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Journal Articles

CD5-Deleted Chimeric Antigen Receptor Cells (Senza5™ CART5) to Enhance Immunotherapy Against T-Cell Non-Hodgkin Lymphoma: A First-in-Human Phase I Clinical Trial

Stefan K. Barta, Marco Ruella, Stephen J. Schuster, Jakub Svoboda, Jordan Carter, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta, Colin Thomas, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Yunlin Zhang, Aditya Nimmagadda, Trang Vu, Lavanya Peddada, Adam E. Snook, Nicholas A. Siciliano, Rosemary Mazanet
Journal: Blood
Blood (2024) 144 (Supplement 1): 7221.
https://doi.org/10.1182/blood-2024-201063
Published: 2024
Journal Articles

Efficacy and Safety of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-Cell Therapies in Patients with Autoimmune Disease and Lymphoma or Myeloma

Luca Paruzzo, Riemke Bouvier, Guido Ghilardi, Eugenio Fardella, Bria Fulmer, Ivan J Cohen, Elise A. Chong, Jakub Svoboda, Sunita D. Nasta, Daniel J. Landsburg, Vrutti Patel, Li Ziyu, Raymone Pajarillo, Adam Waxman, Adam D. Cohen, Dan T. Vogl, Stefan K. Barta, Patrizia Porazzi, Joseph A. Fraietta, Vijay Bhoj, Alfred L. Garfall, Edward A. Stadtmauer, Stephen J. Schuster, Jordan S. Carter, Sokratis A. Apostolidis, Sandra Susanibar-Adaniya, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 7243.
https://doi.org/10.1182/blood-2024-206608
Published: 2024
Journal Articles

Curing CLL: Long-Term Outcomes of Chronic Lymphocytic Leukemia Patients with at Least One Year of Response to CART-19 Therapy

Benjamin F. Frost, Noelle Frey, Elizabeth O. Hexner, Stephen J. Schuster, Sunita D. Nasta, Alison W Loren, Jakub Svoboda, Daniel J. Landsburg, Bruce Levine, Joseph A. Fraietta, J. Joseph Melenhorst, Elizabeth Veloso, Wei-Ting Hwang, Carl H. June, David L. Porter, Saar Gill
Journal: Blood
Blood (2024) 144 (Supplement 1): 588.
https://doi.org/10.1182/blood-2024-204197
Published: 2024
Journal Articles

Real-World Outcomes of Early Relapsed/Refractory Large B Cell Lymphoma Patients Treated with 2 nd Line CAR T Therapy

Michael Schneider, Elise A. Chong, Stefan K. Barta, Sunita D. Nasta, Jakub Svoboda, Jordan Carter, Michael Roderick Cook, Nasheed Hossain, Stephen J. Schuster, Heather Difilippo, John P Plastaras, Michael Lariviere, Marco Ruella, David L. Porter, Noelle Frey, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 5123.
https://doi.org/10.1182/blood-2024-202736
Published: 2024
Journal Articles

Outcomes in Primary CNS Lymphoma: A Single Institution Experience from the Abramson Cancer Center at the University of Pennsylvania

Nikita Dave, Veronica Carvajal, Jordan Carter, Donald Edward Tsai, Stephen J. Schuster, James Gerson, Stefan K. Barta, Jakub Svoboda, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta
Journal: Blood
Blood (2024) 144 (Supplement 1): 1699.
https://doi.org/10.1182/blood-2024-207781
Published: 2024
Journal Articles

Comparison of CRS- and Icans-Related Outcomes for Large B Cell Lymphoma Patients Treated with Commercial Axicabtagene Ciloleucel with or without Prophylactic Dexamethasone

Alison Carulli, Hayden Elliott, Brendan Mangan, James Whittenburg, Elise A. Chong, Sunita D. Nasta, Jakub Svoboda, Stefan K. Barta, David L. Porter, Jordan S. Carter, Michael Roderick Cook, Nasheed Hossain, Saar Gill, Alfred L. Garfall, Christopher Catania, Colleen R. Kucharczuk, Stephen J. Schuster, Noelle Frey, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 2275.
https://doi.org/10.1182/blood-2024-203726
Published: 2024
Journal Articles

Clinical Activity of Tisagenlecleucel in Large B Cell Lymphomas According to the 5 th Edition of the Who Classification

Guido Ghilardi, Emeline R. Chong, Luca Paruzzo, Giulia Gabrielli, Sunita D. Nasta, Vrutti Patel, Eugenio Fardella, Daniel J. Landsburg, Jordan Carter, Colin Thomas, Stefan K. Barta, Elise A. Chong, Jakub Svoboda, Marco Ruella, Stephen J. Schuster
Journal: Blood
Blood (2024) 144 (Supplement 1): 1750.
https://doi.org/10.1182/blood-2024-206027
Published: 2024
Journal Articles

