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Journal Articles

Unraveling CAR Differentiation Dynamics through in Vitro and in silico Perturbations

Wenjun Zhu, Conor Kelly, Keyvan Keyvanfar, Pradeep Dagur, Stefan Cordes

Blood (2024) 144 (Supplement 1): 3616.

https://doi.org/10.1182/blood-2024-211536

Published: 2024

Journal Articles

Optimizing CAR Costimulatory Domains Using Contrastive Learning and Optimal Transport on High-Throughput Screening Data

Conor Kelly, Wenjun Zhu, Keyvan Keyvanfar, Pradeep Dagur, Stefan Cordes

Blood (2024) 144 (Supplement 1): 2048.

https://doi.org/10.1182/blood-2024-211466

Published: 2024

Journal Articles

BTK inhibitors, irrespective of ITK inhibition, increase efficacy of a CD19/CD3-bispecific antibody in CLL

Maissa Mhibik, Erika M. Gaglione, David Eik, Ellen K. Kendall, Amy Blackburn, Keyvan Keyvanfar, Maria Joao Baptista, Inhye E. Ahn, Clare Sun, Junpeng Qi, Christoph Rader, Adrian Wiestner

Blood (2021) 138 (19): 1843–1854.

https://doi.org/10.1182/blood.2020009686

Published: 2021

Includes: Supplemental data

Journal Articles

Gene Delivery Using Baculovirus in Human Hematopoietic Stem and Progenitor Cells Requires Inhibition of Cellular Innate Immune Pathways

Christi Salisbury-Ruf, Richard H. Smith, Fariba Chinian, Daisuke Araki, Keyvan Keyvanfar, Andre Larochelle

Blood (2021) 138 (Supplement 1): 2940.

https://doi.org/10.1182/blood-2021-148825

Published: 2021

Journal Articles

Administration of Granulocyte Colony-Stimulating Factor Post-Transplant Impedes Engraftment of CRISPR-Cas9 Edited Long-Term Repopulating Hematopoietic Stem and Progenitor Cells

Daisuke Araki, Christi Salisbury-Ruf, Waleed Hakami, Keyvan Keyvanfar, Richard H. Smith, Andre Larochelle

Blood (2021) 138 (Supplement 1): 2936.

https://doi.org/10.1182/blood-2021-147352

Published: 2021

Journal Articles

Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib Show Expansion of T-Cell Clonotypes Composed of Antitumor Cytotoxic CD8+ T-Cells

Maria Joao Baptista, PhD PharmD, Sivasubramanian Baskar, Keyvan Keyvanfar, Erika M Gaglione, Inhye E Ahn, MD, Adrian Wiestner, MD PhD, Clare Sun, MD

Blood (2019) 134 (Supplement_1): 3030.

https://doi.org/10.1182/blood-2019-127131

Published: 2019

Journal Articles

A CD19/CD3 Bispecific Antibody Induces Superior T Cell Responses Against Chronic Lymphocytic Leukemia When Combined with Ibrutinib

Maissa Mhibik, PhD, Erika M Gaglione, Amy Blackburn, Keyvan Keyvanfar, Clare Sun, MD, Inhye E Ahn, MD, Maria Joao Baptista, Junpeng Qi, PhD, Christoph Rader, PhD, Adrian Wiestner, MD PhD

Blood (2019) 134 (Supplement_1): 2861.

https://doi.org/10.1182/blood-2019-126186

Published: 2019

Journal Articles

Eltrombopag Improves Erythroid Differentiation in a Human iPSC Model of Diamond Blackfan Anemia

Husam Qanash, MSc, Kaari Linask, Jeanette Beers, Keyvan Keyvanfar, Sara Young-Baird, Waleed Hakami, Richard H. Smith, Jizhong Zou, Andre Larochelle, MD PhD

Blood (2019) 134 (Supplement_1): 1214.

