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Marion Subklewe
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Journal Articles

Honing CAR T cells to tackle acute myeloid leukemia

Sascha Haubner, Marion Subklewe, Michel Sadelain
Journal: Blood
Blood blood.2024024063.
https://doi.org/10.1182/blood.2024024063
Published: 2024
Journal Articles

Development of ALL-Hematotox (ALL-HT): Predicting post CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Clinical Trials & Observations
Monica S Nair, Sara K Silbert, Kai Rejeski, Karilynn A Wilson, Adam Joseph Lamble, Yannis K. Valtis, Bonnie Yates, Alexa Morales Arana, Roni Shouval, Kevin J. Curran, Rebecca A Gardner, Haneen Shalabi, Colleen Annesley, Jae H. Park, Marion Subklewe, Nirali N Shah
Journal: Blood
Blood blood.2024025910.
https://doi.org/10.1182/blood.2024025910
Published: 2024
Includes: Supplemental data
Journal Articles

Pre-Apheresis Prediction of Toxicity and Response in Patients Receiving BCMA-Directed CAR-T for Relapsed/Refractory Multiple Myeloma

Kai Rejeski, Doris K. Hansen, David M. Cordas Dos Santos, Andre De Menezes Silva Corraes, Omar Castaneda, Christen M Dillard, Winfried Alsdorf, Jan H. Frenking, Anna Purcarea, Saurabh Chhabra, Ciara Louise Freeman, Mirco Julian Friedrich, Mahmoud R. Gaballa, Rebecca Gonzalez, Syed Hamza Bin Waqar, Yi Lisa Hwa, Michael D. Jain, Ricardo D. Parrondo, Oren Pasvolsky, Wajma Shahbaz, Roni Shouval, Genevieve Spiess, Haily Stephens, Sebastian Theurich, Florian Bassermann, Judith S. Hecker, Marc S. Raab, Katja C. Weisel, Frederick L. Locke, Marion Subklewe, Krina K. Patel, Yi Lin
Journal: Blood
Blood (2024) 144 (Supplement 1): 895.
https://doi.org/10.1182/blood-2024-208376
Published: 2024
Journal Articles

CSF1R Targeting T Cell Engaging Bispecific Antibodies Enable Safe and Efficient Immunotherapies in Acute Myeloid Leukemia

Gordon Victor Hoffmann, Adrian Gottschlich, Johannes Sam, Samuel Gebhardt, Lisa Rohrbacher, Sayantan Nandi, Emanuele Carlini, Tobias Herold, Michael von Bergwelt-Baildon, Stefan Endres, Marion Subklewe, Peter Bruenker, Christian Klein, Sebastian Kobold
Journal: Blood
Blood (2024) 144 (Supplement 1): 918.
https://doi.org/10.1182/blood-2024-207376
Published: 2024
Journal Articles

Predictive Value of Maximum Tumor Dissemination (Dmax) in Lymphoma Patients Treated with CD19 Specific CAR T-Cell Therapy

Wolfgang G Kunz, Viktoria Blumenberg, Kai Rejeski, Gabriel Sheik, Matthias Brendel, Michael Von Bergwelt, Marion Subklewe, Michael Winkelmann
Journal: Blood
Blood (2024) 144 (Supplement 1): 6552.
https://doi.org/10.1182/blood-2024-209594
Published: 2024
Journal Articles

Cohort Comparison of Therapy-Related Myeloid Neoplasms after CAR T-Cell Therapy, Autologous Stem Cell Transplant, and Standard Cancer Therapies

Jaime Roman Diaz, Saurabh Dahiya, Francesca Emily Sillito, Maeve O'Reilly, Kai Rejeski, Veit L. Buecklein, Marion Subklewe, Gloria Iacoboni, Pere Barba, Claire Roddie, Frederick Locke, Jay Y. Spiegel, Najla H. Al Ali, Zachary Thompson, Jongphil Kim, Rami S. Komrokji, Michael D. Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 7239.
https://doi.org/10.1182/blood-2024-201666
Published: 2024
Journal Articles

