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Journal Articles

Development of a high-affinity antibody specific to the predominant λ light chain amyloid subtype for AL amyloidosis immunotherapy

Michael Hughes, Gavreel Kalantarov, Jing Fu, Miroslav Sekulic, Glen Markowitz, Josefine Krüger, Guifen Liu, HuiHui Ma, Markus Mapara, Suzanne Lentzsch

Blood (2025) 146 (Supplement 1): 576.

https://doi.org/10.1182/blood-2025-576

Published: 2025

Journal Articles

Harnessing phagocytes for amyloid clearance: Development of a novel bispecific phagocyte engager (LC Fibril x CD64) for AL amyloidosis

Jing Fu, Huihui Ma, Gavreel Kalantarov, Michael Hughes, Guifen Liu, Markus Mapara, Suzanne Lentzsch

Blood (2025) 146 (Supplement 1): 3919.

https://doi.org/10.1182/blood-2025-3919

Published: 2025

Journal Articles

Deciphering the IKZF1 and MAP4K2 protein interactome in RASMut multiple myeloma reveals a novel regulatory pathway of IKZF1

Josefine Krüger, Shirong Li, Guifen Liu, Yuen Lam Dora Ng, Michael Hughes, Rajshekhar Chakraborty, Divaya Bhutani, Jan Krönke, Suzanne Lentzsch, Jing Fu

Blood (2025) 146 (Supplement 1): 2150.

https://doi.org/10.1182/blood-2025-2150

Published: 2025

Journal Articles

Development of Anti-Amyloid 11-1F4- CAR Phagocytes for Treatment of AL Amyloidosis

Jing Fu, Huihui Ma, Shirong Li, Michael Sang Hughes, Gavreel Kalantarov, Guifen Liu, Markus Mapara, Suzanne Lentzsch

Blood (2024) 144 (Supplement 1): 360.

https://doi.org/10.1182/blood-2024-202091

Published: 2024

Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Affects Myeloma Bone Disease By Osteoclast Cytoskeleton Remodeling

Jing Fu, Shirong Li, Huihui MA, Lewis M Brown, Markus Mapara, Suzanne Lentzsch

Blood (2023) 142 (Supplement 1): 6610.

https://doi.org/10.1182/blood-2023-189820

Published: 2023

Journal Articles

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

Jing Fu, Shirong Li, Guifen Liu, Huihui MA, Christophe Marcireau, Markus Mapara, Suzanne Lentzsch

Blood (2023) 142 (Supplement 1): 6618.

https://doi.org/10.1182/blood-2023-190740

Published: 2023

Journal Articles

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease

Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Lewis M Brown, Gabriel M. Pagnotti, Stephen J. Weiss, Markus Y. Mapara, Suzanne Lentzsch

Blood (2022) 140 (Supplement 1): 9930–9932.

https://doi.org/10.1182/blood-2022-169921

Published: 2022

Journal Articles

MAP4K2 Inhibition Reinforces the Iberdomide Sensitivity in MM Cells By Inducing IKZF1 Degradation through a CRBN Independent Mechanism

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2022) 140 (Supplement 1): 4224–4225.

https://doi.org/10.1182/blood-2022-168314

Published: 2022

Journal Articles

MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2021) 138 (Supplement 1): 2662.

https://doi.org/10.1182/blood-2021-151844

Published: 2021

Journal Articles

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease

Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Lewis M Brown, Gabriel M. Pagnotti, Stephen J. Weiss, Markus Y. Mapara, Suzanne Lentzsch

Blood (2021) 138 (Supplement 1): 1606.

https://doi.org/10.1182/blood-2021-145599

Published: 2021

Journal Articles

Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2021) 137 (13): 1754–1764.

https://doi.org/10.1182/blood.2020006334

Published: 2021

Includes: Supplemental data

Journal Articles

Gck Inhibition Is a Novel Therapeutic Strategy for RAS Mutated Multiple Myeloma and Overcomes Resistance to IMiDs

Shirong Li, Jing Fu, PhD, Jun Yang, MS, Markus Y Mapara, MD PhD, Christophe Marcireau, Suzanne Lentzsch, MD PhD

Blood (2020) 136 (Supplement 1): 24.

https://doi.org/10.1182/blood-2020-143418

Published: 2020

Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Mediates MMP-13 Induced Osteoclast Activation and Multiple Myeloma Bone Disease

Jing Fu, PhD, Shirong Li, Huihui Ma, MD PhD, Jun Yang, MS, Gabriel M. Pagnotti, PhD, Stephen J. Weiss, MD PhD, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2020) 136 (Supplement 1): 15–16.

https://doi.org/10.1182/blood-2020-142528

Published: 2020

Journal Articles

Role of MMP-13 in Graft-Versus-Host Disease

Hui-Hui Ma, PhD, Jing Fu, PhD, Suzanne Lentzsch, MD PhD, Markus Y Mapara, MD PhD

Blood (2019) 134 (Supplement_1): 1928.

