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Yuta Hasegawa
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Journal Articles

Early Initiation of Calcineurin Inhibitor Induces CD8 + Transitory Exhausted-like and CD4 + Cytotoxic T Cells, Maintaining Responsiveness to PD-1 Blockade and Contributing to the Development of Chronic Gvhd after Post-Transplant Cyclophosphamide

Hajime Senjo, Daigo Hashimoto, Shihori Tsukamoto, Keisuke Kojima, Shimpei I Kubota, Ayumu Ito, Tomoe Ichiki, Satomi Okada, Yumika Saito, Toru Miyajima, Shinpei Harada, Wenyu Li, Zixuan Zhang, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Yoshihiro Inamoto, Masaaki Murakami, Takahiro Fukuda, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 903.
https://doi.org/10.1182/blood-2024-197873
Published: 2024
Journal Articles

Ropeginterferon Alfa-2b Induces Apoptosis and Differentiation of Leukemia Stem Cells and Separates GVL Effects from Gvhd after Allogeneic Hematopoietic Cell Transplantation

Yumika Saito, Daigo Hashimoto, Keisuke Kojima, Shihori Tsukamoto, Tomoe Ichiki, Toru Miyajima, Wenyu Li, Shinpei Harada, Zixuan Zhang, Hajime Senjo, Yuta Hasegawa, Takahide Ara, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 902.
https://doi.org/10.1182/blood-2024-201237
Published: 2024
Journal Articles

Gvhd-Induced Inflammatory Memory in Intestinal Stem Cells Enhances IFN-γ-Induced Antigen Presentation and Apoptosis of Intestinal Epithelial Cells

Toru Miyajima, Daigo Hashimoto, Keisuke Kojima, Shihori Tsukamoto, Tomoe Ichiki, Yumika Saito, Wenyu Li, Zixuan Zhang, Shinpei Harada, Hajime Senjo, Yuki Yokoi, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Kiminori Nakamura, Koji Taniguchi, Takanori Teshima
Journal: Blood
Blood (2024) 144 (Supplement 1): 260.
https://doi.org/10.1182/blood-2024-202926
Published: 2024
Journal Articles

Kinetics of Recipients with Thrombocytopenia and Its Impact on Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation: A Nationwide Retrospective Study

Naoki Kurita, Kazushi Maruo, Fumihiko Kimura, Yachiyo Kuwatsuka, Toshihiro Matsukawa, Takaaki Konuma, Shinichi Kobayashi, Mamiko Sakata-Yanagimoto, Noriko Doki, Masatsugu Tanaka, Naoyuki Uchida, Tetsuya Nishida, Masashi Sawa, Yuta Hasegawa, Hirohisa Nakamae, Shuichi Ota, Makoto Onizuka, Takahiro Fukuda, Fumihiko Ishimaru, Ken Tabuchi, Yoshiko Atsuta, Junya Kanda, Hideki Nakasone
Journal: Blood
Blood (2024) 144 (Supplement 1): 2121.
https://doi.org/10.1182/blood-2024-201927
Published: 2024
Journal Articles

To What Extent Have Post-Transplant Outcomes Improved Following the Introduction of Tyrosine Kinase Inhibitors in Elderly Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia? a Retrospective Nationwide Survey in Japan

Shuichi Mizuta, Tomotaka Ugai, Satoshi Nishiwaki, Noriko Doki, Takahiro Fukuda, Tetsuya Nishida, Yuta Katayama, Shuichi Ota, Yuta Hasegawa, Masatsugu Tanaka, Makoto Onizuka, Tatsuo Ichinohe, Koji Kawamura, Yoshiko Atsuta, Yasuyuki Arai
Journal: Blood
Blood (2024) 144 (Supplement 1): 3569.
https://doi.org/10.1182/blood-2024-201434
Published: 2024
Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Rio Takahashi, Yoshitaka Zaimoku, Kohei Hosokawa, Seishi Ogawa, Yoshiyuki Takahashi, Takako Miyamura, Yasushi Onishi, Takashi Koike, Tetsuya Nishida, Naoyuki Uchida, Noriko Doki, Masatsugu Tanaka, Tetsuya Eto, Mitsuhiro Itagaki, Masashi Sawa, Yuta Hasegawa, Takahiro Fukuda, Makoto Onizuka, Yoshiko Atsuta, Shinji Nakao, Takamasa Katagiri
Journal: Blood
Blood (2024) 144 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2024-197892
Published: 2024
Journal Articles

