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Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Blood (2024) 144 (Supplement 1): 6085.

https://doi.org/10.1182/blood-2024-198652

Published: 2024

Journal Articles

D DX41 -Low Expression Mimics Germline DDX41 -Phenotype in Acute Myeloid Leukemia

Blood (2023) 142 (Supplement 1): 820.

https://doi.org/10.1182/blood-2023-187419

Published: 2023

Journal Articles

Acute Myeloid Leukemia with Isolated Trisomy 4 Is Characterized By Frequent Mutations of TET2 and a Distinct DNA Methylation Signature

Sayantanee Dutta, Paul Kerbs, Maja Rothenberg-Thurley, Bianka Ksienzyk, Stefan Krebs, Helmut Blum, Karsten Spiekermann, Klaus H. Metzeler, Tobias Herold, Sebastian Vosberg, Philipp A. Greif

Blood (2022) 140 (Supplement 1): 8912–8913.

https://doi.org/10.1182/blood-2022-168939

Published: 2022

Journal Articles

Prevalence, Clinical and Molecular Features, and Prognostic Value of Tetraploidy/Near-Tetraploidy in Patients with Acute Myeloid Leukemia

Blood (2022) 140 (Supplement 1): 3454–3455.

https://doi.org/10.1182/blood-2022-166271

Published: 2022

Journal Articles

An Inducible Leukemia-Associated Transcription Factor Facilitates Large-Scale Ex Vivo Generation of Functional Human Macrophages

Blood (2021) 138 (Supplement 1): 2805.

https://doi.org/10.1182/blood-2021-148336

Published: 2021

Journal Articles

Molecular Subgroups of T Cell Acute Lymphoblastic Leukemia in Adults Treated According to GMALL Protocols

Blood (2020) 136 (Supplement 1): 37–38.

https://doi.org/10.1182/blood-2020-141921

Published: 2020

Journal Articles

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Sebastian Vosberg, Paul Kerbs, MSc, Vindi Jurinovic, MSc, Klaus H. Metzeler, MD, Susanne Amler, PhD, Cristina Sauerland, Dennis Görlich, PhD, Wolfgang E. Berdel, MD, Jan Braess, MD, Wolfgang Hiddemann, MD PhD, Karsten Spiekermann, MD, Tobias Herold, MD, Philipp A. Greif, MD PD

Blood (2019) 134 (Supplement_1): 2715.

https://doi.org/10.1182/blood-2019-130047

Published: 2019

Journal Articles

Gene Fusion Detection By RNA-Seq in Acute Myeloid Leukemia (AML)

Paul Kerbs, MSc, Aarif Mohamed Nazeer Batcha, MSc, Sebastian Vosberg, Dirk Metzler, PhD, Tobias Herold, MD, Philipp A. Greif, MD PD

Blood (2019) 134 (Supplement_1): 4655.

https://doi.org/10.1182/blood-2019-125869

Published: 2019

Journal Articles

Clonal Evolution of Relapsed CBFB/MYH11 Rearranged Acute Myeloid Leukemia (AML)

Sabrina Opatz, MD, Sebastian Vosberg, Bianka Ksienzyk, Sebastian Tschuri, Alexander Graf, Stefan Krebs, PhD, Helmut Blum, Dr., Stephanie Schneider, PhD, Martin Neumann, Claudia D. Baldus, MD, Christian Thiede, MD, Jan Moritz Middeke, MD, Friedrich Stoelzel, Stefan K. Bohlander, MD, Karsten Spiekermann, MD, Wolfgang Hiddemann, PhD, Klaus H. Metzeler, MD, Philipp A. Greif, MD PD

Blood (2018) 132 (Supplement 1): 2772.

https://doi.org/10.1182/blood-2018-99-115881

Published: 2018

Journal Articles

Homocygous PAX5 Sequence Mutations Define a Novel Subtype of B Cell Precursor Acute Lymphoblastic Leukemia

Blood (2017) 130 (Supplement 1): 2713.

https://doi.org/10.1182/blood.V130.Suppl_1.2713.2713

Published: 2017

Journal Articles

Multi-Omics of Adult T Cell Acute Lymphoblastic Leukemia

Martin Neumann, Michael P Schroeder, PhD, Lorenz Bastian, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Alva Rani James, Lars R. Fransecky, Sebastian Vosberg, Stefan Krebs, PhD, Helmut Blum, PhD, Stefan Schwartz, MD, Thomas Burmeister, Dieter Hoelzer, MD PhD, Philipp A. Greif, MD, Monika Brüggemann, Nicola Goekbuget, MD, Claudia D. Baldus, MD

