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Sarah E. M. Herman
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Journal Articles

NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts

Deyi Zhang, Hailey M. Harris, Jonathan Chen, Jen Judy, Gabriella James, Aileen Kelly, Joel McIntosh, Austin Tenn-McClellan, Eileen Ambing, Ying Siow Tan, Hao Lu, Stefan Gajewski, Matthew C. Clifton, Stephanie Yung, Daniel W. Robbins, Mehdi Pirooznia, Sigrid S. Skånland, Erika Gaglione, Maissa Mhibik, Chingiz Underbayev, Inhye E. Ahn, Clare Sun, Sarah E. M. Herman, Mark Noviski, Adrian Wiestner
Journal: Blood
Blood (2023) 141 (13): 1584–1596.
https://doi.org/10.1182/blood.2022016934
Published: 2023
Includes: Supplemental data
Journal Articles

Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib

Clinical Trials & Observations
Clare Sun, Pia Nierman, Ellen K. Kendall, Jean Cheung, Michael Gulrajani, Sarah E. M. Herman, Christopher Pleyer, Inhye E. Ahn, Maryalice Stetler-Stevenson, Constance M. Yuan, Irina Maric, Erika M. Gaglione, Hailey M. Harris, Stefania Pittaluga, Min Hui Wang, Priti Patel, Mohammed Z. H. Farooqui, Raquel Izumi, Ahmed Hamdy, Todd Covey, Adrian Wiestner
Journal: Blood
Blood (2020) 136 (1): 93–105.
https://doi.org/10.1182/blood.2019003715
Published: 2020
Includes: Supplemental data
Journal Articles

Whole Exome Sequencing Reveals Multiple Driver Events in Chronic Lymphocytic Leukemia Patients with Acquired Ibrutinib Resistance

Chingiz Underbayev, MD PhD, Inhye E Ahn, MD, Hailey Harris, Lauren T Vaughn, Mehdi Pirooznia, MD PhD, Liqiang Xi, MD, Mark Raffeld, MD, Sarah E. M. Herman, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1287.
https://doi.org/10.1182/blood-2019-127364
Published: 2019
Journal Articles

Highly Potent BTK Degradation Induced By NRX0492 As a Therapeutic Strategy for CLL

Deyi Zhang, PhD, Hailey Harris, Aileen Kelly, PhD, Daniel W Robbins, May Tan, Timothy Ingallinera, Neil Bence, Arthur T Sands, Sivasubramanian Baskar, Sarah E. M. Herman, Adrian Wiestner, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 174.
https://doi.org/10.1182/blood-2019-126921
Published: 2019
Journal Articles

Risk-Adapted, Ofatumumab-Based Chemoimmunotherapy and Maintenance in Treatment-Naïve CLL: A Phase II Study

Sanjal Desai, MD, Dennis Drinkwater, Clifton Craig Mo, MD, Mohammed ZH Farooqui, Susan Soto, Janet Valdez, Erika M Gaglione, Xin Tian, Pia Nierman, Jennifer Lotter, PA-C, Gerald Marti, Cydney Nichols, BS, Alankrita Taneja, MD, Sarah E. M. Herman, PhD, Irina Maric, MD MSci, Laura M Wake, MD, Maryalice Stetler-Stevenson, MD PhD, Constance M. Yuan, MD PhD, Tom Hughes, Pharm.D., Margaret A. Lindorfer, Ronald P. Taylor, Adrian Wiestner, MD PhD, Inhye E Ahn, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5474.
https://doi.org/10.1182/blood-2019-126698
Published: 2019
Journal Articles

Ibrutinib Increases the Clonality of TCR Repertoire in Patients with Chronic Lymphocytic Leukemia

Maria Joao Baptista, PhD PharmD, Neil Basumallik, Sarah E. M. Herman, PhD, Erika M. Cook, Inhye E. Ahn, MD, Adrian Wiestner, MD, Clare C. Sun, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 238.
https://doi.org/10.1182/blood-2018-99-109847
Published: 2018
Journal Articles

