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Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Binje Vick, Vindi Jurinovic, Lena Lagally, Kristina Kuhbandner, Lisa Latzko, Chiara Arnreich, Maja Rothenberg-Thurley, Gerulf Hänel, Amelie Muth, Annika Maria Dufour, Stephanie Schneider, Maya C. Andre, Claudia D Baldus, Martin P Carroll, Martin Ebinger, Katharina S. S. Götze, Pablo Menéndez, Jean-Emmanuel Sarry, Talía Velasco-Hernández, Michael von Bergwelt-Baildon, Klaus H Metzeler, Philipp A. Greif, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias
Journal: Blood
Blood (2024) 144 (Supplement 1): 6085.
https://doi.org/10.1182/blood-2024-198652
Published: 2024
Journal Articles

D DX41 -Low Expression Mimics Germline DDX41 -Phenotype in Acute Myeloid Leukemia

Wajma Shahbaz, Vindi Jurinovic, Aarif M. N. Batcha, Christian Rausch, Maja Rothenberg-Thurley, Annika Maria Dufour, Bianka Ksienzyk, Stephanie Schneider, Michaela Neusser, Maria Cristina Sauerland, Dennis Görlich, Wolfgang E. Berdel, Bernhard J. Woermann, Utz Krug, Jan Braess, Wolfgang Hiddemann, Ulrich Mansmann, Sebastian Vosberg, Philipp A. Greif, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Journal: Blood
Blood (2023) 142 (Supplement 1): 820.
https://doi.org/10.1182/blood-2023-187419
Published: 2023
Journal Articles

Impact of Sex on Clinical Outcomes after CD19 CAR T-Cell Therapy for Large B-Cell Lymphoma: Response and Survival Are Significantly Superior in Female Compared to Male Patients

Veit L. Buecklein, Kai Rejeski, Ariel Perez, Gloria Iacoboni, Vindi Jurinovic, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Rahul Mhaskar, Christian Schmidt, Anthony Wood, Eva Hoster, Andreas Mackensen, Frederick L. Locke, Michael von Bergwelt-Baildon, Fabian Mueller, Pere Barba, Michael D. Jain, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 3787.
https://doi.org/10.1182/blood-2023-186510
Published: 2023
Journal Articles

Risk Stratification of Patients with RUNX1- mutated Acute Myeloid Leukemia

Christian Rausch, Roman Hornung, Aarif M. N. Batcha, Maja Rothenberg-Thurley, Stefanos A. Bamopoulos, Vindi Jurinovic, Bianka Ksienzyk, Stephanie Schneider, Annika Maria Dufour, Michaela Neusser, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard J. Woermann, Jan Braess, Wolfgang Hiddemann, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Johannes Schetelig, Moritz Middeke, Sebastian Stasik, Katharina Egger-Heidrich, Christoph Röllig, Martin Bornhäuser, Christian Thiede, Claudia D Baldus, Carsten Müller-Tidow, Uwe Platzbecker, Hubert Serve, Wendy Stock, Geoffrey L Uy, John C. Byrd, Deedra Nicolet, Ann-Kathrin Eisfeld, Ulrich Mansmann, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Journal: Blood
Blood (2023) 142 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2023-174059
Published: 2023
Journal Articles

WT1 and DNMT3A play essential roles in the growth of certain patient AML cells in mice

Maryam Ghalandary, Yuqiao Gao, Diana Amend, Ginte Kutkaite, Binje Vick, Karsten Spiekermann, Maja Rothenberg-Thurley, Klaus H. Metzeler, Anetta Marcinek, Marion Subklewe, Michael P. Menden, Vindi Jurinovic, Ehsan Bahrami, Irmela Jeremias
Journal: Blood
Blood (2023) 141 (8): 955–960.
https://doi.org/10.1182/blood.2022016411
Published: 2023
Includes: Supplemental data
Journal Articles

Inferior Outcomes of EU Vs. US Patients with Relapsed/Refractory Large B-Cell Lymphoma after CD19 CAR T-Cell Therapy Are Associated with Differences in Tumor Burden, Systemic Inflammation, Bridging Therapy Utilization and CAR-T Product Selection

