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Journal Articles

Early Initiation of Calcineurin Inhibitor Induces CD8 + Transitory Exhausted-like and CD4 + Cytotoxic T Cells, Maintaining Responsiveness to PD-1 Blockade and Contributing to the Development of Chronic Gvhd after Post-Transplant Cyclophosphamide

Hajime Senjo, Daigo Hashimoto, Shihori Tsukamoto, Keisuke Kojima, Shimpei I Kubota, Ayumu Ito, Tomoe Ichiki, Satomi Okada, Yumika Saito, Toru Miyajima, Shinpei Harada, Wenyu Li, Zixuan Zhang, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Yoshihiro Inamoto, Masaaki Murakami, Takahiro Fukuda, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 903.
https://doi.org/10.1182/blood-2024-197873
Published: 2024
Journal Articles

Ropeginterferon Alfa-2b Induces Apoptosis and Differentiation of Leukemia Stem Cells and Separates GVL Effects from Gvhd after Allogeneic Hematopoietic Cell Transplantation

Yumika Saito, Daigo Hashimoto, Keisuke Kojima, Shihori Tsukamoto, Tomoe Ichiki, Toru Miyajima, Wenyu Li, Shinpei Harada, Zixuan Zhang, Hajime Senjo, Yuta Hasegawa, Takahide Ara, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 902.
https://doi.org/10.1182/blood-2024-201237
Published: 2024
Journal Articles

Gvhd-Induced Inflammatory Memory in Intestinal Stem Cells Enhances IFN-γ-Induced Antigen Presentation and Apoptosis of Intestinal Epithelial Cells

Toru Miyajima, Daigo Hashimoto, Keisuke Kojima, Shihori Tsukamoto, Tomoe Ichiki, Yumika Saito, Wenyu Li, Zixuan Zhang, Shinpei Harada, Hajime Senjo, Yuki Yokoi, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Kiminori Nakamura, Koji Taniguchi, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 260.
https://doi.org/10.1182/blood-2024-202926
Published: 2024
Journal Articles

Reduced FDG Uptake in the Brain on Baseline 18FDG PET/CT Predicts Worse Prognosis of Newly Diagnosed Intravascular Large B-Cell Lymphoma and Advanced-Stage Diffuse Large B-Cell Lymphoma

Hajime Senjo, Shinpei Harada, Koh Izumiyama, Hideki Goto, Shiro Watanabe, Keito Suto, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Junichi Sugita, Masao Nakagawa, Kenji Hirata, Takuto Miyagishima, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 3096.
https://doi.org/10.1182/blood-2024-204976
Published: 2024
Journal Articles

GVHD targets organoid-forming bile duct stem cells in a TGF-β–dependent manner

Yuta Hasegawa, Daigo Hashimoto, Zixuan Zhang, Toru Miyajima, Yumika Saito, Wenyu Li, Ryo Kikuchi, Hajime Senjo, Tomoko Sekiguchi, Takahiro Tateno, Xuanzhong Chen, Emi Yokoyama, Shuichiro Takahashi, Hiroyuki Ohigashi, Takahide Ara, Eiko Hayase, Isao Yokota, Takanori Teshima
Journal: Blood
Blood (2024) 144 (8): 904–913.
https://doi.org/10.1182/blood.2023023060
Published: 2024
Includes: Supplemental data
Journal Articles

Addition of High-Dose Methotrexate to Initial Chemotherapy Improved Treatment Outcome of Patients with Newly Diagnosed Intravascular Large B-Cell Lymphoma: A Multicenter, Retrospective Study

Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 440.
https://doi.org/10.1182/blood-2023-181183
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed/Refractory Follicular Lymphoma: Results from the Phase 1/2 BRUIN Study

Nirav N. Shah, Pier Luigi Zinzani, Michael L. Wang, Sunita D. Nasta, Ewa Lech-Maranda, Yoshiaki Ogawa, Bita Fakhri, Bryone Kuss, Kaname Miyashita, Krish Patel, Catherine C. Coombs, Shuo Ma, Manish Patel, Minal A. Barve, Benoit Tessoulin, Anastasios Stathis, Won Seog Kim, Daisuke Ennishi, Daigo Hashimoto, Kensuke Kojima, Andrew D. Zelenetz, Jonathon B. Cohen, Julie M. Vose, Kami J. Maddocks, Talha Munir, Fangfang Sun, Faith Bian, Donald E. Tsai, Paolo Abada, Chan Y. Cheah
Journal: Blood
Blood (2023) 142 (Supplement 1): 3026.
https://doi.org/10.1182/blood-2023-181309
Published: 2023
Journal Articles

