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Ken Ishiyama
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Journal Articles

Efficacy and Safety of Cyclosporine Monotherapy for Patients with Non-Severe Aplastic Anemia Not Requiring Transfusions: Results from a Prospective Multicenter Phase II Study

Naoko Hosono, Ken Ishiyama, Hiroki Yamaguchi, Masahide Yamazaki, Hiroyuki Maruyama, Kensuke Usuki, Kazuki Tanimoto, Hiroyuki Sugiura, Noboru Asada, Seishi Ogawa, Yuzuru Kanakura, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 1312.
https://doi.org/10.1182/blood-2024-198830
Published: 2024
Journal Articles

Efficacy and Safety of Eltrombopag Added to Rabbit Anti-Human Thymocyte Globulin+Cyclosporine in Aplastic Anemia: Results from a Prospective Multicenter Phase II Study

Ken Ishiyama, Ritsuro Suzuki, Kinuko Mitani, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Fumiaki Kiyomi, Itaru Matsumura, Koichi Akashi, Shinji Nakao
Journal: Blood
Blood (2024) 144 (Supplement 1): 2689.
https://doi.org/10.1182/blood-2024-193818
Published: 2024
Journal Articles

Impact of Conditioning Intensity and Regimen on Outcomes after Unrelated Cord Blood Transplantation for Patients with Myelodysplastic Syndrome

Machiko Fujioka, Hidehiro Itonaga, Yasushi Miyazaki, Yoshimitsu Shimomura, Naoyuki Uchida, Satoshi Takahashi, Makoto Onizuka, Yasunori Ueda, Yasufumi Uehara, Masatsugu Tanaka, Yoshiko Matsuhashi, Shigesaburo Miyakoshi, Haruyuki Tanaka, Toshiro Kawakita, Fumihiko Ishimaru, Junya Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Ken Ishiyama
Journal: Blood
Blood (2023) 142 (Supplement 1): 3536.
https://doi.org/10.1182/blood-2023-179157
Published: 2023
Journal Articles

Prognostic Impact of Conditioning Intensity on Outcomes after Allogeneic Transplantation for MDS with Low Blasts

Hidehiro Itonaga, Yasushi Miyazaki, Machiko Fujioka, Ken Ishiyama, Jun Aoki, Noriko Doki, Tetsuya Nishida, Takahiro Fukuda, Naoyuki Uchida, Yasunori Ueda, Yasufumi Uehara, Yuta Katayama, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta
Journal: Blood
Blood (2023) 142 (Supplement 1): 4985.
https://doi.org/10.1182/blood-2023-173567
Published: 2023
Journal Articles

Effect of Early Cytomegalovirus Reactivation on Relapse in Adult Patients with Myelodysplastic Syndromes after Allogeneic Hematopoietic Stem Cell Transplantation: A Registry Study from the Japan Society for Transplantation and Cellular Therapy (JSTCT)

Tatsuya Konishi, Kensuke Matsuda, Hidehiro Itonaga, Noriko Doki, Tetsuya Nishida, Ken-Ichi Matsuoka, Takashi Ikeda, Yoshinobu Kanda, Takahiro Fukuda, Junya Kanda, Hirohisa Nakamae, Tatsuo Ichinohe, Yoshiko Atsuta, Ken Ishiyama
Journal: Blood
Blood (2023) 142 (Supplement 1): 2170.
https://doi.org/10.1182/blood-2023-172414
Published: 2023
Journal Articles

Efficacy of Cord Blood Transplantation for the Management of Chronic Myelomonocytic Leukemia: A Registry-Based Study in Japan

Shuhei Kurosawa, Yoshimitsu Shimomura, Ken Ishiyama, Kyoko Fuse, Yutaka Shimazu, Noriko Doki, Naoyuki Uchida, Masatsugu Tanaka, Satoshi Takahashi, Masatoshi Sakurai, Hikaru Kobayashi, Yuta Katayama, Satoru Takada, Kazutaka Ozeki, Hirohisa Nakamae, Fumihiko Ishimaru, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Hidehiro Itonaga
Journal: Blood
Blood (2023) 142 (Supplement 1): 3577.
https://doi.org/10.1182/blood-2023-173603
Published: 2023
Journal Articles

