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Journal Articles

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

Blood (2024) 144 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2024-197892

Published: 2024

Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 710–711.

https://doi.org/10.1182/blood-2022-165962

Published: 2022

Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 604.

https://doi.org/10.1182/blood-2021-148240

Published: 2021

Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood (2021) 137 (25): 3576–3580.

https://doi.org/10.1182/blood.2020010586

Published: 2021

Includes: Supplemental data

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Eiji Kobayashi, PhD, Yoshiki Akatsuka, MD PhD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Tanabe Mikoto, MD, Noriaki Tsuji, MD, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Thi Mai Anh Nguyen, MD, Takamasa Katagiri, PhD, Kiyomi Shitaoka, PhD, Hiroshi Hamana, PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3751.

https://doi.org/10.1182/blood-2019-125685

Published: 2019

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Tanabe Mikoto, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MD PhD, Luis Espinoza, MD PhD, Kana Maruyama, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3874.

https://doi.org/10.1182/blood-2018-99-118741

Published: 2018

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

Journal Articles

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Takeshi Yoroidaka, MD, Kohei Hosokawa, MD PhD, Tatsuya Imi, MD, Takamasa Katagiri, PhD, Fumihiro Azuma, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 1308.

https://doi.org/10.1182/blood-2018-99-115623

Published: 2018

Journal Articles

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia

Yoshitaka Zaimoku, Hiroyuki Takamatsu, Kazuyoshi Hosomichi, Tatsuhiko Ozawa, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Takamasa Katagiri, Hiroyuki Kishi, Atsushi Tajima, Atsushi Muraguchi, Koichi Kashiwase, Shinji Nakao

Blood (2017) 129 (21): 2908–2916.

https://doi.org/10.1182/blood-2016-11-752378

Published: 2017

Includes: Supplemental data

Journal Articles

HLA Class I Allele-Lacking Hematopoietic Stem/Progenitor Cells Support Long-Term Clonal Hematopoiesis without Oncogenic Driver Mutations in Acquired Aplastic Anemia

Tatsuya Imi, MD, Takamasa Katagiri, Kazuyoshi Hosomichi, PhD, Noriharu Nakagawa, Yoshitaka Zaimoku, MD, Ken Ishiyama, MD PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3894.

https://doi.org/10.1182/blood.V128.22.3894.3894

Published: 2016

Journal Articles

Relatively Low Sensitivity of CD109(-) Hematopoietic Stem/Progenitor Cells (HSPCs) to TGF-β: A Possible Mechanism Responsible for the Preferential Commitment of Piga Mutant HSPCs in Immune-Mediated Bone Marrow Failure

Noriharu Nakagawa, Kohei Hosokawa, Luis Espinoza, Kana Maruyama, Takamasa Katagiri, Hirohito Yamazaki, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3911.

https://doi.org/10.1182/blood.V128.22.3911.3911

Published: 2016

Journal Articles

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

Tatsuya Imi, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MDPhD, Ken Ishiyama, Hirohito Yamazaki, MD PhD, Koichi Kashiwase, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 1168.

https://doi.org/10.1182/blood.V126.23.1168.1168

Published: 2015

Journal Articles

A Cure for Paroxysmal Nocturnal Hemoglobinuria Using Molecular Targeted Therapy Specific to a Driver Mutation

Takamasa Katagiri, PhD, Ryo Tominaga, Keisuke Kataoka, MD PhD, Akio Maeda, Hiroshi Gomyo, Ishikazu Mizuno, Tohru Murayama, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 1215.

https://doi.org/10.1182/blood.V126.23.1215.1215

Published: 2015

Journal Articles

Generation of Ips Cell-Derived Hematopoietic Progenitor Cells from Patients with Acquired Aplastic Anemia Harboring Copy Number Neutral Loss of Heterozygosity of the Short Arm of Chromosome 6

Luis Espinoza, MD PhD, Yoshinori Yoshida, MD PhD, Kazuhisa Chonabayashi, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 2415.

https://doi.org/10.1182/blood.V126.23.2415.2415

Published: 2015

Journal Articles

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

Noriharu Nakagawa, MD, Hiroyuki Maruyama, MD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Chizuru Saito, MD, Takamasa Katagiri, PhD, Kohei Hosokawa, MD PhD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 2418.

https://doi.org/10.1182/blood.V126.23.2418.2418

Published: 2015

Journal Articles

Hematopoiesis in Patients with Acquired Aplastic Anemia Is Supported By a Limited Number of CXCR4(-) Cells at the Common Myeloid Progenitor Level

Takamasa Katagiri, PhD, Atsuo Kasada, MD, Kana Motomiya, MD, Yoshitaka Zaimoku, MD, An T. T. Dao, MD, Hiroyuki Maruyama, MD, Ken Ishiyama, MD, PhD, Shigeki Ohtake, MD PhD, Atsushi Hirao, MD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 4392.

https://doi.org/10.1182/blood.V124.21.4392.4392

Published: 2014

Journal Articles

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

An T. T. Dao, MD, Kohei Hosokawa, MDPhD, Chiharu Sugimori, MD PhD, Luis J. Espinoza, MD PhD, Kana Maruyama, MD, Yoshitaka Zaimoku, MD, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Hirohito Yamazaki, MD PhD, Hiroyuki Takamatsu, MD PhD, Chizuru Saito, MD, Noriko Iwaki, MD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 4384.

https://doi.org/10.1182/blood.V124.21.4384.4384

Published: 2014

NARROW

Frequent Loss of HLA-B*40:02 from Leukocytes in Male Patients with Hepatitis-Associated Aplastic Anemia

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA -Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia

HLA Class I Allele-Lacking Hematopoietic Stem/Progenitor Cells Support Long-Term Clonal Hematopoiesis without Oncogenic Driver Mutations in Acquired Aplastic Anemia

Relatively Low Sensitivity of CD109(-) Hematopoietic Stem/Progenitor Cells (HSPCs) to TGF-β: A Possible Mechanism Responsible for the Preferential Commitment of Piga Mutant HSPCs in Immune-Mediated Bone Marrow Failure

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

A Cure for Paroxysmal Nocturnal Hemoglobinuria Using Molecular Targeted Therapy Specific to a Driver Mutation

Generation of Ips Cell-Derived Hematopoietic Progenitor Cells from Patients with Acquired Aplastic Anemia Harboring Copy Number Neutral Loss of Heterozygosity of the Short Arm of Chromosome 6

Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis

Hematopoiesis in Patients with Acquired Aplastic Anemia Is Supported By a Limited Number of CXCR4(-) Cells at the Common Myeloid Progenitor Level

A Profound Decrease in FoxP3 + Helios + CD4 + T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine

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American Society of Hematology

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