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Carl June
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Journal Articles

Single-day non-activated IL-18-armed CAR T cells with enhanced persistence and durable efficacy

Free
Joseph Durgin, Shin Seo, Shadab Kazmi, Bakir Valentic, Chloe Leff, Xioling Jin, Feng Shen, Nandana Mukherjee, Ashwin Sannecy, Gabriela Plesa, Khatuna Gabunia, John Scholler, Saar Gill, Roddy O'Connor, Carl June, Saba Ghassemi
Journal: Blood
Blood (2025) 146 (Supplement 1): 4187.
https://doi.org/10.1182/blood-2025-4187
Published: 2025
Journal Articles

IL18-armored CAR T cells in patients with CLL/SLL and Richter's transformation after prior BTK inhibitor and venetoclax failure

Free
Jakub Svoboda, Stephen Schuster, David Porter, Michael Cook, Sunita Dwivedy Nasta, Daniel Landsburg, Stefan Barta, Marco Ruella, Elise Chong, Jordan Carter, Colin Thomas, Emily Tomasulo, Noelle Frey, Matthew Connor, Joanne Shea, Amanda Cervini, Jean McConville, Charles Tongue, Megan Four, Amy Marshall, Wei-Ting Hwang, Rachel Leskowitz, Vanessa Gonzalez, Shannon Christensen, Gabriela Plesa, Don Siegel, Julie Jadlowsky, Joseph Fraietta, Bruce Levine, Elizabeth Hexner, Carl June
Journal: Blood
Blood (2025) 146 (Supplement 1): 2394.
https://doi.org/10.1182/blood-2025-2394
Published: 2025
Journal Articles

Lipid nanoparticle-mediated epitope editing in human HSPCs enables resistance to CD45-directed CAR-T cell therapy

Free
Chenchen Li, Vilas Desai, Elahe Kamali Ghahe, Davin Tafuri, Rujul Jagdish Deolikar, Natalie Cooper, Nils Wellhausen, Feng Shen, Reka Geczy, Aruna Balgi, Samuel Clarke, Jennifer Moody, Anne Chew, Carl June, Saar Gill, Friederike Herbst
Journal: Blood
Blood (2025) 146 (Supplement 1): 1048.
https://doi.org/10.1182/blood-2025-1048
Published: 2025
Journal Articles

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Free
Lucy Cain, Yimei Li, Hongyan Liu, Shannon Christensen, Regina Myers, Allison Barz Leahy, Caroline Diorio, Nancy Shapiro, Elizabeth McBride, Colleen Callahan, Diane Baniewicz, Amanda DiNofia, Susan Rheingold, Lisa Wray, Stephen Hunger, Richard Aplenc, Susan McClory, Mackenzie Stewart, Gerald Wertheim, Andrew Fesnak, Gabriela Plesa, Don Siegel, Joseph Fraietta, Vanessa Gonzalez, Caitlin Hopkins, Amy Marshall, Amanda Kotch, Bruce Levine, Anne Chew, Elizabeth Hexner, Carl June, Stephan Grupp, Shannon Maude
Journal: Blood
Blood (2025) 146 (Supplement 1): 646.
https://doi.org/10.1182/blood-2025-646
Published: 2025
Journal Articles

IL18-armored CAR T cells in relapsed/refractory B cell acute lymphoblastic leukemia

Free
Matthew Connor, Wei-Ting Hwang, Saar Gill, Alexander Perl, Ximena Jordan Bruno, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Andrew Matthews, Shannon McCurdy, Pashna Munshi, Keith Pratz, Amanda Cervini, Jean McConville, Joanne Shea, Charles Tongue, Heather Difilippo, Jacob Kesselman, Amy Marshall, Megan Four, Shannon Christensen, Vanessa Gonzalez, Julie Jadlowsky, Gabriela Plesa, Don Siegel, Rachel Leskowitz, Joseph Fraietta, Bruce Levine, David Porter, Elizabeth Hexner, Carl June, Jakub Svoboda, Noelle Frey
Journal: Blood
Blood (2025) 146 (Supplement 1): 812.
https://doi.org/10.1182/blood-2025-812
Published: 2025
Journal Articles

Metabolic conditioning for enhanced CAR T cell function

Free
Yufan Zhou, Andre Kelly, Tyler Quarton, Bakir Valentic, Andrew Frisch, Zhiyang Gan, Alexander Shestov, Noah Ford, Jai Patel, Shimin Liu, Khatuna Gabunia, Joseph Durgin, Xiangyi Fang, Max Wadley, Sophie Trefely, Lindsay Pino, Francisca deLuna Vitorino, Dawei Liu, Eliana Von Krusenstiem, Natalia Romero, John Lawson, Benjamin Garcia, Nathaniel Snyder, Saba Ghassemi, John Scholler, Carl June, Roddy O'Connor
Journal: Blood
Blood (2025) 146 (Supplement 1): 4127.
https://doi.org/10.1182/blood-2025-4127
Published: 2025
Journal Articles

