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Journal Articles

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Franco Locatelli, Peter Lang, Selim Corbacioglu, Donna Wall, Roland Meisel, Amanda M Li, Josu de La Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, Markus Mapara, Robert I. Liem, Maria Domenica Cappellini, Mattia Algeri, Antonis Kattamis, Sujit Sheth, Stephan Grupp, Puja Kohli, Daoyuan Shi, Leorah Ross, Yael Bobruff, Christopher Simard, Lanju Zhang, Phuong Khanh Morrow, William Hobbs, Haydar Frangoul
Journal: Blood
Blood (2023) 142 (Supplement 1): 1053.
https://doi.org/10.1182/blood-2023-190534
Published: 2023
Journal Articles

IL-10 Levels Differentially Regulate IFNg Signaling of CART19 and CART22

Caroline Diorio, Regina M. Myers, Anastasia Frank-Kamenetski, Rawan Shraim, Amanda M. Dinofia, Zachary Martinez, Ohaila Mustafa, Joseph A Fraietta, Vanessa Gonzalez, Vivian Yi, Lahari Uppuluri, Haley Newman, Edward Behrens, Carl June, Scott Canna, Stephan Grupp, David T. Teachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 3431.
https://doi.org/10.1182/blood-2023-182377
Published: 2023
Journal Articles

Flares of Acute Graft-Versus-Host Disease: Mount Sinai Acute Gvhd International Consortium (MAGIC) Study

Yu Akahoshi, Nikolaos Spyrou, Daniela Weber, Paibel Aguayo-Hiraldo, Francis A. Ayuk, Udomsak Bunworasate, Hannah Choe, Matthias Eder, Aaron Etra, Stephan Grupp, Elizabeth O Hexner, William J. Hogan, Carrie L. Kitko, Sabrina Kraus, Pietro Merli, Muna Qayed, Ran Reshef, Tal Schechter-Finkelstein, Evelyn Ullrich, Ingrid Vasova, Matthias Woelfl, Robert Zeiser, Janna Baez, Rahnuma Beheshti, Sigrun Gleich, Nikolaos Katsivelos, Steven Kowalyk, George Morales, Rachel Young, Yi-Bin Chen, James L.M. Ferrara, John Levine, Ryotaro Nakamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 776.
https://doi.org/10.1182/blood-2023-181900
Published: 2023
Journal Articles

The MAGIC Algorithm Probability Predicts Long-Term Outcomes and Treatment Response to Second-Line Therapy for Acute Gvhd

Zachariah Defilipp, Haesook T. Kim, Nikolaos Spyrou, Steven Kowalyk, Gilbert Eng, Rahnuma Beheshti, Janna Baez, Francis A. Ayuk, Hannah Choe, Aaron Etra, Stephan Grupp, Elizabeth O Hexner, William J. Hogan, Carrie L. Kitko, Muna Qayed, Ran Reshef, Ingrid Vasova, Robert Zeiser, Rachel Young, James L.M. Ferrara, Ryotaro Nakamura, John Levine, Yi-Bin Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 3576.
https://doi.org/10.1182/blood-2023-182300
Published: 2023
Journal Articles

Improvements in Health-Related Quality of Life after Exagamglogene Autotemcel in Patients with Severe Sickle Cell Disease

Akshay Sharma, Haydar Frangoul, Markus Mapara, Suzan Imren, Nanxin Li, Tina Liu, Jaime Rubin, Daoyuan Shi, William Hobbs, Stephan Grupp
Journal: Blood
Blood (2023) 142 (Supplement 1): 4999.
https://doi.org/10.1182/blood-2023-190203
Published: 2023
Journal Articles

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Mapara, Lyndsay Molinari, Donna Wall, Robert I. Liem, Paul Telfer, Ami J. Shah, Marina Cavazzana, Selim Corbacioglu, Damiano Rondelli, Roland Meisel, Laurence Dedeken, Stephan Lobitz, Mariane de Montalembert, Martin H. Steinberg, Mark C. Walters, Laura Bower, Suzan Imren, Christopher Simard, Fengjuan Xuan, Weiyu Zhou, Phuong Khanh Morrow, William Hobbs, Stephan Grupp
Journal: Blood
Blood (2023) 142 (Supplement 1): 1052.
https://doi.org/10.1182/blood-2023-190139
Published: 2023
Journal Articles

Outcomes and Toxicities after Allogeneic Hematopoietic Cell Transplant for Remission Consolidation or Relapse Therapy after CD19 Chimeric Antigen Receptor T Cell Therapy in Children and Young Adults with Acute Lymphoblastic Leukemia

Regina M. Myers, Sarah Mumanachit, Shannon L. Maude, Amanda M. Dinofia, Jason L. Freedman, Nancy Bunin, Lisa Wray, Allison Barz Leahy, Timothy S Olson, Stephan Grupp, Alix E. Seif, Caitlin W. Elgarten
Journal: Blood
Blood (2023) 142 (Supplement 1): 3767.
https://doi.org/10.1182/blood-2023-188047
Published: 2023
Journal Articles