The HLA-B Leader MM Genotype Has a Negative Impact on Outcomes in HLA-B One Antigen Mismatched and HLA-B Matched Cord Blood Transplantation without Anti-Thymocyte Globulin: Analysis of the Japanese Society for Transplantation and Cellular Therapy

Minoru Kanaya, Daigo Hashimoto, Yasuo Morishima, Nobuyoshi Arima, Masahiro Hirayama, Makoto Murata, Naoyuki Uchida, Masatsugu Tanaka, Yasufumi Uehara, Shigesaburo Miyakoshi, Kazuya Ishiwata, Makoto Onizuka, Satoshi Takahashi, Hikaru Kobayashi, Masashi Sawa, Koji Kato, Fumihiko Ishimaru, Tatsuo Ichinohe, Yoshiko Atsuta, Satoko Morishima
Journal: Blood
Blood (2023) 142 (Supplement 1): 1048.
https://doi.org/10.1182/blood-2023-178905
Published: 2023
Journal Articles

Delayed Initiation of Calcineurin Inhibitor Is Critical for Tolerance Induction By Posttransplant Cyclophosphamide

Hajime Senjo, Daigo Hashimoto, Satomi Okada, Shimpei I Kubota, Ayumu Ito, Takashi Tanaka, Yumika Saito, Toru Miyajima, Wenyu Li, Zixuan Zhang, Shinpei Harada, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Yoshihiro Inamoto, Masaaki Murakami, Takahiro Fukuda, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2041.
https://doi.org/10.1182/blood-2023-181560
Published: 2023
Journal Articles

Low-Dose ATG Has the Same Risk of CMV Reactivation after Allogeneic PBSCT As Ptcy, but Letemovir Is Effective in Preventing CMV Reactivation

Takahide Ara, Yuta Hasegawa, Hiroyuki Ohigashi, Toshihiro Matsukawa, Souichi Shiratori, Atsushi Yasumoto, Hideki Goto, Masahiro Onozawa, Masao Nakagawa, Kaoru Kahata, Tomoyuki Endo, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 3546.
https://doi.org/10.1182/blood-2023-191306
Published: 2023
Journal Articles

Baseline 18 f-Fluorodeoxyglucose PET/CT Radiomics Predicts Outcome in Newly Diagnosed Intravascular Large B-Cell Lymphoma

Shinpei Harada, Hideki Goto, Hajime Senjo, Keito Suto, Shiro Watanabe, Koh Izumiyama, Masayo Yamamoto, Kazuya Sato, Yasutaka Kakinoki, Tomoyuki Saga, Akio Shigematsu, Hiroto Horiguchi, Mutsumi Takahata, Reiki Ogasawara, Satoshi Yamamoto, Keisuke Yamaguchi, Kentaro Wakasa, Tetsuyuki Igarashi, Yoshihito Haseyama, Shinichi Ito, Katsuya Fujimoto, Junichi Hashiguchi, Masao Nakagawa, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 6321.
https://doi.org/10.1182/blood-2023-188507
Published: 2023
Journal Articles

Ferroptosis Inhibition Generates TCF-1 + CAR-T Cells with Enhanced Persistence and Cytotoxicity

Shinpei Harada, Daigo Hashimoto, Yumika Saito, Toru Miyajima, Wenyu Li, Hajime Senjo, Zixuan Zhang, Ryo Kikuchi, Masahiro Chiba, Hiroyuki Ohigashi, Takahide Ara, Masao Nakagawa, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 97.
https://doi.org/10.1182/blood-2023-179444
Published: 2023
Journal Articles

Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT

Hajime Senjo, Shinpei Harada, Shimpei I. Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita, Masahiro Onozawa, Hideki Goto, Tomoyuki Endo, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima, Daigo Hashimoto
Journal: Blood
Blood (2023) 142 (5): 477–492.
https://doi.org/10.1182/blood.2023019875
Published: 2023
Includes: Supplemental data
Journal Articles

Calcineurin Inhibitors Inhibit Tolerance Induction By Suppressing Terminal Differentiation of Donor Exhausted T Cells after Allogeneic SCT