Veit L Buecklein, Ariel Perez-Perez, Kai Rejeski, Gloria Iacoboni, Vindi Jurinovic, Udo Holtick, Olaf Penack, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Christian Schmidt, Omar Albanyan, Philipp Gödel, Eva Hoster, Lars Bullinger, Andreas Mackensen, Frederick L. Locke, Michael von Bergwelt, Pere Barba, Michael D. Jain, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 2411–2413.
https://doi.org/10.1182/blood-2022-165452
Published: 2022
Journal Articles

Sex-Associated Differences in Frequencies and Outcome Prognostication of Recurrent Molecular Features in Adults with Acute Myeloid Leukemia (AML) (AMLCG, CALGB [Alliance])

Michael P. Ozga, Deedra Nicolet, Krzysztof Mrózek, Selen Yilmaz, Jessica Kohlschmidt, Karilyn T. Larkin, James S. Blachly, Christopher C. Oakes, Jill Buss, Christopher J. Walker, Shelley Orwick, Vindi Jurinovic, Maja Rothenberg-Thurley, Annika Maria Dufour, Stephanie Schneider, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard Josef Woermann, Wolfgang Hiddemann, Jan Braess, Marion Subklewe, Karsten Spiekermann, Andrew J. Carroll, William G. Blum, Bayard L. Powell, Jonathan E. Kolitz, Joseph O. Moore, Robert James Mayer, Richard M. Stone, Geoffrey L. Uy, Wendy Stock, Klaus H. Metzeler, H. Leighton Grimes, John C. Byrd, Nathan Salomonis, Tobias Herold, Alice S. Mims, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2022) 140 (Supplement 1): 936–939.
https://doi.org/10.1182/blood-2022-165395
Published: 2022
Journal Articles

Multi-Dimensional Analysis of Adult Acute Myeloid Leukemia (AML) Landscape Cross-Continents Reveals Age Associated Trends in Mutations and Outcomes

Monica Cusan, Karilyn Larkin, Deedra Nicolet, Vindi Jurinovic, Krzysztof Mrózek, Aarif M. N. Batcha, Maja Rothenberg-Thurley, Stephanie Schneider, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard Josef Woermann, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Jessica Kohlschmidt, James S. Blachly, Alice S. Mims, Christopher J. Walker, Christopher C. Oakes, Shelley Orwick, Andrew J Carroll, William Blum, Bayard L. Powell, Jonathan E Kolitz, Joseph O. Moore, Robert James Mayer, Richard A. Larson, Richard M. Stone, John C. Byrd, Klaus H. Metzeler, Tobias Herold, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2021) 138 (Supplement 1): 685.
https://doi.org/10.1182/blood-2021-153015
Published: 2021
Journal Articles

CHOP but Not Bendamustine Reverses EZH2 Y641 Mutation Induced MHC-I/II Loss in Human Lymphoma Models

Louisa Catharina Adolph, Quentin Fichaux, Carolin Dorothea Strobl, Martina Antoniolli, Verena Passerini, William David Keay, Vindi Jurinovic, Axel Lechner, Daniel J. Hodson, Michael von Bergwelt, Marion Subklewe, Martina Rudelius, Oliver Weigert
Journal: Blood
Blood (2021) 138 (Supplement 1): 2391.
https://doi.org/10.1182/blood-2021-144803
Published: 2021
Journal Articles

An EZH2 Gene Expression Signature Is Predictive of Differential Efficacy of Chemotherapy Irrespective of EZH2 Mutation Status in Patients with Follicular Lymphoma Treated within the Gallium Trial

Verena Passerini, Vindi Jurinovic, Christopher R Bolen, Andrea Knapp, Alessia Bottos, Julia Richter, Jude Fitzgibbon, Wolfram Klapper, Andrew Davies, Robert Marcus, Michael von Bergwelt, Tina Nielsen, Martin H. Dreyling, Wolfgang Hiddemann, Michael Unterhalt, Eva Hoster, Oliver Weigert
Journal: Blood
Blood (2021) 138 (Supplement 1): 39.
https://doi.org/10.1182/blood-2021-147751
Published: 2021
Journal Articles