GVHD targets organoid-forming bile duct stem cells in a TGF-β–dependent manner

Yuta Hasegawa, Daigo Hashimoto, Zixuan Zhang, Toru Miyajima, Yumika Saito, Wenyu Li, Ryo Kikuchi, Hajime Senjo, Tomoko Sekiguchi, Takahiro Tateno, Xuanzhong Chen, Emi Yokoyama, Shuichiro Takahashi, Hiroyuki Ohigashi, Takahide Ara, Eiko Hayase, Isao Yokota, Takanori Teshima
Journal: Blood
Blood (2024) 144 (8): 904–913.
https://doi.org/10.1182/blood.2023023060
Published: 2024
Includes: Supplemental data
Journal Articles

Delayed Initiation of Calcineurin Inhibitor Is Critical for Tolerance Induction By Posttransplant Cyclophosphamide

Hajime Senjo, Daigo Hashimoto, Satomi Okada, Shimpei I Kubota, Ayumu Ito, Takashi Tanaka, Yumika Saito, Toru Miyajima, Wenyu Li, Zixuan Zhang, Shinpei Harada, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Yoshihiro Inamoto, Masaaki Murakami, Takahiro Fukuda, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2041.
https://doi.org/10.1182/blood-2023-181560
Published: 2023
Journal Articles

Low-Dose ATG Has the Same Risk of CMV Reactivation after Allogeneic PBSCT As Ptcy, but Letemovir Is Effective in Preventing CMV Reactivation

Takahide Ara, Yuta Hasegawa, Hiroyuki Ohigashi, Toshihiro Matsukawa, Souichi Shiratori, Atsushi Yasumoto, Hideki Goto, Masahiro Onozawa, Masao Nakagawa, Kaoru Kahata, Tomoyuki Endo, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2023) 142 (Supplement 1): 3546.
https://doi.org/10.1182/blood-2023-191306
Published: 2023
Journal Articles

Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT

Hajime Senjo, Shinpei Harada, Shimpei I. Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita, Masahiro Onozawa, Hideki Goto, Tomoyuki Endo, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima, Daigo Hashimoto
Journal: Blood
Blood (2023) 142 (5): 477–492.
https://doi.org/10.1182/blood.2023019875
Published: 2023
Includes: Supplemental data
Journal Articles

Calcineurin Inhibitors Inhibit Tolerance Induction By Suppressing Terminal Differentiation of Donor Exhausted T Cells after Allogeneic SCT

Hajime Senjo, Daigo Hashimoto, Shinpei Kubota, Yuki Tanaka, Shinpei Harada, Kazuki Yoneda, Zixuan Zhang, Xuanzhong Chen, Ryo Kikuchi, Yuta Hasegawa, Hiroyuki Ohigashi, Takahide Ara, Yoshinori Hasegawa, Masaaki Murakami, Takanori Teshima
Journal: Blood
Blood (2022) 140 (Supplement 1): 1159–1160.
https://doi.org/10.1182/blood-2022-158842
Published: 2022
Journal Articles

Letermovir Is Effective for Prevention of Cytomegalovirus Reactivation in HLA-Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide

Takahide Ara, Yuta Hasegawa, Hiroyuki Ohigashi, Souichi Shiratori, Atsushi Yasumoto, Hideki Goto, Junichi Sugita, Masahiro Onozawa, Masao Nakagawa, Kaoru Kahata, Daigo Hashimoto, Takanori Teshima
Journal: Blood
Blood (2021) 138 (Supplement 1): 2858.
https://doi.org/10.1182/blood-2021-152116
Published: 2021
Journal Articles

Gvhd Targets Organoid-Forming Biliary Epithelial Stem Cells Via a TGF-β-Dependent Manner

Yuta Hasegawa, Daigo Hashimoto, Ryo Kikuchi, Zixuan Zhang, Hajime Senjo, Tomoko Sekiguchi, Eiko Hayase, Takahiro Tateno, Emi Yokoyama, Shuichiro Takahashi, Xuanzhong Chen, Kazuki Yoneda, Hiroyuki Ohigashi, Takahide Ara, Takanori Teshima
Journal: Blood
Blood (2021) 138 (Supplement 1): 90.
https://doi.org/10.1182/blood-2021-149061
Published: 2021