Cytokine receptor armored CAR-T cells enable robust T cell expansion and function in the absence of lymphodepletion

Free
lina zhou, Jiapan Hu, Wancheng Yang, yixuan zhou, yinghao zhu, Fei Yang, Nian Chen, Yingyong Xu, george church, Carl June, Luhan Yang
Journal: Blood
Blood (2025) 146 (Supplement 1): 4104.
https://doi.org/10.1182/blood-2025-4104
Published: 2025
Journal Articles

IL-10 Levels Differentially Regulate IFNg Signaling of CART19 and CART22

Free
Caroline Diorio, Regina M. Myers, Anastasia Frank-Kamenetski, Rawan Shraim, Amanda M. Dinofia, Zachary Martinez, Ohaila Mustafa, Joseph A Fraietta, Vanessa Gonzalez, Vivian Yi, Lahari Uppuluri, Haley Newman, Edward Behrens, Carl June, Scott Canna, Stephan Grupp, David T. Teachey
Journal: Blood
Blood (2023) 142 (Supplement 1): 3431.
https://doi.org/10.1182/blood-2023-182377
Published: 2023
Journal Articles

Cytokine Release Syndrome Results in Reduced AML Killing By CD123 CAR T Cells

Free
Anand S Bhagwat, Leonel Torres, Olga Shestova, Maksim Shestov, Noelle V. Frey, Elizabeth O Hexner, Selina M Luger, Alison W Loren, Mary Ellen Martin, Shannon R McCurdy, Alexander Perl, Edward A. Stadtmauer, James K. Mangan, Jennifer Brogdon, Joseph A Fraietta, Wei-Ting Hwang, Don L. Siegel, Saad S. Kenderian, David L. Porter, Carl June, Saar Gill
Journal: Blood
Blood (2023) 142 (Supplement 1): 217.
https://doi.org/10.1182/blood-2023-182104
Published: 2023
Journal Articles

Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission

Free
Zhiliang Bai, Bing Feng, Susan E. Mcclory, Caroline Diorio, Ziran Zhao, Li Tang, J. Joseph Melenhorst, Carl June, Stephan Grupp, Rong Fan
Journal: Blood
Blood (2023) 142 (Supplement 1): 352.
https://doi.org/10.1182/blood-2023-179480
Published: 2023
Journal Articles

Establishing Safety in the Clinic for the First Lentiviral Vector To Be Tested in Humans.

Free
Boro Dropulic, PhD, Laurent Humeau, PhD, Vladimir Slepushkin, MD, PhD, Xiaobin Lu, PhD, Peter Manilla, MA, Tessio Rebello, PhD, Cathleen Afable, MA, CQA, Kim Lacy, RN, Cathy Ybarra, BSN, RN, Bruce Levine, PhD, Carl June, MD, Rob Roy MacGregor, MD
Journal: Blood
Blood (2004) 104 (11): 411.
https://doi.org/10.1182/blood.V104.11.411.411
Published: 2004
Journal Articles

Enhancing Graft-vs-Tumor (GVT) Activity of Donor Leukocyte Infusions by Ex-Vivo Expansion and Activation with CD3/CD28 Co-Stimulation.

Free
David Porter, MD, Bruce Levine, PhD, Nancy Bunin, MD, Edward Stadtmauer, MD, Selina Luger, MD, Steven Goldstein, MD, Stephen Schuster, MD, Donald Tsai, MD, Sunita Nasta, MD, Alison Loren, MD, Alexander Perl, MD, Julie Oliver, CRNP, Ambika Sohal, Liz Veloso, RN, Stephen Emerson, MD, PhD, Carl June, MD
Journal: Blood
Blood (2004) 104 (11): 1640.
https://doi.org/10.1182/blood.V104.11.1640.1640
Published: 2004
Journal Articles

Dendritic cell–activated CD44 hi CD8 + T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity

Free
Yi Zhang, Gerard Joe, Jiang Zhu, Richard Carroll, Bruce Levine, Elizabeth Hexner, Carl June, Stephen G. Emerson
Journal: Blood
Blood (2004) 103 (10): 3970–3978.
https://doi.org/10.1182/blood-2003-09-3135
Published: 2004