Blood (2017) 130 (Supplement 1): 2725.

https://doi.org/10.1182/blood.V130.Suppl_1.2725.2725

Published: 2017

Journal Articles

Comparison of FLT3-ITD Detection By High-Throughput Amplicon Sequencing to Routine Diagnostics - a Retrospective Analysis of AMLCG Study Patients

Katrin Reiter, MSc, Max Hubmann, MD, Egor Harin, Sebastian Vosberg, Kathrin Bräundl, Bianka Ksienzyk, Stephanie Schneider, PhD, Annika Maria Dufour, PhD, Evelyn Zellmeier, Stefan K. Bohlander, MD, Christina Sauerland, Dipl.-Math, Wolfgang E Berdel, MD, Bernhard J Wörmann, MD, Thomas Büchner, MD, Jan Braess, MD, Wolfgang Hiddemann, MD, Karsten Spiekermann, MD, Philipp A. Greif, MD

Blood (2016) 128 (22): 1682.

https://doi.org/10.1182/blood.V128.22.1682.1682

Published: 2016

Journal Articles

Evolutionary Patterns of Cytogenetically Normal Acute Myeloid Leukemia Correlate with Time to Relapse

Blood (2016) 128 (22): 288.

https://doi.org/10.1182/blood.V128.22.288.288

Published: 2016

Journal Articles

Clones with and without Sensitivity Towards Treatment In Vivo Co-Exist within the Tumor Cells of a Single Patient with ALL

Cornelia Finkenzeller, MSc, Michela Carlet, PhD, Sebastian Vosberg, Christoph Ziegenhain, MSc, Martin Neumann, MD, Kristoffer Riecken, PhD, Kerstin Cornils, PhD, Boris Fehse, PhD, Claudia D. Baldus, MD, Wolfgang Enard, Prof. Dr. rer. nat., Philipp A. Greif, MD, Irmela Jeremias, MD

Blood (2016) 128 (22): 456.

https://doi.org/10.1182/blood.V128.22.456.456

Published: 2016

Journal Articles

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL

Lorenz Bastian, Martin Neumann, MD, Nicola Gökbuget, MD, Cornelia Schlee, Jutta Ortiz Tanchez, Sebastian Vosberg, Alva Rani James, Michael P Schroeder, Stefan Schwartz, MD, Dieter Hoelzer, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Jochen Hecht, Monika Brüggemann, Philipp A. Greif, Claudia D. Baldus, MD PhD

Blood (2015) 126 (23): 2625.

https://doi.org/10.1182/blood.V126.23.2625.2625

Published: 2015

Journal Articles

Detection of Chromosomal Aberrations in Acute Myeloid Leukemia By Copy Number Alteration Analysis of Exome Sequencing Data

Sebastian Vosberg, Luise Hartmann, MSc, Stephanie Schneider, PhD, Klaus H. Metzeler, MD, Bianka Ksienzyk, Kathrin Bräundl, Martin Neumann, MD, Claudia D Baldus, MD, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Karsten Spiekermann, MD, Stefan K. Bohlander, MD, Ulrich Mansmann, PhD, Philipp A. Greif, MD

Blood (2015) 126 (23): 3859.

https://doi.org/10.1182/blood.V126.23.3859.3859

Published: 2015

Journal Articles

Molecular Alterations in Refractory Acute Myeloid Leukemia and Persistent Preleukemic Lesions Are Disclosed Using Mesenchymal Stromal Cells As Germline Control

Martin Neumann, MD, Sebastian Vosberg, Eva Kristin Von Der Heide, BSc, Cornelia Schlee, Jutta Ortiz Tanchez, Konstandina Isaakidis, Liliana H. Mochmann, BS,MSc, Lars R. Fransecky, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Philipp A. Greif, MD, Claudia D Baldus, MD

Blood (2015) 126 (23): 3843.

https://doi.org/10.1182/blood.V126.23.3843.3843

Published: 2015

Journal Articles

Mutations of Genes Linked to Epigenetic Regulation Are Frequently Gained in Relapsed Cytogenetically Normal Acute Myeloid Leukemia

