimmerjahn, Regina Scherließ, Andreas Humpe, Martin Schrappe, Gunnar Cario, Thomas Valerius, Lars Fransecky, Monika Brüggemann, Claudia D Baldus, Martin Gramatzki, Lennart Lenk, Christian Kellner, Matthias Peipp
Journal: Blood
Blood (2023) 142 (Supplement 1): 4190.
https://doi.org/10.1182/blood-2023-185875
Published: 2023
Journal Articles

Blocking the CD47-Sirpa Axis Enhances Tafasitamab-Mediated Phagocytosis

Alexander Biedermann, Doris Mangelberger-Eberl, Dimitrios Mougiakakos, Maike Büttner-Herold, Cindy Flamann, Christian Kellner, Sarah Altmeyer, Jörg Bittenbring, Christian Augsberger, Maria Patra-Kneuer, Karin Landgraf, Kristina Ilieva-Babinsky, Stefan Haskamp, Fabian Beier, Simon Voelkl, Christian Pallasch, Benedikt Jacobs, Stefan Steidl, Christina Heitmüller, Andreas Mackensen, Heiko Bruns
Journal: Blood
Blood (2022) 140 (Supplement 1): 9292–9293.
https://doi.org/10.1182/blood-2022-159955
Published: 2022
Journal Articles

Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL

Kristina Müller, Fotini Vogiatzi, Dorothee Winterberg, Thies Rösner, Lennart Lenk, Lorenz Bastian, Carina L. Gehlert, Marie-Pauline Autenrieb, Monika Brüggemann, Gunnar Cario, Martin Schrappe, Andreas E. Kulozik, Cornelia Eckert, Anke K. Bergmann, Beat Bornhauser, Jean-Pierre Bourquin, Thomas Valerius, Matthias Peipp, Christian Kellner, Denis M. Schewe
Journal: Blood
Blood (2022) 140 (1): 45–57.
https://doi.org/10.1182/blood.2021014485
Published: 2022
Includes: Supplemental data
Journal Articles

Blocking the Don't Eat Me Signal (CD47-SIRPα Axis) to Improve Antibody-Based Immunotherapy of Multiple Myeloma

Katja Klausz, Carina Lynn Gehlert, Ammelie Svea Boje, Marta Lustig, Steffen Krohn, Syeda Maliha Ahmed, Christian Kellner, Thomas Valerius, Lenka Besse, Andrej Besse, Christoph Driessen, Martin Gramatzki, Matthias Peipp
Journal: Blood
Blood (2021) 138 (Supplement 1): 2684.
https://doi.org/10.1182/blood-2021-152208
Published: 2021
Journal Articles

An Inducible Leukemia-Associated Transcription Factor Facilitates Large-Scale Ex Vivo Generation of Functional Human Macrophages

Roland Windisch, Sarah Soliman, Adrian Hoffmann, Linping Chen-Wichmann, Sebastian Lutz, Christian Kellner, Enric Redondo Monte, Sebastian Vosberg, Luise Hartmann, Stephanie Schneider, Fabian Beier, Carolin Dorothea Strobl, Oliver Weigert, Matthias Peipp, Michael Schündeln, Jürgen Bernhagen, Andreas Humpe, Christian Brendel, Hannes Klump, Philipp A. Greif, Christian Wichmann
Journal: Blood
Blood (2021) 138 (Supplement 1): 2805.
https://doi.org/10.1182/blood-2021-148336
Published: 2021
Journal Articles

Co-Targeting of CD38 and CD47 in T Cell Acute Lymphoblastic Leukemia

Fotini Vogiatzi, PhD, Kristina Müller, Dorothee Winterberg, Thies Rösner, PhD, Lennart Lenk, PhD, Gunnar Cario, MD PhD, Martin Schrappe, MDPhD, Andreas E. Kulozik, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Thomas Valerius, MD, Matthias Peipp, PhD, Christian Kellner, PhD, Denis Martin Schewe, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-140270
Published: 2020
Journal Articles

Blockade of CD47-Sirpα Interactions Improved Myeloid Effector Cell Mediated Lymphoma Cell Killing By the HLA-DR Antibody Apolizumab

Judith Petersen, Thies Rösner, PhD, Max Kölling, Katja Klausz, PhD, Christian Kellner, PhD, Andreas Humpe, MD, George J Weiner, MD, Denis Martin Schewe, Matthias Peipp, PhD, Thomas Valerius, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5305.
https://doi.org/10.1182/blood-2019-122940
Published: 2019
Journal Articles

Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia

Fotini Vogiatzi, Dorothee Winterberg, Lennart Lenk, Swantje Buchmann, Gunnar Cario, Martin Schrappe, Matthias Peipp, Paulina Richter-Pechanska, Andreas E. Kulozik, Jana Lentes, Anke K. Bergmann, Thomas Valerius, Fabian-Simon Frielitz, Christian Kellner, Denis M. Schewe
Journal: Blood
Blood (2019) 134 (8): 713–716.
https://doi.org/10.1182/blood.2019000904
Published: 2019
Includes: Supplemental data
Journal Articles