Significant Cytokine Release Syndrome Risk Model with T-Cell Engaging Therapies

Penelope Lafeuille, William Blumentals, Claire Brulle Wohlhueter, Weixi Chen, Chao Sang, Sydney Manning, Silvy Saltzman, Jan Canvin, Susan Richard, Cris Kamperschroer, Giovanni Abbadessa, Aniketh Talwai, Caroline Der-Nigoghossian, Yahav Itzkovich, Vibhu Agarwal, Rahul Jain, Tanmay Jain, Jacob Aptekar, Stephan Grupp
Journal: Blood
Blood (2023) 142 (Supplement 1): 3629.
https://doi.org/10.1182/blood-2023-181985
Published: 2023
Journal Articles

Updated Results of the Phase I BALLI-01 Trial of UCART22 Process 2 (P2), an Anti-CD22 Allogeneic CAR-T Cell Product Manufactured By Cellectis Biologics, in Patients with Relapsed or Refractory (R/R) CD22+ B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Nitin Jain, Patrice Chevallier, Hongtao Liu, Gary J. Schiller, Jean-Baptiste Méar, Daniel J. DeAngelo, Kevin J Curran, Stephan Grupp, Andre Baruchel, Marie Balsat, Alexandra LaCroce, Caroline Roudet, Ana B. Korngold, Kathryn J. Newhall, Eric Laille, Daniel J. Lee, Mark G. Frattini, Richard A. Larson, Nicolas Boissel
Journal: Blood
Blood (2023) 142 (Supplement 1): 4847.
https://doi.org/10.1182/blood-2023-187252
Published: 2023
Journal Articles

Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission

Zhiliang Bai, Bing Feng, Susan E. Mcclory, Caroline Diorio, Ziran Zhao, Li Tang, J. Joseph Melenhorst, Carl June, Stephan Grupp, Rong Fan
Journal: Blood
Blood (2023) 142 (Supplement 1): 352.
https://doi.org/10.1182/blood-2023-179480
Published: 2023
Journal Articles

A Day 14 Endpoint for Acute Gvhd Clinical Trials

Nikolaos Spyrou, Yu Akahoshi, Steven Kowalyk, George Morales, Rahnuma Beheshti, Paibel Aguayo-Hiraldo, MHD Monzr Al Malki, Francis Ayuketang Ayuk, Peter Bader, Janna Baez, Alexandra Capellini, Hannah Choe, Zachariah Defilipp, Matthias Eder, Gilbert Eng, Aaron Etra, Sigrun Gleich, Stephan Grupp, Elizabeth Hexner, Matthias Hoepting, William J. Hogan, Stelios Kasikis, Nikolaos Katsivelos, Carrie L. Kitko, Sabrina Kraus, Deukwoo Kwon, Pietro Merli, Joseph Portelli, Muna Qayed, Ran Reshef, Tal Schechter-Finkelstein, Ingrid Vasova, Matthias Woelfl, Kitsada Wudhikarn, Rachel Young, Ernst Holler, Yi-Bin Chen, Ryotaro Nakamura, John Levine, James L.M. Ferrara
Journal: Blood
Blood (2023) 142 (Supplement 1): 779.
https://doi.org/10.1182/blood-2023-172955
Published: 2023
Journal Articles

Long Term Durable Responses in Relapsed/Refractory (r/r) ALL, DLBCL, and FL Patients Treated with Tisagenlecleucel and Its Association with Persistence of CAR T-Cells

Rakesh Awasthi, Edward Waldron, Stephan Grupp, Michael A. Pulsipher, Peter Bader, Stephen J Schuster, Richard T Maziarz, Edmund K. Waller, Ulrich Jaeger, Catherine Thieblemont, Martin Dreyling, Nathan Fowler, Harald Jakob Maier, Jennifer Willert
Journal: Blood
Blood (2023) 142 (Supplement 1): 4872.
https://doi.org/10.1182/blood-2023-181663
Published: 2023
Journal Articles

Prediction of Patients at Risk of CD19 Neg Relapse Following CD19-Directed CAR T Cell Therapy in B Cell Precursor Acute Lymphoblastic Leukemia

Pablo Domizi, PhD, Astraea Jager, BS, Jolanda Sarno, PhD, Charles G. Mullighan, MBBS, MD, Stephan Grupp, MD PhD, Elena Sotillo, PhD, David M. Barrett, Kara L. Davis, DO
Journal: Blood
Blood (2019) 134 (Supplement_1): 749.
https://doi.org/10.1182/blood-2019-128883
Published: 2019
Journal Articles

Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L Garfall, MD, Michael C. Milone, Lifeng Tian, PhD, Vanessa E. Gonzalez, Saar Gill, MD MRCP, FRCPath, Noelle V. Frey, MD, David M. Barrett, Marco Ruella, MD, Simon F Lacey, PhD, Jakub Svoboda, MD, Elise A. Chong, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Sunita D Nasta, MD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Stephen J. Schuster, MD, Edward A. Stadtmauer, MD FACP, Stephan Grupp, MD PhD, David L. Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 622.
https://doi.org/10.1182/blood-2019-122513
Published: 2019
Journal Articles

The MAGIC Algorithm Probability (MAP): A Novel Laboratory Biomarker for the Response to Treatment of Acute Graft-Versus-Host Disease

Hrishikesh Srinagesh, BA, Umut Ozbek, PhD, Urvi Kapoor, MD, Francis Ayuketang Ayuk, MD, Mina D. Aziz, MD, Kaitlyn Ben-David, Hannah K. Choe, MD, Zachariah Defilipp, MD, Aaron Etra, MD, Stephan Grupp, MD PhD, Matthew Hartwell, MD, Elizabeth O. Hexner, MDMS, William J Hogan, MB, BCh, Carrie Kitko, MD, Steven Kowalyk, Jung-Yi Lin, MS, Hannah Major-Monfried, MD MSCR, Stephan Mielke, MD, Pietro Merli, MD, George Morales, Rainer Ordemann, MD, Michael A. Pulsipher, MD, Muna Qayed, MD MSc, Pavan Reddy, Ran Reshef, MD MSc, Wolf Roesler, MD, Karamjeet S. Sandhu, MD, Tal Schechter-Finkelstein, MD, Jay Shah, MD, Keith Sigel, MD PhD, Daniela Weber, MD, Matthias Wölfl, MD, Kitsada Wudhikarn, MD, Rachel Young, John E. Levine, MDMS, James L. M. Ferrara, MDDSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 367.
https://doi.org/10.1182/blood-2019-122011
Published: 2019
Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

Trends in Inpatient and Intensive Care Resource Utilization after Chimeric Antigen Receptor T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia from 2012-2019

Regina M. Myers, MD, Julie C Fitzgerald, MD, Amanda M. DiNofia, MD, Lisa Wray, MD, Allison Barz Leahy, MD, Yimei Li, PhD, Laura Smith, RN, MSN, CRNP, Evanette Burrows, MPH, Mark Ramos, BS, Laura S Motley, BSc, BSN, RN, Raabia N Khan, MPH, Kelly D Getz, Richard Aplenc, MD PhD, Stephan Grupp, MD PhD, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 61.
https://doi.org/10.1182/blood-2019-126724
Published: 2019
Journal Articles

Tisagenlecleucel Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Children and Young Adults with Acute Lymphoblastic Leukemia (ALL): Real World Experience from the Center for International Blood and Marrow Transplant Research (CIBMTR) and Cellular Therapy (CT) Registry

Stephan Grupp, MD PhD, Zhen-Huan Hu, MPH, Yiyun Zhang, PhD, Amy Keating, MD, Michael A. Pulsipher, MD, Christine Philips, Steven P. Margossian, MD PhD, Joseph Rosenthal, MD MS, Dana Salzberg, MD, Deborah E. Schiff, MD, Gregory Yanik, MD, Kevin J. Curran, MD, Andrew C. Harris, MD, Peiman Hematti, MD, Sarah Nikiforow, MD PhD, Patricia Steinert, PhD, Lan Yi, PhD, Raghav Chawla, MD PhD, Mary M. Horowitz, Eric Bleickardt, MD, Marcelo C. Pasquini, MDMS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2619.
https://doi.org/10.1182/blood-2019-129279
Published: 2019
Journal Articles

Cytogenetic Characteristics and Outcomes of Patients Receiving CTL019 CAR T Cell Therapy

Allison Barz Leahy, MD, Kaitlin J. Stanley, MD, Regina M. Myers, MD, Amanda M. DiNofia, MD, Lisa Wray, MD, Susan R. Rheingold, MD, Colleen Callahan, CRNP, Diane Baniewicz, CRNP, Amy E. Barry, PPCNP-BC, Maria M. Patino, BS, Stephen P. Hunger, MD, Stephan Grupp, MD PhD, David M. Barrett, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1464.
https://doi.org/10.1182/blood-2019-130060
Published: 2019
Journal Articles

Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT

Clinical Trials & Observations
Corey Cutler, Brent Logan, Ryotaro Nakamura, Laura Johnston, Sung Choi, David Porter, William J. Hogan, Marcelo Pasquini, Margaret L. MacMillan, Jack W. Hsu, Edmund K. Waller, Stephan Grupp, Philip McCarthy, Juan Wu, Zhen-Huan Hu, Shelly L. Carter, Mary M. Horowitz, Joseph H. Antin
Journal: Blood
Blood (2014) 124 (8): 1372–1377.
https://doi.org/10.1182/blood-2014-04-567164
Published: 2014