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Journal Articles

The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut

Free
Alix Schwarz, Simon Holzinger, Peter Herhaus, Mareike Verbeek, Klaus Neuhaus, Karin Kleigrewe, Klaus-Peter Janssen, Matthias Edinger, Elisabeth Meedt, Daniel Wolff, Daniela Weber, Ernst Holler, Romana Gerner, Andreas Hiergeist, André Gessner, Peter Neumeister, Wolfgang Herr, Florian Bassermann, Walter Spindelboeck, Christoph Hoegnauer, Hendrik Poeck, Erik Thiele Orberg
Journal: Blood
Blood (2025) 146 (Supplement 1): 4236.
https://doi.org/10.1182/blood-2025-4236
Published: 2025
Journal Articles

Multi-faceted influence of immunomodulatory metabolites on CAR-T cell therapy

Free
Dhyani Shah, Markus Perl, Matthias Fante, Severin Guetter, Simon Holzinger, Luisa-Marie Becker, Misbah Tariq, Philipp Meanauer, Simon Delahais, Gloria Lutzny-Geier, Julian Scherer, Sascha Goettert, Konstantin Herfeld, Paul Heinrich, Klaus-Georg Kreitmeier, Wolfgang Herr, Janina Doerr, Dennis Harrer, Leo Hansmann, Marcel Trefny, Matthias Edinger, Daniel Wolff, Daniela Weber, Elisabeth Meedt, André Gessner, Ernst Holler, Tobias Wertheimer, Klaus Neuhaus, Tingting Zheng, Kai Ziegler-Martin, David M. Cordas Dos Santos, Sebastian Theurich, Melanie Schirmer, Jonas Schluter, Michael Schmitt, Karin Kleigrewe, Markus Feuerer, Christoph Heuser-Loy, Jeremy Baldwin, Michael Hudecek, Luca Gattinoni, Marion Subklewe, Viktoria Blumenberg, Maria-Luisa Schubert, Christoph Stein-Thoeringer, Maik Luu, Sebastian Kobold, Erik Thiele Orberg, Hendrik Poeck
Journal: Blood
Blood (2025) 146 (Supplement 1): 2343.
https://doi.org/10.1182/blood-2025-2343
Published: 2025
Journal Articles

Grade I acute graft-vs-host disease: Treat or not?

Free
Yu Akahoshi, Nikolaos Katsivelos, Ioannis Evangelos Louloudis, Daniela Weber, Francis Ayuk, William Hogan, Yi-Bin Chen, Aaron Etra, Paibel Aguayo-Hiraldo, Chantiya Chanswangphuwana, Hannah Choe, Elizabeth Hexner, Carrie Kitko, Monzr M. Al Malki, Pietro Merli, Timothy Olson, Muna Qayed, Ingrid Vasova, Matthias Woelfl, Janna Baez, Gilbert Eng, Sigrun Gleich, George Morales, Nikolaos Spyrou, Rachel Young, Ryotaro Nakamura, James Ferrara, John Levine
Journal: Blood
Blood (2025) 146 (Supplement 1): 2461.
https://doi.org/10.1182/blood-2025-2461
Published: 2025
Journal Articles

Timed inhibition of the sting pathway improves tissue regeneration and prevents GVHD following allo-HSCT

Free
Sascha Göttert, Chiara Suriano, Omer Khalid, Paul Heinrich, Sakhila Ghimire, Eva Vonbrunn, Elisabeth Meedt, Petra Hoffmann, Matthias Edinger, Daniela Weber, Daniel Wolff, Michael Rehli, Maike Büttner-Herold, Wolfgang Herr, Ernst Holler, Christian Schmidl, Hendrik Poeck
Journal: Blood
Blood (2025) 146 (Supplement 1): 2317.
https://doi.org/10.1182/blood-2025-2317
Published: 2025
Journal Articles

Augmented CD47 expression impairs alloreactive T-cell clearance after allo-HCT

Available to Purchase
Cindy Flamann, Haroon Shaikh, Carina Matos, Marina Kreutz, Hla Ali, Michael A. G. Kern, Maike Büttner-Herold, Benedikt Jacobs, Simon Völkl, Christopher Lischer, Christian Kellner, Johannes Berges, Katrin Bitterer, Domenica Saul, Manisha Goel, Cornelia S. Link-Rachner, Alma Zernecke, Daniela Weber, Dimitrios Mougiakakos, Andreas Mackensen, Andreas Beilhack, Heiko Bruns
Journal: Blood
Blood (2025) 146 (11): 1359–1373.
https://doi.org/10.1182/blood.2023023056
Published: 2025
Includes: Supplemental data
Journal Articles

