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Journal Articles

Efficacy and Safety of Eltrombopag Added to Rabbit Anti-Human Thymocyte Globulin+Cyclosporine in Aplastic Anemia: Results from a Prospective Multicenter Phase II Study

Ken Ishiyama, Ritsuro Suzuki, Kinuko Mitani, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Fumiaki Kiyomi, Itaru Matsumura, Koichi Akashi, Shinji Nakao

Blood (2024) 144 (Supplement 1): 2689.

https://doi.org/10.1182/blood-2024-193818

Published: 2024

Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Blood (2024) 144 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2024-197892

Published: 2024

Journal Articles

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Noriaki Tsuji, Mikoto Tanabe, Noriharu Nakagawa, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Hiroyuki Maruyama, Kohei Hosokawa, Hiroyuki Takamatsu, Hirohito Yamazaki, Kazuya Sakai, Ishikazu Mizuno, Toshihiro Miyamoto, Shinji Nakao

Blood (2024) 144 (Supplement 1): 1307.

https://doi.org/10.1182/blood-2024-208660

Published: 2024

Journal Articles

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

Dung Cao Cao Tran, Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Hiroki Mizumaki, Kohei Hosokawa, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2023) 142 (Supplement 1): 1344.

https://doi.org/10.1182/blood-2023-190964

Published: 2023

Journal Articles

HLA Class I Genotypes Predict the Survival after Hematopoietic Stem Cell Transplantation in Immune Aplastic Anemia

Yoshitaka Zaimoku, Hirohito Yamazaki, Minoru Kanaya, Nobuhiro Hiramoto, Ken Ishiyama, Naoyuki Uchida, Noriko Doki, Ryusuke Yamamoto, Tetsuya Nishida, Koichi Onodera, Shinichiro Machida, Yoshinobu Kanda, Tetsuya Eto, Fumihiko Ishimaru, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Yasushi Onishi

Blood (2023) 142 (Supplement 1): 706.

https://doi.org/10.1182/blood-2023-191332

Published: 2023

Journal Articles

Prevalence and Outcome of Vexas Syndrome in Unrelated Hematopoietic Stem Cell Transplantation

Blood (2023) 142 (Supplement 1): 1354.

https://doi.org/10.1182/blood-2023-190791

Published: 2023

Journal Articles

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

Dung Cao Tran, Kohei Hosokawa, Hiroki Mizumaki, Yoshitaka Zaimoku, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 11453–11454.

https://doi.org/10.1182/blood-2022-170970

Published: 2022

Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 710–711.

https://doi.org/10.1182/blood-2022-165962

Published: 2022

Journal Articles

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

Yoshitaka Zaimoku, Bhavisha A. Patel, Sharon D. Adams, Ruba Shalhoub, Emma M. Groarke, Audrey Ai Chin Lee, Sachiko Kajigaya, Xingmin Feng, Olga Julia Rios, Holly Eager, Lemlem Alemu, Diego Quinones Raffo, Colin O. Wu, Willy A. Flegel, Neal S. Young

Blood (2021) 138 (26): 2799–2809.

https://doi.org/10.1182/blood.2021012895

Published: 2021

Includes: Supplemental data

Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 604.

https://doi.org/10.1182/blood-2021-148240

Published: 2021

Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood (2021) 137 (25): 3576–3580.

https://doi.org/10.1182/blood.2020010586

Published: 2021

Includes: Supplemental data

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

Deficit of Circulating CD19 + CD24 hi CD38 hi Regulatory B Cells in Severe Aplastic Anemia

Yoshitaka Zaimoku, MD PhD, Bhavisha A Patel, MD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Lemlem Alemu, BS, Diego Quinones Raffo, MSc, Emma M. Groarke, MD, Neal S. Young, MD

Blood (2019) 134 (Supplement_1): 1219.

https://doi.org/10.1182/blood-2019-127053

Published: 2019

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

Spectrum and Clinical Significance of HLA Class I Alleles and Their Somatic Mutations in Immune Aplastic Anemia

Yoshitaka Zaimoku, MD PhD, Sharon D. Adams, MT, CHS (ABHI), Bhavisha A Patel, MD, Audrey Ai Chin Lee, MS, CHT (ABHI), Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Olga Rios, RN, Holly DiFebo, RN, Lemlem Alemu, BS, Diego Quinones Raffo, MSc, Emma M. Groarke, MD, Willy A. Flegel, MD, Neal S. Young, MD

Blood (2019) 134 (Supplement_1): 3738.

https://doi.org/10.1182/blood-2019-127359

Published: 2019

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

Journal Articles

Novel Human Anti-HLA-Bw4 and B61 Monoclonal Antibodies Kill Malignant B Cells Via CDC/ADCC While Sparing Normal Peripheral Blood Cells

Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Yoshitaka Zaimoku, MD, Akinori Tsuji, MD, Ichiro Hanamura, MD PhD, Junya Kuroda, MD PhD, Hidenori Tanaka, BS, Shintaro Kawai, PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2069.

https://doi.org/10.1182/blood.V130.Suppl_1.2069.2069

Published: 2017

Journal Articles

Chromosome 6 Loss-of-Heterozygosity in Pre-Transplant Blood Samples of Patients with Severe Aplastic Anemia Is Associated with Lower Risk of Acute Graft- Versus -Host Disease

Shahinaz M Gadalla, MD PhD, Weiyin Zhou, MS, Tao Wang, PhD, Yoshitaka Zaimoku, MD, Shinji Nakao, MD PhD, Laurie Burdette, PhD, Amanda Willis, BS, Medhat Askar, MD PhD, Michael Haagenson, MS, Meredith Yeager, PhD, Youjin Wang, Stephen R. Spellman, Stephen J Chanock, MD, Stephanie J. Lee, MD PhD, Sharon A Savage, MD

Blood (2017) 130 (Supplement 1): 4479.

https://doi.org/10.1182/blood.V130.Suppl_1.4479.4479

Published: 2017

Journal Articles

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

Noriharu Nakagawa, MD, Mahmoud Ibrahim Elbadry, MD, Yoshiki Akatsuka, MD, Hiroshi Hamana, Kiyomi Shitaoka, Yoshinori Yoshida, MD PhD, Kazuhisa Chonabayashi, MD PhD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MD, Katsuto Takenaka, Hiroshi Fujiwara, MD PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2458.

https://doi.org/10.1182/blood.V130.Suppl_1.2458.2458

Published: 2017

NARROW

Efficacy and Safety of Eltrombopag Added to Rabbit Anti-Human Thymocyte Globulin+Cyclosporine in Aplastic Anemia: Results from a Prospective Multicenter Phase II Study

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

HLA Class I Genotypes Predict the Survival after Hematopoietic Stem Cell Transplantation in Immune Aplastic Anemia

Prevalence and Outcome of Vexas Syndrome in Unrelated Hematopoietic Stem Cell Transplantation

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Deficit of Circulating CD19 + CD24 hi CD38 hi Regulatory B Cells in Severe Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Spectrum and Clinical Significance of HLA Class I Alleles and Their Somatic Mutations in Immune Aplastic Anemia

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Novel Human Anti-HLA-Bw4 and B61 Monoclonal Antibodies Kill Malignant B Cells Via CDC/ADCC While Sparing Normal Peripheral Blood Cells

Chromosome 6 Loss-of-Heterozygosity in Pre-Transplant Blood Samples of Patients with Severe Aplastic Anemia Is Associated with Lower Risk of Acute Graft- Versus -Host Disease

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

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American Society of Hematology

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American Society of Hematology

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