https://doi.org/10.1182/blood-2019-127703

Published: 2019

Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Functions As MMP-13 Receptor on Osteoclasts and Mediates MMP-13 Induced Osteoclast Activation in Multiple Myeloma

Jing Fu, PhD, Shirong Li, PhD, Chen Yang, Lewis M Brown, PhD, Stephen J Weiss, MD PhD, Charles G Drake, MD PhD, Markus Y. Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2019) 134 (Supplement_1): 3072.

https://doi.org/10.1182/blood-2019-129177

Published: 2019

Journal Articles

Gck Kinase Activity Is Critical for RAS Mutated Myeloma - a Potential Treatment Approach for Targeting Specific Mutations

Shirong Li, PhD, Jing Fu, PhD, Xiaoming Xu, PhD, Shixian Deng, PhD, Markus Y Mapara, MD PhD, Christophe Marcireau, Suzanne Lentzsch, MD PhD

Blood (2019) 134 (Supplement_1): 1813.

https://doi.org/10.1182/blood-2019-129531

Published: 2019

Journal Articles

The Inhibition of Gck Affect MAPK Cascade in Multiple Myeloma

Shirong Li, Jing Fu, PhD, Shixian Deng, Hsin S Wang, Xiaoming Xu, Markus Y Mapara, MD PhD, Donald W Landry, Suzanne Lentzsch, MD PhD

Blood (2018) 132 (Supplement 1): 3202.

https://doi.org/10.1182/blood-2018-99-117557

Published: 2018

Journal Articles

Personalizing Amyloidosis Therapy with Real Time PET Imaging of Fibril-Reactive Monoclonal Antibody Cael-101

Jing Fu, PhD, Alan Solomon, MD, Patrick Carberry, PhD, John Castrillon, Jongho Kim, MD PhD, Suzanne Lentzsch, MD PhD, Akiva Mintz, MD PhD

Blood (2018) 132 (Supplement 1): 1003.

https://doi.org/10.1182/blood-2018-99-118177

Published: 2018

Journal Articles

Germinal Center Kinase As a Therapeutic Target in Multiple Myeloma

Shirong Li, Jing Fu, PhD, Hsin S Wang, Xiaoming Xu, Shixian Deng, Donald W Landry, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2017) 130 (Supplement 1): 1795.

https://doi.org/10.1182/blood.V130.Suppl_1.1795.1795

Published: 2017

Journal Articles

SYK-Inhibitor Bay 61-3606 Induces Cell Cycle Arrest and Apoptosis in Multiple Myeloma Cells Independent of SYK Inhibitory Effects but Via Degradation of IKZF1/3

Shirong Li, PhD, Jing Fu, PhD, Jing Wu, MD PhD, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2016) 128 (22): 4477.

https://doi.org/10.1182/blood.V128.22.4477.4477

Published: 2016

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Development of a high-affinity antibody specific to the predominant λ light chain amyloid subtype for AL amyloidosis immunotherapy

Harnessing phagocytes for amyloid clearance: Development of a novel bispecific phagocyte engager (LC Fibril x CD64) for AL amyloidosis

Deciphering the IKZF1 and MAP4K2 protein interactome in RASMut multiple myeloma reveals a novel regulatory pathway of IKZF1

Development of Anti-Amyloid 11-1F4- CAR Phagocytes for Treatment of AL Amyloidosis

Checkpoint Inhibitor PD-1H/VISTA Affects Myeloma Bone Disease By Osteoclast Cytoskeleton Remodeling

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease

MAP4K2 Inhibition Reinforces the Iberdomide Sensitivity in MM Cells By Inducing IKZF1 Degradation through a CRBN Independent Mechanism

MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease

Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Gck Inhibition Is a Novel Therapeutic Strategy for RAS Mutated Multiple Myeloma and Overcomes Resistance to IMiDs

Checkpoint Inhibitor PD-1H/VISTA Mediates MMP-13 Induced Osteoclast Activation and Multiple Myeloma Bone Disease

Role of MMP-13 in Graft-Versus-Host Disease

Checkpoint Inhibitor PD-1H/VISTA Functions As MMP-13 Receptor on Osteoclasts and Mediates MMP-13 Induced Osteoclast Activation in Multiple Myeloma

Gck Kinase Activity Is Critical for RAS Mutated Myeloma - a Potential Treatment Approach for Targeting Specific Mutations

The Inhibition of Gck Affect MAPK Cascade in Multiple Myeloma

Personalizing Amyloidosis Therapy with Real Time PET Imaging of Fibril-Reactive Monoclonal Antibody Cael-101

Germinal Center Kinase As a Therapeutic Target in Multiple Myeloma

SYK-Inhibitor Bay 61-3606 Induces Cell Cycle Arrest and Apoptosis in Multiple Myeloma Cells Independent of SYK Inhibitory Effects but Via Degradation of IKZF1/3

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