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Journal Articles

Different Effects of Selective Janus Kinase (JAK) Inhibitors in Murine Bone Marrow Failure

Jibran Durrani, Xingmin Feng, Joshua Glass, Zhijie Wu, Shouguo Gao, Bhavisha A. Patel, Jichun Chen, Neal S. Young, Emma M. Groarke

Blood (2024) 144 (Supplement 1): 1309.

https://doi.org/10.1182/blood-2024-193762

Published: 2024

Journal Articles

CSF1 Receptor Inhibition Augments Murine Immune Bone Marrow Failure: New Evidence Indicative of M1-Type Macrophage Polarization Driving Hematopoietic Failure

Joshua Glass, Xingmin Feng, Jichun Chen, Neal S. Young

Blood (2024) 144 (Supplement 1): 1308.

https://doi.org/10.1182/blood-2024-193143

Published: 2024

Journal Articles

Trial in Progress: A Phase I/II Study of the JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Emma M. Groarke, Jennifer Lotter, Ivana Darden, Alfiya Bikineyeva, Uzoamaka Okeke, Rachel Blair, Julie Erb-Alvarez, Jichun Chen, Xingmin Feng, Jibran Durrani, Neal S. Young, Bhavisha A. Patel

Blood (2024) 144 (Supplement 1): 1323.1.

https://doi.org/10.1182/blood-2024-199789

Published: 2024

Journal Articles

Megakaryocytes Have Immune Characteristics in Murine Immune Bone Marrow Failure

Ashvind Prabahran, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Hiroki Mizumaki, Christian Combs, Jichun Chen, Xingmin Feng, Neal S. Young

Blood (2023) 142 (Supplement 1): 1349.

https://doi.org/10.1182/blood-2023-174597

Published: 2023

Journal Articles

Efficacy of JAK1/2 inhibition in murine immune bone marrow failure

Emma M. Groarke, Xingmin Feng, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Bhavisha A. Patel, Jichun Chen, Neal S. Young

Blood (2023) 141 (1): 72–89.

https://doi.org/10.1182/blood.2022015898

Published: 2023

Includes: Supplemental data

Journal Articles

JAK 1/2 Inhibition Preserves Hematopoietic Progenitor and Stem Cells, Prevents Aplasia, Inhibits Pro-Inflammatory Cytokines, and Prolongs Survival in Murine Immune Bone Marrow Failure

Emma M. Groarke, Xingmin Feng, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Bhavisha A. Patel, Jichun Chen, Neal S. Young

Blood (2022) 140 (Supplement 1): 471–472.

https://doi.org/10.1182/blood-2022-159733

Published: 2022

Journal Articles

Ruxolitinib Stimulates Expansion of Regulatory T Cells in Murine Immune Bone Marrow Failure

Nidhi Aggarwal, Ash Lee Manley, Jichun Chen, Emma M. Groarke, Xingmin Feng, Neal S. Young

Blood (2022) 140 (Supplement 1): 5786–5787.

https://doi.org/10.1182/blood-2022-157206

Published: 2022

Journal Articles

Granulocytic Myeloid-Derived Suppressor Cells in Murine Models of Immune-Mediated Bone Marrow Failure

Xingmin Feng, Jisoo Kim, Gladys Gonzalez Matias, Zhijie Wu, Sabrina Solorzano, Sai Batchu, Shouguo Gao, Jichun Chen, Neal S. Young

Blood (2021) 138 (Supplement 1): 2176.

https://doi.org/10.1182/blood-2021-148467

Published: 2021

Journal Articles

Comparative Single Cell Transcriptomic Analysis of the Hematopoietic System between Human and Mouse

Shouguo Gao, PhD, Zhijie Wu, MD, Xingmin Feng, PhD, Jichun Chen, PhD, Sachiko Kajigaya, PhD, Neal S. Young, MD

Blood (2019) 134 (Supplement_1): 3706.

https://doi.org/10.1182/blood-2019-123204

Published: 2019

Journal Articles

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia

Wanling Sun, Zhijie Wu, Zenghua Lin, Maile Hollinger, Jichun Chen, Xingmin Feng, Neal S. Young

Blood (2018) 132 (26): 2730–2743.

https://doi.org/10.1182/blood-2018-05-844928

Published: 2018

Includes: Supplemental data

Journal Articles

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

Xingmin Feng, PhD, Zenghua Lin, MD, Maile K. Hollinger, BA, Wanling Sun, MD PhD, Zhijie Wu, MD PhD, Kaylind Batey, BS, Keyvan Keyvanfar, BS, Jichun Chen, PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 1310.

https://doi.org/10.1182/blood-2018-99-113488

Published: 2018

Journal Articles

Tumor Necrosis Factor-α in Target Cells but Not in Effector Cells Plays Critical Roles in Development of Murine Immune-Mediated Bone Marrow Failure

Xingmin Feng, PhD, Wanling Sun, MD PhD, Zhijie Wu, MD PhD, Zenghua Lin, MD, Maile K Hollinger, BA, Jichun Chen, PhD, Neal S. Young, MD

Blood (2017) 130 (Supplement 1): 778.

https://doi.org/10.1182/blood.V130.Suppl_1.778.778

Published: 2017

Journal Articles

T Cells Trafficking to Bone Marrow Have Different Characteristics from Those to Other Organs in an Immune-Mediated Bone Marrow Failure Mouse Model

Zenghua Lin, MD, Xingmin Feng, PhD, Wanling Sun, MD PhD, Zhijie Wu, MD PhD, Maile K Hollinger, BA, Jichun Chen, PhD, Hong Liu, MD PhD, Neal S. Young, MD

Blood (2017) 130 (Supplement 1): 2455.

