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Journal Articles

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

Yasutaka Ueda, Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao

Blood (2021) 138 (Supplement 1): 1122.

https://doi.org/10.1182/blood-2021-146353

Published: 2021

Journal Articles

COMPOSER Part 4: An Optimized Dosing Strategy for Crovalimab in the Treatment of Complement Inhibitor-Naïve or -Experienced Patients with Paroxysmal Nocturnal Hemoglobinuria

Regis Peffault De Latour, MD PhD, Simona Sica, MD PhD, Julia Ramos, MD, Jules Hernández-Sánchez, PhD, Jin Seok Kim, MD PhD, Anna Kiialainen, PhD, Sung-Soo Yoon, MD PhD, Sasha Sreckovic, MD, Antoine Soubret, PhD, Haruhiko Ninomiya, MD PhD, Alexandre Sostelly, PhD, Jens Panse, MD, Simon Buatois, PharmD, PhD, Hubert Schrezenmeier, Ido Paz-Priel, MD, Jun-ichi Nishimura, MD PhD, Alexander Röth, MD

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-135841

Published: 2020

Journal Articles

The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria

Blood (2020) 135 (12): 912–920.

https://doi.org/10.1182/blood.2019003399

Published: 2020

Includes: Supplemental data

Journal Articles

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Ken Ishiyama, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, Naoshi Obara, MD PhD, Hideyoshi Noji, MD PhD, Yukari Shirasugi, MD PhD, Yasutaka Ueda, MD PhD, Hiroyuki Takamori, MD PhD, Tsutomu Shichishima, MD PhD, Shigeru Chiba, MD PhD, Haruhiko Ninomiya, MD PhD, Kiyoshi Ando, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Masanori Takahashi, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2466.

https://doi.org/10.1182/blood.V130.Suppl_1.2466.2466

Published: 2017

Journal Articles

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

Yasutaka Ueda, MD PhD, Naoshi Obara, MD PhD, Yuji Yonemura, MD PhD, Hideyoshi Noji, MD PhD, Takahisa Matsuda, Hirozumi Akiyama, Takayuki Ikezoe, MD, PhD, Shigeru Chiba, MD PhD, Yoshinobu Kanda, MD PhD, Tatsuya Kawaguchi, MD PhD, Tsutomu Shichishima, MD PhD, Hideki Nakakuma, MD PhD, Shinichiro Okamoto, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Haruhiko Ninomiya, MD PhD

Blood (2017) 130 (Supplement 1): 4749.

https://doi.org/10.1182/blood.V130.Suppl_1.4749.4749

Published: 2017

Journal Articles

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

Yasutaka Ueda, MD PhD, Jun-Ichi Nishimura, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, MDPhD, Yuji Yonemura, MD PhD, Naoshi Obara, MDPhD, Hideyoshi Noji, MD PhD, Yoshihiko Nakamura, PhD, Yukari Shirasugi, MD PhD, Kiyoshi Ando, Tsutomu Shichishima, MD PhD, Haruhiko Ninomiya, MD PhD, Shigeru Chiba, MD, PhD, Tatsuya Kawaguchi, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3896.

https://doi.org/10.1182/blood.V128.22.3896.3896

Published: 2016

Journal Articles

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

Yukari Shirasugi, MD PhD, Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MDPhD, Shigeru Chiba, MD, PhD, Haruhiko Ninomiya, MD PhD, Yoshihiko Nakamura, PhD, Kiyoshi Ando, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Kohei Hosokawa, MDPhD, Yasutaka Ueda, MDPhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 4781.

https://doi.org/10.1182/blood.V126.23.4781.4781

Published: 2015

Journal Articles

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

Blood (2014) 124 (21): 4870.

https://doi.org/10.1182/blood.V124.21.4870.4870

Published: 2014

Journal Articles

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MD PhD, Kohei Hosokawa, MDPhD, Shigeru Chiba, MD PhD, Yoshihiko Nakamura, MD PhD, Kiyoshi Ando, MD PhD, Satoru Hayashi, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Haruhiko Ninomiya, MD PhD, Jun-ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 1595.

