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Journal Articles

Reni-Cel, an Investigational AsCas12a Gene-Edited Cell Medicine, Led to Sustained Hemoglobin Normalization and Increased Fetal Hemoglobin in Patients with Severe Sickle Cell Disease Treated in the RUBY Trial

Rabi Hanna, Haydar Frangoul, Christopher McKinney, Luis Pineiro, Markus Mapara, Jignesh Dalal, Hemalatha Rangarajan, Harold Atkins, Kai-Hsin Chang, Baisong Mei, Olubunmi Afonja, Mark C. Walters
Journal: Blood
Blood (2024) 144 (Supplement 1): 4955.
https://doi.org/10.1182/blood-2024-210343
Published: 2024
Journal Articles

An Update on Lovotibeglogene Autotemcel (Lovo-cel) Clinical Trials for Sickle Cell Disease (SCD) and Analysis of Early Predictors of Response to Lovo-Cel

Stacey Rifkin-Zenenberg, Julie Kanter, Melissa A. Kinney, Janet L. Kwiatkowski, Robert S. Nickel, Mark C. Walters, Suhag Parikh, Alexis Thompson, Anil P. George, Markus Mapara, Paul L. Martin, Anjulika Chawla, Ankit Lodaya, Lin Pan, Emily Sheldon-Waniga, Francis J. Pierciey, Jr., John Tisdale, Ashish O. Gupta
Journal: Blood
Blood (2024) 144 (Supplement 1): 511.
https://doi.org/10.1182/blood-2024-199743
Published: 2024
Journal Articles

Proteinuria with Preserved Renal Function: A Retrospective Cohort Study of Myeloma Patients with Significant Proteinuria without Acute Kidney Injury

Michael Sang Hughes, Metodi Balev, Jai Radhakrishnan, Divaya Bhutani, Markus Mapara, Andrew Eisenberger, Suzanne Lentzsch, Rajshekhar Chakraborty
Journal: Blood
Blood (2024) 144 (Supplement 1): 6983.
https://doi.org/10.1182/blood-2024-209301
Published: 2024
Journal Articles

Development of Anti-Amyloid 11-1F4- CAR Phagocytes for Treatment of AL Amyloidosis

Jing Fu, Huihui Ma, Shirong Li, Michael Sang Hughes, Gavreel Kalantarov, Guifen Liu, Markus Mapara, Suzanne Lentzsch
Journal: Blood
Blood (2024) 144 (Supplement 1): 360.
https://doi.org/10.1182/blood-2024-202091
Published: 2024
Journal Articles

Trem-Cel, a CRISPR/Cas9 Gene-Edited Allograft Lacking CD33, Shows Rapid Primary Engraftment with CD33-Negative Hematopoiesis in Patients with High-Risk Acute Myeloid Leukemia (AML) and Avoids Hematopoietic Toxicity during Gemtuzumab Ozogamicin (GO) Maintenance Post-Hematopoietic Cell Transplant (HCT)

John DiPersio, Brenda W Cooper, Hyung C Suh, Divya Koura, Lea Bernard, Nirali N. Shah, Roland B. Walter, Miguel-Angel Perales, Markus Mapara, Roni Tamari, Michael R. Loken, Kyle Breitschwerdt, Sritama Nath, Glen D Raffel, Guenther Koehne
Journal: Blood
Blood (2023) 142 (Supplement 1): 483.
https://doi.org/10.1182/blood-2023-190037
Published: 2023
Journal Articles

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Franco Locatelli, Peter Lang, Selim Corbacioglu, Donna Wall, Roland Meisel, Amanda M Li, Josu de La Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, Markus Mapara, Robert I. Liem, Maria Domenica Cappellini, Mattia Algeri, Antonis Kattamis, Sujit Sheth, Stephan Grupp, Puja Kohli, Daoyuan Shi, Leorah Ross, Yael Bobruff, Christopher Simard, Lanju Zhang, Phuong Khanh Morrow, William Hobbs, Haydar Frangoul
Journal: Blood
Blood (2023) 142 (Supplement 1): 1053.
https://doi.org/10.1182/blood-2023-190534
Published: 2023
Journal Articles