Impact of Broad-Spectrum Antibiotic Exposure on CAR-T Therapy Outcomes in B-Cell Lymphoma: A Multicenter International Study

Roni Shouval, Teng Fei, Giulia Gabrielli, Natalie Grier Smith, Guido Ghilardi, John Slingerland, Jonathan U. Peled, Ying Taur, Sunita D. Nasta, Alejandro Luna, Magdalena Corona, Kai Rejeski, Sophia Stock, Ronit Marcus, Noa Golan Accav, Ofrat Beyar-Katz, Hazim Khatib, Sandeep S. Raj, Alexander P. Boardman, Parastoo B Dahi, Richard J. Lin, Michael Scordo, Lorenzo Falchi, Jakub Svoboda, Elise A. Chong, Stefan K. Barta, Daniel J. Landsburg, Avichai Shimoni, Arnon Nagler, Gunjan L. Shah, Maria Lia Palomba, Gilles Salles, Jae H. Park, Stephen J. Schuster, Tsila Zuckerman, Marion Subklewe, Abraham Avigdor, Miguel Angel Perales, Marcel R.M. van den Brink, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 1746.
https://doi.org/10.1182/blood-2024-203871
Published: 2024
Journal Articles

Title: Development of a Pathologic Prognostic Index (PPI) for Newly Diagnosed Large B Cell Lymphoma Patients Treated with R-CHOP

Vincent Ni, Sunita D. Nasta, Stefan K. Barta, Stephen J. Schuster, Elise A. Chong, Jakub Svoboda, Jennifer JD Morrissette, Ashley Barlev, Adam Bagg, Salvatore F. Priore, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 3083.
https://doi.org/10.1182/blood-2024-203448
Published: 2024
Journal Articles

CD5 Expression in Mature T Cell Lymphoma

Miao Cao, Montreh Tavakkoli, Elise A. Chong, Jordan S Carter, Marco Ruella, Daniel J. Landsburg, Sunita D. Nasta, Jakub Svoboda, Stephen J Schuster, Stefan K. Barta
Journal: Blood
Blood (2023) 142 (Supplement 1): 6195.
https://doi.org/10.1182/blood-2023-188043
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed/Refractory Follicular Lymphoma: Results from the Phase 1/2 BRUIN Study

Nirav N. Shah, Pier Luigi Zinzani, Michael L. Wang, Sunita D. Nasta, Ewa Lech-Maranda, Yoshiaki Ogawa, Bita Fakhri, Bryone Kuss, Kaname Miyashita, Krish Patel, Catherine C. Coombs, Shuo Ma, Manish Patel, Minal A. Barve, Benoit Tessoulin, Anastasios Stathis, Won Seog Kim, Daisuke Ennishi, Daigo Hashimoto, Kensuke Kojima, Andrew D. Zelenetz, Jonathon B. Cohen, Julie M. Vose, Kami J. Maddocks, Talha Munir, Fangfang Sun, Faith Bian, Donald E. Tsai, Paolo Abada, Chan Y. Cheah
Journal: Blood
Blood (2023) 142 (Supplement 1): 3026.
https://doi.org/10.1182/blood-2023-181309
Published: 2023
Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL) Patients with Prior cBTKi: Safety and Efficacy Including High-Risk Subgroup Analyses from the Phase 1/2 BRUIN Study

Jonathon B. Cohen, Nirav N. Shah, Wojciech Jurczak, Pier Luigi Zinzani, Chan Y. Cheah, Toby A. Eyre, Chaitra S Ujjani, Youngil Koh, Won Seog Kim, Sunita D. Nasta, Ian W. Flinn, Benoit Tessoulin, Shuo Ma, Alvaro J. Alencar, David Lewis, Jennifer A. Woyach, Kami J. Maddocks, Krish Patel, Yucai Wang, Joanna M. Rhodes, Constantine S. Tam, John F. Seymour, Hirokazu Nagai, Julie M. Vose, Bita Fakhri, Marc S. Hoffmann, Francisco J. Hernandez-Ilizaliturri, Andrew D. Zelenetz, Anita Kumar, Talha Munir, Donald E. Tsai, Minna Balbas, Bin Liu, Amy S. Ruppert, Bastien Nguyen, Lindsey E. Roeker, Michael L. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 981.
https://doi.org/10.1182/blood-2023-181627
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Marginal Zone Lymphoma: Results from Phase 1/2 BRUIN Study

Krish Patel, Julie M. Vose, Sunita D. Nasta, Jennifer R. Brown, Kami J. Maddocks, Jennifer A. Woyach, Nirav N. Shah, Bita Fakhri, Benoit Tessoulin, Shuo Ma, Deepa Jagadeesh, Ewa Lech-Maranda, Catherine C. Coombs, Manish Patel, Joanna M. Rhodes, Chaitra S Ujjani, Marc S. Hoffmann, Chan Y Cheah, Talha Munir, David Lewis, Lydia Scarfo, Toby A. Eyre, Alvaro J. Alencar, Jonathon B. Cohen, Andrew D. Zelenetz, Donald E. Tsai, Mei Li, Faith Bian, Paolo Abada, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1660.
https://doi.org/10.1182/blood-2023-180048
Published: 2023
Journal Articles