https://doi.org/10.1182/blood.V124.21.1595.1595

Published: 2014

Journal Articles

Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group

Kensuke Usuki, MD PhD, Akio Urabe, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Naoyuki Miyasaka, MD, PhD, Osamu Miura, MD, PhD, Eriko Morishita, MD, PhD, Nobuyoshi Arima, MD, PhD, Yasuyoshi Morita, MD, PhD, Kaichi Nishiwaki, MD, Haruhiko Ninomiya, MD, PhD, Akihiko Gotoh, MD, PhD, Shinsaku Imashuku, MD, Tsutomu Shichishima, MD, PhD, Jun-ichi Nishimura, MD, PhD, Yuzuru Kanakura

Blood (2013) 122 (21): 2480.

https://doi.org/10.1182/blood.V122.21.2480.2480

Published: 2013

Journal Articles

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

Naoshi Obara, MD, PhD, Shigeru Chiba, MD, PhD, Kohei Hosokawa, MD, PhD, Chiharu Sugimori, MD, PhD, Masaki Yamamoto, MD, Hideyoshi Noji, MD, PhD, Yuji Yonemura, MD, PhD, Yoshihiko Nakamura, MD, PhD, Kiyoshi Ando, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Tsutomu Shichishima, MD, PhD, Haruhiko Ninomiya, MD, PhD, Jun-ichi Nishimura, MD, PhD, Yuzuru Kanakura, Shinji Nakao, MD, PhD

Blood (2013) 122 (21): 1241.

https://doi.org/10.1182/blood.V122.21.1241.1241

Published: 2013

Journal Articles

Detection of CD55- and CD59-Negative Immature Reticulocytes May Improves Sensitivity/Specificity to Identify a Minor Population of PNH-Type Cells in Patients with Myelodysplastic Syndrome/Aplastic Anemia

Naoshi Obara, MD, PhD, Shoko Satoh, Yasushi Okoshi, MD, PhD, Shigeru Chiba, MD, PhD, Haruhiko Ninomiya, MD, PhD

Blood (2011) 118 (21): 4373.

https://doi.org/10.1182/blood.V118.21.4373.4373

Published: 2011

Journal Articles

c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver

Manabu Kusakabe, Kazuteru Hasegawa, Michito Hamada, Megumi Nakamura, Takayuki Ohsumi, Hirona Suzuki, Tran Thi Nhu Mai, Takashi Kudo, Kazuhiko Uchida, Haruhiko Ninomiya, Shigeru Chiba, Satoru Takahashi

Blood (2011) 118 (5): 1374–1385.

https://doi.org/10.1182/blood-2010-08-300400

Published: 2011

Includes: Supplemental data

Journal Articles

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

Yoshiaki Tomiyama, MD, Yoshitaka Miyakawa, MD, PhD, Shinichiro Okamoto, MD, PhD, Shinya Katsutani, MD, Akiro Kimura, MD, Yasushi Okoshi, MD, PhD, Haruhiko Ninomiya, MD, PhD, Hiroshi Kosugi, MD, PhD, Shosaku Nomura, MD, Katsutoshi Ozaki, MD, Yasuo Ikeda, MD, Nobuyuki Koh, Koichi Katsura, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2009) 114 (22): 1324.

https://doi.org/10.1182/blood.V114.22.1324.1324

Published: 2009

Journal Articles

The Critical Function of c-Myb and CD9 On Megakaryopoiesis.

Harumi Yamamoto Mukai, MD, PhD, Tomoko Kouno, Hozumi Motohashi, Yukinori Kozuma, Hiroshi Kojima, MD, PhD, Haruhiko Ninomiya, MD, PhD, Masayuki Yamamoto, MD, PhD

Blood (2009) 114 (22): 4587.

https://doi.org/10.1182/blood.V114.22.4587.4587

Published: 2009

Journal Articles

Functional Analysis of Transcription Factor c-Maf in Embryonic Hematopoiesis.