Hajime Senjo, Daigo Hashimoto, Shinpei Kubota, Yuki Tanaka, Shinpei Harada, Kazuki Yoneda, Zixuan Zhang, Xuanzhong Chen, Ryo Kikuchi, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima
Journal: Blood
Blood (2022) 140 (Supplement 1): 1159–1160.
https://doi.org/10.1182/blood-2022-158842
Published: 2022
Journal Articles

Intercellular Mitochondrial Transfer Enhances Metabolic Fitness and Anti-Tumor Effects of CAR T Cells

Shinpei Harada, Daigo Hashimoto, Hajime Senjo, Kazuki Yoneda, Zixuan Zhang, Xuanzhong Chen, Ryo Kikuchi, Masahiro Chiba, Hiroyuki Ohigashi, Takahide Ara, Masao Nakagawa, Masashi Suganuma, Rick C. Tsai, Takanori Teshima
Journal: Blood
Blood (2022) 140 (Supplement 1): 2356–2357.
https://doi.org/10.1182/blood-2022-162535
Published: 2022
Journal Articles

Letermovir Is Effective for Prevention of Cytomegalovirus Reactivation in HLA-Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide

Takahide Ara, Yuta Hasegawa, Hiroyuki Ohigashi, Souichi Shiratori, Atsushi Yasumoto, Hideki Goto, Junichi Sugita, Masahiro Onozawa, Masao Nakagawa, Kaoru Kahata, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2021) 138 (Supplement 1): 2858.
https://doi.org/10.1182/blood-2021-152116
Published: 2021
Journal Articles

Gvhd Targets Organoid-Forming Biliary Epithelial Stem Cells Via a TGF-β-Dependent Manner

Yuta Hasegawa, Daigo Hashimoto, Ryo Kikuchi, Zixuan Zhang, Hajime Senjo, Tomoko Sekiguchi, Eiko Hayase, Takahiro Tateno, Emi Yokoyama, Shuichiro Takahashi, Xuanzhong Chen, Kazuki Yoneda, Hiroyuki Ohigashi, Takahide Ara, Takanori Teshima
Journal: Blood
Blood (2021) 138 (Supplement 1): 90.
https://doi.org/10.1182/blood-2021-149061
Published: 2021
Journal Articles

Single-Strand Breaks at Genome Initiate FLT3-ITD Formation

Shota Yokoyama, Masahiro Onozawa, Daisuke Hidaka, Daigo Hashimoto, Masao Nakagawa, Takeshi Kondo, Takanori Teshima
Journal: Blood
Blood (2021) 138 (Supplement 1): 4333.
https://doi.org/10.1182/blood-2021-149451
Published: 2021
Journal Articles

Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL)

Kazuyuki Shimada, MD, Motoko Yamaguchi, MD PhD, Yoshiko Atsuta, MD PhD, Kosei Matsue, MD PhD, Keijiro Sato, MD, Shigeru Kusumoto, MD PhD, Hirokazu Nagai, MD PhD, Jun Takizawa, MD PhD, Noriko Fukuhara, MD PhD, Koji Nagafuji, MD PhD, Kana Miyazaki, MD PhD, Eiichi Ohtsuka, MD, Masataka Okamoto, MD PhD, Yasumasa Sugita, MD PhD, Toshiki Uchida, MD PhD, Satoshi Kayukawa, MD, Atsushi Wake, MD PhD, Daisuke Ennishi, MD PhD, Yukio Kondo, MD, Tohru Izumi, MD, Yoshihiro Kin, MD, Kunihiro Tsukasaki, MD PhD, Daigo Hashimoto, Masaaki Yuge, MD PhD, Atsumi Yanagisawa, Yachiyo Kuwatsuka, MD PhD, Satoko Shimada, MD, Yasufumi Masaki, MD PhD, Nozomi Niitsu, MD PhD, Hitoshi Kiyoi, MD PhD, Ritsuro Suzuki, MD PhD, Takashi Tokunaga, MD PhD, Shigeo Nakamura, MD, Tomohiro Kinoshita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 350.
https://doi.org/10.1182/blood-2019-126798
Published: 2019
Journal Articles

Imetelstat Sensitizes Hematopoietic Malignancy Cells to Genotoxic Agent Via Suppression of Telomerase Mediated DNA Repair Process

Daisuke Hidaka, Masahiro Onozawa, Naohiro Miyashita, Masao Nakagawa, Daigo Hashimoto, Takanori Teshima, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3369.
https://doi.org/10.1182/blood-2019-122999
Published: 2019