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Journal Articles

Mapping proteomic signatures in iPSC-derived neutrophils: Modeling neutropenia

Megha Mukherjee, Alicia-Sophie Schebesta, Daniel Petersheim, Monika Linder, Anne Stolz, Larissa Mantoan, Christopher Radtke, Johannes Mueller-Reif, Christoph Klein

Blood (2025) 146 (Supplement 1): 1212.

https://doi.org/10.1182/blood-2025-1212

Published: 2025

Journal Articles

Human iPSC-derived bone marrow organoids for AML engraftment and immunotherapy testing

Isabel Goek, Savannah Fairley, Daniel Berger, Anne-Sophie Neumann, Martina Kalauz, Larissa Mantoan, Monika Linder, Binje Vick, Remco Megens, Irmela Jeremias, Marion Subklewe, Stephanie Frenz-Wiessner, Christoph Klein

Blood (2025) 146 (Supplement 1): 4960.

https://doi.org/10.1182/blood-2025-4960

Published: 2025

Journal Articles

Increased dosing of blinatumomab in children and adolescents with Relapsed/Refractory B-lineage acute lymphoblastic leukemia – beneficial safety profile with 30µg/m²/day in a single center study

Liana Gahleitner, Christian Braun, Vera Binder-Blaser, Semjon Willier, Tanja Vallée, Irene Schmid, Michael Albert, Christoph Klein, Tobias Feuchtinger

Blood (2025) 146 (Supplement 1): 6857.

https://doi.org/10.1182/blood-2025-6857

Published: 2025

Journal Articles

Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma

Adrian Gottschlich, Ruth Grünmeier, Gordon Victor Hoffmann, Sayantan Nandi, Vladyslav Kavaka, Philipp Jie Müller, Jakob Jobst, Arman Oner, Rainer Kaiser, Jan Gärtig, Ignazio Piseddu, Stephanie Frenz-Wiessner, Savannah D. Fairley, Heiko Schulz, Veronika Igl, Thomas Alexander Janert, Lea Di Fina, Maité Mulkers, Moritz Thomas, Daria Briukhovetska, Donjetë Simnica, Emanuele Carlini, Christina Angeliki Tsiverioti, Marcel P. Trefny, Theo Lorenzini, Florian Märkl, Pedro Mesquita, Ruben Brabenec, Thaddäus Strzalkowski, Sophia Stock, Stefanos Michaelides, Johannes Hellmuth, Martin Thelen, Sarah Reinke, Wolfram Klapper, Pascal Francois Gelebart, Leo Nicolai, Carsten Marr, Eduardo Beltrán, Remco T. A. Megens, Christoph Klein, Fanny Baran-Marszak, Andreas Rosenwald, Michael von Bergwelt-Baildon, Paul J. Bröckelmann, Stefan Endres, Sebastian Kobold

Blood (2025) 145 (14): 1536–1552.

https://doi.org/10.1182/blood.2023022197

Published: 2025

Includes: Supplemental data

Journal Articles

Illuminating the Functional Architecture of iPSC-Derived Neutrophil Granulocytes with Split Fluorescent Proteins

Daniel Petersheim, Monika I Linder, Mehmet T Kiziltug, Johanna Schmid, Almke Bader, Daniela Maier-Begandt, Barbara Walzog, Jörg Renkawitz, Christoph Klein

Blood (2024) 144 (Supplement 1): 2524.

https://doi.org/10.1182/blood-2024-207312

Published: 2024

Journal Articles

Dissection of Single-Cell Landscapes for the Development of Chimeric Antigen Receptor T Cells in Hodgkin Lymphoma

Blood (2024) 144 (Supplement 1): 4796.

https://doi.org/10.1182/blood-2024-207274

Published: 2024

Journal Articles

Gasdermin D drives focal crystalline thrombotic microangiopathy by accelerating immunothrombosis and necroinflammation

Kanako Watanabe-Kusunoki, Chenyu Li, Tâmisa Seeko Bandeira Honda, Danyang Zhao, Yoshihiro Kusunoki, John Ku, Hao Long, Martin Klaus, Chao Han, Attila Braun, Elmina Mammadova-Bach, Andreas Linkermann, Kristof Van Avondt, Mathis Richter, Oliver Soehnlein, Monika I. Linder, Christoph Klein, Stefanie Steiger, Hans-Joachim Anders