https://doi.org/10.1182/blood-2019-121822

Published: 2019

Journal Articles

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

Xingmin Feng, PhD, Zenghua Lin, MD, Maile K. Hollinger, BA, Wanling Sun, MD PhD, Zhijie Wu, MD PhD, Kaylind Batey, BS, Keyvan Keyvanfar, BS, Jichun Chen, PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 1310.

https://doi.org/10.1182/blood-2018-99-113488

Published: 2018

Journal Articles

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era

Hannah R. Robinson, Junpeng Qi, Erika M. Cook, Cydney Nichols, Eman L. Dadashian, Chingiz Underbayev, Sarah E. M. Herman, Nakhle S. Saba, Keyvan Keyvanfar, Clare Sun, Inhye E. Ahn, Sivasubramanian Baskar, Christoph Rader, Adrian Wiestner

Blood (2018) 132 (5): 521–532.

https://doi.org/10.1182/blood-2018-02-830992

Published: 2018

Includes: Supplemental data

Journal Articles

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

Xin Zhao, Shouguo Gao, Zhijie Wu, Sachiko Kajigaya, Xingmin Feng, Qingguo Liu, Danielle M. Townsley, James Cooper, Jinguo Chen, Keyvan Keyvanfar, Maria del Pilar Fernandez Ibanez, Xujing Wang, Neal S. Young

Blood (2017) 130 (25): 2762–2773.

https://doi.org/10.1182/blood-2017-08-803353

Published: 2017

Includes: Supplemental data

Journal Articles

PD-1 Is Not a Reliable Marker of Impending Relapse after Allogeneic Stem Cell Transplantation

Prachi Jain, MD, Xin Tian, PhD, Jinguo Chen, MD, Caroline R Cantilena, Christian Bradley, Reema Panjwani, BS, Keyvan Keyvanfar, Fariba Chinian, MS, Eleftheria Koklanaris, RN, Jeanine Superata, RN, Sara Hauffe, RN, Minoo Battiwalla, MD, A John Barrett, MD, Sawa Ito, MD

Blood (2017) 130 (Supplement 1): 4509.

https://doi.org/10.1182/blood.V130.Suppl_1.4509.4509

Published: 2017

Journal Articles

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

Zhijie Wu, MD, Xin Zhao, MD PhD, Lauren G. Banaszak, BS, Keyvan Keyvanfar, BS, Sachiko Kajigaya, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1529.

https://doi.org/10.1182/blood.V128.22.1529.1529

Published: 2016

Journal Articles

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Kohei Hosokawa, MDPhD, Sachiko Kajigaya, PhD, Keyvan Keyvanfar, BS, Qiao Wangmin, BS, Yanling Xie, MS, Olga Rios, RN, Barbara Weinstein, RN, Maria del Pilar Fernandez Ibanez, BS, Danielle M. Townsley, MD, Xingmin Feng, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 1042.

https://doi.org/10.1182/blood.V128.22.1042.1042

Published: 2016

Journal Articles

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Fernanda Gutierrez-Rodrigues, MSc, PharmD, Sachiko Kajigaya, PhD, Xingmin Feng, PhD, Maria del Pilar Fernandez Ibanez, MS, Marie J. Desierto, BS, Keyvan Keyvanfar, BS, Zejuan Li, MD PhD, Soma Das, PhD, Rodrigo T. Calado, MD PhD, Danielle M. Townsley, MD, Neal S. Young

Blood (2016) 128 (22): 1044.

https://doi.org/10.1182/blood.V128.22.1044.1044

Published: 2016

Journal Articles

Oligoclonal Expansion of Effector Memory CD8+CD57+ T Cells May Sustain Bone Marrow Destruction in Aplastic Anemia

Valentina Giudice, MD, Xingmin Feng, PhD, Lin Zenghua, MD, Maria del Pilar Fernandez Ibanez, MS, Keyvan Keyvanfar, BS, Carmine Selleri, MD, Neal S. Young, MD

Blood (2016) 128 (22): 3898.

https://doi.org/10.1182/blood.V128.22.3898.3898

Published: 2016

Journal Articles

Clofarabine Followed By Lenalidomide for Treatment of High Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia- Preliminary Clinical Outcomes and Potential Immune-Modulating Effects

