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Journal Articles

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Noriaki Tsuji, Mikoto Tanabe, Noriharu Nakagawa, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Hiroyuki Maruyama, Kohei Hosokawa, Hiroyuki Takamatsu, Hirohito Yamazaki, Kazuya Sakai, Ishikazu Mizuno, Toshihiro Miyamoto, Shinji Nakao

Blood (2024) 144 (Supplement 1): 1307.

https://doi.org/10.1182/blood-2024-208660

Published: 2024

Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Blood (2024) 144 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2024-197892

Published: 2024

Journal Articles

Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis

Blood (2024) 144 (Supplement 1): 1310.

https://doi.org/10.1182/blood-2024-193925

Published: 2024

Journal Articles

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

Dung Cao Cao Tran, Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Hiroki Mizumaki, Kohei Hosokawa, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2023) 142 (Supplement 1): 1344.

https://doi.org/10.1182/blood-2023-190964

Published: 2023

Journal Articles

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

Dung Cao Tran, Kohei Hosokawa, Hiroki Mizumaki, Yoshitaka Zaimoku, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 11453–11454.

https://doi.org/10.1182/blood-2022-170970

Published: 2022

Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 710–711.

https://doi.org/10.1182/blood-2022-165962

Published: 2022

Journal Articles

Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga -Mutated Hematopoietic Stem Progenitor Cells

Hiroki Mizumaki, Dung Cao Tran, Kohei Hosokawa, Kazuyoshi Hosomichi, Hiroyuki Takamatsu, Hirohito Yamazaki, Atsushi Tajima, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 2181.

https://doi.org/10.1182/blood-2021-150504

Published: 2021

Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 604.

https://doi.org/10.1182/blood-2021-148240

Published: 2021

Journal Articles

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

Yasutaka Ueda, Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao

Blood (2021) 138 (Supplement 1): 1122.

https://doi.org/10.1182/blood-2021-146353

Published: 2021

Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood (2021) 137 (25): 3576–3580.

https://doi.org/10.1182/blood.2020010586

Published: 2021

Includes: Supplemental data

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Hiroyuki Takamatsu, MDPhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-136893

Published: 2020

Journal Articles

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Kohei Thi Hosokawa, MD PhD, Kohei Hosokawa, MD PhD, Tanabe Mikoto, MD, Md Mohiuddin, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD PhD, Masaya Ueno, PhD, Atsushi Hirao, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 5000.

https://doi.org/10.1182/blood-2019-127767

Published: 2019

Journal Articles

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Tanabe Mikoto, MD, Nguyen Hoang Maianh, MD, Kohei Hosokawa, MD PhD, Noriharu Nakagawa, MD, Luis Espinoza, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3736.

https://doi.org/10.1182/blood-2019-126677

Published: 2019

Journal Articles

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Eiji Kobayashi, PhD, Yoshiki Akatsuka, MD PhD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Tanabe Mikoto, MD, Noriaki Tsuji, MD, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Thi Mai Anh Nguyen, MD, Takamasa Katagiri, PhD, Kiyomi Shitaoka, PhD, Hiroshi Hamana, PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3751.

https://doi.org/10.1182/blood-2019-125685

Published: 2019

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Takeshi Yoroidaka, MD, Tanabe Mikoto, MD, Hiroki Mizumaki, MD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1216.

https://doi.org/10.1182/blood-2019-122798

Published: 2019

Journal Articles

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Tanabe Mikoto, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MD PhD, Luis Espinoza, MD PhD, Kana Maruyama, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3874.

https://doi.org/10.1182/blood-2018-99-118741

Published: 2018

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

NARROW

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga -Mutated Hematopoietic Stem Progenitor Cells

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

A GPI-Anchored Protein, CD109, Protects Hematopoietic Progenitor Cells from Erythroid Differentiation Induced By TGF-β

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

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American Society of Hematology

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American Society of Hematology

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