Localized- and advanced-stage follicular lymphomas differ in their gene expression profiles

Annette M. Staiger, Eva Hoster, Vindi Jurinovic, Stefan Winter, Ellen Leich, Claudia Kalla, Peter Möller, Heinz-Wolfram Bernd, Alfred C. Feller, Karoline Koch, Wolfram Klapper, Harald Stein, Martin-Leo Hansmann, Sylvia Hartmann, Martin Dreyling, Oliver Weigert, Wolfgang Hiddemann, Klaus Herfarth, Andreas Rosenwald, Marianne Engelhard, German Ott, Heike Horn
Journal: Blood
Blood (2020) 135 (3): 181–190.
https://doi.org/10.1182/blood.2019000560
Published: 2020
Includes: Supplemental data
Journal Articles

Evaluation of the m7-FLIPI in Patients with Follicular Lymphoma Treated within the Gallium Trial: EZH2 mutation Status May be a Predictive Marker for Differential Efficacy of Chemotherapy

Vindi Jurinovic, PhD, Verena Passerini, PhD, Mikkel Z Oestergaard, PhD, Andrea Knapp, PhD, Kirsten Mundt, PhD, Shamzah Araf, MRCP, MBBS, PhD, Julia Richter, PhD, Jude Fitzgibbon, PhD, Wolfram Klapper, Robert E. Marcus, FRCP, Andrew Davies, MD PhD, Michael Herold, MD, Wolfgang Hiddemann, PhD, Michael Unterhalt, PhD, Eva Hoster, PhD, Oliver Weigert, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 122.
https://doi.org/10.1182/blood-2019-130208
Published: 2019
Journal Articles

Aberrant Cathepsin S Induces a Supportive Immune Microenvironment in Follicular Lymphoma

Johannes Adrian Hildebrand, MSc, BSc, Deepak Bararia, Sebastian Stolz, Sarah Haebe, MD, Stefan Alig, Michael Bartoschek, Michael Boesl, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinovic, MSc, Monika Szczepanowski, Wolfram Klapper, Abner Louissaint, Jr., MD PhD, Christina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl-Peter Hopfner, Wolfgang Hiddemann, MD PhD, Michael von Bergwelt, Christian Steidl, MD, Robert Kridel, MDMPH,PhD, David M Weinstock, Marc Schmidt-Supprian, Menyhárt B Sárosi, Verena Passerini, Josef Mautner, Oliver Weigert
Journal: Blood
Blood (2019) 134 (Supplement_1): 657.
https://doi.org/10.1182/blood-2019-122663
Published: 2019
Journal Articles

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Sebastian Vosberg, Paul Kerbs, MSc, Vindi Jurinovic, MSc, Klaus H. Metzeler, MD, Susanne Amler, PhD, Cristina Sauerland, Dennis Görlich, PhD, Wolfgang E. Berdel, MD, Jan Braess, MD, Wolfgang Hiddemann, MD PhD, Karsten Spiekermann, MD, Tobias Herold, MD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2715.
https://doi.org/10.1182/blood-2019-130047
Published: 2019
Journal Articles

Chemotherapy-Free Combination of Obinutuzumab and Ibrutinib in First LINE Treatment of Follicular Lymphoma. the Alternative Study By the German Low Grade Lymphoma Study Group (GLSG)

Christian Schmidt, MD, Anna-Katharina Zoellner, Vindi Jurinovic, Martin Sökler, MD, Roswitha Forstpointner, Sascha Haubner, MD, Christian Buske, MD, Andreas Viardot, MD, Ulrich Keller, Christiane Pott, Ullrich Graeven, MD, Reinhard Marks, Mathias Hänel, MD, Ruediger Liersch, Jan Dürig, Eva Hoster, Michael Unterhalt, Wolfgang Hiddemann
Journal: Blood
Blood (2018) 132 (Supplement 1): 448.
https://doi.org/10.1182/blood-2018-99-111692
Published: 2018
Journal Articles

Prognostic Biomarkers Converge on a Germinal Centre Dark Zone Phenotype As a Determinant of Adverse Outcome in Follicular Lymphoma Patients Treated with Rituximab and Chemotherapy

