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Journal Articles

Development of a high-affinity antibody specific to the predominant λ light chain amyloid subtype for AL amyloidosis immunotherapy

Michael Hughes, Gavreel Kalantarov, Jing Fu, Miroslav Sekulic, Glen Markowitz, Josefine Krüger, Guifen Liu, HuiHui Ma, Markus Mapara, Suzanne Lentzsch

Blood (2025) 146 (Supplement 1): 576.

https://doi.org/10.1182/blood-2025-576

Published: 2025

Journal Articles

Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation

Abdul-Hamid Bazarbachi, HuiHui Ma, Simon Zhen, Miriam Klahr, Diane M. George, Christian Gordillo, Samuel Pan, Amer Assal, Andrew Eisenberger, David Diuguid, Ran Reshef, Suzanne Lentzsch, Divaya Bhutani, Rajshekhar Chakraborty, Monica Bhatia, Markus Mapara

Blood (2025) 146 (Supplement 1): 4255.

https://doi.org/10.1182/blood-2025-4255

Published: 2025

Journal Articles

Harnessing phagocytes for amyloid clearance: Development of a novel bispecific phagocyte engager (LC Fibril x CD64) for AL amyloidosis

Jing Fu, Huihui Ma, Gavreel Kalantarov, Michael Hughes, Guifen Liu, Markus Mapara, Suzanne Lentzsch

Blood (2025) 146 (Supplement 1): 3919.

https://doi.org/10.1182/blood-2025-3919

Published: 2025

Journal Articles

Development of Anti-Amyloid 11-1F4- CAR Phagocytes for Treatment of AL Amyloidosis

Jing Fu, Huihui Ma, Shirong Li, Michael Sang Hughes, Gavreel Kalantarov, Guifen Liu, Markus Mapara, Suzanne Lentzsch

Blood (2024) 144 (Supplement 1): 360.

https://doi.org/10.1182/blood-2024-202091

Published: 2024

Journal Articles

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

Jing Fu, Shirong Li, Guifen Liu, Huihui MA, Christophe Marcireau, Markus Mapara, Suzanne Lentzsch

Blood (2023) 142 (Supplement 1): 6618.

https://doi.org/10.1182/blood-2023-190740

Published: 2023

Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Affects Myeloma Bone Disease By Osteoclast Cytoskeleton Remodeling

Jing Fu, Shirong Li, Huihui MA, Lewis M Brown, Markus Mapara, Suzanne Lentzsch

Blood (2023) 142 (Supplement 1): 6610.

https://doi.org/10.1182/blood-2023-189820

Published: 2023

Journal Articles

MAP4K2 Inhibition Reinforces the Iberdomide Sensitivity in MM Cells By Inducing IKZF1 Degradation through a CRBN Independent Mechanism

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2022) 140 (Supplement 1): 4224–4225.

https://doi.org/10.1182/blood-2022-168314

Published: 2022

Journal Articles

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease

Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Lewis M Brown, Gabriel M. Pagnotti, Stephen J. Weiss, Markus Y. Mapara, Suzanne Lentzsch

Blood (2022) 140 (Supplement 1): 9930–9932.

https://doi.org/10.1182/blood-2022-169921

Published: 2022

Journal Articles

Transplantation of Hematopoietic Stem and Progenitor Cells from Cadaveric Organ Donors Leads to Long-Term Multilineage Engraftment in NSG Mice

Lara M Breyer, Hui Wang, Dongsheng Gu, Brian H Johnstone, Huihui Ma, Erik J Woods, Markus Y. Mapara

Blood (2022) 140 (Supplement 1): 7347–7348.

https://doi.org/10.1182/blood-2022-169787

Published: 2022

Journal Articles

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease

Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Lewis M Brown, Gabriel M. Pagnotti, Stephen J. Weiss, Markus Y. Mapara, Suzanne Lentzsch

Blood (2021) 138 (Supplement 1): 1606.