Safety of CAR-T Cell Therapy in Asymptomatic Patients with Positive Respiratory Viral Testing Prior to CAR-T Infusions

Reid M. Muenzen, Emeline R. Chong, Dylan Therwhanger, Daniel J. Landsburg, Sunita D. Nasta, Jakub Svoboda, Stefan K. Barta, Mitchell E. Hughes, Elizabeth Weber, Marco Ruella, Noelle V. Frey, David L. Porter, Stephen J. Schuster, Elise A. Chong
Journal: Blood
Blood (2023) 142 (Supplement 1): 2341.
https://doi.org/10.1182/blood-2023-190434
Published: 2023
Journal Articles

Pirtobrutinib in Post-cBTKi CLL/SLL: ~30 Months Follow-up and Subgroup Analysis With/Without Prior BCL2i from the Phase 1/2 BRUIN Study

Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Lindsey E. Roeker, Krish Patel, Toby A. Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine S. Tam, John F. Seymour, Benoit Tessoulin, Nirav N. Shah, Chaitra S Ujjani, Bita Fakhri, Catherine C. Coombs, Ian W. Flinn, Manish Patel, Sunita D. Nasta, Jonathon B. Cohen, Alvaro J. Alencar, Chan Y. Cheah, Shuo Ma, Joanna M. Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Osterborg, Koji Izutsu, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Amy S. Ruppert, Wojciech Jurczak, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 325.
https://doi.org/10.1182/blood-2023-185852
Published: 2023
Journal Articles

TP53 Mutations Detected By Clinical Laboratory Mutation Analysis Predict for Inferior Clinical Outcomes in Patients with Newly-Diagnosed Aggressive B Cell Lymphomas, Including Those with High-Risk Features

Daniel J. Landsburg, Jennifer JD Morrissette, Sunita D. Nasta, Stefan K. Barta, Stephen J Schuster, Jakub Svoboda, Elise A. Chong, Adam Bagg
Journal: Blood
Blood (2023) 142 (Supplement 1): 1739.
https://doi.org/10.1182/blood-2023-186343
Published: 2023
Journal Articles

Impact of Genetic Mutations on Survival Following Receipt of Commercial CART19 for Patients Diagnosed with Aggressive B Cell Lymphoma

Benjamin Frost, Jennifer JD Morrissette, Stephen J Schuster, Sunita D. Nasta, Jakub Svoboda, Stefan K. Barta, Elise A. Chong, Marco Ruella, Adam Bagg, Daniel J. Landsburg
Journal: Blood
Blood (2023) 142 (Supplement 1): 3518.
https://doi.org/10.1182/blood-2023-186553
Published: 2023
Journal Articles

Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Elise A. Chong, Cécile Alanio, Jakub Svoboda, Sunita D. Nasta, Daniel J. Landsburg, Simon F. Lacey, Marco Ruella, Siddharth Bhattacharyya, E. John Wherry, Stephen J. Schuster
Journal: Blood
Blood (2022) 139 (7): 1026–1038.
https://doi.org/10.1182/blood.2021012634
Published: 2022
Includes: Supplemental data
Journal Articles

Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L Garfall, MD, Michael C. Milone, Lifeng Tian, PhD, Vanessa E. Gonzalez, Saar Gill, MD MRCP, FRCPath, Noelle V. Frey, MD, David M. Barrett, Marco Ruella, MD, Simon F Lacey, PhD, Jakub Svoboda, MD, Elise A. Chong, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Sunita D Nasta, MD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Stephen J. Schuster, MD, Edward A. Stadtmauer, MD FACP, Stephan Grupp, MD PhD, David L. Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 622.
https://doi.org/10.1182/blood-2019-122513
Published: 2019
Journal Articles

Pembrolizumab and Copanlisib for the Treatment of Relapsed or Refractory Mature T-Cell Lymphomas

Stefan K. Barta, MD MRCP, MS, Nathan H. Fowler, MD, Jasmine Zain, MD, Jia Ruan, MD PhD, Sonali M. Smith, MD, Stephen J. Schuster, MD, Sunita D Nasta, MD, Jakub Svoboda, MD, James N Gerson, MD, Daniel J. Landsburg, MD, Elise A. Chong, MD, Henry C. Fung, FRCP,MBBChir, Kerry S Campbell, PhD, Nadia Khan, MD, Richard I. Fisher, MD, Carlyn Rose Tan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4031.
https://doi.org/10.1182/blood-2019-125385
Published: 2019