Manabu Kusakabe, MD, Michito Hamada, PhD, Megumi Nakamura, Takashi Kudo, PhD, Haruhiko Ninomiya, MD, PhD, Satoru Takahashi, MD, PhD

Blood (2009) 114 (22): 3646.

https://doi.org/10.1182/blood.V114.22.3646.3646

Published: 2009

Journal Articles

Chronic Renal Insufficiency in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Improvement with Eculizumab Treatment in the Long-Term Follow-up of the AEGIS Study.

Yuzuru Kanakura, MD, PhD, Kazuma Ohyashiki, MD, PhD, Tsutomu Shichishima, MD, PhD, Shinichiro Okamoto, MD, PhD, Kiyoshi Ando, MD, PhD, Haruhiko Ninomiya, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Shinji Nakao, MD, PhD, Hideki Nakakuma, MD, PhD, Jun-ichi Nishimura, MD, PhD, Taroh Kinoshita, PhD, Camille Bedrosian, MD, Marye Ellen Valentine, MS, Keiya Ozawa, MD, PhD, Mitsuhiro Omine, MD

Blood (2009) 114 (22): 1980.

https://doi.org/10.1182/blood.V114.22.1980.1980

Published: 2009

Journal Articles

Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria: AEGIS Phase II Clinical Study Results.

Yuzuru Kanakura, MD, PhD, Kazuma Ohyashiki, MD, Tsutomu Shichishima, MD, PhD, Shinichiro Okamoto, MD, PhD, Kiyoshi Ando, MD, Haruhiko Ninomiya, MD, PhD, Tatsuya Kawaguchi, MD, PhD, Shinji Nakao, MD, Hideki Nakakuma, MD, PhD, Jun-Ichi Nishimura, MD, PhD, Taroh Kinoshita, PhD, Camille Bedrosian, MD, Marye Ellen Valentine, MS, Keiya Ozawa, MD, PhD, Mitsuhiro Omine, MD

Blood (2008) 112 (11): 3438.

https://doi.org/10.1182/blood.V112.11.3438.3438

Published: 2008

Journal Articles

Functional Analysis of CD9 during Megakaryopoiesis

Tomoko Kono, Harumi Mukai, MD, PhD, Yukinori Kozuma, Hiroshi Kojima, MD, PhD, Haruhiko Ninomiya, MD, PhD

Blood (2008) 112 (11): 891.

https://doi.org/10.1182/blood.V112.11.891.891

Published: 2008

Journal Articles

PNH-Affected RBC’s Mean Life Span Estimated by Reticulocyte-Gated Flow Cytometry Reflects In Vivo Hemolysis in PNH.

Haruhiko Ninomiya, MD, Shoko Sato, Yuichi Hasegawa, MD, Hiroshi Kojima, MD, Toshiro Nagasawa, MD

Blood (2007) 110 (11): 3679.

https://doi.org/10.1182/blood.V110.11.3679.3679

Published: 2007

NARROW

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

COMPOSER Part 4: An Optimized Dosing Strategy for Crovalimab in the Treatment of Complement Inhibitor-Naïve or -Experienced Patients with Paroxysmal Nocturnal Hemoglobinuria

The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group

Baseline Assessment Of GPI-Anchored Protein Deficient Blood Cells In Patients With Bone Marrow Failure (The OPTIMA study)

Detection of CD55- and CD59-Negative Immature Reticulocytes May Improves Sensitivity/Specificity to Identify a Minor Population of PNH-Type Cells in Patients with Myelodysplastic Syndrome/Aplastic Anemia

c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

The Critical Function of c-Myb and CD9 On Megakaryopoiesis.

Functional Analysis of Transcription Factor c-Maf in Embryonic Hematopoiesis.

Chronic Renal Insufficiency in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Improvement with Eculizumab Treatment in the Long-Term Follow-up of the AEGIS Study.

Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Japanese Patients with Paroxysmal Nocturnal Hemoglobinuria: AEGIS Phase II Clinical Study Results.

Functional Analysis of CD9 during Megakaryopoiesis

PNH-Affected RBC’s Mean Life Span Estimated by Reticulocyte-Gated Flow Cytometry Reflects In Vivo Hemolysis in PNH.

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