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Kosuke Yusa
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Journal Articles

Inhibition of p300/CBP Overcomes BTK Inhibitor Resistance in MCL By Counteracting IL-6/JAK/STAT3 Signaling

Yusuke Tashiro, Kotaro Shirakawa, Hiroshi Arima, Ryosuke Nomura, Yoshihito Horisawa, Stanford Emani, Suguru Takeuchi, Jelagat Caroline, Yasuhiro Kazuma, Hiroyuki Matsui, Tadahiko Matsumoto, Kosuke Yusa, Akifumi Takaori-Kondo
Journal: Blood
Blood (2024) 144 (Supplement 1): 5843.
https://doi.org/10.1182/blood-2024-206382
Published: 2024
Journal Articles

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia

Kazunari Aoki, Mizuki Hyuga, Yusuke Tarumoto, Gohei Nishibuchi, Atsushi Ueda, Yotaro Ochi, Seiichi Sugino, Takashi Mikami, Hirokazu Kobushi, Itaru Kato, Koshi Akahane, Takeshi Inukai, Akifumi Takaori-Kondo, Junko Takita, Seishi Ogawa, Kosuke Yusa
Journal: Blood
Blood (2024) 143 (7): 604–618.
https://doi.org/10.1182/blood.2023020857
Published: 2024
Includes: Supplemental data
Journal Articles

CNOT4 Knockout Induces Proteasome Inhibitor Resistance in Multiple Myeloma Cells

Yoshihito Horisawa, Kotaro Shirakawa, Suguru Takeuchi, Ryosuke Nomura, Yusuke Tashiro, Stanford Emani, Jelagat Caroline, Yasuhiro Kazuma, Kosuke Yusa, Akifumi Takaori-Kondo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1444.
https://doi.org/10.1182/blood-2023-185862
Published: 2023
Journal Articles

Inhibition of Lysine Acetyltransferases p300/CBP Overcomes BTK Inhibitor Resistance in Mantle Cell Lymphoma Cells

Yusuke Tashiro, Kotaro Shirakawa, Ryosuke Nomura, Yoshihito Horisawa, Stanford Emani, Suguru Takeuchi, Jelagat Caroline, Yasuhiro Kazuma, Kosuke Yusa, Akifumi Takaori-Kondo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2816.
https://doi.org/10.1182/blood-2023-179993
Published: 2023
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

SRPK1 Is a Therapeutic Vulnerability in Acute Myeloid Leukemia through Its Effects on Alternative Isoforms of Epigenetic Regulators Including BRD4

Konstantinos Tzelepis, PhD, Etienne De Braekeleer, PhD, Isaia Barbieri, PhD, Vijay Baskar, PhD, Demetrios Aspris, MSc, Francisco Hermida Prado, PhD, Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Hannes Postingl, PhD, David Bates, PhD, Andrew Bannister, PhD, Brian J.P Huntly, Cristina Pina, MDDPhil, Allan Bradley, PhD, Kosuke Yusa, PhD, Tony Kouzarides, PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 781.
https://doi.org/10.1182/blood.V130.Suppl_1.781.781
Published: 2017
Journal Articles

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1 -mutant acute myeloid leukemia

Oliver M. Dovey, Jonathan L. Cooper, Annalisa Mupo, Carolyn S. Grove, Claire Lynn, Nathalie Conte, Robert M. Andrews, Suruchi Pacharne, Konstantinos Tzelepis, M. S. Vijayabaskar, Paul Green, Roland Rad, Mark Arends, Penny Wright, Kosuke Yusa, Allan Bradley, Ignacio Varela, George S. Vassiliou
Journal: Blood
Blood (2017) 130 (17): 1911–1922.
https://doi.org/10.1182/blood-2017-01-760595
Published: 2017
Includes: Supplemental data
Journal Articles

A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

Konstantinos Tzelepis, MSc, Hiroko Koike-Yusa, MD, Etienne De Braekeleer, PhD, Yilong Li, Emmanouil Metzakopian, PhD, Oliver M. Dovey, PhD, Annalisa Mupo, PhD, Vera Grinkevich, PhD, Milena M. Mazan, PhD, Malgorzata Gozdecka, PhD, Jonathan L. Cooper, Miten Patel, MD, Thomas David Hardman McKerrell, MD, Bin Chen, Hannes Ponstingl, PhD, Brian J.P Huntly, MD PhD, Ultan McDermott, MD PhD, Julio Saez-Rodriguez, PhD, Francesco Iorio, PhD, Kosuke Yusa, PhD, George S. Vassiliou, MD PhD
Journal: Blood
Blood (2015) 126 (23): 554.
https://doi.org/10.1182/blood.V126.23.554.554
Published: 2015
Journal Articles

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation

Anastasia Nijnik, Simon Clare, Christine Hale, Claire Raisen, Rebecca E. McIntyre, Kosuke Yusa, Aaron R. Everitt, Lynda Mottram, Christine Podrini, Mark Lucas, Jeanne Estabel, David Goulding, Sanger Institute Microarray Facility, Sanger Mouse Genetics Project, Niels Adams, Ramiro Ramirez-Solis, Jacqui K. White, David J. Adams, Robert E. W. Hancock, Gordon Dougan
Journal: Blood
Blood (2012) 119 (6): 1370–1379.
https://doi.org/10.1182/blood-2011-05-352666
Published: 2012
Includes: Supplemental data