Evaluation of the Individual Components of the International Metabolic Prognostic Index (IMPI) in the Context of CAR T-Cell Treatment of Lymphoma

Michael Winkelmann, Kai Rejeski, Viktoria Blumenberg, Gabriel Sheikh, Veit L. Buecklein, Matthias Brendel, Michael Von Bergwelt, Marion Subklewe, Wolfgang G Kunz
Journal: Blood
Blood (2024) 144 (Supplement 1): 7508.
https://doi.org/10.1182/blood-2024-207418
Published: 2024
Journal Articles

Serially Transplantable, Genetically Modified Patient Derived Xenograft Models of Acute Myeloid Leukemia Represent Primary Patients' Cells and Enable Reliable and Reproducible Preclinical Therapy Trials

Binje Vick, Vindi Jurinovic, Lena Lagally, Kristina Kuhbandner, Lisa Latzko, Chiara Arnreich, Maja Rothenberg-Thurley, Gerulf Hänel, Amelie Muth, Annika Maria Dufour, Stephanie Schneider, Maya C. Andre, Claudia D Baldus, Martin P Carroll, Martin Ebinger, Katharina S. S. Götze, Pablo Menéndez, Jean-Emmanuel Sarry, Talía Velasco-Hernández, Michael von Bergwelt-Baildon, Klaus H Metzeler, Philipp A. Greif, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias
Journal: Blood
Blood (2024) 144 (Supplement 1): 6085.
https://doi.org/10.1182/blood-2024-198652
Published: 2024
Journal Articles

Real-World Practice Patterns of Patient Management in the Peri-CAR T-Cell Therapy Setting for Patients with Mantle Cell Lymphoma: An International Survey on Behalf of the EBMT Lymphoma Working Party

Gloria Iacoboni, Pere Barba, Irma Khvedelidze, Maud Ngoya, Paolo Corradini, Pierre Sesques, Marion Subklewe, Maria Gomes Da Silva, Gilles Crochet, Jarosław Dybko, Izaskun Zeberio, Alejandro Martín García-Sancho, Tom van Meerten, Maeve O'Reilly, Bertram Glass, Ana Maria Sureda Balari, Peter Dreger, Olivier Hermine, Ali Bazarbachi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3656.
https://doi.org/10.1182/blood-2024-205389
Published: 2024
Journal Articles

Characterizing Environmental Adaption and Virulence of Gut Microbiome Enterococcus Spp. from Patients Receiving CD19-Targeted CAR-T Cell Therapy

Niklas Deschl, Viktoria Blumenberg, Maria-Luisa Schubert, Anita Schmitt, Michael Schmitt, Marion Subklewe, Christoph Stein-Thoeringer
Journal: Blood
Blood (2024) 144 (Supplement 1): 3415.
https://doi.org/10.1182/blood-2024-205390
Published: 2024
Journal Articles

Resolve AML 001: An Adaptive Open-Label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of Cctx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients with r/r AML

Marion Subklewe, Nicolas Boissel, Stephan Mielke, Pere Barba, Elisa Sala, Eric Deconinck, Olivia Fiere, Jonathan Jaeger, Chloe Vasseghi, Marina Deschamps, Christophe Ferrand, Edouard De Dreuzy, Richard Sainson, Jens Hasskarl
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.2.
https://doi.org/10.1182/blood-2024-203204
Published: 2024
Journal Articles

Site-Specific Analysis of Extranodal Involvement Reveals Distinct Efficacy Outcomes with CAR T-Cell Therapy in Large B-Cell Lymphoma Patients