Reduced Early Mortality with Daratumumab-Based Frontline Therapy in Systemic AL Amyloidosis- Experience from the Columbia Amyloidosis Multidisciplinary Program

Rajshekhar Chakraborty, Divaya Bhutani, Markus Mapara, Ran Reshef, Mathew S Maurer, Jai Radhakrishnan, Suzanne Lentzsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 4780.
https://doi.org/10.1182/blood-2023-187214
Published: 2023
Journal Articles

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

Jing Fu, Shirong Li, Guifen Liu, Huihui MA, Christophe Marcireau, Markus Mapara, Suzanne Lentzsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 6618.
https://doi.org/10.1182/blood-2023-190740
Published: 2023
Journal Articles

AsCas12a Gene Editing of HBG1/2 Promoters with EDIT-301 Results in Rapid and Sustained Normalization of Hemoglobin and Increased Fetal Hemoglobin in Patients with Severe Sickle Cell Disease and Transfusion-Dependent Beta-Thalassemia

Rabi Hanna, Haydar Frangoul, Christopher McKinney, Luis Pineiro, Markus Mapara, Jignesh Dalal, Kai-Hsin Chang, Michael Jaskolka, Keunpyo Kim, Daphne L. Farrington, Maha Wally, Baisong Mei, Adebayo Lawal, Olubunmi O. Afonja, Mark C. Walters
Journal: Blood
Blood (2023) 142 (Supplement 1): 4996.
https://doi.org/10.1182/blood-2023-187397
Published: 2023
Journal Articles

Excellent PFS and OS of Newly Diagnosed Multiple Myeloma Patients Receiving Carfilzomib, Bendamustine, and Dexamethasone (KBD): A 6.5 Year Follow-up

Michael Sang Hughes, Siyang Leng, Rajshekhar Chakraborty, Divaya Bhutani, Markus Mapara, Shahzad Raza, Suzanne Lentzsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 6576.
https://doi.org/10.1182/blood-2023-182842
Published: 2023
Journal Articles

Post CAR-T Peripheral Lymphocytosis and Its Kinetics Are a Potential Biomarker for Response and Immune Mediated Toxicities

Mateo Mejia Saldarriaga, Caitlin Unkenholz, Joshua A Fein, Jorge Monge, Cara Rosenbaum, Roger Pearse, Markus Mapara, Giorgio Inghirami, Suzanne Lentzsch, Ran Reshef, Ruben Niesvizky, Mark Bustoros
Journal: Blood
Blood (2023) 142 (Supplement 1): 3341.
https://doi.org/10.1182/blood-2023-187832
Published: 2023
Journal Articles

Efficacy, Safety, and Health-Related Quality of Life (HRQOL) in Patients with Sickle Cell Disease (SCD) Who Have Received Lovotibeglogene Autotemcel (Lovo-cel) Gene Therapy: Up to 60 Months of Follow-up

Julie Kanter, Alexis A. Thompson, Janet L. Kwiatkowski, Suhag Parikh, Markus Mapara, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Ashish O. Gupta, Lixin Zhang, Emily Sheldon-Waniga, Meghan Gallagher, Katiana Gruppioni, Anjulika Chawla, Heidi Elliot, Francis J. Pierciey, Mark C. Walters, John F. Tisdale
Journal: Blood
Blood (2023) 142 (Supplement 1): 1051.
https://doi.org/10.1182/blood-2023-174229
Published: 2023
Journal Articles

Improvements in Health-Related Quality of Life after Exagamglogene Autotemcel in Patients with Severe Sickle Cell Disease

Akshay Sharma, Haydar Frangoul, Markus Mapara, Suzan Imren, Nanxin Li, Tina Liu, Jaime Rubin, Daoyuan Shi, William Hobbs, Stephan Grupp
Journal: Blood
Blood (2023) 142 (Supplement 1): 4999.
https://doi.org/10.1182/blood-2023-190203
Published: 2023
Journal Articles

