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Journal Articles

Clonal evolution and therapeutic vulnerabilities in SETBP1-mutated leukemia: Insights from physiological mouse model and integrative functional screens

Free
Wataru Saika, Koutarou Nishimura, Atsushi Tanaka, June Takeda, Ayana Kon, Akinori Yoda, Kazunari Aoki, Masaki Nomura, Yui Koike, Hiromi Yamazaki, Seigi Oshima, Shinri Okada, Daichi Morii, Weijia Zang, Takaya Yamasaki, Hiromi Ito, Manabu Nakayama, Hiromi Tatsumi, Masashi Matsuda, Chien-Chin Lin, Kosuke Yusa, Haruhiko Koseki, Makoto Murata, Seishi Ogawa, Daichi Inoue
Journal: Blood
Blood (2025) 146 (Supplement 1): 989.
https://doi.org/10.1182/blood-2025-989
Published: 2025
Journal Articles

Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis

Free
Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Masanori Motomura, Ryunosuke Saiki, Yotaro Ochi, Ayana Kon, Lanying Zhao, Koji Okazaki, Xingxing Qi, Akinori Yoda, Nobuyuki Kakiuchi, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 632.
https://doi.org/10.1182/blood-2025-632
Published: 2025
Journal Articles

Transcriptional and splicing dysregulation by U2AF1 mutations contribute to inflammatory and migratory alterations in MDS

Free
Yuki Hodo, Azumi Tomita, Xingxing Qi, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa, Ayana Kon
Journal: Blood
Blood (2025) 146 (Supplement 1): 5018.
https://doi.org/10.1182/blood-2025-5018
Published: 2025
Journal Articles

Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML

Free
Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzen, Benedicte Piauger, Stefan Deneberg, Martin Jadersten, Vladimir Lazarevic, Jörg Cammenga, Anna Robelius, Lovisa Wennström, Emma Olander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Yu Watanabe, Masanori Motomura, Masahiro Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Suguru Morimoto, Akinori Yoda, Rurika Okuda, Shintaro Komatsu, Guoxiang Xie, Albin Osterroos, Ayana Kon, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Shuichi Matsuda, Akifumi Takaori-Kondo, Hiroyuki Aburatani, Hiroshi Suzuki, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Soren Lehmann, Seishi Ogawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 5005.
https://doi.org/10.1182/blood-2025-5005
Published: 2025
Journal Articles

Impacts of Monoallelic and Biallelic DDX41 Mutations on Hematopoiesis and the Development of Myeloid Malignancies

Free
Ayana Kon, Masahiro M Nakagawa, Azumi Tomita, Keisuke Kataoka, Nobuyuki Kakiuchi, Manabu Nakayama, Haruhiko Koseki, Hideki Makishima, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 4116.
https://doi.org/10.1182/blood-2024-209922
Published: 2024
Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single-Cell Multi-Omics Sequencing

Free
Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Ayana Kon, Masanori Motomura, Yotaro Ochi, Lanying Zhao, Koji Okazaki, June Takeda, Xingxing Qi, Akinori Yoda, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 5630.
https://doi.org/10.1182/blood-2024-210050
Published: 2024
Journal Articles

Pathogenic Mechanisms of DDX41 Mutations in the Development of Myeloid Malignancies

Free
Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Nobuyuki Kakiuchi, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 952.
https://doi.org/10.1182/blood-2023-184519
Published: 2023
Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Free
Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2023) 141 (5): 534–549.
https://doi.org/10.1182/blood.2022018221
Published: 2023
Includes: Supplemental data
Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Free
Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 2881–2882.
https://doi.org/10.1182/blood-2022-168149
Published: 2022
Journal Articles

Expression of Gata1s Followed By Stag2 Deficiency Promotes Abnormal Megakaryocytopoiesis and Induces Lethal Myelofibrosis

Free
Yutaro Suzuki, Yaeko Nakajima-Takagi, Shuhei Kurosawa, Ola Rizq, Ayana Kon, Etsuro Ito, Seishi Ogawa, Atsushi Iwama
Journal: Blood
Blood (2022) 140 (Supplement 1): 6726–6727.
https://doi.org/10.1182/blood-2022-156543
Published: 2022
Journal Articles

Cooperative Effects of SRSF2 and STAG2 mutations on Development of Myelodysplastic Syndrome and Its Related Disorders

Free
Takuto Mori, Yotaro Ochi, Ayana Kon, Tetsuichi Yoshizato, Haruhiko Koseki, Manabu Nakayama, Akinori Yoda, Masahiro Marshall Nakagawa, June Takeda, Ryunosuke Saiki, Rurika Okuda, Yasunobu Nagata, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Akifumi Takaori-Kondo, Jaroslaw P. Maciejewski, Yoshiko Atsuta, Torsten Haferlach, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 4022–4023.
https://doi.org/10.1182/blood-2022-158748
Published: 2022
Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Free
Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 208–210.
https://doi.org/10.1182/blood-2022-158851
Published: 2022
Journal Articles

Der(1;7)(q10;p10) Presents with a Unique Genetic Profile and Frequent ETNK1 Mutations in Myeloid Neoplasms