Blood (2024) 144 (3): 308–322.

https://doi.org/10.1182/blood.2023021949

Published: 2024

Includes: Supplemental data

Journal Articles

Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival

Tanja C. Vallée, Jannik S. Glasmacher, Hannes Buchner, Peter D. Arkwright, Uta Behrends, Anastasia Bondarenko, Michael J. Browning, David Buchbinder, Alessandro Cattoni, Liudmyla Chernyshova, Peter Ciznar, Theresa Cole, Wojciech Czogała, Gregor Dueckers, John David M. Edgar, Fatih Erbey, Anders Fasth, Francesca Ferrua, Renata Formankova, Eleonora Gambineri, Andrew R. Gennery, Frederick D. Goldman, Luis I. Gonzalez-Granado, Carsten Heilmann, Tarja Heiskanen-Kosma, Hanna Juntti, Leena Kainulainen, Hirokazu Kanegane, Neslihan E. Karaca, Sara S. Kilic, Christoph Klein, Sylwia Kołtan, Irina Kondratenko, Isabelle Meyts, Gulnara M. Nasrullayeva, Lucia D. Notarangelo, Srdjan Pasic, Isabelle Pellier, Claudio Pignata, Siraj Misbah, Ansgar Schulz, Gesmar R. Segundo, Anna Shcherbina, Mary Slatter, Robert Sokolic, Pere Soler-Palacin, Polina Stepensky, Joris M. van Montfrans, Samppa Ryhänen, Beata Wolska-Kuśnierz, John B. Ziegler, Xiaodong Zhao, Alessandro Aiuti, Hans D. Ochs, Michael H. Albert

Blood (2024) 143 (24): 2504–2516.

https://doi.org/10.1182/blood.2023021411

Published: 2024

Includes: Supplemental data

Journal Articles

Clinical and functional spectrum of RAC2-related immunodeficiency

Blood (2024) 143 (15): 1476–1487.

https://doi.org/10.1182/blood.2023022098

Published: 2024

Includes: Supplemental data

Journal Articles

CD28 CAR T Cells for the Treatment of T Cell Malignancies

Semjon Willier, Julian Färber, Theodora Ispyrlidou, Dana Stenger, Sophia LM Nikolaides, Paulina Ferrada Ernst, Annika E Peters, Jonas Wilhelm, Nadine Stoll, Maike Breidenbach, Fiona AG Becker-Dettling, Franziska Blaeschke, Theresa Kaeuferle, Abdallah AHA Yassin, Christoph Klein, Tobias Feuchtinger

Blood (2023) 142 (Supplement 1): 3448.

https://doi.org/10.1182/blood-2023-180584

Published: 2023

Journal Articles

Human Induced Pluripotent Stem Cell-Derived Bone Marrow Organoids to Model Hematopoietic Development

Blood (2023) 142 (Supplement 1): 2708.

https://doi.org/10.1182/blood-2023-184523

Published: 2023

Journal Articles

Immunological Footprints of Pediatric Acute Myeloid Leukemia in Local Bone Marrow T Cells

Paula Rothämel, Semjon Willier, Jonas Wilhelm, Fiona AG Becker-Dettling, Theresa Kaeuferle, Franziska Blaeschke, Meino Rohlfs, Irene Schmid, Vera Binder, Christoph Klein, Thomas Walzthoeni, Matthias Heinig, Tobias Feuchtinger

Blood (2023) 142 (Supplement 1): 1587.

https://doi.org/10.1182/blood-2023-188947

Published: 2023

Journal Articles

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes

Blood (2023) 141 (6): 645–658.

https://doi.org/10.1182/blood.2022016783

Published: 2023

Includes: Supplemental data

Journal Articles

Generation of Human Induced Pluripotent Stem Cell-Derived Bone Marrow Organoids

Stephanie Frenz, Isabel Goek, Maximilian Buser, Kirill Salewskij, Savannah Fairley, Raffaele Conca, Nicole Drexler, Gustav Jonsson, Moritz Thomas, Yoko Mizoguchi, Martina Rudelius, Thomas Heuser, Carsten Marr, Josef M Penninger, Christoph Klein

Blood (2022) 140 (Supplement 1): 1682–1683.

https://doi.org/10.1182/blood-2022-166653

Published: 2022

Journal Articles

Spatially Confined T-Cell Mediated Anti-AML Tumor Immunity By Dual Recognition Antibodies (CD123/CD200)

