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Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Transcription Factor Gata2 Regulates the Myeloid-Lymphoid Fate Decision in Multipotent Progenitors

Yuya Tanaka, Hiroki Kato, Sayaka Sano, Daigo Michimata, Kazuki Sakurai, Kazuki Hashimoto, Naoya Morota, Koichi Onodera, Shunsuke Hatta, Noriko Fukuhara, Yasushi Onishi, Tohru Fujiwara, Hideo Harigae
Journal: Blood
Blood (2024) 144 (Supplement 1): 4037.
https://doi.org/10.1182/blood-2024-207236
Published: 2024
Journal Articles

Efficacy and Safety of Eltrombopag Added to Rabbit Anti-Human Thymocyte Globulin+Cyclosporine in Aplastic Anemia: Results from a Prospective Multicenter Phase II Study

Ken Ishiyama, Ritsuro Suzuki, Kinuko Mitani, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Fumiaki Kiyomi, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 2689.
https://doi.org/10.1182/blood-2024-193818
Published: 2024
Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Rio Takahashi, Yoshitaka Zaimoku, Kohei Hosokawa, Seishi Ogawa, Yoshiyuki Takahashi, Takako Miyamura, Yasushi Onishi, Takashi Koike, Tetsuya Nishida, Naoyuki Uchida, Noriko Doki, Masatsugu Tanaka, Tetsuya Eto, Mitsuhiro Itagaki, Masashi Sawa, Yuta Hasegawa, Takahiro Fukuda, Makoto Onizuka, Yoshiko Atsuta, Shinji Nakao, Takamasa Katagiri
Journal: Blood
Blood (2024) 144 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2024-197892
Published: 2024
Journal Articles

RNA Methyltransferase Mettl16 Is Indispensable for the Survival of Naïve CD4 + T Cells In Vivo

Daigo Michimata, Hiroki Kato, Naoya Morota, Yuya Tanaka, Kazuki Sakurai, Kazuki Hashimoto, Koichi Onodera, Shunsuke Hatta, Yasushi Onishi, Noriko Fukuhara, Hideo Harigae
Journal: Blood
Blood (2024) 144 (Supplement 1): 2534.
https://doi.org/10.1182/blood-2024-198338
Published: 2024
Journal Articles

HLA Class I Genotypes Predict the Survival after Hematopoietic Stem Cell Transplantation in Immune Aplastic Anemia

Yoshitaka Zaimoku, Hirohito Yamazaki, Minoru Kanaya, Nobuhiro Hiramoto, Ken Ishiyama, Naoyuki Uchida, Noriko Doki, Ryusuke Yamamoto, Tetsuya Nishida, Koichi Onodera, Shinichiro Machida, Yoshinobu Kanda, Tetsuya Eto, Fumihiko Ishimaru, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Yasushi Onishi
Journal: Blood
Blood (2023) 142 (Supplement 1): 706.
https://doi.org/10.1182/blood-2023-191332
Published: 2023
Journal Articles

Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration

Sayaka Sano, Hiroki Kato, Yan Yan, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Tohru Fujiwara, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 1182.
https://doi.org/10.1182/blood-2023-178454
Published: 2023
Journal Articles

Outcomes of Hematopoietic Cell Transplantation for Patients with Refractory Cytopenia with Multilineage Dysplasia: A Comparison Children with Adolescents and Young Adults

Asahito Hama, Nao Yoshida, Daisuke Hasegawa, Motohiro Kato, Kenichiro Watanabe, Daiichiro Hasegawa, Tetsuya Nishida, Noriko Doki, Maho Sato, Yasushi Onishi, Takuro Nishikawa, Hiroshi Tujimoto, Katsuyoshi Koh, Tetsuya Mori, Koji Kato, Yoshiko Hashii, Atsushi Sato, Ken Tabuchi, Jun Aoki, Shohei Yamamoto
Journal: Blood
Blood (2023) 142 (Supplement 1): 2202.
https://doi.org/10.1182/blood-2023-189000
Published: 2023
Journal Articles

Roles for Heme Synthesis in the Maintenance of Hematopoietic Stem and Progenitor Cells

Yan Yan, Hiroki Kato, Sayaka Sano, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Tohru Fujiwara, Yasushi Onishi, Noriko Fukuhara, Hisayuki Yokoyama, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 2682.
https://doi.org/10.1182/blood-2023-174202
Published: 2023
Journal Articles

Hematopoietic Stem/Progenitor Cell Intrinsic SAM Synthesis Is Required to Prevent p53 Pathway Activation By Maintaining DNA Stability

Eijiro Furukawa, Hiroki Kato, Sayaka Sano, Yan Yan, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Daisuke Saigusa, Tohru Fujiwara, Kazuhiko Igarashi, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 4049.
https://doi.org/10.1182/blood-2023-180384
Published: 2023
Journal Articles

Risk Stratified Therapy with Nelarabine and Intensified Administration of L-Asparaginase for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia in Adolescents and Young Adults (JPLSG T-11/JALSG T-ALL-211-U): An Intergroup Phase 2 Study

Yoshihiro Hatta, Atsushi Sato, Akiko Kada, Akiko Moriya Saito, Fumihiko Hayakawa, Arata Watanabe, Tatsuhiro Sakamoto, Katsuhiro Miura, Yoshifumi Shimizu, Junya Kanda, Yasushi Onishi, Noboru Asada, Yasuhiro Okamoto, Chihaya Imai, Koichi Oshima, Katsuyoshi Koh, Atsushi Manabe, Keizo Horibe, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2022) 140 (Supplement 1): 124–126.
https://doi.org/10.1182/blood-2022-156613
Published: 2022
Journal Articles