Free
Rurika Okuda, Yasuhito Nannya, Yotaro Ochi, Maria Creignou, Hideki Makishima, Tetsuichi Yoshizato, Yasunobu Nagata, June Takeda, Kenichi Yoshida, Masashi Sanada, Ayana Kon, Yuichi Shiraishi, Satoru Miyano, Wolfgang Kern, Constance Baer, Niroshan Nadarajah, Claudia Haferlach, Yoshiko Atsuta, Senji Kasahara, Hiroshi Handa, Shigeru Chiba, Kazuma Ohyashiki, Torsten Haferlach, Eva Hellstrom Lindberg, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 1513.
https://doi.org/10.1182/blood-2021-149556
Published: 2021
Journal Articles

Functional Roles of DDX41 Mutations in the Development of Myeloid Malignancies

Free
Ayana Kon, Masahiro Marshall Nakagawa, Keisuke Kataoka, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 150.
https://doi.org/10.1182/blood-2021-152269
Published: 2021
Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Free
Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Journal: Blood
Blood (2021) 138 (Supplement 1): 1092.
https://doi.org/10.1182/blood-2021-152219
Published: 2021
Journal Articles

Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Free
Hideki Makishima, MD PhD, Yasuhito Nannya, MD PhD, June Takeda, MD, Yukihide Momozawa, DVM,PhD, Ryunosuke Saiki, MD, Tetsuichi Yoshizato, MD PhD, Yoshiko Atsuta, MD PhD, Yuka Iijima-Yamashita, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD PhD, Yusuke Shiozawa, MD PhD, Makoto Onizuka, MD PhD, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, MD, Yotaro Ochi, MD, Hiroo Ueno, MD PhD, Hidehiro Itonaga, MD PhD, Yoshinobu Kanda, MD PhD, Masashi Sanada, MD, Ayana Kon, MD PhD, Yasushi Miyazaki, MD PhD, Keizo Horibe, MD PhD, Maria Creignou, Magnus Tobiasson, MD, Hisashi Tsurumi, MD PhD, Senji Kasahara, MD PhD, Chantana Polprasert, MD, Eva Hellstrom Lindberg, MD PhD, Akifumi Kondo Takaori, MD PhD, Toru Kiguchi, MD PhD, Mario Cazzola, MD, Fumihiko Matsuda, MD PhD, Kazuma Ohyashiki, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Torsten Haferlach, MD, Yoichiro Kamatani, MDPhD, Michiaki Kubo, MDPhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–40.
https://doi.org/10.1182/blood-2020-140174
Published: 2020
Journal Articles

Analysis of Clonal Evolution of AML Using Simultaneous Single-Cell DNA/RNA Analysis

Free
Ryosaku Inagaki, MSc, Masahiro Marshall Nakagawa, MDPhD, Yasuhito Nannya, MD PhD, Qi Xingxing, PhD, Lanying Zhao, MD, PhD, June Takeda, MD, Akinori Yoda, PhD, Ayana Kon, MD PhD, Hisashi Tsurumi, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-143320
Published: 2020
Journal Articles

Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies

Free
Ayana Kon, MD PhD, Masahiro Marshall Nakagawa, MDPhD, Ryosaku Inagaki, MSc, Keisuke Kataoka, MD PhD, Hideki Makishima, MD PhD, Yotaro Ochi, MD, Manabu Nakayama, PhD, Haruhiko Koseki, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-143318
Published: 2020
Journal Articles

Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia

Free
June Takeda, MD, Kenichi Yoshida, MDPhD, Akinori Yoda, PhD, Lee-Yung Shih, MD, Yasuhito Nannya, MD PhD, Yotaro Ochi, MD, Ayana Kon, MD PhD, Kenichi Chiba, Yuichi Shiraishi, PhD, Yusuke Shiozawa, MD PhD, Tetsuichi Yoshizato, MD PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Toshiyuki Kitano, MD PhD, Akira Hangaishi, MD PhD, Ken Ishiyama, MD PhD, Hisashi Tsurumi, MD PhD, Yasushi Miyazaki, MD PhD, Nobuhiro Hiramoto, MD, Takayuki Ishikawa, MD PhD, Masahiro Marshall Nakagawa, MDPhD, Akifumi Takaori-Kondo, MD PhD, Shigeru Chiba, MD PhD, Hideyuki Nakazawa, MD PhD, Ming-Chung Kuo, MD, Keisuke Kataoka, MD PhD, Ryunosuke Saiki, MD, Hiroko Tanaka, Kensuke Usuki, MD PhD, Shuichi Miyawaki, MD PhD, Satoru Miyano, PhD, Jaroslaw P. Maciejewski, MD PhD, Arnold Ganser, Michael Heuser, Prof., MD, Felicitas Thol, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-141750
Published: 2020
Journal Articles

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Free
Masahiro Marshall Nakagawa, MDPhD, Ryosaku Inagaki, MSc, Yutaka Kuroda, MD, PhD, Yasuhito Nannya, MD PhD, Lanying Zhao, MD, PhD, Yotaro Ochi, MD, June Takeda, MD, Qi Xingxing, PhD, Akinori Yoda, PhD, Ayana Kon, MD PhD, Nobuyuki Kakiuchi, MD, Hideki Makishima, MD PhD, Shuichi Matsuda, MD, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-142157
Published: 2020