Serial Clinical and Biomarker Monitoring during Treatment Can Stratify Patients with Low Risk Gvhd

Free
Nikolaos Katsivelos, Nikolaos Spyrou, Daniela Weber, Ingrid Vasova, Francis A. Ayuk, Hannah Choe, William J. Hogan, Zachariah Defilipp, Muna Qayed, Aaron Etra, Karamjeet S Sandhu, Sabrina Kraus, Timothy S. Olson, Elizabeth O. Hexner, Paibel Aguayo-Hiraldo, Ran Reshef, Evelyn Ullrich, Tal Schechter-Finkelstein, Carrie L. Kitko, Chantiya Chanswangphuwana, Pietro Merli, Yu Akahoshi, Janna Baez, Gilbert Eng, Rahnuma Beheshti, Steven Kowalyk, George Morales, Ioannis Evangelos Louloudis, Rachel Young, Ernst Holler, Ryotaro Nakamura, James L.M. Ferrara, John Levine
Journal: Blood
Blood (2024) 144 (Supplement 1): 380.
https://doi.org/10.1182/blood-2024-204010
Published: 2024
Journal Articles

Recovery of the Intestinal Microbiome in Patients at Day +100 after Allogeneic Stem Cell Transplantation Is Defined By Microbial Metabolite Profiles and Linked to Long-Term Outcomes

Free
Alix Schwarz, Tina Eismann, Tingting Zheng, Sophia Goeldel, Mats Urban, Mohsen Pourjam, Klaus Neuhaus, Ilias Lagkouvardos, Daniel Wolff, Peter Herhaus, Mareike Verbeek, Ernst Holler, Wolfgang Herr, Karin Kleigrewe, Simon M Heidegger, Klaus-Peter Janssen, Florian Bassermann, Melanie Schirmer, Hendrik Poeck, Daniela Weber, Erik Thiele Orberg
Journal: Blood
Blood (2024) 144 (Supplement 1): 780.
https://doi.org/10.1182/blood-2024-199035
Published: 2024
Journal Articles

Immunomodulatory Microbial Metabolites Protect Against Graft-Vs-Host Disease and Enhance Anti-Leukemia Responses in Mice and Patients Receiving Stem Cell Transplantation

Free
Sascha Göttert, Erik Thiele-Orberg, Kaiji Fan, Paul Heinrich, Daniel Wolff, Daniela Weber, Florian Bassermann, Petra Hoffmann, Matthias Edinger, Natalie Koehler, André Gessner, Wolfgang Herr, Simon M Heidegger, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2024) 144 (Supplement 1): 264.
https://doi.org/10.1182/blood-2024-205921
Published: 2024
Journal Articles

Novel MAGIC composite scores using both clinical symptoms and biomarkers best predict treatment outcomes of acute GVHD

Free
Clinical Trials & Observations
Yu Akahoshi, Nikolaos Spyrou, Daniela Weber, Paibel Aguayo-Hiraldo, Francis Ayuk, Chantiya Chanswangphuwana, Hannah K. Choe, Matthias Eder, Aaron M. Etra, Stephan A. Grupp, Elizabeth O. Hexner, William J. Hogan, Carrie L. Kitko, Sabrina Kraus, Monzr M. Al Malki, Pietro Merli, Muna Qayed, Ran Reshef, Tal Schechter, Evelyn Ullrich, Ingrid Vasova, Matthias Wölfl, Robert Zeiser, Janna Baez, Rahnuma Beheshti, Gilbert Eng, Sigrun Gleich, Nikolaos Katsivelos, Steven Kowalyk, George Morales, Rachel Young, Yi-Bin Chen, Ryotaro Nakamura, John E. Levine, James L. M. Ferrara
Journal: Blood
Blood (2024) 144 (9): 1010–1021.
https://doi.org/10.1182/blood.2024025106
Published: 2024
Includes: Supplemental data
Journal Articles

