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Ruud Delwel
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Journal Articles

Targeting Super-Enhancers Driving EVI1 Expression in Leukemia By Inhibition of p300/CBP

Dorien Pastoors, Claudia Erpelinck, Stanley Van Herk, Roger Mulet-Lazaro, Marije Havermans, Eric Bindels, Sophie Ottema, Ruud Delwel
Journal: Blood
Blood (2023) 142 (Supplement 1): 710.
https://doi.org/10.1182/blood-2023-181741
Published: 2023
Journal Articles

EVI1 drives leukemogenesis through aberrant ERG activation

Johannes Schmoellerl, Inês A.M. Barbosa, Martina Minnich, Florian Andersch, Leonie Smeenk, Marije Havermans, Thomas Eder, Tobias Neumann, Julian Jude, Michaela Fellner, Anja Ebert, Monika Steininger, Ruud Delwel, Florian Grebien, Johannes Zuber
Journal: Blood
Blood (2023) 141 (5): 453–466.
https://doi.org/10.1182/blood.2022016592
Published: 2023
Includes: Supplemental data
Journal Articles

Oncogene EVI1 Drives Acute Myeloid Leukemia Via a Targetable EVI1-CtBP1/2 Interaction and By Repressing Myeloid Regulator CEBPA

Dorien Pastoors, Marije Havermans, Remco Hoogenboezem, Roger Mulet-Lazaro, Duncan Brian, Leonie Smeenk, Claudia Erpelinck-Verschueren, Stanley van Herk, Bas Wouters, Jeroen A.A. Demmers, Johannes Zuber, Tariq Enver, Richard WJ Groen, Eric Bindels, Ruud Delwel
Journal: Blood
Blood (2022) 140 (Supplement 1): 83–84.
https://doi.org/10.1182/blood-2022-156994
Published: 2022
Journal Articles

Cohesin-STAG2 Mutations Alter Chromatin Structure and Gene Regulation in Human Acute Myeloid Leukemia

Alexander Fischer, Roger Mulet-Lazaro, Margit Nützel, Stanley van Herk, Hanna Stanewsky, Ute Ackermann, Edith Reuschel, Nicholas Strieder, Inmaculada Hernandez-Lopez, Wolfgang Herr, Peter J.M. Valk, Michael Rehli, Ruud Delwel, Claudia Gebhard
Journal: Blood
Blood (2022) 140 (Supplement 1): 3379–3380.
https://doi.org/10.1182/blood-2022-162219
Published: 2022
Journal Articles

Aberrant EVI1 splicing contributes to EVI1 -rearranged leukemia

Atsushi Tanaka, Taizo A. Nakano, Masaki Nomura, Hiromi Yamazaki, Jan P. Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C. Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue
Journal: Blood
Blood (2022) 140 (8): 875–888.
https://doi.org/10.1182/blood.2021015325
Published: 2022
Includes: Supplemental data
Journal Articles

The CBFβ-SMMHC/NRP1 Axis Regulates FLT3 and TGF-Beta Pathways in Inv(16) Acute Myeloid Leukemia

Mahesh Hegde, Mohd Hafiz Ahmad, Rui Li, Anneliese Carrascoso, Roger Mulet-Lazaro, Ruud Delwel, John H. Bushweller, Monica L. Guzman, Scot A. Wolfe, Julie Zhu, Lucio H. Castilla
Journal: Blood
Blood (2021) 138 (Supplement 1): 3314.
https://doi.org/10.1182/blood-2021-153275
Published: 2021
Journal Articles

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Roger Mulet-Lazaro, Stanley van Herk, Claudia Erpelinck, Eric Bindels, Mathijs A. Sanders, Carlo Vermeulen, Ivo Renkens, Peter Valk, Ari M. Melnick, Jeroen de Ridder, Michael Rehli, Claudia Gebhard, Ruud Delwel, Bas J. Wouters
Journal: Blood
Blood (2021) 138 (2): 160–177.
https://doi.org/10.1182/blood.2020009244
Published: 2021
Includes: Supplemental data
Journal Articles

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Kimihito C. Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J. Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J. Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E. Mason, Ari Melnick, Monica L. Guzman
Journal: Blood
Blood (2021) 137 (6): 812–825.
https://doi.org/10.1182/blood.2019001745
Published: 2021
Includes: Supplemental data
Journal Articles

Core Binding Factor Leukemias Utilize a Physiologic Sense/Antisense Promoter Switch Employed By T-Cells

Emiel van der Kouwe, PharmD, Gerwin Heller, PhD, Akos Czibere, MD, Lucio H. Castilla, PhD, Ruud Delwel, PhD, Annalisa Di Ruscio, MD PhD, Alexander Ebralidze, PhD, Maurizio Forte, MSc, Lukas Kazianka, MD, Christoph Kornauth, Trang Le, BSc, Karin Lind, MSc, Ines Barbosa, PhD, Alexander Pichler, MD, John Pulikkan, PhD, Ann-Sofie Schmolke, MD, Heinz Sill, MD, Wolfgang R. Sperr, MD, Andreas Spittler, MD, Bon Q. Trinh, PhD, Peter Valent, MD, Katrina Vanura, PhD, Robert Welner, PhD, Johannes Zuber, PhD, Daniel G. Tenen, MD, Philipp B. Staber, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-140776
Published: 2020
Journal Articles