Daniel Bergér, Steffen Dickopf, Binje Vick, Katharina Weinlich, Irmela Jeremias, Ulrich Brinkmann, Christoph Klein

Blood (2022) 140 (Supplement 1): 2249–2250.

https://doi.org/10.1182/blood-2022-163104

Published: 2022

Journal Articles

Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

Blood (2022) 139 (13): 2066–2079.

https://doi.org/10.1182/blood.2021014687

Published: 2022

Includes: Supplemental data

Journal Articles

Induced Pluripotent Stem Cell-Derived Neutrophil Granulocytes - Flow Cytometry Analysis Reveals Distinct Subpopulations

Stephanie Frenz, Raffaele Conca, Sebastian Hesse, Monika I. Linder, Christoph Klein

Blood (2021) 138 (Supplement 1): 3126.

https://doi.org/10.1182/blood-2021-150495

Published: 2021

Journal Articles

Mammalian VPS45 orchestrates trafficking through the endosomal system

Laura Frey, Natalia Ziętara, Marcin Łyszkiewicz, Benjamin Marquardt, Yoko Mizoguchi, Monika I. Linder, Yanshan Liu, Florian Giesert, Wolfgang Wurst, Maik Dahlhoff, Marlon R. Schneider, Eckhard Wolf, Raz Somech, Christoph Klein

Blood (2021) 137 (14): 1932–1944.

https://doi.org/10.1182/blood.2020006871

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Semjon Willier, Paula Rothämel, Maximilian Hastreiter, Jonas Wilhelm, Dana Stenger, Franziska Blaeschke, Meino Rohlfs, Theresa Kaeuferle, Irene Schmid, Michael H. Albert, Vera Binder, Marion Subklewe, Christoph Klein, Tobias Feuchtinger

Blood (2021) 137 (8): 1037–1049.

https://doi.org/10.1182/blood.2020006921

Published: 2021

Includes: Supplemental data

Journal Articles

Novel Immune Checkpoint Deficiency and Susceptibility to EBV-Associated Lymphoma

Ido Somekh, Thomas Magg, PhD, Alejandro Gallón Duque, Tali Stauber, MD, Atar Lev, MSc, Ekrem Unal, MD, Amos J. Simon, PhD, Meino Rohlfs, PhD, Raffaele Conca, MSc, Megumi Tatematsu, PhD, Fabian Hauck, MD PhD, Raz Somech, MD PhD, Christoph Klein, MD PhD

Blood (2019) 134 (Supplement_1): 2326.

https://doi.org/10.1182/blood-2019-128296

Published: 2019

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Mapping proteomic signatures in iPSC-derived neutrophils: Modeling neutropenia

Human iPSC-derived bone marrow organoids for AML engraftment and immunotherapy testing

Increased dosing of blinatumomab in children and adolescents with Relapsed/Refractory B-lineage acute lymphoblastic leukemia – beneficial safety profile with 30µg/m²/day in a single center study

Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma

Illuminating the Functional Architecture of iPSC-Derived Neutrophil Granulocytes with Split Fluorescent Proteins

Dissection of Single-Cell Landscapes for the Development of Chimeric Antigen Receptor T Cells in Hodgkin Lymphoma

Gasdermin D drives focal crystalline thrombotic microangiopathy by accelerating immunothrombosis and necroinflammation

Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival

Clinical and functional spectrum of RAC2-related immunodeficiency

CD28 CAR T Cells for the Treatment of T Cell Malignancies

Human Induced Pluripotent Stem Cell-Derived Bone Marrow Organoids to Model Hematopoietic Development

Immunological Footprints of Pediatric Acute Myeloid Leukemia in Local Bone Marrow T Cells

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes

Generation of Human Induced Pluripotent Stem Cell-Derived Bone Marrow Organoids

Spatially Confined T-Cell Mediated Anti-AML Tumor Immunity By Dual Recognition Antibodies (CD123/CD200)

Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

Induced Pluripotent Stem Cell-Derived Neutrophil Granulocytes - Flow Cytometry Analysis Reveals Distinct Subpopulations

Mammalian VPS45 orchestrates trafficking through the endosomal system

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Novel Immune Checkpoint Deficiency and Susceptibility to EBV-Associated Lymphoma

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American Society of Hematology

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