The Genomic Landscape and Its Clinical Implication in NPM1 -Mutated AML Patients: A Study within the AMLSG 09-09 Clinical Trial

Free
Sibylle Cocciardi, Nina Weiß, Maral Saadati, Sabrina Skambraks, Daniela Weber, Isabelle Schneider, Annika Meid, Sophia Aicher, Kathrin Bengesser-Kuhn, Andrea Corbacioglu, Verena I. Gaidzik, Frauke Theis, Walter Fiedler, Michael Kühn, Ulrich Germing, Karin T. Mayer, Michael Lübbert, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2023) 142 (Supplement 1): 4311.
https://doi.org/10.1182/blood-2023-185566
Published: 2023
Journal Articles

Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients

Free
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Alix Schwarz, Klaus-Peter Janssen, Peter Herhaus, Mareike Verbeek, Marcel R.M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2023) 142 (Supplement 1): 477.
https://doi.org/10.1182/blood-2023-172457
Published: 2023
Journal Articles

Flares of Acute Graft-Versus-Host Disease: Mount Sinai Acute Gvhd International Consortium (MAGIC) Study

Free
Yu Akahoshi, Nikolaos Spyrou, Daniela Weber, Paibel Aguayo-Hiraldo, Francis A. Ayuk, Udomsak Bunworasate, Hannah Choe, Matthias Eder, Aaron Etra, Stephan Grupp, Elizabeth O Hexner, William J. Hogan, Carrie L. Kitko, Sabrina Kraus, Pietro Merli, Muna Qayed, Ran Reshef, Tal Schechter-Finkelstein, Evelyn Ullrich, Ingrid Vasova, Matthias Woelfl, Robert Zeiser, Janna Baez, Rahnuma Beheshti, Sigrun Gleich, Nikolaos Katsivelos, Steven Kowalyk, George Morales, Rachel Young, Yi-Bin Chen, James L.M. Ferrara, John Levine, Ryotaro Nakamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 776.
https://doi.org/10.1182/blood-2023-181900
Published: 2023
Journal Articles

Identification of Bacterial and Viral Consortia for the Production of Intestinal Microbiota-Derived Metabolites Associated with Protection in Allogeneic Stem Cell Transplantation Patients

Free
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Karin Kleigrewe, Julius Clemens Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Christian Schulz, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk Busch, Wolfgang Herr, Florian Bassermann, Li Deng, Andre Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2022) 140 (Supplement 1): 7619–7621.
https://doi.org/10.1182/blood-2022-157423
Published: 2022
Journal Articles

Gemtuzumab Ozogamicin Plus Intensive Chemotherapy for Patients with NPM1 -Mutated Acute Myeloid Leukemia

Free
Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Mohammad Wattad, Katharina Götze, Lars Fransecky, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Mark Ringhoffer, Richard Greil, Bernd Hertenstein, Jürgen Krauter, Uwe M. Martens, David Nachbaur, Maisun Abu Samra, Sigrid Machherndl-Spandl, Nadezda Basara, Claudia Leis, Anika Schrade, Silke Kapp-Schwoerer, Lars Bullinger, Felicitas R. Thol, Michael Heuser, Peter Paschka, Verena I. Gaidzik, Maral Saadati, Axel Benner, Richard F. Schlenk, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood (2022) 140 (Supplement 1): 2010–2013.
https://doi.org/10.1182/blood-2022-166084
Published: 2022
Journal Articles

Analysis of Patient-Level Data from 3 Cooperative Group Trials Confirms a Survival Advantage for NPM1 m Patients Achieving MRD-Negative CR after Intensive Induction

Free
Konstanze Döhner, Hartmut Döhner, Daniela Weber, Silke Kapp-Schwoerer, Amanda Gilkes, Ian Thomas, Sean Johnson, Nicola Potter, Yana Bevan, Jad Othman, Nigel H. Russell, Christoph Röllig, Christian Thiede, Martin Bornhaeuser, Thomas Oellerich, Jenna Elder, Luis A. Carvajal, Zung To, Jorge DiMartino, Richard Dillon
Journal: Blood
Blood (2022) 140 (Supplement 1): 6293–6294.
https://doi.org/10.1182/blood-2022-159212
Published: 2022
Journal Articles

