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Bruce Levine
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Journal Articles

IL18-armored CAR T cells in patients with CLL/SLL and Richter's transformation after prior BTK inhibitor and venetoclax failure

Free
Jakub Svoboda, Stephen Schuster, David Porter, Michael Cook, Sunita Dwivedy Nasta, Daniel Landsburg, Stefan Barta, Marco Ruella, Elise Chong, Jordan Carter, Colin Thomas, Emily Tomasulo, Noelle Frey, Matthew Connor, Joanne Shea, Amanda Cervini, Jean McConville, Charles Tongue, Megan Four, Amy Marshall, Wei-Ting Hwang, Rachel Leskowitz, Vanessa Gonzalez, Shannon Christensen, Gabriela Plesa, Don Siegel, Julie Jadlowsky, Joseph Fraietta, Bruce Levine, Elizabeth Hexner, Carl June
Journal: Blood
Blood (2025) 146 (Supplement 1): 2394.
https://doi.org/10.1182/blood-2025-2394
Published: 2025
Journal Articles

IL18-armored CAR T cells in relapsed/refractory B cell acute lymphoblastic leukemia

Free
Matthew Connor, Wei-Ting Hwang, Saar Gill, Alexander Perl, Ximena Jordan Bruno, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Andrew Matthews, Shannon McCurdy, Pashna Munshi, Keith Pratz, Amanda Cervini, Jean McConville, Joanne Shea, Charles Tongue, Heather Difilippo, Jacob Kesselman, Amy Marshall, Megan Four, Shannon Christensen, Vanessa Gonzalez, Julie Jadlowsky, Gabriela Plesa, Don Siegel, Rachel Leskowitz, Joseph Fraietta, Bruce Levine, David Porter, Elizabeth Hexner, Carl June, Jakub Svoboda, Noelle Frey
Journal: Blood
Blood (2025) 146 (Supplement 1): 812.
https://doi.org/10.1182/blood-2025-812
Published: 2025
Journal Articles

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Free
Lucy Cain, Yimei Li, Hongyan Liu, Shannon Christensen, Regina Myers, Allison Barz Leahy, Caroline Diorio, Nancy Shapiro, Elizabeth McBride, Colleen Callahan, Diane Baniewicz, Amanda DiNofia, Susan Rheingold, Lisa Wray, Stephen Hunger, Richard Aplenc, Susan McClory, Mackenzie Stewart, Gerald Wertheim, Andrew Fesnak, Gabriela Plesa, Don Siegel, Joseph Fraietta, Vanessa Gonzalez, Caitlin Hopkins, Amy Marshall, Amanda Kotch, Bruce Levine, Anne Chew, Elizabeth Hexner, Carl June, Stephan Grupp, Shannon Maude
Journal: Blood
Blood (2025) 146 (Supplement 1): 646.
https://doi.org/10.1182/blood-2025-646
Published: 2025
Journal Articles

Deciphering the Impact of Immunological Aging in CLL CAR T Cell Therapy

Free
Julia Han Noll, Humza Hemani, Jiang Yuan Li, Kevin R. Amses, Bruce Levine, Carl H. June, Nan-Ping Weng, Joseph A. Fraietta
Journal: Blood
Blood (2024) 144 (Supplement 1): 2051.
https://doi.org/10.1182/blood-2024-200721
Published: 2024
Journal Articles

In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Free
Caitlin R. Hopkins, Amanda M. DiNofia, Shannon L. Maude, Gregory M. Chen, Kwame Attah M. Boateng-Antwi, Jessica Perazzelli, Andres F. Mendez Corea, Alexander Shestov, Mercy Gohil, Yimei Li, Wei-Ting Hwang, Bakir Valentić, Shannon Christensen, Julie Jadlowsky, Regina M. Myers, Caroline Diorio, Megan M. Davis, Theresa Colligon, Gabriela Plesa, Don L. Siegel, Bruce Levine, Carl H. June, Roddy S. O'Connor, Stephan A. Grupp, Joseph A. Fraietta
Journal: Blood
Blood (2024) 144 (Supplement 1): 3473.
https://doi.org/10.1182/blood-2024-210324
Published: 2024
Journal Articles