Luise Hartmann, MSc, Sebastian Vosberg, Klaus H. Metzeler, MD, Daniela Schumacher, Friederike Pastore, MD, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola P Konstandin, PhD, Stephanie Schneider, PhD, Stefan Krebs, PhD, Alexander Graf, PhD, Helmut Blum, PhD, Martin Neumann, MD, Claudia D Baldus, MD, Stefan K. Bohlander, MD, Wolfgang Hiddemann, MD, Karsten Spiekermann, MD, Philipp A. Greif, MD

Blood (2015) 126 (23): 690.

https://doi.org/10.1182/blood.V126.23.690.690

Published: 2015

Journal Articles

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

Patricia Silva, Martin Neumann, MD, Sebastian Vosberg, Cornelia Schlee, Konstandina Isaakidis, Michael P Schroeder, Jutta Ortiz-Tánchez, Lars R. Fransecky, Teresa Hartung, Alexander Graf, PhD, Stefan Krebs, PhD, Helmut Blum, PhD, Gerhard Ehninger, Hubert Serve, MD, Wolfgang E Berdel, MD, Philipp A. Greif, Christoph Röllig, MD, Claudia D Baldus, MD

Blood (2015) 126 (23): 804.

https://doi.org/10.1182/blood.V126.23.804.804

Published: 2015

Journal Articles

Functional Diversity of Single Stem Cell Clones in Patients' Acute Lymphoblastic Leukemia Growing in Mice: An Adverse Subclone with Distinct DNA-Methylation Pattern, Slow Growth In Vivo and Drug Resistance

Cornelia Finkenzeller, M.Sc., Michela Carlet, PhD, Sebastian Vosberg, Philipp A. Greif, MD, Irmela Jeremias, MD

Blood (2015) 126 (23): 3062.

https://doi.org/10.1182/blood.V126.23.3062.3062

Published: 2015

NARROW

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

D DX41 -Low Expression Mimics Germline DDX41 -Phenotype in Acute Myeloid Leukemia

Acute Myeloid Leukemia with Isolated Trisomy 4 Is Characterized By Frequent Mutations of TET2 and a Distinct DNA Methylation Signature

Prevalence, Clinical and Molecular Features, and Prognostic Value of Tetraploidy/Near-Tetraploidy in Patients with Acute Myeloid Leukemia

An Inducible Leukemia-Associated Transcription Factor Facilitates Large-Scale Ex Vivo Generation of Functional Human Macrophages

Molecular Subgroups of T Cell Acute Lymphoblastic Leukemia in Adults Treated According to GMALL Protocols

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Gene Fusion Detection By RNA-Seq in Acute Myeloid Leukemia (AML)

Clonal Evolution of Relapsed CBFB/MYH11 Rearranged Acute Myeloid Leukemia (AML)

Homocygous PAX5 Sequence Mutations Define a Novel Subtype of B Cell Precursor Acute Lymphoblastic Leukemia

Multi-Omics of Adult T Cell Acute Lymphoblastic Leukemia

Comparison of FLT3-ITD Detection By High-Throughput Amplicon Sequencing to Routine Diagnostics - a Retrospective Analysis of AMLCG Study Patients

Evolutionary Patterns of Cytogenetically Normal Acute Myeloid Leukemia Correlate with Time to Relapse

Clones with and without Sensitivity Towards Treatment In Vivo Co-Exist within the Tumor Cells of a Single Patient with ALL

Genomic Profiling Reveals Gain of Mutations in Histone Methylation Regulators in Relapsed Adult B Cell Precursor ALL

Detection of Chromosomal Aberrations in Acute Myeloid Leukemia By Copy Number Alteration Analysis of Exome Sequencing Data

Molecular Alterations in Refractory Acute Myeloid Leukemia and Persistent Preleukemic Lesions Are Disclosed Using Mesenchymal Stromal Cells As Germline Control

Mutations of Genes Linked to Epigenetic Regulation Are Frequently Gained in Relapsed Cytogenetically Normal Acute Myeloid Leukemia

Acute Myeloid Leukemia in the Elderly Is Characterized By a Distinct Genetic Landscape

Functional Diversity of Single Stem Cell Clones in Patients' Acute Lymphoblastic Leukemia Growing in Mice: An Adverse Subclone with Distinct DNA-Methylation Pattern, Slow Growth In Vivo and Drug Resistance

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American Society of Hematology

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American Society of Hematology

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