Longitudinal Analysis of Gut Bacteriome, Mycobiome, Virome and Metabolome in Allogeneic Stem Cell Transplantation Reveals Susceptibility for Acute Graft-Versus-Host Disease

Free
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Tina Eismann, Sophia Göldel, Peter Herhaus, Mareike Verbeek, Florian Bassermann, Michael Quante, Daniela Weber, Matthias Edinger, Daniel Wolff, Wolfgang Herr, Li Deng, André Gessner, Ernst Holler, Hendrik Poeck
Journal: Blood
Blood (2021) 138 (Supplement 1): 332.
https://doi.org/10.1182/blood-2021-153026
Published: 2021
Journal Articles

Midostaurin Plus Intensive Chemotherapy for Younger and Older Patients with Acute Myeloid Leukemia and FLT3 Internal Tandem Duplications

Free
Hartmut Döhner, Daniela Weber, Julia Krzykalla, Walter Fiedler, Gerald Wulf, Helmut R. Salih, Michael Lübbert, Michael W.M. Kühn, Thomas Schroeder, Hans Salwender, Katharina S. Götze, Jörg Westermann, Lars Fransecky, Karin Mayer, Bernd Hertenstein, Mark Ringhoffer, Hans-Joachim Tischler, Sigrid Machherndl-Spandl, Anika Schrade, Peter Paschka, Verena I Gaidzik, Frauke Theis, Felicitas R Thol, Michael Heuser, Richard F. Schlenk, Lars Bullinger, Maral Saadati, Axel Benner, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood (2021) 138 (Supplement 1): 692.
https://doi.org/10.1182/blood-2021-147256
Published: 2021
Journal Articles

Prognostic Value of Elafin in Acute Graft-Versus-Host Disease

Free
Makda Getachew Zewde, George Morales, Isha Gandhi, Umut Ozbek, Paibel Aguayo-Hiraldo, Francis A. Ayuk, Janna Baez, Chantiya Chanswangphuwana, Hannah Choe, Zachariah DeFilipp, Aaron Etra, Stephan A. Grupp, Elizabeth O. Hexner, William J Hogan, Rebeka Javorniczky, Stelios Kasikis, Carrie Lynn Kitko, Steven Kowalyk, Elisabeth Meedt, Pietro Merli, Ryotaro Nakamura, Muna Qayed, Ran Reshef, Wolf Roesler, Tal Schechter-Finkelstein, Daniela Weber, Matthias Wölfl, Gregory A Yanik, Rachel Young, John E. Levine, James L. Ferrara, Yi-Bin Chen
Journal: Blood
Blood (2021) 138 (Supplement 1): 3900.
https://doi.org/10.1182/blood-2021-154302
Published: 2021
Journal Articles

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1 -mutated AML: results from the AMLSG 09-09 trial

Free
Clinical Trials & Observations
Silke Kapp-Schwoerer, Daniela Weber, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Jan Krönke, Frauke Theis, Frank G. Rücker, Maria-Veronica Teleanu, Ekaterina Panina, Nikolaus Jahn, Julia Herzig, Lena Kubanek, Anika Schrade, Gudrun Göhring, Walter Fiedler, Thomas Kindler, Thomas Schroeder, Karin T. Mayer, Michael Lübbert, Mohammed Wattad, Katharina S. Götze, Heinz A. Horst, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Martin Bentz, Jürgen Krauter, Lars Bullinger, Julia Krzykalla, Axel Benner, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (26): 3041–3050.
https://doi.org/10.1182/blood.2020005998
Published: 2020
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication ( FLT3 -ITD + AML) Treated with Additional Midostaurin

Free
Julia K. Herzig, PhD, Frank G. Rücker, MD, Laura K. Schmalbrock, MD, Tamara J. Blätte, PhD, Daniela Weber, MSc, Sabrina Skambraks, Silke Kapp-Schwoerer, MD, Andrea Corbacioglu, PhD, Verena I Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Nikolaus Jahn, MD, Anika Schrade, PhD, Frauke Theis, MD, Sibylle Cocciardi, PhD, Walter Fiedler, MD, Helmut R. Salih, Gerald Wulf, MD, Hans Salwender, MD, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, MD, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, MD, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137568
Published: 2020