Altered Transcription By GATA1 Impairs Autophagy and Prevents Ferroptosis in X-Linked Sideroblastic Anemia

Koya Ono, Tohru Fujiwara, Hiroki Shima, Hironari Nishizawa, Chie Suzuki, Noriyuki Takahashi, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Kazuhiko Igarashi, Hideo Harigae
Journal: Blood
Blood (2022) 140 (Supplement 1): 2467–2468.
https://doi.org/10.1182/blood-2022-163073
Published: 2022
Journal Articles

The Outcomes of Systemic Chronic Active EBV Infection Treatment By Allogeneic Hematopoietic Stem Cell Transplantation: An Analysis of Japanese Registry Data

Ayako Arai, Masahide Yamamoto, Maho Sato, Yasushi Onishi, Yoji Sasahara, Hideki Sano, Masayoshi Masuko, Hirohisa Nakamae, Ken-Ichi Matsuoka, Takahide Ara, Kana Washio, Makoto Onizuka, Kenichiro Watanabe, Tsuneaki Hirakawa, Miwako Nishio, Chizuko Sakashita, Tohru Kobayashi, Akihisa Sawada, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Hashii, Yoshiko Atsuta
Journal: Blood
Blood (2021) 138 (Supplement 1): 3965.
https://doi.org/10.1182/blood-2021-147046
Published: 2021
Journal Articles

Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

Seitaro Terakura, MD PhD, Tetsuya Nishida, MD PhD, Masashi Sawa, MD PhD, Tomonori Kato, MD PhD, Kotaro Miyao, MD PhD, Yukiyasu Ozawa, MD PhD, Tatsunori Goto, MD, Akio Kohno, MD, Kazutaka Ozeki, MD PhD, Yasushi Onishi, MD PhD, Noriko Fukuhara, MD PhD, Nobuharu Fujii, MD PhD, Hisayuki Yokoyama, MD PhD, Masanobu Kasai, MD PhD, Hiroatsu Iida, MD PhD, Nobuhiro Kanemura, MD PhD, Tomoyuki Endo, MD PhD, Hiroatsu Ago, MD, Makoto Onizuka, MD PhD, Satoshi Iyama, MD PhD, Yuichiro Nawa, MD, Mika Nakamae, MD PhD, Yasuyuki Nagata, MD PhD, Shingo Kurahashi, MD PhD, Yasuo Tomiya, MD, Atsumi Yanagisawa, Ritsuro Suzuki, MD PhD, Yachiyo Kuwatsuka, MD PhD, Yoshiko Atsuta, MD PhD, Koichi Miyamura, MD PhD, Makoto Murata, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4587.
https://doi.org/10.1182/blood-2019-124634
Published: 2019
Journal Articles

Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?

Tohru Fujiwara, MD PhD, Chie Suzuki, Tetsuro Ochi, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2232.
https://doi.org/10.1182/blood-2019-123918
Published: 2019
Journal Articles

Proteomic Analysis of Mitochondrial Membrane Protein FAM210B in Erythroid Cells

Chie Suzuki, Tohru Fujiwara, MD PhD, Hiroki Shima, Koya Ono, MD, Kei Saito, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Shinichi Fujimaki, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3523.
https://doi.org/10.1182/blood-2019-122618
Published: 2019
Journal Articles

Molecular Characterization and Novel Therapeutic Strategy for X-Linked Sideroblastic Anemia Associated with ALAS2 Missense Variants

Koya Ono, MD, Tohru Fujiwara, MD PhD, Kei Saito, MD PhD, Chie Suzuki, Noriyuki Takahashi, Koichi Onodera, MD PhD, Satoshi Ichikawa, MD PhD, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Hisayuki Yokoyama, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3530.
https://doi.org/10.1182/blood-2019-124810
Published: 2019
Journal Articles

Dasatinib-Based Two-Step Induction Prior to Allogeneic Hematopoietic Cell Transplantation for Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of the JALSG Ph+ALL213 Study

Isamu Sugiura, MD, Noriko Doki, MD PhD, Tomoko Hata, MD, PhD, Ryuko CHO, MD PhD, Toshiro Ito, MD, Youko Suehiro, MD PhD, Heiwa Kanamori, MD PhD, Shinichi Kako, MD, Mitsuhiro Matsuda, MD PhD, Hisayuki Yokoyama, MD PhD, Yasuhiro Taniguchi, MD, Maki Hagihara, MD PhD, Yukiyasu Ozawa, MD PhD, Shin Fujisawa, MD PhD, Nobuaki Dobashi, MD, Yoshihiro Hatta, MD, Noboru Asada, MD PhD, Kazuteru Ohashi, MD PhD, Yasushi Onishi, MD PhD, Koh Shiro, MD PhD, Satoshi Nishiwaki, MD PhD, Yoshiko Atsuta, MD PhD, Fumihiko Hayakawa, MD PhD, Shigeki Ohtake, MD PhD, Yasushi Miyazaki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 743.
https://doi.org/10.1182/blood-2019-123382
Published: 2019
Journal Articles

Generation and Molecular Characterization of Human Ring Sideroblasts

Kei Saito, Tohru Fujiwara, MD PhD, Shunsuke Hatta, Chie Suzuki, Noriko Fukuhara, MD PhD, Yasushi Onishi, MD PhD, Yukio Nakamura, MD PhD, Hideo Harigae, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3613.
https://doi.org/10.1182/blood-2018-99-111066
Published: 2018