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Kenji Shinomiya
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Journal Articles

The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria

Clinical Trials & Observations
Alexander Röth, Jun-ichi Nishimura, Zsolt Nagy, Julia Gaàl-Weisinger, Jens Panse, Sung-Soo Yoon, Miklos Egyed, Satoshi Ichikawa, Yoshikazu Ito, Jin Seok Kim, Haruhiko Ninomiya, Hubert Schrezenmeier, Simona Sica, Kensuke Usuki, Flore Sicre de Fontbrune, Juliette Soret, Alexandre Sostelly, James Higginson, Andreas Dieckmann, Brittany Gentile, Judith Anzures-Cabrera, Kenji Shinomiya, Gregor Jordan, Marta Biedzka-Sarek, Barbara Klughammer, Angelika Jahreis, Christoph Bucher, Régis Peffault de Latour
Journal: Blood
Blood (2020) 135 (12): 912–920.
https://doi.org/10.1182/blood.2019003399
Published: 2020
Includes: Supplemental data
Journal Articles

Characterizing C5 Inhibition with the SMART-Ig Anti-hC5 Antibody Crovalimab in PNH Patients Using Free Available Paratopes

Alexandre Sostelly, M.Eng., PhD, Antoine Soubret, Christoph Bucher, MD, Simon Buatois, Jean-Eric Charoin, Gregor Jordan, Barbara Klughammer, PhD, Andreas Dieckmann, Taku Fukuzawa, PhD, Keisuke Gotanda, Kenji Shinomiya, Sung-Soo Yoon, MD PhD, Jens P. Panse, Junichi Nishimura, MD PhD, Alexander Röth, MD PhD, Zsolt Nagy, MD PhD, Régis Peffault de Latour, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1227.
https://doi.org/10.1182/blood-2019-126911
Published: 2019
Journal Articles

Exposure-Response Relationship of the SMART-Ig Anti-hC5 Antibody Crovalimab (SKY59): Results from the Umbrella Phase 1/2 Composer Trial in Healthy Volunteers and PNH Patients

Alexandre Sostelly, M.Eng., PhD, Simon Buatois, Antoine Soubret, Erica Winter, PharmD, Barbara Klughammer, PhD, Joy C. Hsu, Gregor Jordan, Christoph Bucher, MD, Jean-Eric Charoin, Keisuke Gotanda, Kenji Shinomiya, Zsolt Nagy, MD PhD, Jens P. Panse, Sung-Soo Yoon, MD PhD, Régis Peffault de Latour, MD PhD, Junichi Nishimura, MD PhD, Alexander Röth, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3745.
https://doi.org/10.1182/blood-2019-124258
Published: 2019
Journal Articles

The SMART Anti-hC5 Antibody (SKY59/RO7112689) Shows Good Safety and Efficacy in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

Alexander Röth, MD, Miklos Egyed, MD PhD, Satochi Ichikawa, MD, Jin Seok Kim, MD PhD, Zsolt Nagy, MD PhD, Julia Gaàl Weisinger, Jens P. Panse, MD, Regis Peffault De Latour, Flore Sicre De Fontbrune, MD PhD, Simona Sica, MD, Kensuke Usuki, MD PhD, Sung-Soo Yoon, MD PhD, Erica Winter, PharmD, Joy C. Hsu, Andreas Dieckmann, Judith Anzures-Cabrera, Gregor Jordan, Kenji Shinomiya, Barbara Klughammer, PhD, Christoph Bucher, MD, Angelika Jahreis, MD PhD, Jun-Ichi Nishimura, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 535.
https://doi.org/10.1182/blood-2018-99-113274
Published: 2018
Journal Articles

The SMART-IgG Anti-hC5 Antibody (SKY59/RO7112689) Has Favorable PK, PD, Subcutaneous Bioavailability, and Safety Profile in Phase I HV Study

Alexander Roeth, MD, Nagy Zsolt, MD PhD, Miklos Egyed, MD, Erica Winter, Joy Hsu, Andreas Dieckmann, Judith Anzures-Cabrera, Marie Mannino, Elana Fernandez, PhD, Gregor Jordan, Barbara Klughammer, PhD, Kenji Shinomiya, Naoki Kotani, Ido Paz-Priel, MD, Angelika Jahreis., MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4750.
https://doi.org/10.1182/blood.V130.Suppl_1.4750.4750
Published: 2017