https://doi.org/10.1182/blood.V130.Suppl_1.2455.2455

Published: 2017

Journal Articles

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

Jichun Chen, Xingmin Feng, Marie J. Desierto, Keyvan Keyvanfar, Neal S. Young

Blood (2015) 126 (24): 2621–2631.

https://doi.org/10.1182/blood-2015-06-652453

Published: 2015

Includes: Supplemental data

Journal Articles

Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine

Xingmin Feng, PhD, Zenghua Lin, MD PhD, Marie Desierto, Keyvan Keyvanfar, BS, Daniela Malide, PhD, Jichun Chen, PhD, Neal S. Young, MD

Blood (2015) 126 (23): 1202.

https://doi.org/10.1182/blood.V126.23.1202.1202

Published: 2015

Journal Articles

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Pawel Muranski, MD, Xingmin Feng, PhD, Keyvan Keyvanfar, BS, Danielle M. Townsley, MD, Bogdan Dumitriu, MD, Jichun Chen, PhD, Sachiko Kajigaya, PhD, James G. Taylor, MD, Christopher S. Hourigan, MD PhD, John Barrett, MD, Neal S. Young, MD

Blood (2014) 124 (21): 2940.

https://doi.org/10.1182/blood.V124.21.2940.2940

Published: 2014

Journal Articles

Adipocytes and Aplastic Anemia: Peroxisome Proliferator-Activated Receptor-γ (PPAR- γ) Antagonists Attenuate Bone Marrow Failure in an Aplastic Anemia Mouse Model but Not in Radiation Marrow Destruction

Kazuya Sato, MD, PhD, Xingmin Feng, PhD, Jichun Chen, PhD, Marie J. Desierto, Keyvan Keyvanfar, Daniela Malide, PhD, Sachiko Kajigaya, PhD, Neal S. Young, MD

Blood (2012) 120 (21): 3483.

https://doi.org/10.1182/blood.V120.21.3483.3483

Published: 2012

Journal Articles

Hematological Abnormalities in Aged Telomerase RNA Component Deficient Mice Are Associated with Intestinal Epithelial Degeneration and Bone Marrow Stromal Dysfunction

Jichun Chen, PhD, James J. Dent, BS, Marie J. Desierto, Mark A. Bryant, DVM, Nolan Sheppard, BA, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2012) 120 (21): 1244.

https://doi.org/10.1182/blood.V120.21.1244.1244

Published: 2012

Journal Articles

Androgen Treatment Mitigates Hematopoietic Cell Telomere Attrition In Vivo

Jichun Chen, PhD, Marie J. Desierto, James J. Dent, BS, Maria J. Bachman, BS, Rodrigo T. Calado, MD, PhD, Constantine A. Stratakis, MD, Neal S. Young, MD

Blood (2012) 120 (21): 516.

https://doi.org/10.1182/blood.V120.21.516.516

Published: 2012

Journal Articles

The NSG – Human CLL Xenograft Model Recapitulates the Human Lymph Node Microenvironment in Regards to B-Cell Activation and Tumor Proliferation

Xiameng Sun, BS, Sarah E. M. Herman, PhD, Matthew M. Hsieh, MD, John F. Tisdale, Jichun Chen, PhD, Georg Aue, M.D., Patricia Perez-Galan, PhD, Adrian Wiestner, MD, PhD

Blood (2011) 118 (21): 973.

https://doi.org/10.1182/blood.V118.21.973.973

Published: 2011

NARROW

Different Effects of Selective Janus Kinase (JAK) Inhibitors in Murine Bone Marrow Failure

CSF1 Receptor Inhibition Augments Murine Immune Bone Marrow Failure: New Evidence Indicative of M1-Type Macrophage Polarization Driving Hematopoietic Failure

Trial in Progress: A Phase I/II Study of the JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure

Megakaryocytes Have Immune Characteristics in Murine Immune Bone Marrow Failure

Efficacy of JAK1/2 inhibition in murine immune bone marrow failure

JAK 1/2 Inhibition Preserves Hematopoietic Progenitor and Stem Cells, Prevents Aplasia, Inhibits Pro-Inflammatory Cytokines, and Prolongs Survival in Murine Immune Bone Marrow Failure

Ruxolitinib Stimulates Expansion of Regulatory T Cells in Murine Immune Bone Marrow Failure

Granulocytic Myeloid-Derived Suppressor Cells in Murine Models of Immune-Mediated Bone Marrow Failure

Comparative Single Cell Transcriptomic Analysis of the Hematopoietic System between Human and Mouse

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

Tumor Necrosis Factor-α in Target Cells but Not in Effector Cells Plays Critical Roles in Development of Murine Immune-Mediated Bone Marrow Failure

T Cells Trafficking to Bone Marrow Have Different Characteristics from Those to Other Organs in an Immune-Mediated Bone Marrow Failure Mouse Model

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine

Altered microRNAs in T Cells from Patients with Acquired Aplastic Anemia

Adipocytes and Aplastic Anemia: Peroxisome Proliferator-Activated Receptor-γ (PPAR- γ) Antagonists Attenuate Bone Marrow Failure in an Aplastic Anemia Mouse Model but Not in Radiation Marrow Destruction

Hematological Abnormalities in Aged Telomerase RNA Component Deficient Mice Are Associated with Intestinal Epithelial Degeneration and Bone Marrow Stromal Dysfunction

Androgen Treatment Mitigates Hematopoietic Cell Telomere Attrition In Vivo

The NSG – Human CLL Xenograft Model Recapitulates the Human Lymph Node Microenvironment in Regards to B-Cell Activation and Tumor Proliferation

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American Society of Hematology

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American Society of Hematology

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