Exagamglogene Autotemcel for Severe Sickle Cell Disease

Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Mapara, Lyndsay Molinari, Donna Wall, Robert I. Liem, Paul Telfer, Ami J. Shah, Marina Cavazzana, Selim Corbacioglu, Damiano Rondelli, Roland Meisel, Laurence Dedeken, Stephan Lobitz, Mariane de Montalembert, Martin H. Steinberg, Mark C. Walters, Laura Bower, Suzan Imren, Christopher Simard, Fengjuan Xuan, Weiyu Zhou, Phuong Khanh Morrow, William Hobbs, Stephan Grupp
Journal: Blood
Blood (2023) 142 (Supplement 1): 1052.
https://doi.org/10.1182/blood-2023-190139
Published: 2023
Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Affects Myeloma Bone Disease By Osteoclast Cytoskeleton Remodeling

Jing Fu, Shirong Li, Huihui MA, Lewis M Brown, Markus Mapara, Suzanne Lentzsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 6610.
https://doi.org/10.1182/blood-2023-189820
Published: 2023
Journal Articles

Phase 1a/b study of monoclonal antibody CAEL-101 (11-1F4) in patients with AL amyloidosis

Clinical Trials & Observations
Camille Vanessa Edwards, Nisha Rao, Divaya Bhutani, Markus Mapara, Jai Radhakrishnan, Sofia Shames, Mathew S. Maurer, Siyang Leng, Alan Solomon, Suzanne Lentzsch, Andrew Eisenberger
Journal: Blood
Blood (2021) 138 (25): 2632–2641.
https://doi.org/10.1182/blood.2020009039
Published: 2021
Includes: Supplemental data
Journal Articles

Analysis of the Phase 1a/b Study of Chimeric Fibril-Reactive Monoclonal Antibody 11-1F4 in Patients with AL Amyloidosis

Camille V Edwards, MD, Julia Gould, BA, Arielle L Langer, MD MPH, Markus Mapara, MD PhD, Jai Radhakrishnan, MD, Matthew S Maurer, MD, Shahzad Raza, MD, John G Mears, MD, Jonathan S Wall, PhD, Alan Solomon, MD, Suzanne Lentzsch, MD PhD
Journal: Blood
Blood (2016) 128 (22): 643.
https://doi.org/10.1182/blood.V128.22.643.643
Published: 2016
Journal Articles

Interferon-Gamma Signaling in the Pathogenesis of Idiopathic Pneumonia Syndrome Following Allogeneic Bone Marrow Transplantation

Hui-Hui Ma, PhD, Biin Sung, MS, Caisheng Lu, MDPhD, Liangsong Song, MDPhD, Rika Gomi, MDPhD, Wenzhu Wu, BS, Jing Fu, PhD, Suzanne Lentzsch, MD PhD, Stefan Worgall, MDPhD, Markus Mapara, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3075.
https://doi.org/10.1182/blood.V126.23.3075.3075
Published: 2015
Journal Articles

Mechanism Study of Matrix Metalloproteinase 13 Effects on Osteoclast Activation and Lytic Bone Lesions in Multiple Myeloma

Jing Fu, PhD, Shirong Li, PhD, G. David Roodman, MD PhD, Markus Mapara, MD PhD, Stephen J. Weiss, MD, Suzanne Lentzsch, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3009.
https://doi.org/10.1182/blood.V126.23.3009.3009
Published: 2015
Journal Articles

Results of Phase I Study of Chimeric Fibril-Reactive Monoclonal Antibody 11-1F4 in Patients with AL Amyloidosis

Arielle L Langer, MD MPH, Susanna Miao, Markus Mapara, MD PhD, Jai Radhakrishnan, MD, Mathew S. Maurer, MD, Shahzad Raza, MD, John G. Mears, MD, Alan Solomon, MD, Suzanne Lentzsch, MD PhD
Journal: Blood
Blood (2015) 126 (23): 188.
https://doi.org/10.1182/blood.V126.23.188.188
Published: 2015