https://doi.org/10.1182/blood-2021-145599

Published: 2021

Journal Articles

MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2021) 138 (Supplement 1): 2662.

https://doi.org/10.1182/blood-2021-151844

Published: 2021

Journal Articles

Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Shirong Li, Jing Fu, Jun Yang, Huihui Ma, Divaya Bhutani, Markus Y. Mapara, Christophe Marcireau, Suzanne Lentzsch

Blood (2021) 137 (13): 1754–1764.

https://doi.org/10.1182/blood.2020006334

Published: 2021

Includes: Supplemental data

Journal Articles

Checkpoint Inhibitor PD-1H/VISTA Mediates MMP-13 Induced Osteoclast Activation and Multiple Myeloma Bone Disease

Jing Fu, PhD, Shirong Li, Huihui Ma, MD PhD, Jun Yang, MS, Gabriel M. Pagnotti, PhD, Stephen J. Weiss, MD PhD, Markus Y Mapara, MD PhD, Suzanne Lentzsch, MD PhD

Blood (2020) 136 (Supplement 1): 15–16.

https://doi.org/10.1182/blood-2020-142528

Published: 2020

Journal Articles

Glucagon-like Peptide-2 (GLP-2) Treatment Reduces Gvhd-Related Mortality in a Pre-Clinical Transplant Model Via Expansion of Macrophages with Tolerogenic Potential

David W Harle, BBiomedSc, Rodney J Macedo Gonzales, MD PhD, Felix D Rozenberg, BSc, Alexandra Matschiner, Rajat Bansal, MD, Stephen M Lagana, MD, Huihui Ma, MD PhD, Elisha Pinker, Kirubel S Belay, BSc, Ximi K Wang, BSc, Tiffany Thomas, PhD, Markus Y Mapara, MD PhD, Anne-Catrin Uhlemann, MD, Yi Zhang, MD PhD, Ran Reshef, MDMSc

Blood (2020) 136 (Supplement 1): 26–28.

https://doi.org/10.1182/blood-2020-143105

Published: 2020

Journal Articles

Interferon Gamma (IFNγ)/STAT1 Signaling in Host Antigen Present Cells Suppresses MHC Class II-Dependent Presentation of Self-Antigens and Development of Graft Versus Host Disease (GVHD)

Caisheng Lu, MD PhD, Huihui Ma, MD, PhD, Liangsong Song, MD, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD PhD, Markus Y Mapara, MD PhD

Blood (2016) 128 (22): 2147.

https://doi.org/10.1182/blood.V128.22.2147.2147

Published: 2016

Journal Articles

Knockdown Of Matrix Metalloproteinase 13 (MMP13) In 5TGM1 Multiple Myeloma Cells Inhibits Development Of Lytic Bone Lesions In Vivo

Jing Fu, PhD, Shirong Li, PHD, Huihui Ma, PhD, G. David Roodman, M.D., Ph.D., Markus Y. Mapara, MD PhD, Stephen J Weiss, MD, Suzanne Lentzsch, MD, PhD

Blood (2013) 122 (21): 879.

https://doi.org/10.1182/blood.V122.21.879.879

Published: 2013

Journal Articles

IFN-γ/STAT1-Dependent Regulation Of Antigen Presenting Cell (APC) Function: Role In Graft-Versus-Host Disease (GVHD)

Caisheng Lu, PHD, Huihui Ma, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD, PhD, Markus Mapara, MD, PhD

Blood (2013) 122 (21): 3252.

https://doi.org/10.1182/blood.V122.21.3252.3252

Published: 2013

Journal Articles

Matrix Metalloproteinase 13 (MMP13) Upregulation Is Essential for Multiple Myeloma Related Bone Lytic Lesion

Jing Fu, Ph D, Shirong Li, PhD, Rentian Feng, PhD, Huihui Ma, PhD, Farideh Sabeh, PhD, G David Roodman, MD, PhD, Markus Mapara, MD PhD, Stephen J Weiss, MD, Suzanne Lentzsch, MD, PhD