Curing CLL: Long-Term Outcomes of Chronic Lymphocytic Leukemia Patients with at Least One Year of Response to CART-19 Therapy

Free
Benjamin F. Frost, Noelle Frey, Elizabeth O. Hexner, Stephen J. Schuster, Sunita D. Nasta, Alison W Loren, Jakub Svoboda, Daniel J. Landsburg, Bruce Levine, Joseph A. Fraietta, J. Joseph Melenhorst, Elizabeth Veloso, Wei-Ting Hwang, Carl H. June, David L. Porter, Saar Gill
Journal: Blood
Blood (2024) 144 (Supplement 1): 588.
https://doi.org/10.1182/blood-2024-204197
Published: 2024
Journal Articles

Schedule Dependent Effects of Adoptively Transferred Autologous T Cells After AutoSCT for Myeloma: Accelerated Immune Recovery Is Associated with Improved Event-Free Survival.

Free
Aaron P. Rapoport, MD, Nicole A. Aqui, MD, Edward A. Stadtmauer, MD, Dan T. Vogl, MD, Hong-Bin Fang, PhD, Stephen Janofsky, BS, Jan Storek, MD, PhD, Anne Chew, PhD, Elizabeth Veloso, JD, Gorgun Akpek, MD, MS, Saul Yanovich, MD, Ming T. Tan, PhD, Yin Wu, MD, Alan Cross, MD, Sunita Philip, MPH, Heather Murphy, Rita Bhagat, RN, Yiping Liu, Bruce Levine, PhD, Robert H. Vonderheide, MD, DPhil, Carl H. June, MD
Journal: Blood
Blood (2009) 114 (22): 784.
https://doi.org/10.1182/blood.V114.22.784.784
Published: 2009
Journal Articles

Influenza (flu) Vaccine Administration to Patients with Multiple Myeloma (MM) Prior to Autologous T-Cell Harvest Leads to Better Reconstitution of Flu Immunity After High Dose Melphalan and Autologous Stem Cell Transplant (ASCT) and Reinfusion of Primed Ex-Vivo Co-Stimulated Autologous T-Cells and Post-ASCT Second Flu Vaccination Than Post-ASCT Flu Vaccination Alone.

Free
Edward A. Stadtmauer, MD, Dan T. Vogl, MD, Nicole A. Aqui, MD, Aaron P. Rapoport, MD, Kenyetta Macdonald, Heather Murphy, Rita Bhagat, RN, Patricia A. Mangan, APRN, BC, Anne Chew, PhD, Elizabeth Veloso, RN, JD, Bruce Levine, PhD, Robert H. Vonderheide, MD, DPhil, Carl H. June, MD, Kathleen Sullivan, MD
Journal: Blood
Blood (2009) 114 (22): 797.
https://doi.org/10.1182/blood.V114.22.797.797
Published: 2009
Journal Articles

Rapamycin-Induced Autophagy Generates Anti-Apoptotic Th1/Tc1 Cells That Mediate Increased Xenogeneic Gvhd.

Free
Shoba Amarnath, PhD, Carliann M Costanzo, Jason Foley, MS, MBA, Jacopo Mariotti, Daniel M Konecki, ANu Gangopadhyay, Michael Eckhaus, Susan Wong, Bruce Levine, PhD, Carl H. June, MD, Daniel H. Fowler
Journal: Blood
Blood (2009) 114 (22): 2456.
https://doi.org/10.1182/blood.V114.22.2456.2456
Published: 2009
Journal Articles

Ex Vivo Manufacture of Rapamycin-Resistant Human Th1/Tc1 Cells.