Gloria Iacoboni, Kai Rejeski, Victor Navarro Garces, Tom van Meerten, Alex Rampotas, Ana Africa Martin Lopez, Juan Luis Reguera, Mariana Bastos-Oreiro, Claire Roddie, Ana Benzaquen, Cecilia Carpio, Javier Delgado Serrano, Maria Landwehr, Sophia Stock, Pablo Silva De Tena, Pau Abrisqueta Costa, Janneke W. De Boer, Lucia Lopez Corral, Rafael Hernani, Marion Subklewe, Mi Kwon, Maeve O'Reilly, Pere Barba
Journal: Blood
Blood (2024) 144 (Supplement 1): 471.
https://doi.org/10.1182/blood-2024-205809
Published: 2024
Journal Articles

A Phase 1, Open-Label, Dose Escalation and Dose Expansion Study of Cln-049 for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease

Jonas S. Heitmann, Juliane S. Walz, Helmut R. Salih, Klaus H Metzeler, Daniel Heudobler, Felicitas R Thol, Hermann Einsele, Veit L. Buecklein, Pau Montesinos, Ana Alfonso Pierola, Gala Vega, Eduardo Rodriguez Arboli, Juan Miguel Bergua Burgues, Suhail Chaudhry, Judith Inumerable, Todd Shearer, Laura Liu, Sandeep Kaur, Kaida Wu, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.1.
https://doi.org/10.1182/blood-2024-201478
Published: 2024
Journal Articles

Divergent Population Dynamics and Gene Signaling in Monocytes Distinctly Influence Responses to CD19-Targeted CAR T-Cells in Relapsed/Refractory B-NHL

Viktoria Blumenberg, Maryam Kazerani, Tobias Straub, Francesco Corrado, Vadim Borisov, Stephan Baumann, Galina Busch, Jan Wulf, Agnese Petrera, Kai Rejeski, Christian Schmidt, Benjamin Tast, Michael von Bergwelt-Baildon, Christoph Stein-Thöringer, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 3425.
https://doi.org/10.1182/blood-2024-208938
Published: 2024
Journal Articles

CAR-Tography: Longitudinal Mapping of CAR-T Toxicities across B-Cell Malignancies Reveals Biologically Distinct and Prognostically Relevant Toxicity Phenotypes

Kai Rejeski, Teng Fei, Alejandro Luna, Mohammad Alhomoud, Yannis K. Valtis, Noriko Nishimura, Marina Gomez-Llobell, Noa Golan Accav, Ofrat Beyar-Katz, Sandeep S. Raj, Magdalena Corona, Alfredo Rivas-Delgado, Hamza Hashmi, Sridevi Rajeeve, Efrat Luttwak, Michael Scordo, Gunjan L. Shah, Maria Lia Palomba, Michael von Bergwelt-Baildon, Marion Subklewe, Abraham Avigdor, Ronit Marcus, Avichai Shimoni, Arnon Nagler, Tsila Zuckerman, Jabour Halloun, Uri Greenbaum, Sham Mailankody, Saad Z. Usmani, Gilles Salles, Jae H. Park, Miguel Angel Perales, Roni Shouval
Journal: Blood
Blood (2024) 144 (Supplement 1): 912.
https://doi.org/10.1182/blood-2024-203520
Published: 2024
Journal Articles

MP0533 (CD33 x CD123 x CD70 x CD3), a Tetra-Specific CD3-Engaging Darpin for the Treatment of Patients with Relapsed/Refractory AML or MDS/AML: Results of an Ongoing Phase 1/2a Study

Mojca Jongen-Lavrencic, Thomas Pabst, Pierre Bories, Laimonas Griškevičius, Gerwin Huls, David C. de Leeuw, Steffen Boettcher, Arnaud Pigneux, Nicolas Boissel, Mariola Dymkowska, Christiane Andrieu, Oliver Schönborn-Kellenberger, Paul G. Baverel, Zita Arany, Elena Fernandez, Ana-Maria Florescu, Michael P. Sanderson, Anne Goubier, Vladimir Kirkin, Philippe Legenne, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2881.
https://doi.org/10.1182/blood-2024-199211
Published: 2024
Journal Articles