Venetoclax Enhances the Efficacy of Therapeutic Antibodies in B-Cell Malignancies

Fotini Vogiatzi, PhD, Julia Heymann, Thies Rösner, PhD, Lennart Lenk, PhD MSc, Gunnar Cario, MD, Martin Schrappe, MD PhD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Simon Bomken, MD, Thomas Valerius, MD, Matthias Peipp, PhD, Christian Kellner, PhD, Denis Martin Schewe, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4177.
https://doi.org/10.1182/blood-2018-99-114677
Published: 2018
Journal Articles

Targeting the Glyco-Antigen CD75s with the Tetravalent, Fc-Engineered Antibody 'Ebu-141 Tetra' Induces Potent Killing of B Cell Lymphoma and Plasma Cell Tumors

Katja Klausz, PhD, Amir Karimzadeh-Tabrizi, Malena Buck, Steffen Krohn, Anna-Kathrin Otte, PhD, Christian Kellner, PhD, Giorgio Alberto Croci, MD, Wolfram Klapper, MD, Matthias Peipp, PhD, Martin Gramatzki, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4178.
https://doi.org/10.1182/blood-2018-99-118068
Published: 2018
Journal Articles

AFM26 - Targeting B Cell Maturation Antigen (BCMA) for NK Cell-Mediated Immunotherapy of Multiple Myeloma

Thorsten Gantke, PhD, Uwe Reusch, PhD, Christian Kellner, PhD, Katja Klausz, PhD, Torsten Haneke, PhD, Stefan Knackmuss, PhD, Thomas Müller, Kristina Ellwanger, PhD, Ivica Fucek, Ute Schniegler-Mattox, Joachim Koch, PhD, Anne Kerber, MD, Matthias Peipp, PhD, Martin Treder, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3082.
https://doi.org/10.1182/blood.V130.Suppl_1.3082.3082
Published: 2017
Journal Articles

CD75s Represents a Therapeutic Target for Antibody-Based Immunotherapy of B Cell Lymphoma and Multiple Myeloma

Katja Klausz, PhD, Malena Buck, Steffen Krohn, Renate Burger, PhD, Christian Kellner, PhD, Martin Gramatzki, MD, Matthias Peipp, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1810.
https://doi.org/10.1182/blood.V130.Suppl_1.1810.1810
Published: 2017
Journal Articles

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL -rearranged acute lymphoblastic leukemia xenografts

Denis M. Schewe, Ameera Alsadeq, Cornelia Sattler, Lennart Lenk, Fotini Vogiatzi, Gunnar Cario, Simon Vieth, Thomas Valerius, Sophia Rosskopf, Fabian Meyersieck, Julia Alten, Martin Schrappe, Martin Gramatzki, Matthias Peipp, Christian Kellner
Journal: Blood
Blood (2017) 130 (13): 1543–1552.
https://doi.org/10.1182/blood-2017-01-764316
Published: 2017
Includes: Supplemental data
Journal Articles

CD20 Antibodies of Human IgA Isotype Mediate CDC, and ADCC By Myeloid Effector Cells

Anna Kretschmer, Stefan Lohse, PhD, Thies Rösner, PhD, Marco J.H. Jansen, Christian Kellner, PhD, Matthias Peipp, PhD, Mark S Cragg, PhD, Ameera Alsadeq, PhD, Denis M Schewe, MD, Jeanette H.W. Leusen, PhD, Thomas Valerius, MD
Journal: Blood
Blood (2016) 128 (22): 1835.
https://doi.org/10.1182/blood.V128.22.1835.1835
Published: 2016
Journal Articles

The Novel ADCC-Optimized Human CD54 (ICAM-1) Antibody MSH-TP15e Has Potent Anti-Myeloma Activity

Katja Klausz, PhD, Renate Burger, PhD, Christian Kellner, PhD, Andreas Guenther, MD, Matthias Peipp, PhD, Martin Gramatzki, MD
Journal: Blood
Blood (2016) 128 (22): 4471.
https://doi.org/10.1182/blood.V128.22.4471.4471
Published: 2016
Journal Articles

An Fc-Engineered CD19 Antibody Engages Macrophages and Is Effective in Xenograft Models of Pediatric Acute Lymphoblastic Leukemia

Denis M Schewe, MD, Ameera Alsadeq, PhD, Gunnar Cario, MD, Simon Vieth, MD, Thomas Valerius, MD, Martin Schrappe, MD PhD, Martin Gramatzki, MD, Matthias Peipp, PhD, Christian Kellner, PhD
Journal: Blood
Blood (2016) 128 (22): 277.
https://doi.org/10.1182/blood.V128.22.277.277
Published: 2016