Free
Emily Bunce, Justin Taylor, Jason Foley, MS, MBA, Bruce Levine, PhD, Carl H. June, MD, Marianna Sabatino, Vicki Fellowes, David Stroncek, Daniel H Fowler, MD, Shoba Amarnath, PhD
Journal: Blood
Blood (2009) 114 (22): 501.
https://doi.org/10.1182/blood.V114.22.501.501
Published: 2009
Journal Articles

PD-L1 Immuno-Gene Therapy Under Cell Fate Control: Persistence of Cellular Delivery Vehicle and Transgene Expression.

Free
Shoba Amarnath, PhD, James CM Wang, Paul R. Massey, James L. Riley, Bruce Levine, PhD, Carl H. June, MD, Jeffrey A. Medin, PhD, Daniel Fowler, MD
Journal: Blood
Blood (2009) 114 (22): 3580.
https://doi.org/10.1182/blood.V114.22.3580.3580
Published: 2009
Journal Articles

Artificial Antigen Presenting Cells (aAPC) Expanded NK-Mediated Enhanced Lysis of Allogeneic Tumor Cells Regardless of HLA Class I/KIR Mismatch and Its Implication of Use in Eradicating Acute Lymphoblastic Leukemia (ALL).

Free
Hua Zhang, Bruce Levine, PhD, Nga Voong, Alan S. Wayne, MD, Carl H. June, MD, Crystal L. Mackall, M.D.
Journal: Blood
Blood (2009) 114 (22): 3023.
https://doi.org/10.1182/blood.V114.22.3023.3023
Published: 2009
Journal Articles

First Report of the Prophylactic Administration of Ex Vivo Co-Stimulated Donor Lymphocyte Infusion (DLI) from Related and Unrelated Donors after Reduced Intensity Conditioning for High Risk Hematologic Malignancies

Free
Steven C Goldstein, MD, Bruce Levine, PhD, Jacqueline Smith, MSN, CRNP, Joanne Hinkle, RN, BSN, OCN, Selina Luger, MD, Alexander Perl, MD, Alison Loren, MD, Noelle Frey, MD, Edward Stadtmauer, MD, Daniel Schullery, PhD, Jean Boyer, PhD, Dennis L. Confer, MD, David Porter, MD, Carl H. June, MD
Journal: Blood
Blood (2008) 112 (11): 468.
https://doi.org/10.1182/blood.V112.11.468.468
Published: 2008
Journal Articles

Establishing Safety in the Clinic for the First Lentiviral Vector To Be Tested in Humans.

Free
Boro Dropulic, PhD, Laurent Humeau, PhD, Vladimir Slepushkin, MD, PhD, Xiaobin Lu, PhD, Peter Manilla, MA, Tessio Rebello, PhD, Cathleen Afable, MA, CQA, Kim Lacy, RN, Cathy Ybarra, BSN, RN, Bruce Levine, PhD, Carl June, MD, Rob Roy MacGregor, MD
Journal: Blood
Blood (2004) 104 (11): 411.
https://doi.org/10.1182/blood.V104.11.411.411
Published: 2004
Journal Articles

Enhancing Graft-vs-Tumor (GVT) Activity of Donor Leukocyte Infusions by Ex-Vivo Expansion and Activation with CD3/CD28 Co-Stimulation.

Free
David Porter, MD, Bruce Levine, PhD, Nancy Bunin, MD, Edward Stadtmauer, MD, Selina Luger, MD, Steven Goldstein, MD, Stephen Schuster, MD, Donald Tsai, MD, Sunita Nasta, MD, Alison Loren, MD, Alexander Perl, MD, Julie Oliver, CRNP, Ambika Sohal, Liz Veloso, RN, Stephen Emerson, MD, PhD, Carl June, MD
Journal: Blood
Blood (2004) 104 (11): 1640.
https://doi.org/10.1182/blood.V104.11.1640.1640
Published: 2004
Journal Articles

Dendritic cell–activated CD44 hi CD8 + T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity

Free
Yi Zhang, Gerard Joe, Jiang Zhu, Richard Carroll, Bruce Levine, Elizabeth Hexner, Carl June, Stephen G. Emerson
Journal: Blood
Blood (2004) 103 (10): 3970–3978.
https://doi.org/10.1182/blood-2003-09-3135
Published: 2004