Validation of Clinical Prognostic Models and Integration of Genetic Biomarkers of Drug Resistance in CLL Patients Treated with Ibrutinib

Inhye E. Ahn, MD, Xin Tian, Maher Albitar, MD, Sarah E. M. Herman, PhD, Erika M. Cook, Susan Soto, Wanlong Ma, David Ipe, L. Claire Tsao, Mei Cheng, James P. Dean, Adrian Wiestner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 186.
https://doi.org/10.1182/blood-2018-99-110326
Published: 2018
Journal Articles

Acalabrutinib in Patients with Relapsed/Refractory (R/R) and High-Risk, Treatment-Naive (TN) Chronic Lymphocytic Leukemia (CLL)

Clare C. Sun, MD, Pia Nierman, RN, Inhye E. Ahn, MD, Janet Valdez, Jennifer Lotter, Susan Soto, Sarah E. M. Herman, PhD, Todd Covey, PhD, Ahmed Hamdy, MD, Raquel Izumi, PhD, Dongmei Liu, PhD, Priti Patel, MD, Adrian Wiestner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4424.
https://doi.org/10.1182/blood-2018-99-110395
Published: 2018
Journal Articles

Variable Bruton Tyrosine Kinase (BTK) Resynthesis across Patients with Chronic Lymphocytic Leukemia (CLL) on Acalabrutinib Therapy Affect Target Occupancy and Reactivation of B-Cell Receptor (BCR) Signaling

Anfal A. Alsadhan, Jean Cheung, Michael Gulrajani, Erika M. Cook, Stefania Pittaluga, MD PhD, Theresa Davies-Hill, Raquel Izumi, PhD, Clare C. Sun, MD, Todd Covey, PhD, Adrian Wiestner, MD, Sarah E. M. Herman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4401.
https://doi.org/10.1182/blood-2018-99-110391
Published: 2018
Journal Articles

Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling

Lili Wang, MDPhD, Shanye Yin, PhD, Aina zurita Martinez, Fara Faye Regis, BS, Angela Brooks, PhD, Sarah E. M. Herman, PhD, Elisa Ten Hacken, PhD, Esther Obeng, MD PhD, Dean Campagna, BS, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MDPhD, Adrian Wiestner, MD, Ignaty Leshchiner, PhD, Gad Getz, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 947.
https://doi.org/10.1182/blood-2018-99-117691
Published: 2018
Journal Articles

Durable Responses to Single-Agent Ibrutinib in Monoallelic—but Not in Biallelic— TP53 Aberrated Patients with Chronic Lymphocytic Leukemia

Christian Brieghel, Inhye E. Ahn, MD, Sarah E. M. Herman, PhD, Adrian Wiestner, MD, Carsten Utoft Niemann
Journal: Blood
Blood (2018) 132 (Supplement 1): 3111.
https://doi.org/10.1182/blood-2018-99-114472
Published: 2018
Journal Articles

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era

Hannah R. Robinson, Junpeng Qi, Erika M. Cook, Cydney Nichols, Eman L. Dadashian, Chingiz Underbayev, Sarah E. M. Herman, Nakhle S. Saba, Keyvan Keyvanfar, Clare Sun, Inhye E. Ahn, Sivasubramanian Baskar, Christoph Rader, Adrian Wiestner
Journal: Blood
Blood (2018) 132 (5): 521–532.
https://doi.org/10.1182/blood-2018-02-830992
Published: 2018
Includes: Supplemental data
Journal Articles

Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study

Inhye E. Ahn, Mohammed Z. H. Farooqui, Xin Tian, Janet Valdez, Clare Sun, Susan Soto, Jennifer Lotter, Stephanie Housel, Maryalice Stetler-Stevenson, Constance M. Yuan, Irina Maric, Katherine R. Calvo, Pia Nierman, Thomas E. Hughes, Nakhle S. Saba, Gerald E. Marti, Stefania Pittaluga, Sarah E. M. Herman, Carsten U. Niemann, Lone B. Pedersen, Christian H. Geisler, Richard Childs, Georg Aue, Adrian Wiestner
Journal: Blood
Blood (2018) 131 (21): 2357–2366.
https://doi.org/10.1182/blood-2017-12-820910
Published: 2018
Includes: Supplemental data
Journal Articles

The future of kinase inhibitors for DLBCL?

