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Journal Articles

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Shigeki Hirabayashi, June Takeda, Kyoko Fukushi, Momoka Tsuruhara, Jumpei Nogami, Yuichiro Semba, Shoko Tarumoto, Ami Kamano, Moe Shinagawa, Daisuke Ishihara, Yuta Kikuchi, Kohta Miyawaki, Koichi Akashi, Takuya Yamamoto, Masahito Ohue, Masataka Ishimura, Kenichi Yoshida, Taro Tsujimura, Takahiro Maeda

Blood (2025) 146 (Supplement 1): 3215.

https://doi.org/10.1182/blood-2025-3215

Published: 2025

Journal Articles

Clonal evolution and therapeutic vulnerabilities in SETBP1-mutated leukemia: Insights from physiological mouse model and integrative functional screens

Blood (2025) 146 (Supplement 1): 989.

https://doi.org/10.1182/blood-2025-989

Published: 2025

Journal Articles

Targeting metabolic vulnerabilities in Acute Myeloid Leukemia: Therapeutic potential of l-asparaginase and synergy with venetoclax

Blood (2025) 146 (Supplement 1): 3283.

https://doi.org/10.1182/blood-2025-3283

Published: 2025

Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single-Cell Multi-Omics Sequencing

Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Ayana Kon, Masanori Motomura, Yotaro Ochi, Lanying Zhao, Koji Okazaki, June Takeda, Xingxing Qi, Akinori Yoda, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa

Blood (2024) 144 (Supplement 1): 5630.

https://doi.org/10.1182/blood-2024-210050

Published: 2024

Journal Articles

Prognostic Impact of Chromosomal Abnormalities in TP53 -Mutated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Blood (2023) 142 (Supplement 1): 4328.

https://doi.org/10.1182/blood-2023-180291

Published: 2023

Journal Articles

Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia

Fumiya Wada, Shoya Kato, Shruti Bhagat, Shigeki Hirabayashi, Raku Son, Akiko Oguchi, Kazuhiro Takeuchi, Sho Sekito, Tomoya Hirai, Zhiwei Zhang, Yoshihito Horisawa, Makoto Iwasaki, June Takeda, Junya Kanda, Takashi Sakamoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, Yasuhiro Murakawa

Blood (2023) 142 (Supplement 1): 1583.

https://doi.org/10.1182/blood-2023-188008

Published: 2023

Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa

Blood (2023) 141 (5): 534–549.

https://doi.org/10.1182/blood.2022018221

Published: 2023

Includes: Supplemental data

Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa

Blood (2022) 140 (Supplement 1): 2881–2882.

https://doi.org/10.1182/blood-2022-168149

Published: 2022

Journal Articles

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Blood (2022) 140 (Supplement 1): 4022–4023.

https://doi.org/10.1182/blood-2022-158748

Published: 2022

Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa

Blood (2022) 140 (Supplement 1): 208–210.

https://doi.org/10.1182/blood-2022-158851

Published: 2022

Journal Articles

CTX-712, a Novel Splicing Modulator Targeting Myeloid Neoplasms

Akinori Yoda, Daisuke Morishita, Yotaro Ochi, Akio Mizutani, Takuto Mori, June Takeda, Hirokazu Tozaki, Yoshihiko Satoh, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake, Seishi Ogawa

Blood (2022) 140 (Supplement 1): 489–490.

https://doi.org/10.1182/blood-2022-159338

Published: 2022

Journal Articles

Der(1;7)(q10;p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms

Blood (2021) 138 (Supplement 1): 1513.

https://doi.org/10.1182/blood-2021-149556

Published: 2021

Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Blood (2021) 138 (Supplement 1): 1092.

https://doi.org/10.1182/blood-2021-152219

Published: 2021

Journal Articles

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

Blood (2021) 138 (Supplement 1): 610.

https://doi.org/10.1182/blood-2021-152800

Published: 2021

Journal Articles

CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation

Akinori Yoda, Daisuke Morishita, Yotaro Ochi, Akio Mizutani, June Takeda, Hirokazu Tozaki, Yoshihiko Satoh, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake, Seishi Ogawa

Blood (2021) 138 (Supplement 1): 205.

https://doi.org/10.1182/blood-2021-148205

Published: 2021

Journal Articles

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-134648

Published: 2020

Journal Articles

Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Hideki Makishima, MD PhD, Yasuhito Nannya, MD PhD, June Takeda, MD, Yukihide Momozawa, DVM,PhD, Ryunosuke Saiki, MD, Tetsuichi Yoshizato, MD PhD, Yoshiko Atsuta, MD PhD, Yuka Iijima-Yamashita, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD PhD, Yusuke Shiozawa, MD PhD, Makoto Onizuka, MD PhD, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, MD, Yotaro Ochi, MD, Hiroo Ueno, MD PhD, Hidehiro Itonaga, MD PhD, Yoshinobu Kanda, MD PhD, Masashi Sanada, MD, Ayana Kon, MD PhD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Maria Creignou, Magnus Tobiasson, MD, Hisashi Tsurumi, MD PhD, Senji Kasahara, MD PhD, Chantana Polprasert, MD, Eva Hellstrom Lindberg, MD PhD, Akifumi Kondo Takaori, MD PhD, Toru Kiguchi, MD PhD, Mario Cazzola, MD, Fumihiko Matsuda, MD PhD, Kazuma Ohyashiki, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Torsten Haferlach, MD, Yoichiro Kamatani, MDPhD, Michiaki Kubo, MDPhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD

Blood (2020) 136 (Supplement 1): 38–40.

https://doi.org/10.1182/blood-2020-140174

Published: 2020

Journal Articles

Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic Myeloid Leukemia

Blood (2020) 136 (Supplement 1): 3–4.

https://doi.org/10.1182/blood-2020-140629

Published: 2020

Journal Articles

Analysis of Clonal Evolution of AML Using Simultaneous Single-Cell DNA/RNA Analysis

Ryosaku Inagaki, MSc, Masahiro Marshall Nakagawa, MDPhD, Yasuhito Nannya, MD PhD, Qi Xingxing, PhD, Lanying Zhao, MD, PhD, June Takeda, MD, Akinori Yoda, PhD, Ayana Kon, MD PhD, Hisashi Tsurumi, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-143320

Published: 2020

Journal Articles

Post-Treatment Clone Size Predicts Survival Independently of IPSS-R and Response after Azacitidine Therapy for MDS.

Blood (2020) 136 (Supplement 1): 12–13.

https://doi.org/10.1182/blood-2020-139082

Published: 2020

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Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Clonal evolution and therapeutic vulnerabilities in SETBP1-mutated leukemia: Insights from physiological mouse model and integrative functional screens

Targeting metabolic vulnerabilities in Acute Myeloid Leukemia: Therapeutic potential of l-asparaginase and synergy with venetoclax

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single-Cell Multi-Omics Sequencing

Prognostic Impact of Chromosomal Abnormalities in TP53 -Mutated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Identification of Novel Transcripts and Potential Therapeutic Targets for Acute Leukemia

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

CTX-712, a Novel Splicing Modulator Targeting Myeloid Neoplasms

Der(1;7)(q10;p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic Myeloid Leukemia

Analysis of Clonal Evolution of AML Using Simultaneous Single-Cell DNA/RNA Analysis

Post-Treatment Clone Size Predicts Survival Independently of IPSS-R and Response after Azacitidine Therapy for MDS.

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American Society of Hematology

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