Atypical 3q26/ MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia

Sophie Ottema, Roger Mulet-Lazaro, H. Berna Beverloo, Claudia Erpelinck, Stanley van Herk, Robert van der Helm, Marije Havermans, Tim Grob, Peter J. M. Valk, Eric Bindels, Torsten Haferlach, Claudia Haferlach, Leonie Smeenk, Ruud Delwel
Journal: Blood
Blood (2020) 136 (2): 224–234.
https://doi.org/10.1182/blood.2019003701
Published: 2020
Includes: Supplemental data
Journal Articles

Allele-Specific Expression of GATA2 in AML with CEBPA Biallelic Mutations

Roger Mulet-Lazaro, MSc, Stanley van Herk, B.Sc., Claudia Erpelinck-Verschueren, B.Sc., Mathijs A. Sanders, PhD MSc, Eric Bindels, PhD, Peter Valk, PhD, Michael Rehli, PhD, Claudia Gebhard, PhD, Ruud Delwel, PhD, B.J. Wouters
Journal: Blood
Blood (2019) 134 (Supplement_1): 1235.
https://doi.org/10.1182/blood-2019-129766
Published: 2019
Journal Articles

Temporal autoregulation during human PU.1 locus SubTAD formation

Daniel Schuetzmann, Carolin Walter, Boet van Riel, Sabrina Kruse, Thorsten König, Tabea Erdmann, Alexander Tönges, Eric Bindels, Andre Weilemann, Claudia Gebhard, Klaus Wethmar, Chiara Perrod, Julia Minderjahn, Michael Rehli, Ruud Delwel, Georg Lenz, Stefan Gröschel, Martin Dugas, Frank Rosenbauer
Journal: Blood
Blood (2018) 132 (25): 2643–2655.
https://doi.org/10.1182/blood-2018-02-834721
Published: 2018
Includes: Supplemental data
Journal Articles

Integrated Analysis of Global DNA Methylation and Transcription Reveals a Leukemia Subtype with Extreme Hypermethylation Associated with Silencing of Regulators of Differentiation

Claudia Gebhard, PhD, Roger Mulet-Lazaro, B.Sc., Lucia Schwarzfischer, Dagmar Glatz, Margit Nuetzel, Daniel Heudobler, MD, Sandra Pohl, Wolfgang Herr, MD, Gerhard Ehninger, MD, Claudia Erpelinck-Verschueren, B.Sc., Stanley van Herk, B.Sc., B.J. Wouters, Christian Thiede, MD, Ruud Delwel, PhD, Michael Rehli, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2608.
https://doi.org/10.1182/blood-2018-99-118521
Published: 2018
Journal Articles

Complex 3q26/EVI1 Rearrangements Genocopy Inv(3)/t(3;3) Acute Myeloid Leukemias By Enhancer Hijacking, EVI1 Overexpression, Absent MDS1-EVI1 and Low GATA2 Expression

Sophie Ottema, MSc, Roger Mulet-Lazaro, B.Sc., Berna Beverloo, PhD, Marije Havermans, Ir, Claudia Erpelinck-Verschueren, B.Sc., Tim Grob, MD, Peter Valk, PhD, Eric Bindels, PhD, Torsten Haferlach, MD, Claudia Haferlach, MD, Leonie Smeenk, PhD, Ruud Delwel, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2766.
https://doi.org/10.1182/blood-2018-99-113339
Published: 2018
Journal Articles

Puzzling pieces of chromosome 7 loss or deletion

Rebekka K. Schneider, Ruud Delwel
Journal: Blood
Blood (2018) 131 (26): 2871–2872.
https://doi.org/10.1182/blood-2018-04-844746
Published: 2018
Journal Articles

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Sheng Li, PhD, Xiaowen Chen, PhD, Jihui Wang, MS, Cem Meydan, PhD, Jacob L Glass, MDPhD, Alan H. Shih, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 243.
https://doi.org/10.1182/blood.V130.Suppl_1.243.243
Published: 2017
Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1208.
https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208
Published: 2017
Journal Articles

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation

Roberto Avellino, Ruud Delwel
Journal: Blood
Blood (2017) 129 (15): 2083–2091.
https://doi.org/10.1182/blood-2016-09-687822
Published: 2017
Journal Articles

An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs A. Sanders, Remco Hoogenboezem, Harmen J. G. van de Werken, Elwin Rombouts, Kirsten van Lom, Paulina M. H. van Strien, Claudia Gebhard, Michael Rehli, John Pimanda, Dominik Beck, Stefan Erkeland, Thijs Kuiken, Hans de Looper, Stefan Gröschel, Ivo Touw, Eric Bindels, Ruud Delwel
Journal: Blood
Blood (2016) 127 (24): 2991–3003.
https://doi.org/10.1182/blood-2016-01-695759
Published: 2016
Includes: Supplemental data
Journal Articles

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

Clinical Trials & Observations
Bas J. Wouters, Ruud Delwel
Journal: Blood
Blood (2016) 127 (1): 42–52.
https://doi.org/10.1182/blood-2015-07-604512
Published: 2016