Sarah E. M. Herman
Journal: Blood
Blood (2018) 131 (21): 2278–2280.
https://doi.org/10.1182/blood-2018-04-841908
Published: 2018
Journal Articles

Serum B-Cell Maturation Antigen As a Biomarker for Chronic Lymphocytic Leukemia Treated with Ibrutinib

Clare Sun, MD, Camilia Soof, BS, Alankrita Taneja, MD, Sarah E. M. Herman, PhD, Erika Cook, BA, Kyle Udd, BA, Haiming Chen, MD PhD, Eric Sanchez, BA, Xin Tian, PhD, Inhye E. Ahn, MD, James R Berenson, MD, Adrian Wiestner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4031.
https://doi.org/10.1182/blood.V130.Suppl_1.4031.4031
Published: 2017
Journal Articles

Transcriptome Analysis of the Lymph Node Microenvironment in Chronic Lymphocytic Leukemia

Clare Sun, MD, Delong Liu, PhD, Nakhle S. Saba, MD, Sarah E. M. Herman, PhD, Mehdi Pirooznia, MD PhD, Adrian Wiestner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1718.
https://doi.org/10.1182/blood.V130.Suppl_1.1718.1718
Published: 2017
Journal Articles

Activity of CD19/CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia

Hannah R. Robinson, BA, Junpeng Qi, PhD, Sivasubramanian Baskar, PhD, Erika Cook, BA, Inhye E. Ahn, MD, Sarah E. M. Herman, PhD, Christoph Rader, PhD, Adrian Wiestner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 799.
https://doi.org/10.1182/blood.V130.Suppl_1.799.799
Published: 2017
Journal Articles

Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia

Inhye E. Ahn, Chingiz Underbayev, Adam Albitar, Sarah E. M. Herman, Xin Tian, Irina Maric, Diane C. Arthur, Laura Wake, Stefania Pittaluga, Constance M. Yuan, Maryalice Stetler-Stevenson, Susan Soto, Janet Valdez, Pia Nierman, Jennifer Lotter, Liqiang Xi, Mark Raffeld, Mohammed Farooqui, Maher Albitar, Adrian Wiestner
Journal: Blood
Blood (2017) 129 (11): 1469–1479.
https://doi.org/10.1182/blood-2016-06-719294
Published: 2017
Includes: Supplemental data
Journal Articles

The Landscape of Dynamic Genetic Changes in Ibrutinib-Treated CLL

Dan A. Landau, MD PhD, Clare Sun, MD, Daniel Rosebrock, Mariela Campbell, Sarah E. M. Herman, PhD, Julia Hoellenriegel, MS, Mohammed Farooqui, Wandi Zhang, MD, Donna S. Neuberg, ScD, Dimitri Livitz, Ignaty Leshchiner, Gad Getz, PhD, Jan Burger, MD PhD, Adrian Wiestner, MD PhD, Catherine J Wu, MD
Journal: Blood
Blood (2016) 128 (22): 188.
https://doi.org/10.1182/blood.V128.22.188.188
Published: 2016
Journal Articles

Dynamic Alterations in Gene Expression in Ibrutinib Treated CLL Reveal Profound Impact on Multiple Signaling Pathways

Sarah E. M. Herman, PhD, Delong Liu, PhD, Dan A. Landau, MD PhD, Clare Sun, MD, Mohammed Farooqui, Catherine J Wu, MD, Adrian Wiestner, MDPhD
Journal: Blood
Blood (2016) 128 (22): 189.
https://doi.org/10.1182/blood.V128.22.189.189
Published: 2016