HLA Class I Genotypes Predict the Survival after Hematopoietic Stem Cell Transplantation in Immune Aplastic Anemia

Yoshitaka Zaimoku, Hirohito Yamazaki, Minoru Kanaya, Nobuhiro Hiramoto, Ken Ishiyama, Naoyuki Uchida, Noriko Doki, Ryusuke Yamamoto, Tetsuya Nishida, Koichi Onodera, Shinichiro Machida, Yoshinobu Kanda, Tetsuya Eto, Fumihiko Ishimaru, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Yasushi Onishi
Journal: Blood
Blood (2023) 142 (Supplement 1): 706.
https://doi.org/10.1182/blood-2023-191332
Published: 2023
Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao
Journal: Blood
Blood (2022) 140 (Supplement 1): 710–711.
https://doi.org/10.1182/blood-2022-165962
Published: 2022
Journal Articles

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

Dung Cao Tran, Kohei Hosokawa, Hiroki Mizumaki, Yoshitaka Zaimoku, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Toshihiro Miyamoto, Shinji Nakao
Journal: Blood
Blood (2022) 140 (Supplement 1): 11453–11454.
https://doi.org/10.1182/blood-2022-170970
Published: 2022
Journal Articles

Outcomes of Transplant-Eligible Patients with Myelodysplastic Syndrome-Refractory Anemia with Excess Blasts Registered in a Prospective Observational Study: The JALSG-CS11-MDS-SCT

Noriharu Nakagawa, Ken Ishiyama, Kensuke Usuki, Satoru Takada, Tatsuki Tomikawa, Hiroshi Handa, Yuna Katsuoka, Daiki Hirano, Nobuo Sezaki, Masahiko Sumi, Shin Fujisawa, Yasuhiro Taniguchi, Takuro Yoshimura, Eiichi Ohtsuka, Ken Takase, Youko Suehiro, Shuichi Ota, Tomohiro Kajiguchi, Tomoya Maeda, Masahide Yamamoto, Shigeki Ohtake, Akira Katsumi, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2021) 138 (Supplement 1): 2925.
https://doi.org/10.1182/blood-2021-147587
Published: 2021
Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao
Journal: Blood
Blood (2021) 138 (Supplement 1): 604.
https://doi.org/10.1182/blood-2021-148240
Published: 2021
Journal Articles

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

June Takeda, Kenichi Yoshida, Masahiro Marshall Nakagawa, Yasuhito Nannya, Akinori Yoda, Daisuke Morishita, Ryunosuke Saiki, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Ming-Chung Kuo, Cassandra M Kerr, Yasunobu Nagata, Nobuhiro Hiramoto, Akira Hangaishi, Hideyuki Nakazawa, Ken Ishiyama, Satoru Miyano, Shigeru Chiba, Yasushi Miyazaki, Toshiyuki Kitano, Kensuke Usuki, Nobuo Sezaki, Hisashi Tsurumi, Shuichi Miyawaki, Jaroslaw P. Maciejewski, Takayuki Ishikawa, Kazuma Ohyashiki, Arnold Ganser, Michael Heuser, Felicitas Thol, Lee-Yung Shih, Akifumi Takaori-Kondo, Hideki Makishima, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 610.
https://doi.org/10.1182/blood-2021-152800
Published: 2021
Journal Articles

Comparison of Myeloablative Versus Reduced-Intensity Fludarabine/Busulfan Regimen in Patients with Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Shuhei Kurosawa, Yoshimitsu Shimomura, Hidehiro Itonaga, Yuho Najima, Takeshi Kobayashi, Yukiyasu Ozawa, Yoshinobu Kanda, Shinichi Kako, Toshiro Kawakita, Ken-Ichi Matsuoka, Yumiko Maruyama, Shuichi Ota, Hideyuki Nakazawa, Kazunori Imada, Takafumi Kimura, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Ken Ishiyama
Journal: Blood
Blood (2021) 138 (Supplement 1): 3692.
https://doi.org/10.1182/blood-2021-144689
Published: 2021
Journal Articles

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

Yasutaka Ueda, Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao
Journal: Blood
Blood (2021) 138 (Supplement 1): 1122.
https://doi.org/10.1182/blood-2021-146353
Published: 2021
Journal Articles

Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga -Mutated Hematopoietic Stem Progenitor Cells

