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Akihiko Yokoyama
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Journal Articles

Metabolic Reprogramming By PRDM16 Drives Cytarabine Resistance in Acute Myeloid Leukemia

Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Takayuki Kurosawa, Masanobu Takeuchi, Ayaka Miura, Koichi Murakami, Ikuma Kato, Takako Hishiki, Noriyo Hayakawa, Tomomi Matsuura, Megumi Funakoshi-Tago, Akihiko Yokoyama, Kenichi Yoshida, Daisuke Tomizawa, Satoru Miyano, Akio Tawa, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi, Norio Shiba, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima
Journal: Blood
Blood (2023) 142 (Supplement 1): 2740.
https://doi.org/10.1182/blood-2023-181740
Published: 2023
Journal Articles

Aberrant EVI1 splicing contributes to EVI1 -rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Journal: Blood
Blood (2022) 140 (8): 875–888.
https://doi.org/10.1182/blood.2021015325
Published: 2022
Includes: Supplemental data
Journal Articles

Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL -Rearrangement or NPM1 Mutation

Ken Eguchi, Takafumi Shimizu, Daiki Kato, Yudai Furuta, Seiji Kamioka, Hitoshi Ban, Setsuko Ymamoto, Akihiko Yokoyama, Issay Kitabayashi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3339.
https://doi.org/10.1182/blood-2021-152050
Published: 2021
Journal Articles

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P. Maciejewski, Toshio Kitamura
Journal: Blood
Blood (2020) 136 (14): 1670–1684.
https://doi.org/10.1182/blood.2019004613
Published: 2020
Includes: Supplemental data
Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Reina Takeda, MD, Shuhei Asada, MD PhD, Sung-Joon Park, PhD, Akihiko Yokoyama, PhD, Akinori Kanai, PhD, Valeria Visconte, PhD, Courtney Hershberger, BS, Yasutaka Hayashi, MD PhD, Taishi Yonezawa, MSc, Moe Tamura, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, PhD, Kenta Nakai, PhD, Toshiya Inaba, MD PhD, Tatsuhiro Shibata, MD PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Susumu Goyama, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2525.
https://doi.org/10.1182/blood-2019-126663
Published: 2019
Journal Articles

Successful MPB Therapy Followed By Bortezomib Maintenance for Non-Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma: Japanese Phase 2 Study - Broad-J Study

Michihide Tokuhira, MD, Naoki Takezako, MD PhD, Yoichi Imai, MD PhD, Tadao Ishida, MD, Tomonori Nakazato, MD PhD, Kinuko Mitani, MD, PhD, Tohru Ikuta, MDPhD, Morio Matsumoto, MD, Takayuki Ikezoe, MD, PhD, Jun Taguchi, MD PhD, Kensuke Usuki, MD PhD, Takeshi Shimomura, MD, Kenkou Chin, MD, Shunya Arai, MD PhD, Kazuma Ohyashiki, MD, Miho Nara, MD, Kenji Kishi, MD, Yoshiaki Kuroda, MD, Yuichi Nakamura, MD, Hisashi Wakita, MD PhD, Makoto Sasaki, MD PhD, Hirotoshi Kamata, MD, Yoshikazu Ichikawa, MD, Akihiko Yokoyama, MD, Kenshi Suzuki, Masahiro Kizaki, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5432.
https://doi.org/10.1182/blood.V130.Suppl_1.5432.5432
Published: 2017
Journal Articles

The Role of MLL1 and MLL2 in MLL Fusion Oncoprotein-Initiated Leukemia

Patricia Ernst, PhD, Konstantinos Anastassiadis, PhD, Andrea Kranz, PhD, A. Francis Stewart, PhD, Kathrin Arndt, PhD, Claudia Waskow, PhD, Akihiko Yokoyama, PhD, Kenneth Jones, PhD, Tobias Neff, MD, Yufei Chen
Journal: Blood
Blood (2016) 128 (22): 573.
https://doi.org/10.1182/blood.V128.22.573.573
Published: 2016
Journal Articles

The Molecular Mechanism of Transcriptional Activation By MLL-AEP Fusion Proteins

Akihiko Yokoyama, PhD, Hiroshi Okuda, PhD
Journal: Blood
Blood (2015) 126 (23): 2435.
https://doi.org/10.1182/blood.V126.23.2435.2435
Published: 2015
Journal Articles

The Roles of MLL Holocomplex in Embryogenesis, Hematopoiesis and Tumor Suppression.

Akihiko Yokoyama, PhD, Francesca Ficara, PhD, Issay Kitabayashi, PhD, Michael L. Cleary, MD
Journal: Blood
Blood (2009) 114 (22): 2969.
https://doi.org/10.1182/blood.V114.22.2969.2969
Published: 2009
Journal Articles

The Menin Tumor Suppressor Functions as a Molecular Adapter That Tethers LEDGF to MLL Proteins in Leukemogenesis.

Akihiko Yokoyama, PhD, Michael Cleary, MD
Journal: Blood
Blood (2008) 112 (11): 1795.
https://doi.org/10.1182/blood.V112.11.1795.1795
Published: 2008
Journal Articles

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis.

Akihiko Yokoyama, PhD, Tim Somervaille, MD, PhD, Michael L. Cleary, MD
Journal: Blood
Blood (2005) 106 (11): 665.
https://doi.org/10.1182/blood.V106.11.665.665
Published: 2005
Journal Articles

Leukemia Proto-Oncoprotein MLL Forms a SET1 like Complex with Menin to Regulate Hox Gene Expression.

Akihiko Yokoyama, Ph.D, Zhong Wang, Ph.D, Joanna Wysocka, Ph.D, Mrinmoy Sanyal, Ph.D, Deborah J. Aufiero, Issay Kitabayashi, Ph.D, Winship Herr, Ph.D, Michael L. Cleary, M.D
Journal: Blood
Blood (2004) 104 (11): 2550.
https://doi.org/10.1182/blood.V104.11.2550.2550
Published: 2004
Journal Articles

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

Akihiko Yokoyama, Issay Kitabayashi, Paul M. Ayton, Michael L. Cleary, Misao Ohki
Journal: Blood
Blood (2002) 100 (10): 3710–3718.
https://doi.org/10.1182/blood-2002-04-1015
Published: 2002