Blood (2012) 120 (21): 4025.

https://doi.org/10.1182/blood.V120.21.4025.4025

Published: 2012

Journal Articles

IL-12 hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent Apoptosis of Alloreactive CD4 + T Cells and Limit Graft-Versus-Host Diseas

Elizabeth O. Stenger, MD, Brian R. Rosborough, BS, Lisa Mathews, BS, Huihui Ma, Markus Mapara, MD PhD, Angus W. Thomson, PhD, Heth R. Turnquist, PhD

Blood (2012) 120 (21): 4110.

https://doi.org/10.1182/blood.V120.21.4110.4110

Published: 2012

Journal Articles

Absence of STAT1 Signaling in Host Hematopoietic Cells Leads to Enhanced Gvhd Induction and Involves Increased Expression of MHC Class II and Reduced PD-L1 Expression on Dendritic Cells,

Caisheng Lu, PhD, Huihui Ma, M.D., Ph.D., Ailing Liu, PhD, MeiHua Jin, PhD, Shirong Li, PhD, Suzanne Lentzsch, MD, PhD, Markus Y. Mapara, MD, PhD

Blood (2011) 118 (21): 4026.

https://doi.org/10.1182/blood.V118.21.4026.4026

Published: 2011

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Development of a high-affinity antibody specific to the predominant λ light chain amyloid subtype for AL amyloidosis immunotherapy

Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation

Harnessing phagocytes for amyloid clearance: Development of a novel bispecific phagocyte engager (LC Fibril x CD64) for AL amyloidosis

Development of Anti-Amyloid 11-1F4- CAR Phagocytes for Treatment of AL Amyloidosis

Synergistic Anti-Tumor Effects in RAS Mut Multiple Myeloma By Targeting MAP4K2 and RAS Pathways

Checkpoint Inhibitor PD-1H/VISTA Affects Myeloma Bone Disease By Osteoclast Cytoskeleton Remodeling

MAP4K2 Inhibition Reinforces the Iberdomide Sensitivity in MM Cells By Inducing IKZF1 Degradation through a CRBN Independent Mechanism

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Cytoskeleton Regulation and Multiple Myeloma Bone Disease

Transplantation of Hematopoietic Stem and Progenitor Cells from Cadaveric Organ Donors Leads to Long-Term Multilineage Engraftment in NSG Mice

The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease

MAP4K2 Silencing Overcomes IMiDs-Resistance in Multiple Myeloma

Targeting the GCK pathway: a novel and selective therapeutic strategy against RAS-mutated multiple myeloma

Checkpoint Inhibitor PD-1H/VISTA Mediates MMP-13 Induced Osteoclast Activation and Multiple Myeloma Bone Disease

Glucagon-like Peptide-2 (GLP-2) Treatment Reduces Gvhd-Related Mortality in a Pre-Clinical Transplant Model Via Expansion of Macrophages with Tolerogenic Potential

Interferon Gamma (IFNγ)/STAT1 Signaling in Host Antigen Present Cells Suppresses MHC Class II-Dependent Presentation of Self-Antigens and Development of Graft Versus Host Disease (GVHD)

Knockdown Of Matrix Metalloproteinase 13 (MMP13) In 5TGM1 Multiple Myeloma Cells Inhibits Development Of Lytic Bone Lesions In Vivo

IFN-γ/STAT1-Dependent Regulation Of Antigen Presenting Cell (APC) Function: Role In Graft-Versus-Host Disease (GVHD)

Matrix Metalloproteinase 13 (MMP13) Upregulation Is Essential for Multiple Myeloma Related Bone Lytic Lesion

IL-12 hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent Apoptosis of Alloreactive CD4 + T Cells and Limit Graft-Versus-Host Diseas

Absence of STAT1 Signaling in Host Hematopoietic Cells Leads to Enhanced Gvhd Induction and Involves Increased Expression of MHC Class II and Reduced PD-L1 Expression on Dendritic Cells,

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