Hiroki Mizumaki, Dung Cao Tran, Kohei Hosokawa, Kazuyoshi Hosomichi, Hiroyuki Takamatsu, Hirohito Yamazaki, Atsushi Tajima, Ken Ishiyama, Shinji Nakao
Journal: Blood
Blood (2021) 138 (Supplement 1): 2181.
https://doi.org/10.1182/blood-2021-150504
Published: 2021
Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Kohei Hosokawa, Hiroki Mizumaki, Takeshi Yoroidaka, Hiroyuki Maruyama, Tatsuya Imi, Noriaki Tsuji, Ryota Urushihara, Mikoto Tanabe, Yoshitaka Zaimoku, Mai Anh Thi Nguyen, Dung Cao Tran, Ken Ishiyama, Hirohito Yamazaki, Takamasa Katagiri, Hiroyuki Takamatsu, Kazuyoshi Hosomichi, Atsushi Tajima, Fumihiro Azuma, Seishi Ogawa, Shinji Nakao
Journal: Blood
Blood (2021) 137 (25): 3576–3580.
https://doi.org/10.1182/blood.2020010586
Published: 2021
Includes: Supplemental data
Journal Articles

Epigenetic Loss of the HLA-DR15 Expression on Hematopoietic Stem Progenitor Cells in Patients with Acquired Aplastic Anemia Characterized By Cyclosporine Dependency: A Novel Mechanism Underlying the Immune Escape of Hematopoietic Stem Progenitor Cells

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Hiroyuki Takamatsu, MDPhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-136893
Published: 2020
Journal Articles

Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia

June Takeda, MD, Kenichi Yoshida, MDPhD, Akinori Yoda, PhD, Lee-Yung Shih, MD, Yasuhito Nannya, MD PhD, Yotaro Ochi, MD, Ayana Kon, MD PhD, Kenichi Chiba, Yuichi Shiraishi, PhD, Yusuke Shiozawa, MD PhD, Tetsuichi Yoshizato, MD PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Toshiyuki Kitano, MD PhD, Akira Hangaishi, MD PhD, Ken Ishiyama, MD PhD, Hisashi Tsurumi, MD PhD, Yasushi Miyazaki, MD PhD, Nobuhiro Hiramoto, MD, Takayuki Ishikawa, MD PhD, Masahiro Marshall Nakagawa, MDPhD, Akifumi Takaori-Kondo, MD PhD, Shigeru Chiba, MD PhD, Hideyuki Nakazawa, MD PhD, Ming-Chung Kuo, MD, Keisuke Kataoka, MD PhD, Ryunosuke Saiki, MD, Hiroko Tanaka, Kensuke Usuki, MD PhD, Shuichi Miyawaki, MD PhD, Satoru Miyano, PhD, Jaroslaw P. Maciejewski, MD PhD, Arnold Ganser, Michael Heuser, Prof., MD, Felicitas Thol, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-141750
Published: 2020
Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-138636
Published: 2020
Journal Articles

Novel Molecular Pathogenesis and Therapeutic Target in Acute Erythroid Leukemia

June Takeda, MD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Lee-Yung Shih, MD, Ayana Kon, MD PhD, Akinori Yoda, PhD, Yotaro Ochi, MD, Yusuke Shiozawa, MD PhD, Tetsuichi Yoshizato, MD PhD, Cassandra M Kerr, MS, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Yasunobu Nagata, MD PhD, Akira Hangaishi, MD PhD, Toshiyuki Kitano, MD PhD, Ken Ishiyama, Hisashi Tsurumi, MD PhD, Yasushi Miyazaki, MD PhD, Nobuhiro Hiramoto, MD, Takayuki Ishikawa, MD PhD, Akifumi Takaori-Kondo, MD PhD, Masahiro Nakagawa, MD PhD, Masashi Sanada, MD, Hideyuki Nakazawa, MD PhD, Keisuke Kataoka, MD PhD, Ryunosuke Saiki, Hiroko Tanaka, BA, Kensuke Usuki, MD PhD, Shuichi Miyawaki, MD PhD, Satoru Miyano, PhD, Arnold Ganser, MD, Michael Heuser, MD, Jaroslaw P. Maciejewski, MD PhD, Felicitas Thol, MD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 914.
https://doi.org/10.1182/blood-2019-129940
Published: 2019