Inflammation-Based Scores Predict Survival after CD3xCD20 Bispecific T Cell Engagers in R/R LBCL

Giulia Magno, Kai Rejeski, Giulia Rappa, Sissi Kupf, Sophia Stock, Alessandra M. E. Holzem, Julia Katharina Scholz, Rebecca Wurm-Kuczera, Shimrit Harlev, Nadine Kutsch, Giuliano Filippini Velazquez, Stephanie Mayer, Maria Landwehr, Jamila Mammadova, Sandeep S. Raj, Roni Shouval, Fabian Mueller, Björn Chapuy, Ofrat Beyar-Katz, Udo Holtick, Christoph Schmidt, Hendrik Poeck, Gloria Iacoboni, Pere Barba, Ning Dong, Veit L. Buecklein, Marion Subklewe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1714.
https://doi.org/10.1182/blood-2024-211459
Published: 2024
Journal Articles

Impact of Broad-Spectrum Antibiotic Exposure on CAR-T Therapy Outcomes in B-Cell Lymphoma: A Multicenter International Study

Roni Shouval, Teng Fei, Giulia Gabrielli, Natalie Grier Smith, Guido Ghilardi, John Slingerland, Jonathan U. Peled, Ying Taur, Sunita D. Nasta, Alejandro Luna, Magdalena Corona, Kai Rejeski, Sophia Stock, Ronit Marcus, Noa Golan Accav, Ofrat Beyar-Katz, Hazim Khatib, Sandeep S. Raj, Alexander P. Boardman, Parastoo B Dahi, Richard J. Lin, Michael Scordo, Lorenzo Falchi, Jakub Svoboda, Elise A. Chong, Stefan K. Barta, Daniel J. Landsburg, Avichai Shimoni, Arnon Nagler, Gunjan L. Shah, Maria Lia Palomba, Gilles Salles, Jae H. Park, Stephen J. Schuster, Tsila Zuckerman, Marion Subklewe, Abraham Avigdor, Miguel Angel Perales, Marcel R.M. van den Brink, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 1746.
https://doi.org/10.1182/blood-2024-203871
Published: 2024
Journal Articles

Antibiotic-induced loss of gut microbiome metabolic output correlates with clinical responses to CAR T-cell therapy

Rishika Prasad, Abdur Rehman, Lubna Rehman, Faezeh Darbaniyan, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Eli Zamir, Sabine Schmidt, Tomo Hayase, Chang Chia-Chi, Lauren Kelley McDaniel, Ivonne Flores, Paolo Strati, Ranjit Nair, Dai Chihara, Luis E. Fayad, Sairah Ahmed, Swaminathan P. Iyer, Michael L Wang, Preetesh Jain, Loretta J. Nastoupil, Jason R Westin, Reetakshi Arora, Joel Gordon Turner, Fareed Khawaja, Ranran Wu, Jennifer B Dennison, Meghan Menges, Melanie Hidalgo-Vargas, Kayla M. Reid, Marco L. Davila, Peter Dreger, Felix Korell, Anita Schmitt, Mark R Tanner, Richard E. Champlin, Christopher R. Flowers, Elizabeth J Shpall, Samir Hanash, Sattva S. Neelapu, Michael Schmitt, Marion Subklewe, Johannes Fahrmann, Christoph Stein-Thoeringer, Eran Elinav, Michael D Jain, Eiko Hayase, Robert R Jenq, Neeraj Y Saini
Journal: Blood
Blood blood.2024025366.
https://doi.org/10.1182/blood.2024025366
Published: 2024
Includes: Supplemental data
Journal Articles

T cells take aim in AML: targeting IDH2

Marion Subklewe
Journal: Blood
Blood (2024) 143 (17): 1681–1682.
https://doi.org/10.1182/blood.2024023892
Published: 2024