Prachi Jain, MD, Sawa Ito, MD PhD, Neil Dunavin, MD, Jeffrey K. Klotz, MD, Kit Lu, MD, Eleftheria Koklanaris, RN, BSN, Debbie Draper, RN, BSN, Jeanine Superata, RN, Fariba Chinian, Quan Yu, MS, Keyvan Keyvanfar, BS, Susan Wong, Pawel Muranski, MD, John Barrett, MD, Minoo Battiwalla, MDMS

Blood (2016) 128 (22): 5553.

https://doi.org/10.1182/blood.V128.22.5553.5553

Published: 2016

Journal Articles

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xin Zhao, MD PhD, Shouguo Gao, PhD, Xingmin Feng, PhD, Delong Liu, PhD, Sachiko Kajigaya, PhD, Zhijie Wu, MD, Qingguo Liu, MD, Keyvan Keyvanfar, BS, Marie J. Desierto, BS, Danielle M. Townsley, MD, Xujing Wang, PhD, Neal S. Young, MD

Blood (2016) 128 (22): 574.

https://doi.org/10.1182/blood.V128.22.574.574

Published: 2016

Journal Articles

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

Lauren G. Banaszak, BS, Valentina Giudice, MD, Xin Zhao, MD PhD, Zhijie Wu, MD, Kohei Hosokawa, MD PhD, Keyvan Keyvanfar, BS, Danielle Townsley, MD, Sachiko Kajigaya, PhD, Neal S. Young

Blood (2016) 128 (22): 2704.

https://doi.org/10.1182/blood.V128.22.2704.2704

Published: 2016

Journal Articles

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

Jichun Chen, Xingmin Feng, Marie J. Desierto, Keyvan Keyvanfar, Neal S. Young

Blood (2015) 126 (24): 2621–2631.

https://doi.org/10.1182/blood-2015-06-652453

Published: 2015

Includes: Supplemental data

NARROW

Unraveling CAR Differentiation Dynamics through in Vitro and in silico Perturbations

Optimizing CAR Costimulatory Domains Using Contrastive Learning and Optimal Transport on High-Throughput Screening Data

BTK inhibitors, irrespective of ITK inhibition, increase efficacy of a CD19/CD3-bispecific antibody in CLL

Gene Delivery Using Baculovirus in Human Hematopoietic Stem and Progenitor Cells Requires Inhibition of Cellular Innate Immune Pathways

Administration of Granulocyte Colony-Stimulating Factor Post-Transplant Impedes Engraftment of CRISPR-Cas9 Edited Long-Term Repopulating Hematopoietic Stem and Progenitor Cells

Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib Show Expansion of T-Cell Clonotypes Composed of Antitumor Cytotoxic CD8+ T-Cells

A CD19/CD3 Bispecific Antibody Induces Superior T Cell Responses Against Chronic Lymphocytic Leukemia When Combined with Ibrutinib

Eltrombopag Improves Erythroid Differentiation in a Human iPSC Model of Diamond Blackfan Anemia

Sirolimus Augments Hematopoietic Stem and Progenitor Cell Recovery from Hematopoietic Stress

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

PD-1 Is Not a Reliable Marker of Impending Relapse after Allogeneic Stem Cell Transplantation

Crispr/Cas9-Mediated ASXL1 knockout in U937 Human Leukemic Cells Perturbs Myeloid Differentiation

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening

Oligoclonal Expansion of Effector Memory CD8+CD57+ T Cells May Sustain Bone Marrow Destruction in Aplastic Anemia

Clofarabine Followed By Lenalidomide for Treatment of High Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia- Preliminary Clinical Outcomes and Potential Immune-Modulating Effects

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Crispr/Cas9-Induced DNMT3A Mutations in the K562 Human Leukemic Cell Line As a Model of DNMT3A -Mutated Leukemogenesis

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

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American Society of Hematology

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American Society of Hematology

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