Anjali Silva, PhD MSc, BSc, Clementine Sarkozy, MD, Tracy Lackraj, PhD BSc, Anja Mottok, Vindi Jurinovic, MSc, Laurie H Sehn, MD MPH, Oliver Weigert, MD, Christian Steidl, MD, Robert Kridel, PhD MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4095.
https://doi.org/10.1182/blood-2018-99-112689
Published: 2018
Journal Articles

Clinicogenetic Risk Models in Patients Randomized to Receive Consolidative Autologous Stem-Cell Transplantation after Frontline R-CHOP for Advanced Follicular Lymphoma: An Analysis from the GLSG2000 Trial

Stefan Alig, MD, Alessandro Pastore, Vindi Jurinovic, Sarah Häbe, Deepak Bararia, PhD, Verena Passerini, PhD, William Keay, Johannes Hellmuth, Andreas Rosenwald, Wolfram Klapper, MD, Harald Stein, MD PhD Dr. h.c., Alfred Feller, German Ott, MD, Annette M. Staiger, PhD, Heike Horn, Martin-Leo Hansmann, Christiane Pott, Roswitha Forstpointner, Wolf-Karsten Hofmann, Norbert Schmitz, MD, Georg Hess, Michael Unterhalt, Martin H. Dreyling, MD PhD, Anna-Katharina Zoellner, Christian Schmidt, MD, Eva Hoster, Wolfgang Hiddemann, Oliver Weigert, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4096.
https://doi.org/10.1182/blood-2018-99-118000
Published: 2018
Journal Articles

FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab and chemotherapy

Anja Mottok, Vindi Jurinovic, Pedro Farinha, Andreas Rosenwald, Ellen Leich, German Ott, Heike Horn, Wolfram Klapper, Michael Boesl, Wolfgang Hiddemann, Christian Steidl, Joseph M. Connors, Laurie H. Sehn, Randy D. Gascoyne, Eva Hoster, Oliver Weigert, Robert Kridel
Journal: Blood
Blood (2018) 131 (2): 226–235.
https://doi.org/10.1182/blood-2017-08-799080
Published: 2018
Includes: Supplemental data
Journal Articles

FOXP1 Expression Is a Prognostic Biomarker in Follicular Lymphoma Treated with Immunochemotherapy and Is Associated with Distinct Molecular Features

Robert Kridel, Vindi Jurinovic, Pedro Farinha, Andreas Rosenwald, Ellen Leich, German Ott, MD, Heike Horn, Wolfram Klapper, MD, Michael Boesl, Wolfgang Hiddemann, Christian Steidl, MD, Joseph M Connors, MD, Laurie H. Sehn, MDMPH, Randy D. Gascoyne, MD, Eva Hoster, Oliver Weigert, Anja Mottok
Journal: Blood
Blood (2017) 130 (Supplement 1): 2748.
https://doi.org/10.1182/blood.V130.Suppl_1.2748.2748
Published: 2017
Journal Articles

PS29MRC - a Novel Predictive Score for Response to Therapy in Acute Myeloid Leukemia

Tobias Herold, MD, Vindi Jurinovic, Klaus H. Metzeler, MD, Aarif Batcha, Stefan Bamopoulos, Maja Rothenberg-Thurley, PhD, Bianka Ksienzyk, Luise Hartmann, MSc, Philipp Greif, Julia Phillippou-Massier, Stefan Krebs, Helmut Blum, Susanne Amler, Stephanie Schneider, PhD, Christina Sauerland, Dipl.-Math, Dennis Görlich, Thomas Büchner, Wolfgang E Berdel, MD, Bernhard J Wörmann, MD, Marion Subklewe, MD, Michael Fiegl, MD, Stefan K. Bohlander, MD, Jan Braess, Wolfgang Hiddemann, MD, PhD, Ulrich Mansmann, PhD, Karsten Spiekermann, MD
Journal: Blood
Blood (2016) 128 (22): 1209.
https://doi.org/10.1182/blood.V128.22.1209.1209
Published: 2016