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Journal Articles

Single-Cell Multi-Omics Analysis Reveals Dysfunctional Features of the Immune Responses in Vexas Syndrome

Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Xingmin Feng, Fernanda Gutierrez-Rodrigues, Lemlem Alemu, Diego Quinones Raffo, Ivana Darden, Sachiko Kajigaya, Emma M. Groarke, Neal S. Young, Bhavisha A. Patel

Blood (2024) 144 (Supplement 1): 4056.

https://doi.org/10.1182/blood-2024-198166

Published: 2024

Journal Articles

Complement Mediated Immune Activation in HLA Class I Alloimmunized Immune Aplastic Anemia Imputed from Single Cell Analysis of Peripheral Cell Subsets

Jibran Durrani, Leonard Chen, Nuri Cha, Zhijie Wu, Shouguo Gao, Hiroki Mizumaki, Jennifer Lotter, Olga Rios, Colin O. Wu, Willy Albert Flegel, Neal S. Young, Emma M. Groarke, Bhavisha A. Patel

Blood (2024) 144 (Supplement 1): 2693.

https://doi.org/10.1182/blood-2024-200879

Published: 2024

Journal Articles

Allogeneic Hematopoietic Cell Transplantation in Adult Acute Myeloid Leukemia with t(16;21)(p11;q22)

Satoshi Mitsuyuki, Yoshimitsu Shimomura, Hiroki Mizumaki, Masamitsu Yanada, Shohei Mizuno, Naoyuki Uchida, Noriko Doki, Ayumu Ito, Masatsugu Tanaka, Tetsuya Nishida, Yuta Katayama, Satoshi Yoshihara, Tetsuya Eto, Koji Kawamura, Makoto Onizuka, Takahiro Fukuda, Marie Ohbiki, Yoshiko Atsuta, Takaaki Konuma

Blood (2024) 144 (Supplement 1): 1469.

https://doi.org/10.1182/blood-2024-198750

Published: 2024

Journal Articles

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Noriaki Tsuji, Mikoto Tanabe, Noriharu Nakagawa, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Hiroyuki Maruyama, Kohei Hosokawa, Hiroyuki Takamatsu, Hirohito Yamazaki, Kazuya Sakai, Ishikazu Mizuno, Toshihiro Miyamoto, Shinji Nakao

Blood (2024) 144 (Supplement 1): 1307.

https://doi.org/10.1182/blood-2024-208660

Published: 2024

Journal Articles

Characterization of Hematopoietic Stem and Progenitor Cells of PNH Patients Using Single-Cell RNA Sequencing Analysis

Hiroki Mizumaki, Shouguo Gao, Zhijie Wu, Emma M. Groarke, Lemlem Alemu, Diego Quinones Raffo, Olga Rios, Sachiko Kajigaya, Bhavisha A. Patel, Neal S. Young

Blood (2023) 142 (Supplement 1): 4085.

https://doi.org/10.1182/blood-2023-181078

Published: 2023

Journal Articles

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

Dung Cao Cao Tran, Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Hiroki Mizumaki, Kohei Hosokawa, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2023) 142 (Supplement 1): 1344.

https://doi.org/10.1182/blood-2023-190964

Published: 2023

Journal Articles

Megakaryocytes Have Immune Characteristics in Murine Immune Bone Marrow Failure

Ashvind Prabahran, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Hiroki Mizumaki, Christian Combs, Jichun Chen, Xingmin Feng, Neal S. Young

Blood (2023) 142 (Supplement 1): 1349.

https://doi.org/10.1182/blood-2023-174597

Published: 2023

Journal Articles

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

Dung Cao Tran, Kohei Hosokawa, Hiroki Mizumaki, Yoshitaka Zaimoku, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 11453–11454.

https://doi.org/10.1182/blood-2022-170970

Published: 2022

Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 710–711.

https://doi.org/10.1182/blood-2022-165962

Published: 2022

Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 604.

https://doi.org/10.1182/blood-2021-148240

Published: 2021

Journal Articles

Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga -Mutated Hematopoietic Stem Progenitor Cells

Hiroki Mizumaki, Dung Cao Tran, Kohei Hosokawa, Kazuyoshi Hosomichi, Hiroyuki Takamatsu, Hirohito Yamazaki, Atsushi Tajima, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 2181.

https://doi.org/10.1182/blood-2021-150504

Published: 2021

Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood (2021) 137 (25): 3576–3580.

https://doi.org/10.1182/blood.2020010586

Published: 2021

Includes: Supplemental data

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

Noriaki Tsuji, MD, Kohei Hosokawa, MD PhD, Takeshi Yoroidaka, MD, Tanabe Mikoto, MD, Hiroki Mizumaki, MD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1216.

https://doi.org/10.1182/blood-2019-122798

Published: 2019

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Eiji Kobayashi, PhD, Yoshiki Akatsuka, MD PhD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Tanabe Mikoto, MD, Noriaki Tsuji, MD, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Thi Mai Anh Nguyen, MD, Takamasa Katagiri, PhD, Kiyomi Shitaoka, PhD, Hiroshi Hamana, PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 3751.

https://doi.org/10.1182/blood-2019-125685

Published: 2019

Journal Articles

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Kohei Thi Hosokawa, MD PhD, Kohei Hosokawa, MD PhD, Tanabe Mikoto, MD, Md Mohiuddin, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD PhD, Masaya Ueno, PhD, Atsushi Hirao, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 5000.

https://doi.org/10.1182/blood-2019-127767

Published: 2019

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

Journal Articles

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

Hiroki Mizumaki, MD, Hirohito Yamazaki, MD PhD, Kazuyoshi Hosomichi, PhD, Noriharu Nakagawa, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Hiromi Iwasaki, MD PhD, Mika Kuroiwa, Ryosuke Ogawa, MDPhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 1176.

https://doi.org/10.1182/blood.V130.Suppl_1.1176.1176

Published: 2017

NARROW

Single-Cell Multi-Omics Analysis Reveals Dysfunctional Features of the Immune Responses in Vexas Syndrome

Complement Mediated Immune Activation in HLA Class I Alloimmunized Immune Aplastic Anemia Imputed from Single Cell Analysis of Peripheral Cell Subsets

Allogeneic Hematopoietic Cell Transplantation in Adult Acute Myeloid Leukemia with t(16;21)(p11;q22)

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Characterization of Hematopoietic Stem and Progenitor Cells of PNH Patients Using Single-Cell RNA Sequencing Analysis

Single-Cell Dissection Reveals a Distinct Origin of Small Paroxysmal Nocturnal Hemoglobinuria Clones in Immune Aplastic Anemia and Healthy Individuals

Megakaryocytes Have Immune Characteristics in Murine Immune Bone Marrow Failure

Clinical Significance of a Miniscule GPI(-) Granulocyte Population in Patients with Bone Marrow Failure

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Minor GPI(-) Granulocyte Populations in Patients with Acquired Aplastic Anemia and Healthy Individuals Are Derived from a Few Piga -Mutated Hematopoietic Stem Progenitor Cells

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Distinct Escape Mechanisms of HLA Class I Allele-Lacking Hematopoietic Stem Progenitor Cells (HSPCs) from GPI-Deficient HSPCs in Acquired Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Identification of T-Cell Receptors Specific to Antigens Presented By HLA-B4002 and B5401 in Acquired Aplastic Anemia

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

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American Society of Hematology

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American Society of Hematology

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